WO2006135902A3 - Systems and methods for a multiple angle light scattering (mals) instrument having two-dimensional dectector array - Google Patents

Systems and methods for a multiple angle light scattering (mals) instrument having two-dimensional dectector array Download PDF

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Publication number
WO2006135902A3
WO2006135902A3 PCT/US2006/023043 US2006023043W WO2006135902A3 WO 2006135902 A3 WO2006135902 A3 WO 2006135902A3 US 2006023043 W US2006023043 W US 2006023043W WO 2006135902 A3 WO2006135902 A3 WO 2006135902A3
Authority
WO
WIPO (PCT)
Prior art keywords
light
dectector
mals
instrument
array
Prior art date
Application number
PCT/US2006/023043
Other languages
French (fr)
Other versions
WO2006135902A2 (en
Inventor
John A Adams
Scott H Bloom
Victor J Chan
Kristina M Crousore
Joseph S Gottlieb
Oscar Hemberg
John J Lyon
Brett A Spivey
Original Assignee
Jmar Res Inc
John A Adams
Scott H Bloom
Victor J Chan
Kristina M Crousore
Joseph S Gottlieb
Oscar Hemberg
John J Lyon
Brett A Spivey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/381,346 external-priority patent/US7564551B2/en
Application filed by Jmar Res Inc, John A Adams, Scott H Bloom, Victor J Chan, Kristina M Crousore, Joseph S Gottlieb, Oscar Hemberg, John J Lyon, Brett A Spivey filed Critical Jmar Res Inc
Priority to EP06773081A priority Critical patent/EP1904807A4/en
Publication of WO2006135902A2 publication Critical patent/WO2006135902A2/en
Publication of WO2006135902A3 publication Critical patent/WO2006135902A3/en

Links

Classifications

    • G01N15/1433—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1434—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1456—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1468—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/18—Water
    • G01N33/1893—Water using flow cells
    • G01N2015/019—

Abstract

A particle detection system uses a reflective optic comprising a curved surface to detect high angle scattered light generated by a particle in a liquid medium, when a laser beam is incident on the particle. When the particles transit the laser beam, light is scattered in all directions and is described by MIE scattering theory for particles about the size of the wavelength of light and larger or Rayleigh Scattering when the particles are smaller than the wavelength of light. By using the reflective optic, the scattered light can be detected over angles that are greater than normally obtainable.
PCT/US2006/023043 2005-06-13 2006-06-13 Systems and methods for a multiple angle light scattering (mals) instrument having two-dimensional dectector array WO2006135902A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06773081A EP1904807A4 (en) 2005-06-13 2006-06-13 Systems and methods for a multiple angle light scattering (mals) instrument having two-dimensional dectector array

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US69053505P 2005-06-13 2005-06-13
US60/690,535 2005-06-13
US11/381,346 2006-05-02
US11/381,346 US7564551B2 (en) 2005-05-02 2006-05-02 Systems and methods for a high capture angle, multiple angle light scattering (MALS) instrument

Publications (2)

Publication Number Publication Date
WO2006135902A2 WO2006135902A2 (en) 2006-12-21
WO2006135902A3 true WO2006135902A3 (en) 2007-11-08

Family

ID=37532906

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/023043 WO2006135902A2 (en) 2005-06-13 2006-06-13 Systems and methods for a multiple angle light scattering (mals) instrument having two-dimensional dectector array

Country Status (2)

Country Link
EP (1) EP1904807A4 (en)
WO (1) WO2006135902A2 (en)

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4877747A (en) * 1985-04-12 1989-10-31 Plessey Overseas Limited Optical assay: method and apparatus
US5125737A (en) * 1987-03-13 1992-06-30 Coulter Electronics, Inc. Multi-part differential analyzing apparatus utilizing light scatter techniques
US5633503A (en) * 1993-11-26 1997-05-27 Toa Medical Electronics Co., Ltd. Particle analyzer
US5760900A (en) * 1989-03-18 1998-06-02 Canon Kabushiki Kaisha Method and apparatus for optically measuring specimen
US6177994B1 (en) * 1998-08-22 2001-01-23 Malvern Instruments Limited Relating to the measurement of particle size distribution
US6263227B1 (en) * 1996-05-22 2001-07-17 Moor Instruments Limited Apparatus for imaging microvascular blood flow
US20020093641A1 (en) * 2000-08-25 2002-07-18 Ortyn William E. Measuring the velocity of small moving objects such as cells
US20030035105A1 (en) * 2001-08-03 2003-02-20 Quist Gregory M. Identification of particles in fluid
US20030227545A1 (en) * 2002-06-10 2003-12-11 Hideki Soya Photographic apparatus and photographic method using same
US20040004716A1 (en) * 2002-07-05 2004-01-08 Rashid Mavliev Method and apparatus for detecting individual particles in a flowable sample

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2101113A (en) 1933-02-16 1937-12-07 Teletypesetter Corp Control unit for line casting machines
DE3000034A1 (en) 1979-01-02 1980-07-31 Coulter Electronics METHOD AND DEVICE FOR MEASURING THE DIRECTIONAL DISTRIBUTION PROPERTIES OF THE RADIATION ENERGY REFLECTED BY A PARTICLE
US4606636A (en) * 1983-10-25 1986-08-19 Universite De Saint-Etienne Optical apparatus for identifying the individual multiparametric properties of particles or bodies in a continuous flow
US5101113A (en) * 1989-05-16 1992-03-31 Arizona Board Of Regents Ensemble scattering particle sizing system with axial spatial resolution
US5141609A (en) 1990-11-16 1992-08-25 The Trustees Of The Leland Stanford Junior University Method and device employing time-delayed integration for detecting sample components after separation
US5614726A (en) * 1995-03-23 1997-03-25 Beckman Instruments, Inc. Automated optical alignment system and method using Raman scattering of capillary tube contents
US6608682B2 (en) * 1999-01-25 2003-08-19 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
US6794671B2 (en) 2002-07-17 2004-09-21 Particle Sizing Systems, Inc. Sensors and methods for high-sensitivity optical particle counting and sizing

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4877747A (en) * 1985-04-12 1989-10-31 Plessey Overseas Limited Optical assay: method and apparatus
US5125737A (en) * 1987-03-13 1992-06-30 Coulter Electronics, Inc. Multi-part differential analyzing apparatus utilizing light scatter techniques
US5760900A (en) * 1989-03-18 1998-06-02 Canon Kabushiki Kaisha Method and apparatus for optically measuring specimen
US5633503A (en) * 1993-11-26 1997-05-27 Toa Medical Electronics Co., Ltd. Particle analyzer
US6263227B1 (en) * 1996-05-22 2001-07-17 Moor Instruments Limited Apparatus for imaging microvascular blood flow
US6177994B1 (en) * 1998-08-22 2001-01-23 Malvern Instruments Limited Relating to the measurement of particle size distribution
US20020093641A1 (en) * 2000-08-25 2002-07-18 Ortyn William E. Measuring the velocity of small moving objects such as cells
US20030035105A1 (en) * 2001-08-03 2003-02-20 Quist Gregory M. Identification of particles in fluid
US20030227545A1 (en) * 2002-06-10 2003-12-11 Hideki Soya Photographic apparatus and photographic method using same
US20040004716A1 (en) * 2002-07-05 2004-01-08 Rashid Mavliev Method and apparatus for detecting individual particles in a flowable sample

Also Published As

Publication number Publication date
WO2006135902A2 (en) 2006-12-21
EP1904807A4 (en) 2011-04-20
EP1904807A2 (en) 2008-04-02

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