WO2006073484A3 - Treating inflammatory disorders by electrical vagus nerve stimulation - Google Patents

Treating inflammatory disorders by electrical vagus nerve stimulation Download PDF

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Publication number
WO2006073484A3
WO2006073484A3 PCT/US2005/022409 US2005022409W WO2006073484A3 WO 2006073484 A3 WO2006073484 A3 WO 2006073484A3 US 2005022409 W US2005022409 W US 2005022409W WO 2006073484 A3 WO2006073484 A3 WO 2006073484A3
Authority
WO
WIPO (PCT)
Prior art keywords
vagus nerve
nerve stimulation
inflammatory disorders
treating inflammatory
electrical vagus
Prior art date
Application number
PCT/US2005/022409
Other languages
French (fr)
Other versions
WO2006073484A2 (en
Inventor
Jared M Huston
Kevin J Tracey
Original Assignee
Long Island Jewish Res Inst
Jared M Huston
Kevin J Tracey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Long Island Jewish Res Inst, Jared M Huston, Kevin J Tracey filed Critical Long Island Jewish Res Inst
Priority to AU2005323463A priority Critical patent/AU2005323463B2/en
Priority to CN200580048379.2A priority patent/CN101124012B/en
Priority to EP05856845A priority patent/EP1833559B1/en
Priority to DE602005025020T priority patent/DE602005025020D1/en
Priority to CA2593079A priority patent/CA2593079C/en
Priority to JP2007548183A priority patent/JP2008525102A/en
Priority to AT05856845T priority patent/ATE489132T1/en
Publication of WO2006073484A2 publication Critical patent/WO2006073484A2/en
Publication of WO2006073484A3 publication Critical patent/WO2006073484A3/en
Priority to HK08108040.5A priority patent/HK1112432A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36053—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for vagal stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36114—Cardiac control, e.g. by vagal stimulation

Abstract

A method and an apparatus for treating a patient suffering from, or at risk for, a condition mediated by the inflammatory cytokine cascade, by electrically stimulating vagus nerve activity in an amount sufficient to inhibit the inflammatory cytokine cascade.
PCT/US2005/022409 2004-12-27 2005-06-22 Treating inflammatory disorders by electrical vagus nerve stimulation WO2006073484A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AU2005323463A AU2005323463B2 (en) 2004-12-27 2005-06-22 Treating inflammatory disorders by electrical vagus nerve stimulation
CN200580048379.2A CN101124012B (en) 2004-12-27 2005-06-22 Device for treating inflammatory disorders by electrical vagus nerve stimulation
EP05856845A EP1833559B1 (en) 2004-12-27 2005-06-22 Treating inflammatory disorders by electrical vagus nerve stimulation
DE602005025020T DE602005025020D1 (en) 2004-12-27 2005-06-22 TREATMENT OF INFLAMMATORY DISEASES BY EL
CA2593079A CA2593079C (en) 2004-12-27 2005-06-22 Treating inflammatory disorders by electrical vagus nerve stimulation
JP2007548183A JP2008525102A (en) 2004-12-27 2005-06-22 Treatment of inflammatory disorders by electrical vagus nerve stimulation
AT05856845T ATE489132T1 (en) 2004-12-27 2005-06-22 TREATMENT OF INFLAMMATORY DISEASES BY ELECTRICAL STIMULATION OF THE VAGUS NERVE
HK08108040.5A HK1112432A1 (en) 2004-12-27 2008-07-22 Device for treating inflammatory disorders by electrical vagus nerve stimulation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63933204P 2004-12-27 2004-12-27
US60/639,332 2004-12-27

Publications (2)

Publication Number Publication Date
WO2006073484A2 WO2006073484A2 (en) 2006-07-13
WO2006073484A3 true WO2006073484A3 (en) 2006-10-05

Family

ID=36540221

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/022409 WO2006073484A2 (en) 2004-12-27 2005-06-22 Treating inflammatory disorders by electrical vagus nerve stimulation

Country Status (10)

Country Link
US (1) US11344724B2 (en)
EP (2) EP1833559B1 (en)
JP (1) JP2008525102A (en)
CN (2) CN101124012B (en)
AT (1) ATE489132T1 (en)
AU (2) AU2005323463B2 (en)
CA (1) CA2593079C (en)
DE (1) DE602005025020D1 (en)
HK (1) HK1112432A1 (en)
WO (1) WO2006073484A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8855767B2 (en) 2009-12-23 2014-10-07 Setpoint Medical Corporation Neural stimulation devices and systems for treatment of chronic inflammation
US9211410B2 (en) 2009-05-01 2015-12-15 Setpoint Medical Corporation Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation

Families Citing this family (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8914114B2 (en) 2000-05-23 2014-12-16 The Feinstein Institute For Medical Research Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
US20080077192A1 (en) 2002-05-03 2008-03-27 Afferent Corporation System and method for neuro-stimulation
EP1558320B1 (en) 2002-11-08 2016-04-27 ResMed Limited Headgear assembly for a respiratory mask assembly
US20040226556A1 (en) 2003-05-13 2004-11-18 Deem Mark E. Apparatus for treating asthma using neurotoxin
US7979137B2 (en) 2004-02-11 2011-07-12 Ethicon, Inc. System and method for nerve stimulation
US8751003B2 (en) * 2004-02-11 2014-06-10 Ethicon, Inc. Conductive mesh for neurostimulation
US8165695B2 (en) * 2004-02-11 2012-04-24 Ethicon, Inc. System and method for selectively stimulating different body parts
US10912712B2 (en) 2004-03-25 2021-02-09 The Feinstein Institutes For Medical Research Treatment of bleeding by non-invasive stimulation
EP1734941A2 (en) 2004-03-25 2006-12-27 The Feinstein Institute for Medical Research Neural tourniquet
EP1833559B1 (en) 2004-12-27 2010-11-24 The Feinstein Institute for Medical Research Treating inflammatory disorders by electrical vagus nerve stimulation
US11207518B2 (en) 2004-12-27 2021-12-28 The Feinstein Institutes For Medical Research Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway
US7676275B1 (en) 2005-05-02 2010-03-09 Pacesetter, Inc. Endovascular lead for chronic nerve stimulation
US8588930B2 (en) * 2005-06-07 2013-11-19 Ethicon, Inc. Piezoelectric stimulation device
US9126050B2 (en) 2009-03-20 2015-09-08 ElectroCore, LLC Non-invasive vagus nerve stimulation devices and methods to treat or avert atrial fibrillation
US8676324B2 (en) 2005-11-10 2014-03-18 ElectroCore, LLC Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders
US10537728B2 (en) 2005-11-10 2020-01-21 ElectroCore, LLC Vagal nerve stimulation to avert or treat stroke or transient ischemic attack
US11351363B2 (en) 2005-11-10 2022-06-07 Electrocore, Inc. Nerve stimulation devices and methods for treating cardiac arrhythmias
US11297445B2 (en) 2005-11-10 2022-04-05 Electrocore, Inc. Methods and devices for treating primary headache
US7747324B2 (en) 2005-11-10 2010-06-29 Electrocore Llc Electrical stimulation treatment of bronchial constriction
US8041428B2 (en) 2006-02-10 2011-10-18 Electrocore Llc Electrical stimulation treatment of hypotension
US20110125203A1 (en) 2009-03-20 2011-05-26 ElectroCore, LLC. Magnetic Stimulation Devices and Methods of Therapy
US8676330B2 (en) 2009-03-20 2014-03-18 ElectroCore, LLC Electrical and magnetic stimulators used to treat migraine/sinus headache and comorbid disorders
US8874227B2 (en) 2009-03-20 2014-10-28 ElectroCore, LLC Devices and methods for non-invasive capacitive electrical stimulation and their use for vagus nerve stimulation on the neck of a patient
US9174066B2 (en) 2009-03-20 2015-11-03 ElectroCore, LLC Devices and methods for non-invasive capacitive electrical stimulation and their use for vagus nerve stimulation on the neck of a patient
US8868177B2 (en) * 2009-03-20 2014-10-21 ElectroCore, LLC Non-invasive treatment of neurodegenerative diseases
US8812112B2 (en) 2005-11-10 2014-08-19 ElectroCore, LLC Electrical treatment of bronchial constriction
US9119953B2 (en) * 2005-11-10 2015-09-01 ElectroCore, LLC Non-invasive treatment of a medical condition by vagus nerve stimulation
US8983628B2 (en) 2009-03-20 2015-03-17 ElectroCore, LLC Non-invasive vagal nerve stimulation to treat disorders
US10441780B2 (en) 2005-11-10 2019-10-15 Electrocore, Inc. Systems and methods for vagal nerve stimulation
US7725188B2 (en) 2006-02-10 2010-05-25 Electrocore Llc Electrical stimulation treatment of hypotension
US9037247B2 (en) 2005-11-10 2015-05-19 ElectroCore, LLC Non-invasive treatment of bronchial constriction
US7630760B2 (en) * 2005-11-21 2009-12-08 Cardiac Pacemakers, Inc. Neural stimulation therapy system for atherosclerotic plaques
US20070156183A1 (en) * 2006-01-05 2007-07-05 Rhodes Donald A Treatment of various ailments
US7813805B1 (en) * 2006-01-11 2010-10-12 Pacesetter, Inc. Subcardiac threshold vagal nerve stimulation
US7869869B1 (en) 2006-01-11 2011-01-11 Pacesetter, Inc. Subcardiac threshold vagal nerve stimulation
CN101400402A (en) 2006-02-10 2009-04-01 电子核心公司 Electrical stimulation treatment of hypotension
US20100174340A1 (en) * 2006-04-18 2010-07-08 Electrocore, Inc. Methods and Apparatus for Applying Energy to Patients
US20080183237A1 (en) * 2006-04-18 2008-07-31 Electrocore, Inc. Methods And Apparatus For Treating Ileus Condition Using Electrical Signals
US20130165824A1 (en) * 2006-05-17 2013-06-27 The Research Foundation Of The State University Of New York Method and system for physical stimulation of tissue
US20100217347A1 (en) * 2006-12-16 2010-08-26 Greatbatch, Inc. Neurostimulation for the treatment of pulmonary disorders
US9616227B2 (en) 2006-12-22 2017-04-11 MED-EL Elektromedizinishce Geraete GmbH Adaptive airway treatment of dorsal displacement disorders in horses
US8676325B2 (en) 2006-12-22 2014-03-18 Med-El Elektromedizinische Geraete Gmbh Adaptive airway treatment of dorsal displacement disorders in horses
US9352152B2 (en) * 2006-12-22 2016-05-31 Med-El Elektromedizinische Geraete Gmbh Equine airway disorders
EP2129352B1 (en) * 2007-03-13 2016-03-09 The Feinstein Institute for Medical Research Treatment of inflammation by non-invasive stimulation
JP5191275B2 (en) * 2007-05-30 2013-05-08 独立行政法人国立循環器病研究センター Regenerative therapy device and method of operating the same
WO2009029614A1 (en) * 2007-08-27 2009-03-05 The Feinstein Institute For Medical Research Devices and methods for inhibiting granulocyte activation by neural stimulation
US9314321B2 (en) 2007-09-05 2016-04-19 Biolectrics Llc Concurrent treatment of oral and systemic maladies in animals using electrical current
US9168370B2 (en) 2007-09-05 2015-10-27 Biolectrics Llc Concurrent treatment of oral and systemic maladies using direct current electricity
AU2008297476B2 (en) 2007-09-13 2011-09-15 Cardiac Pacemakers, Inc. Systems for avoiding neural stimulation habituation
US8233976B2 (en) 2007-12-05 2012-07-31 The Invention Science Fund I, Llc System for transdermal chemical modulation of neural activity
US8160695B2 (en) * 2007-12-05 2012-04-17 The Invention Science Fund I, Llc System for chemical modulation of neural activity
US8483831B1 (en) 2008-02-15 2013-07-09 Holaira, Inc. System and method for bronchial dilation
US9662490B2 (en) 2008-03-31 2017-05-30 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug
US9211409B2 (en) 2008-03-31 2015-12-15 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation of T-cell activity
EP3047874B1 (en) * 2008-04-04 2022-03-09 ReShape Lifesciences Inc. Systems for glucose regulation and methods of making such systems
EP2529686B1 (en) 2008-05-09 2015-10-14 Holaira, Inc. System for treating a bronchial tree
WO2010005482A1 (en) 2008-07-08 2010-01-14 Cardiac Pacemakers, Inc. Systems for delivering vagal nerve stimulation
WO2010027993A2 (en) * 2008-09-05 2010-03-11 Setpoint Medical Corporation Systems for stimulation of the cholinergic anti-inflammatory pathway via a superior vena cava lead
US9079031B2 (en) * 2008-09-11 2015-07-14 Trifectas Medical Corp. Method for improving functional recovery after stroke by electrical stimulation of a cranial nerve
US8412338B2 (en) 2008-11-18 2013-04-02 Setpoint Medical Corporation Devices and methods for optimizing electrode placement for anti-inflamatory stimulation
US8983629B2 (en) 2009-03-20 2015-03-17 ElectroCore, LLC Non-invasive vagal nerve stimulation to treat disorders
US9248286B2 (en) 2009-03-20 2016-02-02 ElectroCore, LLC Medical self-treatment using non-invasive vagus nerve stimulation
US10376696B2 (en) 2009-03-20 2019-08-13 Electrocore, Inc. Medical self-treatment using non-invasive vagus nerve stimulation
US10286212B2 (en) 2009-03-20 2019-05-14 Electrocore, Inc. Nerve stimulation methods for averting imminent onset or episode of a disease
US10252074B2 (en) 2009-03-20 2019-04-09 ElectroCore, LLC Nerve stimulation methods for averting imminent onset or episode of a disease
US10220207B2 (en) 2009-03-20 2019-03-05 Electrocore, Inc. Nerve stimulation methods for averting imminent onset or episode of a disease
US8918178B2 (en) 2009-03-20 2014-12-23 ElectroCore, LLC Non-invasive vagal nerve stimulation to treat disorders
US10512769B2 (en) 2009-03-20 2019-12-24 Electrocore, Inc. Non-invasive magnetic or electrical nerve stimulation to treat or prevent autism spectrum disorders and other disorders of psychological development
US11229790B2 (en) 2013-01-15 2022-01-25 Electrocore, Inc. Mobile phone for treating a patient with seizures
US9333347B2 (en) 2010-08-19 2016-05-10 ElectroCore, LLC Devices and methods for non-invasive electrical stimulation and their use for vagal nerve stimulation on the neck of a patient
US9403001B2 (en) 2009-03-20 2016-08-02 ElectroCore, LLC Non-invasive magnetic or electrical nerve stimulation to treat gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders
US10232178B2 (en) 2009-03-20 2019-03-19 Electrocore, Inc. Non-invasive magnetic or electrical nerve stimulation to treat or prevent dementia
US9375571B2 (en) 2013-01-15 2016-06-28 ElectroCore, LLC Mobile phone using non-invasive nerve stimulation
US9174045B2 (en) 2009-03-20 2015-11-03 ElectroCore, LLC Non-invasive electrical and magnetic nerve stimulators used to treat overactive bladder and urinary incontinence
US9254383B2 (en) 2009-03-20 2016-02-09 ElectroCore, LLC Devices and methods for monitoring non-invasive vagus nerve stimulation
WO2010111506A1 (en) * 2009-03-27 2010-09-30 Ethicon, Inc. Piezoelectric stimulation device
US8996116B2 (en) 2009-10-30 2015-03-31 Setpoint Medical Corporation Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction
CA2761156C (en) * 2009-05-07 2017-03-14 University Of Cincinnati Methods of preventing ischemic injury using peripheral nociceptive stimulation
AU2010258792B2 (en) 2009-06-09 2015-07-02 Setpoint Medical Corporation Nerve cuff with pocket for leadless stimulator
US9649153B2 (en) 2009-10-27 2017-05-16 Holaira, Inc. Delivery devices with coolable energy emitting assemblies
US8911439B2 (en) 2009-11-11 2014-12-16 Holaira, Inc. Non-invasive and minimally invasive denervation methods and systems for performing the same
CA2780608C (en) 2009-11-11 2019-02-26 Innovative Pulmonary Solutions, Inc. Systems, apparatuses, and methods for treating tissue and controlling stenosis
WO2014169145A1 (en) 2013-04-10 2014-10-16 Setpoint Medical Corporation Closed-loop vagus nerve stimulation
US9833621B2 (en) 2011-09-23 2017-12-05 Setpoint Medical Corporation Modulation of sirtuins by vagus nerve stimulation
WO2011078676A1 (en) * 2009-12-23 2011-06-30 Hitops Gmbh New use of pulsed radio frequency
US9358381B2 (en) 2011-03-10 2016-06-07 ElectroCore, LLC Non-invasive vagal nerve stimulation to treat disorders
US11191953B2 (en) 2010-08-19 2021-12-07 Electrocore, Inc. Systems and methods for vagal nerve stimulation
US20200086108A1 (en) 2010-08-19 2020-03-19 Electrocore, Inc. Vagal nerve stimulation to reduce inflammation associated with an aneurysm
US11400288B2 (en) 2010-08-19 2022-08-02 Electrocore, Inc Devices and methods for electrical stimulation and their use for vagus nerve stimulation on the neck of a patient
US20120158086A1 (en) * 2010-12-17 2012-06-21 Medtronic, Inc. Aortic pacing to reduce heart rate
US11432760B2 (en) 2011-01-12 2022-09-06 Electrocore, Inc. Devices and methods for remote therapy and patient monitoring
US11511109B2 (en) 2011-03-10 2022-11-29 Electrocore, Inc. Non-invasive magnetic or electrical nerve stimulation to treat gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders
US10173048B2 (en) 2011-03-10 2019-01-08 Electrocore, Inc. Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders
US9399134B2 (en) 2011-03-10 2016-07-26 ElectroCore, LLC Non-invasive vagal nerve stimulation to treat disorders
US11458297B2 (en) 2011-03-10 2022-10-04 Electrocore, Inc Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders
EP2707094B1 (en) 2011-05-09 2016-02-03 Setpoint Medical Corporation Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
US9566426B2 (en) 2011-08-31 2017-02-14 ElectroCore, LLC Systems and methods for vagal nerve stimulation
WO2013070384A1 (en) * 2011-10-13 2013-05-16 Microtransponder, Inc. Methods, systems, and devices for pairing vagus nerve stimulation with motor therapy in stroke patients
US9572983B2 (en) 2012-03-26 2017-02-21 Setpoint Medical Corporation Devices and methods for modulation of bone erosion
US8504161B1 (en) 2012-08-07 2013-08-06 Medtronic, Inc. Modulate vagal signals to reduce inflammation
US9398933B2 (en) 2012-12-27 2016-07-26 Holaira, Inc. Methods for improving drug efficacy including a combination of drug administration and nerve modulation
US10293160B2 (en) 2013-01-15 2019-05-21 Electrocore, Inc. Mobile phone for treating a patient with dementia
US9174049B2 (en) 2013-01-27 2015-11-03 ElectroCore, LLC Systems and methods for electrical stimulation of sphenopalatine ganglion and other branches of cranial nerves
US9427581B2 (en) 2013-04-28 2016-08-30 ElectroCore, LLC Devices and methods for treating medical disorders with evoked potentials and vagus nerve stimulation
US9205258B2 (en) 2013-11-04 2015-12-08 ElectroCore, LLC Nerve stimulator system
AU2014364214B2 (en) * 2013-12-10 2019-09-26 Jodi Ventures, Inc. Concurrent treatment of oral and systemic maladies in animals using electrical current
WO2015105873A1 (en) 2014-01-07 2015-07-16 Animal Oralectrics Llc Treatment of oral maladies using electrical current
US10130809B2 (en) 2014-06-13 2018-11-20 Nervana, LLC Transcutaneous electrostimulator and methods for electric stimulation
US9782584B2 (en) 2014-06-13 2017-10-10 Nervana, LLC Transcutaneous electrostimulator and methods for electric stimulation
WO2016046587A1 (en) * 2014-09-23 2016-03-31 Inria Institut National De Recherche En Informatique Et En Automatique Method and device for stimulating myelinated and unmyelinated small diameter vagal neurons
US11311725B2 (en) 2014-10-24 2022-04-26 Setpoint Medical Corporation Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation
US11406833B2 (en) 2015-02-03 2022-08-09 Setpoint Medical Corporation Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator
AU2016252497A1 (en) * 2015-04-24 2017-11-09 Academisch Medisch Centrum Neuromodulation device
US20180193643A1 (en) * 2015-06-05 2018-07-12 The Johns Hopkins University Method and device for sacral nerve stimulation
US11878160B2 (en) * 2015-08-21 2024-01-23 Galvani Bioelectronics Limited Neuromodulation device
WO2017065239A1 (en) * 2015-10-14 2017-04-20 国立大学法人熊本大学 Device for suppressing inflammation and hyperimmunity, and method for suppressing inflammation and hyperimmunity
US10596367B2 (en) 2016-01-13 2020-03-24 Setpoint Medical Corporation Systems and methods for establishing a nerve block
WO2017127756A1 (en) 2016-01-20 2017-07-27 Setpoint Medical Corporation Control of vagal stimulation
US11471681B2 (en) 2016-01-20 2022-10-18 Setpoint Medical Corporation Batteryless implantable microstimulators
US10314501B2 (en) 2016-01-20 2019-06-11 Setpoint Medical Corporation Implantable microstimulators and inductive charging systems
US10583304B2 (en) 2016-01-25 2020-03-10 Setpoint Medical Corporation Implantable neurostimulator having power control and thermal regulation and methods of use
EP3551280B1 (en) 2016-12-12 2023-08-09 The Regents of the University of California Implantable and non-invasive stimulators for gastrointestinal therapeutics
EP3668402A4 (en) 2017-08-14 2021-05-19 Setpoint Medical Corporation Vagus nerve stimulation pre-screening test
US11464978B2 (en) * 2017-12-20 2022-10-11 Galvani Bioelectronics Limited Treatment of acute medical conditions
CN111787975A (en) * 2017-12-20 2020-10-16 加尔瓦尼生物电子有限公司 Stimulation of nerves supplying the spleen
US20220323745A1 (en) * 2017-12-22 2022-10-13 Electrocore, Inc Nerve stimulation therapy for maintaining telomere lengths
US11894148B2 (en) * 2017-12-22 2024-02-06 Electrocore, Inc. Systems and methods for treating patients with diseases associated with viruses
BR112020021286A2 (en) 2018-04-19 2021-01-26 Iota Biosciences, Inc. implants using ultrasonic communication to modulate splenic nerve activity
JP2021522033A (en) 2018-04-19 2021-08-30 イオタ バイオサイエンシズ， インコーポレイテッドＩｏｔａ Ｂｉｏｓｃｉｅｎｃｅｓ， Ｉｎｃ． Embedding using ultrasound communication for nerve sensing and stimulation
US11660443B2 (en) 2018-04-20 2023-05-30 The Feinstein Institutes For Medical Research Methods and apparatuses for reducing bleeding via electrical trigeminal nerve stimulation
JP2022502139A (en) 2018-09-24 2022-01-11 ネソス コープ Auricular nerve stimulation to deal with a patient's disease, as well as related systems and methods
US11260229B2 (en) 2018-09-25 2022-03-01 The Feinstein Institutes For Medical Research Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation
CN110496310A (en) * 2019-08-22 2019-11-26 西安八水健康科技有限公司 A kind of neck non-intruding vagal stimulation equipment activating immune anti-inflammatory pathway
CN113491827B (en) * 2020-04-07 2023-12-29 浙江迈达佩思医疗科技有限公司 Sacral nerve stimulation system and method for determining configuration parameters of sacral nerve stimulation system
WO2021213767A1 (en) 2020-04-20 2021-10-28 Xphelyum System comprising particles and a removable device for therapeutic purposes
WO2021213756A1 (en) 2020-04-20 2021-10-28 Xphelyum System comprising genetically modified cells and/or modified nerve fibers and a removable device for therapeutic purposes
WO2021213759A1 (en) 2020-04-20 2021-10-28 Xphelyum Particles for therapeutic purposes
JP2023526080A (en) 2020-05-21 2023-06-20 ザ・フェインステイン・インスティチュート・フォー・メディカル・リサーチ Systems and methods for vagus nerve stimulation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5916239A (en) * 1996-03-29 1999-06-29 Purdue Research Foundation Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation
US20030023282A1 (en) * 2001-07-28 2003-01-30 Barrett Burke T. Treatment of neuropsychiatric disorders by near-diaphragmatic nerve stimulation
WO2004064918A1 (en) * 2003-01-14 2004-08-05 Department Of Veterans Affairs, Office Of General Counsel Cervical wagal stimulation induced weight loss
US20040199210A1 (en) * 2002-06-12 2004-10-07 Shelchuk Anne M. Vagal stimulation for improving cardiac function in heart failure or CHF patients

Family Cites Families (442)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB191404133A (en) 1914-02-17 1915-01-07 British Thomson Houston Co Ltd Improvements in and relating to Protective Devices for Electric Distribution Systems.
US2164121A (en) 1938-05-04 1939-06-27 Pescador Hector Electric hearing apparatus for the deaf
US3363623A (en) 1965-07-28 1968-01-16 Charles F. Atwell Hand-held double-acting nerve reflex massager
US3631534A (en) 1969-09-05 1971-12-28 Matsushita Electric Ind Co Ltd Variable inductance device
FR2315274A1 (en) 1975-06-27 1977-01-21 Parcor NEW DERIVATIVES OF THIENO (2,3-C) PYRIDINE, THEIR PREPARATION AND THEIR APPLICATIONS
US4073296A (en) 1976-01-02 1978-02-14 Mccall Francis J Apparatus for acupressure treatment
US4098277A (en) 1977-01-28 1978-07-04 Sherwin Mendell Fitted, integrally molded device for stimulating auricular acupuncture points and method of making the device
US4305402A (en) 1979-06-29 1981-12-15 Katims Jefferson J Method for transcutaneous electrical stimulation
US4503863A (en) 1979-06-29 1985-03-12 Katims Jefferson J Method and apparatus for transcutaneous electrical stimulation
US4702254A (en) 1983-09-14 1987-10-27 Jacob Zabara Neurocybernetic prosthesis
US4867164A (en) 1983-09-14 1989-09-19 Jacob Zabara Neurocybernetic prosthesis
US5025807A (en) 1983-09-14 1991-06-25 Jacob Zabara Neurocybernetic prosthesis
US4590946A (en) 1984-06-14 1986-05-27 Biomed Concepts, Inc. Surgically implantable electrode for nerve bundles
US4573481A (en) 1984-06-25 1986-03-04 Huntington Institute Of Applied Research Implantable electrode array
US4649936A (en) 1984-10-11 1987-03-17 Case Western Reserve University Asymmetric single electrode cuff for generation of unidirectionally propagating action potentials for collision blocking
US4632095A (en) 1984-11-05 1986-12-30 Tamiko Inc. Pressure-point attachment for use with electrical hand-held massagers
US4930516B1 (en) 1985-11-13 1998-08-04 Laser Diagnostic Instr Inc Method for detecting cancerous tissue using visible native luminescence
US4929734A (en) 1987-03-31 1990-05-29 Warner-Lambert Company Tetrahydropyridine oxime compounds
US4840793A (en) 1987-06-11 1989-06-20 Dana-Farber Cancer Institute Method of reducing tissue damage at an inflammatory site using a monoclonal antibody
US4935234A (en) 1987-06-11 1990-06-19 Dana-Farber Cancer Institute Method of reducing tissue damage at an inflammatory site using a monoclonal antibody
US5019648A (en) 1987-07-06 1991-05-28 Dana-Farber Cancer Institute Monoclonal antibody specific for the adhesion function domain of a phagocyte cell surface protein
DE3736664A1 (en) 1987-10-29 1989-05-11 Boehringer Ingelheim Kg TETRAHYDRO-FURO- AND -THIENO (2,3-C) PYRIDINE, THEIR USE AS A MEDICAMENT AND METHOD FOR THE PRODUCTION THEREOF
US5038781A (en) 1988-01-21 1991-08-13 Hassan Hamedi Multi-electrode neurological stimulation apparatus
US5049659A (en) 1988-02-09 1991-09-17 Dana Farber Cancer Institute Proteins which induce immunological effector cell activation and chemattraction
US4920979A (en) 1988-10-12 1990-05-01 Huntington Medical Research Institute Bidirectional helical electrode for nerve stimulation
US4991578A (en) 1989-04-04 1991-02-12 Siemens-Pacesetter, Inc. Method and system for implanting self-anchoring epicardial defibrillation electrodes
US5106853A (en) 1989-05-15 1992-04-21 Merck Sharp & Dohme, Ltd. Oxadiazole and its salts, their use in treating dementia
US4979511A (en) 1989-11-03 1990-12-25 Cyberonics, Inc. Strain relief tether for implantable electrode
US5179950A (en) 1989-11-13 1993-01-19 Cyberonics, Inc. Implanted apparatus having micro processor controlled current and voltage sources with reduced voltage levels when not providing stimulation
US5154172A (en) 1989-11-13 1992-10-13 Cyberonics, Inc. Constant current sources with programmable voltage source
US5186170A (en) 1989-11-13 1993-02-16 Cyberonics, Inc. Simultaneous radio frequency and magnetic field microprocessor reset circuit
US5235980A (en) 1989-11-13 1993-08-17 Cyberonics, Inc. Implanted apparatus disabling switching regulator operation to allow radio frequency signal reception
US6147204A (en) 1990-06-11 2000-11-14 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand complexes
WO1991019813A1 (en) 1990-06-11 1991-12-26 The University Of Colorado Foundation, Inc. Nucleic acid ligands
US5503978A (en) 1990-06-11 1996-04-02 University Research Corporation Method for identification of high affinity DNA ligands of HIV-1 reverse transcriptase
US6127119A (en) 1990-06-11 2000-10-03 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands of tissue target
US5726017A (en) 1990-06-11 1998-03-10 Nexstar Pharmaceuticals, Inc. High affinity HIV-1 gag nucleic acid ligands
US5472841A (en) 1990-06-11 1995-12-05 Nexstar Pharmaceuticals, Inc. Methods for identifying nucleic acid ligands of human neutrophil elastase
US5637459A (en) 1990-06-11 1997-06-10 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chimeric selex
US5496938A (en) 1990-06-11 1996-03-05 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands to HIV-RT and HIV-1 rev
US5712375A (en) 1990-06-11 1998-01-27 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: tissue selex
US5683867A (en) 1990-06-11 1997-11-04 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: blended SELEX
US6168778B1 (en) 1990-06-11 2001-01-02 Nexstar Pharmaceuticals, Inc. Vascular endothelial growth factor (VEGF) Nucleic Acid Ligand Complexes
US6083696A (en) 1990-06-11 2000-07-04 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands exponential enrichment: blended selex
US6140490A (en) 1996-02-01 2000-10-31 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands of complement system proteins
US5705337A (en) 1990-06-11 1998-01-06 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-SELEX
US5654151A (en) 1990-06-11 1997-08-05 Nexstar Pharmaceuticals, Inc. High affinity HIV Nucleocapsid nucleic acid ligands
US5580737A (en) 1990-06-11 1996-12-03 Nexstar Pharmaceuticals, Inc. High-affinity nucleic acid ligands that discriminate between theophylline and caffeine
US5567588A (en) 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
US6124449A (en) 1990-06-11 2000-09-26 Nexstar Pharmaceuticals, Inc. High affinity TGFβ nucleic acid ligands and inhibitors
US5073560A (en) 1990-07-20 1991-12-17 Fisons Corporation Spiro-isoxazolidine derivatives as cholinergic agents
US5111815A (en) 1990-10-15 1992-05-12 Cardiac Pacemakers, Inc. Method and apparatus for cardioverter/pacer utilizing neurosensing
US5263480A (en) 1991-02-01 1993-11-23 Cyberonics, Inc. Treatment of eating disorders by nerve stimulation
US5188104A (en) 1991-02-01 1993-02-23 Cyberonics, Inc. Treatment of eating disorders by nerve stimulation
US5269303A (en) 1991-02-22 1993-12-14 Cyberonics, Inc. Treatment of dementia by nerve stimulation
US5335657A (en) 1991-05-03 1994-08-09 Cyberonics, Inc. Therapeutic treatment of sleep disorder by nerve stimulation
US5251634A (en) 1991-05-03 1993-10-12 Cyberonics, Inc. Helical nerve electrode
US5299569A (en) 1991-05-03 1994-04-05 Cyberonics, Inc. Treatment of neuropsychiatric disorders by nerve stimulation
US5215086A (en) 1991-05-03 1993-06-01 Cyberonics, Inc. Therapeutic treatment of migraine symptoms by stimulation
US6028186A (en) 1991-06-10 2000-02-22 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands of cytokines
US5205285A (en) 1991-06-14 1993-04-27 Cyberonics, Inc. Voice suppression of vagal stimulation
EP0600916A4 (en) 1991-07-22 1995-11-02 Cyberonics Inc Treatment of respiratory disorders by nerve stimulation.
US5222494A (en) 1991-07-31 1993-06-29 Cyberonics, Inc. Implantable tissue stimulator output stabilization system
US5231988A (en) 1991-08-09 1993-08-03 Cyberonics, Inc. Treatment of endocrine disorders by nerve stimulation
US5582981A (en) 1991-08-14 1996-12-10 Gilead Sciences, Inc. Method for identifying an oligonucleotide aptamer specific for a target
US5175166A (en) 1991-08-27 1992-12-29 The University Of Toledo Muscarinic agonists
US5215089A (en) 1991-10-21 1993-06-01 Cyberonics, Inc. Electrode assembly for nerve stimulation
US5304206A (en) 1991-11-18 1994-04-19 Cyberonics, Inc. Activation techniques for implantable medical device
US5237991A (en) 1991-11-19 1993-08-24 Cyberonics, Inc. Implantable medical device with dummy load for pre-implant testing in sterile package and facilitating electrical lead connection
US5203326A (en) 1991-12-18 1993-04-20 Telectronics Pacing Systems, Inc. Antiarrhythmia pacer using antiarrhythmia pacing and autonomic nerve stimulation therapy
US5330507A (en) 1992-04-24 1994-07-19 Medtronic, Inc. Implantable electrical vagal stimulation for prevention or interruption of life threatening arrhythmias
US5330515A (en) 1992-06-17 1994-07-19 Cyberonics, Inc. Treatment of pain by vagal afferent stimulation
EP0659078B1 (en) 1992-08-31 2003-01-15 University Of Florida Research Foundation, Inc. Anabaseine derivatives useful in the treatment of degenerative diseases of the nervous system
US5977144A (en) 1992-08-31 1999-11-02 University Of Florida Methods of use and compositions for benzylidene- and cinnamylidene-anabaseines
SE9202792D0 (en) * 1992-09-28 1992-09-28 Siemens Elema Ab ELECTRODING SYSTEM FOR PACEMAKER
WO1994017771A2 (en) 1993-02-10 1994-08-18 Siemens Aktiengesellschaft Process and apparatus for analgesic therapy and/or for influencing the vegetative nervous system
US5344438A (en) 1993-04-16 1994-09-06 Medtronic, Inc. Cuff electrode
CA2163966A1 (en) 1993-06-01 1994-12-08 Judith A. Kelleher Alkaline and acid phosphatase inhibitors in treatment of neurological disorders
US5594106A (en) 1993-08-23 1997-01-14 Immunex Corporation Inhibitors of TNF-α secretion
US5599984A (en) 1994-01-21 1997-02-04 The Picower Institute For Medical Research Guanylhydrazones and their use to treat inflammatory conditions
JP3269125B2 (en) 1994-01-28 2002-03-25 東レ株式会社 Atopic dermatitis drug
US6083905A (en) 1994-04-22 2000-07-04 Stichting Sanquin Bloedvoorziening Method and means for detecting and treating disorders in the blood coagulation cascade
US5458625A (en) 1994-05-04 1995-10-17 Kendall; Donald E. Transcutaneous nerve stimulation device and method for using same
US6017891A (en) 1994-05-06 2000-01-25 Baxter Aktiengesellschaft Stable preparation for the treatment of blood coagulation disorders
US6405732B1 (en) 1994-06-24 2002-06-18 Curon Medical, Inc. Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors
ATE192157T1 (en) 1994-08-24 2000-05-15 Astra Ab THERAPEUTIC SPIRO-AZABICYCLIC COMPOUNDS
US5531778A (en) 1994-09-20 1996-07-02 Cyberonics, Inc. Circumneural electrode assembly
US5540734A (en) 1994-09-28 1996-07-30 Zabara; Jacob Cranial nerve stimulation treatments using neurocybernetic prosthesis
US5571150A (en) 1994-12-19 1996-11-05 Cyberonics, Inc. Treatment of patients in coma by nerve stimulation
US5487756A (en) 1994-12-23 1996-01-30 Simon Fraser University Implantable cuff having improved closure
US5604231A (en) 1995-01-06 1997-02-18 Smith; Carr J. Pharmaceutical compositions for prevention and treatment of ulcerative colitis
US5540730A (en) * 1995-06-06 1996-07-30 Cyberonics, Inc. Treatment of motility disorders by nerve stimulation
US5707400A (en) 1995-09-19 1998-01-13 Cyberonics, Inc. Treating refractory hypertension by nerve stimulation
US5700282A (en) 1995-10-13 1997-12-23 Zabara; Jacob Heart rhythm stabilization using a neurocybernetic prosthesis
AU7286996A (en) 1995-10-18 1997-05-07 Ciba-Geigy Ag Thermopile powered transdermal drug delivery device
US5607459A (en) 1995-10-27 1997-03-04 Intermedics, Inc. Implantable cardiac stimulation device with time-of-day selectable warning system
US5611350A (en) 1996-02-08 1997-03-18 John; Michael S. Method and apparatus for facilitating recovery of patients in deep coma
US6096728A (en) 1996-02-09 2000-08-01 Amgen Inc. Composition and method for treating inflammatory diseases
US5913876A (en) 1996-02-20 1999-06-22 Cardiothoracic Systems, Inc. Method and apparatus for using vagus nerve stimulation in surgery
US5651378A (en) 1996-02-20 1997-07-29 Cardiothoracic Systems, Inc. Method of using vagal nerve stimulation in surgery
US6051017A (en) 1996-02-20 2000-04-18 Advanced Bionics Corporation Implantable microstimulator and systems employing the same
SE9600683D0 (en) 1996-02-23 1996-02-23 Astra Ab Azabicyclic esters of carbamic acids useful in therapy
HUP9700603A3 (en) 1996-03-20 2001-08-28 Baxter Ag Pharmaceutical preparation for the treatment of blood coagulation disorders
US5618818A (en) 1996-03-20 1997-04-08 The University Of Toledo Muscarinic agonist compounds
EP0796634B1 (en) 1996-03-21 2005-11-16 BIOTRONIK Mess- und Therapiegeräte GmbH & Co Ingenieurbüro Berlin Implantable stimulation electrode
US5726179A (en) 1996-04-01 1998-03-10 The University Of Toledo Muscarinic agonists
US6166048A (en) 1999-04-20 2000-12-26 Targacept, Inc. Pharmaceutical compositions for inhibition of cytokine production and secretion
US6628987B1 (en) 2000-09-26 2003-09-30 Medtronic, Inc. Method and system for sensing cardiac contractions during vagal stimulation-induced cardiopalegia
US6006134A (en) 1998-04-30 1999-12-21 Medtronic, Inc. Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers
USRE38705E1 (en) 1996-04-30 2005-02-22 Medtronic, Inc. Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers
US7269457B2 (en) * 1996-04-30 2007-09-11 Medtronic, Inc. Method and system for vagal nerve stimulation with multi-site cardiac pacing
US6904318B2 (en) 2000-09-26 2005-06-07 Medtronic, Inc. Method and system for monitoring and controlling systemic and pulmonary circulation during a medical procedure
US6449507B1 (en) 1996-04-30 2002-09-10 Medtronic, Inc. Method and system for nerve stimulation prior to and during a medical procedure
US6735471B2 (en) 1996-04-30 2004-05-11 Medtronic, Inc. Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure
US6532388B1 (en) 1996-04-30 2003-03-11 Medtronic, Inc. Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure
US7225019B2 (en) 1996-04-30 2007-05-29 Medtronic, Inc. Method and system for nerve stimulation and cardiac sensing prior to and during a medical procedure
US20040199209A1 (en) 2003-04-07 2004-10-07 Hill Michael R.S. Method and system for delivery of vasoactive drugs to the heart prior to and during a medical procedure
US5853005A (en) 1996-05-02 1998-12-29 The United States Of America As Represented By The Secretary Of The Army Acoustic monitoring system
AU3304997A (en) 1996-05-31 1998-01-05 Southern Illinois University Methods of modulating aspects of brain neural plasticity by vagus nerve stimulation
US5792210A (en) 1996-06-10 1998-08-11 Environmental Behavior Modification Inc. Electrical tongue stimulator and method for addiction treatment
JPH1094613A (en) 1996-08-02 1998-04-14 Mieko Sato Appetite adjusting implement
US5718912A (en) 1996-10-28 1998-02-17 Merck & Co., Inc. Muscarine agonists
US20050191661A1 (en) 1996-11-06 2005-09-01 Tetsuya Gatanaga Treatment of inflammatory disease by cleaving TNF receptors
JP2001503775A (en) 1996-11-15 2001-03-21 ザ ピコワー インスティテュート フォー メディカル リサーチ Guanylhydrazone useful for treating diseases associated with T cell activation
US6164284A (en) 1997-02-26 2000-12-26 Schulman; Joseph H. System of implantable devices for monitoring and/or affecting body parameters
US6208894B1 (en) 1997-02-26 2001-03-27 Alfred E. Mann Foundation For Scientific Research And Advanced Bionics System of implantable devices for monitoring and/or affecting body parameters
US5788656A (en) 1997-02-28 1998-08-04 Mino; Alfonso Di Electronic stimulation system for treating tinnitus disorders
US5919216A (en) 1997-06-16 1999-07-06 Medtronic, Inc. System and method for enhancement of glucose production by stimulation of pancreatic beta cells
AR013184A1 (en) 1997-07-18 2000-12-13 Astrazeneca Ab SPYROZOBICYCLIC HETERO CYCLIC AMINES, PHARMACEUTICAL COMPOSITION, USE OF SUCH AMINES TO PREPARE MEDICINES AND METHOD OF TREATMENT OR PROPHYLAXIS
US5824027A (en) 1997-08-14 1998-10-20 Simon Fraser University Nerve cuff having one or more isolated chambers
US6479523B1 (en) 1997-08-26 2002-11-12 Emory University Pharmacologic drug combination in vagal-induced asystole
US6011005A (en) 1997-09-18 2000-01-04 The Picower Institute For Medical Research Prevention of pregnancy miscarriages
US6141590A (en) 1997-09-25 2000-10-31 Medtronic, Inc. System and method for respiration-modulated pacing
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
US6018682A (en) 1998-04-30 2000-01-25 Medtronic, Inc. Implantable seizure warning system
US5928272A (en) 1998-05-02 1999-07-27 Cyberonics, Inc. Automatic activation of a neurostimulator device using a detection algorithm based on cardiac activity
US6002964A (en) 1998-07-15 1999-12-14 Feler; Claudio A. Epidural nerve root stimulation
US7231254B2 (en) 1998-08-05 2007-06-12 Bioneuronics Corporation Closed-loop feedback-driven neuromodulation
US8762065B2 (en) 1998-08-05 2014-06-24 Cyberonics, Inc. Closed-loop feedback-driven neuromodulation
US7242984B2 (en) 1998-08-05 2007-07-10 Neurovista Corporation Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
US7209787B2 (en) 1998-08-05 2007-04-24 Bioneuronics Corporation Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
US7599736B2 (en) 2001-07-23 2009-10-06 Dilorenzo Biomedical, Llc Method and apparatus for neuromodulation and physiologic modulation for the treatment of metabolic and neuropsychiatric disease
US6269270B1 (en) 1998-10-26 2001-07-31 Birinder Bob Boveja Apparatus and method for adjunct (add-on) therapy of Dementia and Alzheimer's disease utilizing an implantable lead and external stimulator
US6356788B2 (en) 1998-10-26 2002-03-12 Birinder Bob Boveja Apparatus and method for adjunct (add-on) therapy for depression, migraine, neuropsychiatric disorders, partial complex epilepsy, generalized epilepsy and involuntary movement disorders utilizing an external stimulator
US6505074B2 (en) 1998-10-26 2003-01-07 Birinder R. Boveja Method and apparatus for electrical stimulation adjunct (add-on) treatment of urinary incontinence and urological disorders using an external stimulator
US6366814B1 (en) 1998-10-26 2002-04-02 Birinder R. Boveja External stimulator for adjunct (add-on) treatment for neurological, neuropsychiatric, and urological disorders
US6208902B1 (en) 1998-10-26 2001-03-27 Birinder Bob Boveja Apparatus and method for adjunct (add-on) therapy for pain syndromes utilizing an implantable lead and an external stimulator
US6611715B1 (en) 1998-10-26 2003-08-26 Birinder R. Boveja Apparatus and method for neuromodulation therapy for obesity and compulsive eating disorders using an implantable lead-receiver and an external stimulator
US7076307B2 (en) 2002-05-09 2006-07-11 Boveja Birinder R Method and system for modulating the vagus nerve (10th cranial nerve) with electrical pulses using implanted and external components, to provide therapy neurological and neuropsychiatric disorders
US6615081B1 (en) 1998-10-26 2003-09-02 Birinder R. Boveja Apparatus and method for adjunct (add-on) treatment of diabetes by neuromodulation with an external stimulator
US20050137644A1 (en) 1998-10-26 2005-06-23 Boveja Birinder R. Method and system for vagal blocking and/or vagal stimulation to provide therapy for obesity and other gastrointestinal disorders
US6564102B1 (en) 1998-10-26 2003-05-13 Birinder R. Boveja Apparatus and method for adjunct (add-on) treatment of coma and traumatic brain injury with neuromodulation using an external stimulator
US20030212440A1 (en) 2002-05-09 2003-11-13 Boveja Birinder R. Method and system for modulating the vagus nerve (10th cranial nerve) using modulated electrical pulses with an inductively coupled stimulation system
US6668191B1 (en) 1998-10-26 2003-12-23 Birinder R. Boveja Apparatus and method for electrical stimulation adjunct (add-on) therapy of atrial fibrillation, inappropriate sinus tachycardia, and refractory hypertension with an external stimulator
US6205359B1 (en) 1998-10-26 2001-03-20 Birinder Bob Boveja Apparatus and method for adjunct (add-on) therapy of partial complex epilepsy, generalized epilepsy and involuntary movement disorders utilizing an external stimulator
US5994330A (en) 1998-11-09 1999-11-30 El Khoury; Georges F. Topical application of muscarinic agents such as neostigmine for treatment of acne and other inflammatory conditions
FR2786770B1 (en) 1998-12-04 2001-01-19 Synthelabo NONANE 1,4-DIAZABICYCLO [3.2.2.] DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
US6376675B2 (en) 1999-01-22 2002-04-23 The University Of Toledo Muscarinic receptor agonists
US6303321B1 (en) 1999-02-11 2001-10-16 North Shore-Long Island Jewish Research Institute Methods for diagnosing sepsis
US6341236B1 (en) 1999-04-30 2002-01-22 Ivan Osorio Vagal nerve stimulation techniques for treatment of epileptic seizures
US6233488B1 (en) 1999-06-25 2001-05-15 Carl A. Hess Spinal cord stimulation as a treatment for addiction to nicotine and other chemical substances
JP2003503119A (en) 1999-06-25 2003-01-28 エモリ ユニバーシティ Vagal nerve stimulation device and method
US6587719B1 (en) 1999-07-01 2003-07-01 Cyberonics, Inc. Treatment of obesity by bilateral vagus nerve stimulation
US6804558B2 (en) 1999-07-07 2004-10-12 Medtronic, Inc. System and method of communicating between an implantable medical device and a remote computer system or health care provider
US6171795B1 (en) 1999-07-29 2001-01-09 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands to CD40ligand
US6210321B1 (en) 1999-07-29 2001-04-03 Adm Tronics Unlimited, Inc. Electronic stimulation system for treating tinnitus disorders
US6304775B1 (en) 1999-09-22 2001-10-16 Leonidas D. Iasemidis Seizure warning and prediction
US6636767B1 (en) 1999-09-29 2003-10-21 Restore Medical, Inc. Implanatable stimulation device for snoring treatment
US6473644B1 (en) 1999-10-13 2002-10-29 Cyberonics, Inc. Method to enhance cardiac capillary growth in heart failure patients
US20020026141A1 (en) 1999-11-04 2002-02-28 Medtronic, Inc. System for pancreatic stimulation and glucose measurement
EP1244496A1 (en) 1999-12-17 2002-10-02 Advanced Bionics Corporation Magnitude programming for implantable electrical stimulator
FR2803186B1 (en) 2000-01-05 2002-08-09 Guy Charvin METHOD AND APPARATUS FOR COLLECTING HEARING MESSAGE POTENTIALS
US6447443B1 (en) 2001-01-13 2002-09-10 Medtronic, Inc. Method for organ positioning and stabilization
US20060085046A1 (en) 2000-01-20 2006-04-20 Ali Rezai Methods of treating medical conditions by transvascular neuromodulation of the autonomic nervous system
US6885888B2 (en) 2000-01-20 2005-04-26 The Cleveland Clinic Foundation Electrical stimulation of the sympathetic nerve chain
US6356787B1 (en) 2000-02-24 2002-03-12 Electro Core Techniques, Llc Method of treating facial blushing by electrical stimulation of the sympathetic nerve chain
US6826428B1 (en) 2000-04-11 2004-11-30 The Board Of Regents Of The University Of Texas System Gastrointestinal electrical stimulation
AU2001210798A1 (en) 2000-04-11 2001-10-23 The Board Of Regents Of The University Of Texas System Gastrointestinal electrical stimulation
US6610713B2 (en) 2000-05-23 2003-08-26 North Shore - Long Island Jewish Research Institute Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
US8914114B2 (en) 2000-05-23 2014-12-16 The Feinstein Institute For Medical Research Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
US6511500B1 (en) 2000-06-06 2003-01-28 Marc Mounir Rahme Use of autonomic nervous system neurotransmitters inhibition and atrial parasympathetic fibers ablation for the treatment of atrial arrhythmias and to preserve drug effects
WO2002016357A2 (en) 2000-08-18 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands)
US6487446B1 (en) 2000-09-26 2002-11-26 Medtronic, Inc. Method and system for spinal cord stimulation prior to and during a medical procedure
ATE332668T1 (en) 2000-09-26 2006-08-15 Medtronic Inc MEDICAL DEVICE FOR BLOOD FLOW CONTROL
US20020077675A1 (en) 2000-09-26 2002-06-20 Transneuronix, Inc. Minimally invasive surgery placement of stimulation leads in mediastinal structures
WO2002030508A2 (en) 2000-10-11 2002-04-18 Riso Ronald R Nerve cuff electrode
US7011638B2 (en) 2000-11-14 2006-03-14 Science Medicus, Inc. Device and procedure to treat cardiac atrial arrhythmias
US6832114B1 (en) 2000-11-21 2004-12-14 Advanced Bionics Corporation Systems and methods for modulation of pancreatic endocrine secretion and treatment of diabetes
US6633779B1 (en) 2000-11-27 2003-10-14 Science Medicus, Inc. Treatment of asthma and respiratory disease by means of electrical neuro-receptive waveforms
ATE385497T1 (en) 2000-12-01 2008-02-15 Neurosearch As 3-SUBSTITUTED QUINUCLIDINE DERIVATIVES AND THEIR USE AS NICOTINIC AGONISTS
US20020086871A1 (en) 2000-12-29 2002-07-04 O'neill Brian Thomas Pharmaceutical composition for the treatment of CNS and other disorders
US6609025B2 (en) 2001-01-02 2003-08-19 Cyberonics, Inc. Treatment of obesity by bilateral sub-diaphragmatic nerve stimulation
US7519421B2 (en) 2001-01-16 2009-04-14 Kenergy, Inc. Vagal nerve stimulation using vascular implanted devices for treatment of atrial fibrillation
WO2002057275A1 (en) 2001-01-17 2002-07-25 University Of Kentucky Research Foundation Boron-containing nicotine analogs for use in the treatment of cns pathologies
US6735475B1 (en) 2001-01-30 2004-05-11 Advanced Bionics Corporation Fully implantable miniature neurostimulator for stimulation as a therapy for headache and/or facial pain
US7167751B1 (en) 2001-03-01 2007-01-23 Advanced Bionics Corporation Method of using a fully implantable miniature neurostimulator for vagus nerve stimulation
WO2002081026A2 (en) 2001-04-05 2002-10-17 Med-El Elektromedizinische Geräte Ges.m.b.H. Pacemaker for bilateral vocal cord autoparalysis
US7369897B2 (en) 2001-04-19 2008-05-06 Neuro And Cardiac Technologies, Llc Method and system of remotely controlling electrical pulses provided to nerve tissue(s) by an implanted stimulator system for neuromodulation therapies
US6901294B1 (en) 2001-05-25 2005-05-31 Advanced Bionics Corporation Methods and systems for direct electrical current stimulation as a therapy for prostatic hypertrophy
US6684105B2 (en) 2001-08-31 2004-01-27 Biocontrol Medical, Ltd. Treatment of disorders by unidirectional nerve stimulation
US20050240229A1 (en) 2001-04-26 2005-10-27 Whitehurst Tood K Methods and systems for stimulation as a therapy for erectile dysfunction
US6928320B2 (en) 2001-05-17 2005-08-09 Medtronic, Inc. Apparatus for blocking activation of tissue or conduction of action potentials while other tissue is being therapeutically activated
US6947782B2 (en) 2001-06-18 2005-09-20 Alfred E. Mann Foundation For Scientific Research Miniature implantable connectors
US7054692B1 (en) 2001-06-22 2006-05-30 Advanced Bionics Corporation Fixation device for implantable microdevices
US20060116736A1 (en) 2001-07-23 2006-06-01 Dilorenzo Daniel J Method, apparatus, and surgical technique for autonomic neuromodulation for the treatment of obesity
US20060167498A1 (en) 2001-07-23 2006-07-27 Dilorenzo Daniel J Method, apparatus, and surgical technique for autonomic neuromodulation for the treatment of disease
US6622038B2 (en) 2001-07-28 2003-09-16 Cyberonics, Inc. Treatment of movement disorders by near-diaphragmatic nerve stimulation
EP1417001B1 (en) 2001-08-17 2008-01-16 Advanced Bionics Corporation Gradual recruitment of muscle/neural excitable tissue using high-rate electrical stimulation parameters
US6600956B2 (en) 2001-08-21 2003-07-29 Cyberonics, Inc. Circumneural electrode assembly
US6622041B2 (en) 2001-08-21 2003-09-16 Cyberonics, Inc. Treatment of congestive heart failure and autonomic cardiovascular drive disorders
US6760626B1 (en) 2001-08-29 2004-07-06 Birinder R. Boveja Apparatus and method for treatment of neurological and neuropsychiatric disorders using programmerless implantable pulse generator system
US7054686B2 (en) 2001-08-30 2006-05-30 Biophan Technologies, Inc. Pulsewidth electrical stimulation
US7778711B2 (en) 2001-08-31 2010-08-17 Bio Control Medical (B.C.M.) Ltd. Reduction of heart rate variability by parasympathetic stimulation
US7734355B2 (en) 2001-08-31 2010-06-08 Bio Control Medical (B.C.M.) Ltd. Treatment of disorders by unidirectional nerve stimulation
US20140046407A1 (en) 2001-08-31 2014-02-13 Bio Control Medical (B.C.M.) Ltd. Nerve stimulation techniques
US8571653B2 (en) 2001-08-31 2013-10-29 Bio Control Medical (B.C.M.) Ltd. Nerve stimulation techniques
US7885709B2 (en) 2001-08-31 2011-02-08 Bio Control Medical (B.C.M.) Ltd. Nerve stimulation for treating disorders
US7778703B2 (en) 2001-08-31 2010-08-17 Bio Control Medical (B.C.M.) Ltd. Selective nerve fiber stimulation for treating heart conditions
US7974693B2 (en) 2001-08-31 2011-07-05 Bio Control Medical (B.C.M.) Ltd. Techniques for applying, configuring, and coordinating nerve fiber stimulation
US20040002546A1 (en) 2001-09-15 2004-01-01 Eric Altschuler Methods for treating crohn's and other TNF associated diseases
US6934583B2 (en) 2001-10-22 2005-08-23 Pacesetter, Inc. Implantable lead and method for stimulating the vagus nerve
US6745079B2 (en) 2001-11-07 2004-06-01 Medtronic, Inc. Electrical tissue stimulation apparatus and method
CN2516176Y (en) * 2002-01-21 2002-10-16 姜炜 Vagus nerve stimulation instrument
US7155284B1 (en) 2002-01-24 2006-12-26 Advanced Bionics Corporation Treatment of hypertension
US6721603B2 (en) 2002-01-25 2004-04-13 Cyberonics, Inc. Nerve stimulation as a treatment for pain
CA2476896A1 (en) 2002-02-26 2003-09-04 North Shore-Long Island Jewish Research Institute Inhibition of inflammatory cytokine production by stimulation of brain muscarinic receptors
US7689276B2 (en) 2002-09-13 2010-03-30 Leptos Biomedical, Inc. Dynamic nerve stimulation for treatment of disorders
US7937145B2 (en) 2002-03-22 2011-05-03 Advanced Neuromodulation Systems, Inc. Dynamic nerve stimulation employing frequency modulation
US7465555B2 (en) 2002-04-02 2008-12-16 Becton, Dickinson And Company Early detection of sepsis
US6978787B1 (en) 2002-04-03 2005-12-27 Michael Broniatowski Method and system for dynamic vocal fold closure with neuro-electrical stimulation
US20080213331A1 (en) 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US20030191404A1 (en) 2002-04-08 2003-10-09 Klein George J. Method and apparatus for providing arrhythmia discrimination
US6990372B2 (en) 2002-04-11 2006-01-24 Alfred E. Mann Foundation For Scientific Research Programmable signal analysis device for detecting neurological signals in an implantable device
AU2003241373A1 (en) 2002-05-03 2003-11-17 Musc Foundation For Research Development Method, apparatus and system for determining effects and optimizing parameters of vagus nerve stimulation
US20050165458A1 (en) 2002-05-09 2005-07-28 Boveja Birinder R. Method and system to provide therapy for depression using electroconvulsive therapy(ECT) and pulsed electrical stimulation to vagus nerve(s)
US20060009815A1 (en) 2002-05-09 2006-01-12 Boveja Birinder R Method and system to provide therapy or alleviate symptoms of involuntary movement disorders by providing complex and/or rectangular electrical pulses to vagus nerve(s)
US20060079936A1 (en) 2003-05-11 2006-04-13 Boveja Birinder R Method and system for altering regional cerebral blood flow (rCBF) by providing complex and/or rectangular electrical pulses to vagus nerve(s), to provide therapy for depression and other medical disorders
US20050209654A1 (en) 2002-05-09 2005-09-22 Boveja Birinder R Method and system for providing adjunct (add-on) therapy for depression, anxiety and obsessive-compulsive disorders by providing electrical pulses to vagus nerve(s)
US7191012B2 (en) 2003-05-11 2007-03-13 Boveja Birinder R Method and system for providing pulsed electrical stimulation to a craniel nerve of a patient to provide therapy for neurological and neuropsychiatric disorders
US20050154426A1 (en) 2002-05-09 2005-07-14 Boveja Birinder R. Method and system for providing therapy for neuropsychiatric and neurological disorders utilizing transcranical magnetic stimulation and pulsed electrical vagus nerve(s) stimulation
US20050216070A1 (en) 2002-05-09 2005-09-29 Boveja Birinder R Method and system for providing therapy for migraine/chronic headache by providing electrical pulses to vagus nerve(s)
US20070067004A1 (en) 2002-05-09 2007-03-22 Boveja Birinder R Methods and systems for modulating the vagus nerve (10th cranial nerve) to provide therapy for neurological, and neuropsychiatric disorders
US8036745B2 (en) 2004-06-10 2011-10-11 Bio Control Medical (B.C.M.) Ltd. Parasympathetic pacing therapy during and following a medical procedure, clinical trauma or pathology
US7885711B2 (en) 2003-06-13 2011-02-08 Bio Control Medical (B.C.M.) Ltd. Vagal stimulation for anti-embolic therapy
US7321793B2 (en) 2003-06-13 2008-01-22 Biocontrol Medical Ltd. Vagal stimulation for atrial fibrillation therapy
US20060116739A1 (en) 2002-05-23 2006-06-01 Nir Betser Electrode assembly for nerve control
US20050065553A1 (en) 2003-06-13 2005-03-24 Omry Ben Ezra Applications of vagal stimulation
US20040015202A1 (en) 2002-06-14 2004-01-22 Chandler Gilbert S. Combination epidural infusion/stimulation method and system
US20040015205A1 (en) 2002-06-20 2004-01-22 Whitehurst Todd K. Implantable microstimulators with programmable multielectrode configuration and uses thereof
US7203548B2 (en) * 2002-06-20 2007-04-10 Advanced Bionics Corporation Cavernous nerve stimulation via unidirectional propagation of action potentials
US7292890B2 (en) 2002-06-20 2007-11-06 Advanced Bionics Corporation Vagus nerve stimulation via unidirectional propagation of action potentials
KR100553516B1 (en) 2002-06-24 2006-02-20 정종필 Apparatus for inducing alpha -wave by electrical stimulation
US20040049240A1 (en) 2002-09-06 2004-03-11 Martin Gerber Electrical and/or magnetic stimulation therapy for the treatment of prostatitis and prostatodynia
US20040049121A1 (en) 2002-09-06 2004-03-11 Uri Yaron Positioning system for neurological procedures in the brain
US7209790B2 (en) 2002-09-30 2007-04-24 Medtronic, Inc. Multi-mode programmer for medical device communication
US7079977B2 (en) 2002-10-15 2006-07-18 Medtronic, Inc. Synchronization and calibration of clocks for a medical device and calibrated clock
EP1558130A4 (en) 2002-10-15 2009-01-28 Medtronic Inc Screening techniques for management of a nervous system disorder
AU2003285888A1 (en) 2002-10-15 2004-05-04 Medtronic Inc. Medical device system with relaying module for treatment of nervous system disorders
EP1629341A4 (en) 2002-10-15 2008-10-15 Medtronic Inc Multi-modal operation of a medical device system
EP1583464B1 (en) 2002-10-15 2014-04-09 Medtronic, Inc. Clustering of recorded patient neurological activity to determine length of a neurological event
AU2003284968A1 (en) 2002-10-25 2004-05-13 University Of South Florida Methods and compounds for disruption of cd40r/cd40l signaling in the treatment of alzheimer's disease
US20030229380A1 (en) 2002-10-31 2003-12-11 Adams John M. Heart failure therapy device and method
US7305265B2 (en) 2002-11-25 2007-12-04 Terumo Kabushiki Kaisha Heart treatment equipment for treating heart failure
EP1426078A1 (en) 2002-12-04 2004-06-09 Terumo Kabushiki Kaisha Heart treatment equipment for preventing fatal arrhythmia
US7238715B2 (en) 2002-12-06 2007-07-03 The Feinstein Institute For Medical Research Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists
CN1735414A (en) * 2002-12-06 2006-02-15 北岸长岛犹太人研究学院 Inhibition of inflamation using alpha 7 receptor-binding cholinergic agonists
US20040111139A1 (en) 2002-12-10 2004-06-10 Mccreery Douglas B. Apparatus and methods for differential stimulation of nerve fibers
TR200202651A2 (en) 2002-12-12 2004-07-21 Met�N�Tulgar the vücutádışındanádirekátedaviásinyaliátransferliáábeyinápil
JP2004201901A (en) 2002-12-25 2004-07-22 Yoshimi Kurokawa Stomach electrostimulator
EP1596805A2 (en) 2003-01-15 2005-11-23 Alfred E. Mann Institute for Biomedical Engineering at the University of Southern California Treatments for snoring using injectable neuromuscular stimulators
US20050143781A1 (en) 2003-01-31 2005-06-30 Rafael Carbunaru Methods and systems for patient adjustment of parameters for an implanted stimulator
US20040172084A1 (en) 2003-02-03 2004-09-02 Knudson Mark B. Method and apparatus for treatment of gastro-esophageal reflux disease (GERD)
US7167750B2 (en) 2003-02-03 2007-01-23 Enteromedics, Inc. Obesity treatment with electrically induced vagal down regulation
CN1964630A (en) 2003-02-13 2007-05-16 耶希瓦大学艾伯塔·爱恩斯坦医学院 Regulation of food intake and glucose production by modulation of long-chain fatty acyl-coa levels in the hypothalamus
US7269455B2 (en) 2003-02-26 2007-09-11 Pineda Jaime A Method and system for predicting and preventing seizures
US7430449B2 (en) 2003-03-14 2008-09-30 Endovx, Inc. Methods and apparatus for testing disruption of a vagal nerve
US6814418B2 (en) 2003-03-14 2004-11-09 D'orso Ronald Locker organizer
US7783358B2 (en) 2003-03-14 2010-08-24 Endovx, Inc. Methods and apparatus for treatment of obesity with an ultrasound device movable in two or three axes
US20060015151A1 (en) 2003-03-14 2006-01-19 Aldrich William N Method of using endoscopic truncal vagoscopy with gastric bypass, gastric banding and other procedures
JP4252830B2 (en) 2003-03-24 2009-04-08 テルモ株式会社 Heart treatment equipment
US7155279B2 (en) 2003-03-28 2006-12-26 Advanced Bionics Corporation Treatment of movement disorders with drug therapy
US7228167B2 (en) 2003-04-10 2007-06-05 Mayo Foundation For Medical Education Method and apparatus for detecting vagus nerve stimulation
US7065412B2 (en) 2003-04-25 2006-06-20 Medtronic, Inc. Implantable trial neurostimulation device
US7187979B2 (en) 2003-04-25 2007-03-06 Medtronic, Inc. Medical device synchronization
US7706871B2 (en) 2003-05-06 2010-04-27 Nellcor Puritan Bennett Llc System and method of prediction of response to neurological treatment using the electroencephalogram
BRPI0410296A (en) 2003-05-06 2006-05-16 Aspect Medical Systems Inc system and method for determining the efficacy of treatment of neurological disorders using electroencephalogram
DE10320863B3 (en) 2003-05-09 2004-11-11 Siemens Audiologische Technik Gmbh Attaching a hearing aid or earmold in the ear
US7444184B2 (en) 2003-05-11 2008-10-28 Neuro And Cardial Technologies, Llc Method and system for providing therapy for bulimia/eating disorders by providing electrical pulses to vagus nerve(s)
US20050197678A1 (en) 2003-05-11 2005-09-08 Boveja Birinder R. Method and system for providing therapy for Alzheimer's disease and dementia by providing electrical pulses to vagus nerve(s)
US20060074450A1 (en) 2003-05-11 2006-04-06 Boveja Birinder R System for providing electrical pulses to nerve and/or muscle using an implanted stimulator
US20050187590A1 (en) 2003-05-11 2005-08-25 Boveja Birinder R. Method and system for providing therapy for autism by providing electrical pulses to the vagus nerve(s)
US20060173508A1 (en) 2003-05-16 2006-08-03 Stone Robert T Method and system for treatment of eating disorders by means of neuro-electrical coded signals
US20060064137A1 (en) 2003-05-16 2006-03-23 Stone Robert T Method and system to control respiration by means of simulated action potential signals
WO2004103459A2 (en) 2003-05-16 2004-12-02 Science Medicus, Inc. Respiratory control by means of neuro-electrical coded signals
US20060111755A1 (en) 2003-05-16 2006-05-25 Stone Robert T Method and system to control respiration by means of neuro-electrical coded signals
US20060287679A1 (en) 2003-05-16 2006-12-21 Stone Robert T Method and system to control respiration by means of confounding neuro-electrical signals
US7620454B2 (en) 2003-05-19 2009-11-17 Medtronic, Inc. Gastro-electric stimulation for reducing the acidity of gastric secretions or reducing the amounts thereof
US7742818B2 (en) 2003-05-19 2010-06-22 Medtronic, Inc. Gastro-electric stimulation for increasing the acidity of gastric secretions or increasing the amounts thereof
JP4213522B2 (en) 2003-05-30 2009-01-21 テルモ株式会社 Heart treatment equipment
US7149574B2 (en) 2003-06-09 2006-12-12 Palo Alto Investors Treatment of conditions through electrical modulation of the autonomic nervous system
US7738952B2 (en) 2003-06-09 2010-06-15 Palo Alto Investors Treatment of conditions through modulation of the autonomic nervous system
DE10328816A1 (en) 2003-06-21 2005-01-05 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Implantable stimulation electrode with a coating to increase tissue compatibility
EP2289504A3 (en) 2003-07-01 2012-05-23 President and Fellows of Harvard College SIRT1 modulators for manipulating cell/organism lifespan/stress response
WO2005007223A2 (en) 2003-07-16 2005-01-27 Sasha John Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations
WO2005007120A2 (en) * 2003-07-18 2005-01-27 The Johns Hopkins University System and method for treating nausea and vomiting by vagus nerve stimulation
US7174218B1 (en) 2003-08-12 2007-02-06 Advanced Bionics Corporation Lead extension system for use with a microstimulator
JP4439215B2 (en) 2003-08-26 2010-03-24 テルモ株式会社 Heart treatment equipment
US7263405B2 (en) 2003-08-27 2007-08-28 Neuro And Cardiac Technologies Llc System and method for providing electrical pulses to the vagus nerve(s) to provide therapy for obesity, eating disorders, neurological and neuropsychiatric disorders with a stimulator, comprising bi-directional communication and network capabilities
US7797058B2 (en) 2004-08-04 2010-09-14 Ndi Medical, Llc Devices, systems, and methods employing a molded nerve cuff electrode
US20050070970A1 (en) 2003-09-29 2005-03-31 Knudson Mark B. Movement disorder stimulation with neural block
US20050070974A1 (en) 2003-09-29 2005-03-31 Knudson Mark B. Obesity and eating disorder stimulation treatment with neural block
US7418292B2 (en) 2003-10-01 2008-08-26 Medtronic, Inc. Device and method for attenuating an immune response
US20050075702A1 (en) 2003-10-01 2005-04-07 Medtronic, Inc. Device and method for inhibiting release of pro-inflammatory mediator
US20050153885A1 (en) 2003-10-08 2005-07-14 Yun Anthony J. Treatment of conditions through modulation of the autonomic nervous system
US7062320B2 (en) 2003-10-14 2006-06-13 Ehlinger Jr Philip Charles Device for the treatment of hiccups
US20050180974A1 (en) 2003-10-24 2005-08-18 Medtronic, Inc. Extracellular TNF inhibitors for treating CNS disorders
KR20050039445A (en) 2003-10-25 2005-04-29 대한민국(경북대학교 총장) Wireless power transmission equipment for totally middle ear implant
DE20316509U1 (en) 2003-10-27 2004-03-11 Lukl, Alfred Ear acupressure and massage unit covers whole ear and applies sprung pins from commercial massage unit
US20050131467A1 (en) 2003-11-02 2005-06-16 Boveja Birinder R. Method and apparatus for electrical stimulation therapy for at least one of atrial fibrillation, congestive heart failure, inappropriate sinus tachycardia, and refractory hypertension
US7317941B2 (en) 2003-11-13 2008-01-08 Medtronic, Inc. Time syncrhonization of data
AU2004293463A1 (en) 2003-11-20 2005-06-09 Angiotech International Ag Implantable sensors and implantable pumps and anti-scarring agents
US20090312817A1 (en) 2003-11-26 2009-12-17 Wicab, Inc. Systems and methods for altering brain and body functions and for treating conditions and diseases of the same
US20050137645A1 (en) 2003-12-05 2005-06-23 Juha Voipio Novel method for the adjustment of human and animal vagus nerve stimulation
WO2005062829A2 (en) 2003-12-19 2005-07-14 Advanced Bionics Corporation Skull-mounted electrical stimulation system and method for treating patients
US20050149129A1 (en) 2003-12-24 2005-07-07 Imad Libbus Baropacing and cardiac pacing to control output
US7460906B2 (en) 2003-12-24 2008-12-02 Cardiac Pacemakers, Inc. Baroreflex stimulation to treat acute myocardial infarction
US7486991B2 (en) 2003-12-24 2009-02-03 Cardiac Pacemakers, Inc. Baroreflex modulation to gradually decrease blood pressure
US7422555B2 (en) 2003-12-30 2008-09-09 Jacob Zabara Systems and methods for therapeutically treating neuro-psychiatric disorders and other illnesses
US8147561B2 (en) 2004-02-26 2012-04-03 Endosphere, Inc. Methods and devices to curb appetite and/or reduce food intake
US7542803B2 (en) 2004-03-16 2009-06-02 Medtronic, Inc. Sensitivity analysis for selecting therapy parameter sets
US7255675B2 (en) 2004-03-23 2007-08-14 Michael Gertner Devices and methods to treat a patient
EP1734941A2 (en) 2004-03-25 2006-12-27 The Feinstein Institute for Medical Research Neural tourniquet
EP1750799A2 (en) 2004-05-04 2007-02-14 The Cleveland Clinic Foundation Methods of treating medical conditions by neuromodulation of the sympathetic nervous system
US20060111644A1 (en) 2004-05-27 2006-05-25 Children's Medical Center Corporation Patient-specific seizure onset detection system
CA2567848A1 (en) 2004-06-04 2006-01-05 Washington University Methods and compositions for treating neuropathies
US7565197B2 (en) 2004-06-18 2009-07-21 Medtronic, Inc. Conditional requirements for remote medical device programming
US7664551B2 (en) 2004-07-07 2010-02-16 Medtronic Transneuronix, Inc. Treatment of the autonomic nervous system
US7711432B2 (en) 2004-07-26 2010-05-04 Advanced Neuromodulation Systems, Inc. Stimulation system and method for treating a neurological disorder
US7751891B2 (en) 2004-07-28 2010-07-06 Cyberonics, Inc. Power supply monitoring for an implantable device
US7204815B2 (en) 2004-08-11 2007-04-17 Georgia K. Connor Mastoid ear cuff and system
US8452407B2 (en) 2004-08-16 2013-05-28 Boston Scientific Neuromodulation Corporation Methods for treating gastrointestinal disorders
US7373204B2 (en) 2004-08-19 2008-05-13 Lifestim, Inc. Implantable device and method for treatment of hypertension
US20050154425A1 (en) * 2004-08-19 2005-07-14 Boveja Birinder R. Method and system to provide therapy for neuropsychiatric disorders and cognitive impairments using gradient magnetic pulses to the brain and pulsed electrical stimulation to vagus nerve(s)
WO2006029257A2 (en) 2004-09-08 2006-03-16 Spinal Modulation Inc. Neurostimulation methods and systems
US20060161216A1 (en) 2004-10-18 2006-07-20 John Constance M Device for neuromuscular peripheral body stimulation and electrical stimulation (ES) for wound healing using RF energy harvesting
WO2006047264A1 (en) 2004-10-21 2006-05-04 Advanced Neuromodulation Systems, Inc. Peripheral nerve stimulation to treat auditory dysfunction
US7672733B2 (en) 2004-10-29 2010-03-02 Medtronic, Inc. Methods and apparatus for sensing cardiac activity via neurological stimulation therapy system or medical electrical lead
US7818342B2 (en) 2004-11-12 2010-10-19 Sap Ag Tracking usage of data elements in electronic business communications
WO2006055849A1 (en) 2004-11-18 2006-05-26 Cardiac Pacemakers, Inc. System for closed-loop neural stimulation
US8332047B2 (en) 2004-11-18 2012-12-11 Cardiac Pacemakers, Inc. System and method for closed-loop neural stimulation
US9089691B2 (en) 2004-12-07 2015-07-28 Cardiac Pacemakers, Inc. Stimulator for auricular branch of vagus nerve
US7366571B2 (en) 2004-12-10 2008-04-29 Cyberonics, Inc. Neurostimulator with activation based on changes in body temperature
US20060161217A1 (en) 2004-12-21 2006-07-20 Jaax Kristen N Methods and systems for treating obesity
US11207518B2 (en) 2004-12-27 2021-12-28 The Feinstein Institutes For Medical Research Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway
EP1833559B1 (en) 2004-12-27 2010-11-24 The Feinstein Institute for Medical Research Treating inflammatory disorders by electrical vagus nerve stimulation
JP2008527002A (en) 2005-01-13 2008-07-24 サートリス ファーマシューティカルズ， インコーポレイテッド Novel composition for preventing and treating neurodegenerative disorders and blood coagulation disorders
US8788044B2 (en) 2005-01-21 2014-07-22 Michael Sasha John Systems and methods for tissue stimulation in medical treatment
US8825166B2 (en) 2005-01-21 2014-09-02 John Sasha John Multiple-symptom medical treatment with roving-based neurostimulation
US8609082B2 (en) 2005-01-25 2013-12-17 Bio Control Medical Ltd. Administering bone marrow progenitor cells or myoblasts followed by application of an electrical current for cardiac repair, increasing blood supply or enhancing angiogenesis
DE102005003735B4 (en) 2005-01-26 2008-04-03 Cerbomed Gmbh Device for transcutaneous stimulation of a nerve of the human body
US8600521B2 (en) 2005-01-27 2013-12-03 Cyberonics, Inc. Implantable medical device having multiple electrode/sensor capability and stimulation based on sensed intrinsic activity
US7454245B2 (en) 2005-01-28 2008-11-18 Cyberonics, Inc. Trained and adaptive response in a neurostimulator
US7561918B2 (en) 2005-01-28 2009-07-14 Cyberonics, Inc. Autocapture in a neurostimulator
US20060173493A1 (en) 2005-01-28 2006-08-03 Cyberonics, Inc. Multi-phasic signal for stimulation by an implantable device
WO2006085065A2 (en) 2005-02-08 2006-08-17 Janssen Pharmaceutica N.V. Vagal afferent neurons as targets for treatment
US8185199B2 (en) 2005-02-10 2012-05-22 Zoll Medical Corporation Monitoring physiological signals during external electrical stimulation
US7548780B2 (en) 2005-02-22 2009-06-16 Cardiac Pacemakers, Inc. Cell therapy and neural stimulation for cardiac repair
US20060200219A1 (en) 2005-03-01 2006-09-07 Ndi Medical, Llc Systems and methods for differentiating and/or identifying tissue regions innervated by targeted nerves for diagnostic and/or therapeutic purposes
US8700163B2 (en) 2005-03-04 2014-04-15 Cyberonics, Inc. Cranial nerve stimulation for treatment of substance addiction
US7613511B2 (en) 2005-03-09 2009-11-03 Cardiac Pacemakers, Inc. Implantable vagal stimulator for treating cardiac ischemia
US7702385B2 (en) 2005-11-16 2010-04-20 Boston Scientific Neuromodulation Corporation Electrode contact configurations for an implantable stimulator
US7499748B2 (en) 2005-04-11 2009-03-03 Cardiac Pacemakers, Inc. Transvascular neural stimulation device
US20060229681A1 (en) 2005-04-11 2006-10-12 Fischell Robert E Implantable system for the treatment of atrial fibrillation
US7881782B2 (en) 2005-04-20 2011-02-01 Cardiac Pacemakers, Inc. Neural stimulation system to prevent simultaneous energy discharges
US20060282121A1 (en) 2005-04-25 2006-12-14 Payne Bryan R Vagus nerve stimulation for chronic intractable hiccups
US7899540B2 (en) 2005-04-29 2011-03-01 Cyberonics, Inc. Noninvasively adjustable gastric band
US7310557B2 (en) 2005-04-29 2007-12-18 Maschino Steven E Identification of electrodes for nerve stimulation in the treatment of eating disorders
US7835796B2 (en) 2005-04-29 2010-11-16 Cyberonics, Inc. Weight loss method and device
EP1896127B1 (en) 2005-05-04 2013-05-29 St. Jude Medical AB Synchronization of implantable medical devices
US7734348B2 (en) 2005-05-10 2010-06-08 Cardiac Pacemakers, Inc. System with left/right pulmonary artery electrodes
US7765000B2 (en) 2005-05-10 2010-07-27 Cardiac Pacemakers, Inc. Neural stimulation system with pulmonary artery lead
US7617003B2 (en) 2005-05-16 2009-11-10 Cardiac Pacemakers, Inc. System for selective activation of a nerve trunk using a transvascular reshaping lead
US20060292099A1 (en) 2005-05-25 2006-12-28 Michael Milburn Treatment of eye disorders with sirtuin modulators
US7584004B2 (en) 2005-06-13 2009-09-01 Cardiac Pacemakers, Inc. Vascularly stabilized peripheral nerve cuff assembly
US8036750B2 (en) 2005-06-13 2011-10-11 Cardiac Pacemakers, Inc. System for neural control of respiration
US20060293721A1 (en) 2005-06-28 2006-12-28 Cyberonics, Inc. Vagus nerve stimulation for treatment of depression with therapeutically beneficial parameter settings
US20070016262A1 (en) 2005-07-13 2007-01-18 Betastim, Ltd. Gi and pancreatic device for treating obesity and diabetes
US7711419B2 (en) 2005-07-13 2010-05-04 Cyberonics, Inc. Neurostimulator with reduced size
US8140159B2 (en) 2005-07-21 2012-03-20 Cyberonics, Inc. Safe-mode operation of an implantable medical device
US20070021786A1 (en) 2005-07-25 2007-01-25 Cyberonics, Inc. Selective nerve stimulation for the treatment of angina pectoris
US20070027504A1 (en) 2005-07-27 2007-02-01 Cyberonics, Inc. Cranial nerve stimulation to treat a hearing disorder
US7840280B2 (en) 2005-07-27 2010-11-23 Cyberonics, Inc. Cranial nerve stimulation to treat a vocal cord disorder
US20070027497A1 (en) 2005-07-27 2007-02-01 Cyberonics, Inc. Nerve stimulation for treatment of syncope
US7706874B2 (en) 2005-07-28 2010-04-27 Cyberonics, Inc. Stimulating cranial nerve to treat disorders associated with the thyroid gland
US20070027484A1 (en) 2005-07-28 2007-02-01 Cyberonics, Inc. Autonomic nerve stimulation to treat a pancreatic disorder
US8660647B2 (en) 2005-07-28 2014-02-25 Cyberonics, Inc. Stimulating cranial nerve to treat pulmonary disorder
US7856273B2 (en) 2005-07-28 2010-12-21 Cyberonics, Inc. Autonomic nerve stimulation to treat a gastrointestinal disorder
US20070027499A1 (en) 2005-07-29 2007-02-01 Cyberonics, Inc. Neurostimulation device for treating mood disorders
US7499752B2 (en) 2005-07-29 2009-03-03 Cyberonics, Inc. Selective nerve stimulation for the treatment of eating disorders
US20070025608A1 (en) 2005-07-29 2007-02-01 Cyberonics, Inc. Enhancing intrinsic neural activity using a medical device to treat a patient
US7532935B2 (en) 2005-07-29 2009-05-12 Cyberonics, Inc. Selective neurostimulation for treating mood disorders
JP5203195B2 (en) 2005-08-04 2013-06-05 サートリス ファーマシューティカルズ， インコーポレイテッド Benzothiazole and thiazolopyridines as sirtuin modulators
US7672727B2 (en) 2005-08-17 2010-03-02 Enteromedics Inc. Neural electrode treatment
US7822486B2 (en) 2005-08-17 2010-10-26 Enteromedics Inc. Custom sized neural electrodes
WO2007041463A2 (en) 2005-10-03 2007-04-12 Combinatorx, Incorporated Electrical devices and anti-scarring drug combinations
US7860566B2 (en) 2005-10-06 2010-12-28 The Cleveland Clinic Foundation System and method for achieving regular slow ventricular rhythm in response to atrial fibrillation
US7856264B2 (en) 2005-10-19 2010-12-21 Advanced Neuromodulation Systems, Inc. Systems and methods for patient interactive neural stimulation and/or chemical substance delivery
US7616990B2 (en) 2005-10-24 2009-11-10 Cardiac Pacemakers, Inc. Implantable and rechargeable neural stimulator
US7620455B2 (en) 2005-10-25 2009-11-17 Cyberonics, Inc. Cranial nerve stimulation to treat eating disorders
US20070100263A1 (en) 2005-10-27 2007-05-03 Merfeld Daniel M Mechanical actuator for a vestibular stimulator
US7555344B2 (en) 2005-10-28 2009-06-30 Cyberonics, Inc. Selective neurostimulation for treating epilepsy
US20070100377A1 (en) 2005-10-28 2007-05-03 Cyberonics, Inc. Providing multiple signal modes for a medical device
US7957796B2 (en) 2005-10-28 2011-06-07 Cyberonics, Inc. Using physiological sensor data with an implantable medical device
US8812112B2 (en) 2005-11-10 2014-08-19 ElectroCore, LLC Electrical treatment of bronchial constriction
US10537728B2 (en) 2005-11-10 2020-01-21 ElectroCore, LLC Vagal nerve stimulation to avert or treat stroke or transient ischemic attack
US7747324B2 (en) 2005-11-10 2010-06-29 Electrocore Llc Electrical stimulation treatment of bronchial constriction
US7630760B2 (en) 2005-11-21 2009-12-08 Cardiac Pacemakers, Inc. Neural stimulation therapy system for atherosclerotic plaques
US7650192B2 (en) 2005-12-02 2010-01-19 Medtronic, Inc. Passive charge of implantable medical device utilizing external power source and method
US7596414B2 (en) 2005-12-05 2009-09-29 Boston Scientific Neuromodulation Corporation Cuff electrode arrangement for nerve stimulation and methods of treating disorders
US7570999B2 (en) 2005-12-20 2009-08-04 Cardiac Pacemakers, Inc. Implantable device for treating epilepsy and cardiac rhythm disorders
US20070150027A1 (en) 2005-12-22 2007-06-28 Rogers Lesco L Non-invasive device and method for electrical stimulation of neural tissue
EP2129352B1 (en) 2007-03-13 2016-03-09 The Feinstein Institute for Medical Research Treatment of inflammation by non-invasive stimulation
US8233976B2 (en) 2007-12-05 2012-07-31 The Invention Science Fund I, Llc System for transdermal chemical modulation of neural activity
US9211409B2 (en) 2008-03-31 2015-12-15 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation of T-cell activity
US9662490B2 (en) 2008-03-31 2017-05-30 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug
US20090275997A1 (en) 2008-05-01 2009-11-05 Michael Allen Faltys Vagus nerve stimulation electrodes and methods of use
US8412338B2 (en) 2008-11-18 2013-04-02 Setpoint Medical Corporation Devices and methods for optimizing electrode placement for anti-inflamatory stimulation
US9211410B2 (en) 2009-05-01 2015-12-15 Setpoint Medical Corporation Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
AU2010258792B2 (en) 2009-06-09 2015-07-02 Setpoint Medical Corporation Nerve cuff with pocket for leadless stimulator
WO2014169145A1 (en) 2013-04-10 2014-10-16 Setpoint Medical Corporation Closed-loop vagus nerve stimulation
US20160331952A1 (en) 2009-11-17 2016-11-17 Michael A. Faltys External programmer
US20150241447A1 (en) 2009-11-17 2015-08-27 Ralph J. ZITNIK Vagus nerve stimulation screening test
EP3636314B1 (en) 2009-12-23 2021-09-08 Setpoint Medical Corporation Neural stimulation devices and systems for treatment of chronic inflammation
US9572983B2 (en) 2012-03-26 2017-02-21 Setpoint Medical Corporation Devices and methods for modulation of bone erosion
US11311725B2 (en) 2014-10-24 2022-04-26 Setpoint Medical Corporation Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation
US11406833B2 (en) 2015-02-03 2022-08-09 Setpoint Medical Corporation Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator
US10596367B2 (en) 2016-01-13 2020-03-24 Setpoint Medical Corporation Systems and methods for establishing a nerve block
US11471681B2 (en) 2016-01-20 2022-10-18 Setpoint Medical Corporation Batteryless implantable microstimulators
US10314501B2 (en) 2016-01-20 2019-06-11 Setpoint Medical Corporation Implantable microstimulators and inductive charging systems
WO2017127756A1 (en) 2016-01-20 2017-07-27 Setpoint Medical Corporation Control of vagal stimulation
US10583304B2 (en) 2016-01-25 2020-03-10 Setpoint Medical Corporation Implantable neurostimulator having power control and thermal regulation and methods of use
EP3668402A4 (en) 2017-08-14 2021-05-19 Setpoint Medical Corporation Vagus nerve stimulation pre-screening test

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5916239A (en) * 1996-03-29 1999-06-29 Purdue Research Foundation Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation
US20030023282A1 (en) * 2001-07-28 2003-01-30 Barrett Burke T. Treatment of neuropsychiatric disorders by near-diaphragmatic nerve stimulation
US20040199210A1 (en) * 2002-06-12 2004-10-07 Shelchuk Anne M. Vagal stimulation for improving cardiac function in heart failure or CHF patients
WO2004064918A1 (en) * 2003-01-14 2004-08-05 Department Of Veterans Affairs, Office Of General Counsel Cervical wagal stimulation induced weight loss

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9211410B2 (en) 2009-05-01 2015-12-15 Setpoint Medical Corporation Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
US8855767B2 (en) 2009-12-23 2014-10-07 Setpoint Medical Corporation Neural stimulation devices and systems for treatment of chronic inflammation

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