WO2006065975A3 - Methods of treating ankylosing spondylitis using anti-tnf antibodies and peptides of human tumor necrosis factor - Google Patents

Methods of treating ankylosing spondylitis using anti-tnf antibodies and peptides of human tumor necrosis factor Download PDF

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Publication number
WO2006065975A3
WO2006065975A3 PCT/US2005/045388 US2005045388W WO2006065975A3 WO 2006065975 A3 WO2006065975 A3 WO 2006065975A3 US 2005045388 W US2005045388 W US 2005045388W WO 2006065975 A3 WO2006065975 A3 WO 2006065975A3
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WO
WIPO (PCT)
Prior art keywords
methods
necrosis factor
tumor necrosis
human tumor
ankylosing spondylitis
Prior art date
Application number
PCT/US2005/045388
Other languages
French (fr)
Other versions
WO2006065975A8 (en
WO2006065975A2 (en
WO2006065975B1 (en
Inventor
Junming Le
Jan T Vilcek
Peter E Daddona
John Ghrayeb
David M Knight
Scott A Siegel
David Shealey
Original Assignee
Centocor Inc
Univ New York
Junming Le
Jan T Vilcek
Peter E Daddona
John Ghrayeb
David M Knight
Scott A Siegel
David Shealey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Inc, Univ New York, Junming Le, Jan T Vilcek, Peter E Daddona, John Ghrayeb, David M Knight, Scott A Siegel, David Shealey filed Critical Centocor Inc
Priority to US11/792,734 priority Critical patent/US20090041762A1/en
Publication of WO2006065975A2 publication Critical patent/WO2006065975A2/en
Publication of WO2006065975A3 publication Critical patent/WO2006065975A3/en
Publication of WO2006065975B1 publication Critical patent/WO2006065975B1/en
Publication of WO2006065975A8 publication Critical patent/WO2006065975A8/en
Priority to US12/885,406 priority patent/US20110195063A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, including ankylosing spondylitis, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
PCT/US2005/045388 2000-08-07 2005-12-13 Methods of treating ankylosing spondylitis using anti-tnf antibodies and peptides of human tumor necrosis factor WO2006065975A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US11/792,734 US20090041762A1 (en) 2004-12-13 2005-12-13 Methods of treating ankylosing spondylitis using anti-TNF antibodies and peptides of human tumor necrosis factor
US12/885,406 US20110195063A1 (en) 2000-08-07 2010-09-17 Methods of Treating Ankylosing Spondylitis Using Anti-TNF Antibodies and Peptides of Human Tumor Necrosis Factor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/010,954 US20050249735A1 (en) 2000-08-07 2004-12-13 Methods of treating ankylosing spondylitis using anti-TNF antibodies and peptides of human tumor necrosis factor
US11/010,954 2004-12-13

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US11/010,954 Continuation US20050249735A1 (en) 2000-08-07 2004-12-13 Methods of treating ankylosing spondylitis using anti-TNF antibodies and peptides of human tumor necrosis factor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/885,406 Continuation US20110195063A1 (en) 2000-08-07 2010-09-17 Methods of Treating Ankylosing Spondylitis Using Anti-TNF Antibodies and Peptides of Human Tumor Necrosis Factor

Publications (4)

Publication Number Publication Date
WO2006065975A2 WO2006065975A2 (en) 2006-06-22
WO2006065975A3 true WO2006065975A3 (en) 2006-08-31
WO2006065975B1 WO2006065975B1 (en) 2006-10-19
WO2006065975A8 WO2006065975A8 (en) 2007-02-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/045388 WO2006065975A2 (en) 2000-08-07 2005-12-13 Methods of treating ankylosing spondylitis using anti-tnf antibodies and peptides of human tumor necrosis factor

Country Status (2)

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US (2) US20050249735A1 (en)
WO (1) WO2006065975A2 (en)

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WO2006065975A8 (en) 2007-02-08
US20080025976A1 (en) 2008-01-31
US20050249735A1 (en) 2005-11-10
WO2006065975A2 (en) 2006-06-22
WO2006065975B1 (en) 2006-10-19

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