WO2007002409A3 - Dynamic fixation device and method of use - Google Patents

Dynamic fixation device and method of use Download PDF

Info

Publication number
WO2007002409A3
WO2007002409A3 PCT/US2006/024491 US2006024491W WO2007002409A3 WO 2007002409 A3 WO2007002409 A3 WO 2007002409A3 US 2006024491 W US2006024491 W US 2006024491W WO 2007002409 A3 WO2007002409 A3 WO 2007002409A3
Authority
WO
WIPO (PCT)
Prior art keywords
fixation device
dynamic fixation
flexible
limits
vertebrae
Prior art date
Application number
PCT/US2006/024491
Other languages
French (fr)
Other versions
WO2007002409A2 (en
Inventor
Stephen Ritland
Original Assignee
Stephen Ritland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stephen Ritland filed Critical Stephen Ritland
Priority to CN2006800301055A priority Critical patent/CN101247764B/en
Priority to AU2006262057A priority patent/AU2006262057A1/en
Priority to EP06785447.1A priority patent/EP1898813B9/en
Priority to JP2008518436A priority patent/JP5435943B2/en
Priority to CA002612943A priority patent/CA2612943A1/en
Publication of WO2007002409A2 publication Critical patent/WO2007002409A2/en
Publication of WO2007002409A3 publication Critical patent/WO2007002409A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
    • A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
    • A61B17/7002—Longitudinal elements, e.g. rods
    • A61B17/7011—Longitudinal element being non-straight, e.g. curved, angled or branched
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
    • A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
    • A61B17/7002—Longitudinal elements, e.g. rods
    • A61B17/7019—Longitudinal elements having flexible parts, or parts connected together, such that after implantation the elements can move relative to each other
    • A61B17/7023—Longitudinal elements having flexible parts, or parts connected together, such that after implantation the elements can move relative to each other with a pivot joint
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
    • A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
    • A61B17/7002—Longitudinal elements, e.g. rods
    • A61B17/7019—Longitudinal elements having flexible parts, or parts connected together, such that after implantation the elements can move relative to each other
    • A61B17/7026—Longitudinal elements having flexible parts, or parts connected together, such that after implantation the elements can move relative to each other with a part that is flexible due to its form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
    • A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
    • A61B17/7002—Longitudinal elements, e.g. rods
    • A61B17/7004—Longitudinal elements, e.g. rods with a cross-section which varies along its length
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
    • A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
    • A61B17/7002—Longitudinal elements, e.g. rods
    • A61B17/7004—Longitudinal elements, e.g. rods with a cross-section which varies along its length
    • A61B17/7007—Parts of the longitudinal elements, e.g. their ends, being specially adapted to fit around the screw or hook heads
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive

Abstract

A dynamic fixation device is provided that allows the vertebrae to which it is attached to move in flexion within the normal physiological limits of motion, while also providing structural support that limits the amount of translation motion beyond normal physiological limits. The present invention includes a flexible portion and two ends that are adapted for connection to pedicle screws. In at least one embodiment of the present invention, the normal axis of rotation of the vertebrae is substantially duplicated by the dynamic fixation device. The flexible portion of the dynamic fixation device can include a flexible anterior-posterior segment, an anterior-posterior segment bounded by one or more zones with cuts in the rod portions, a flexible accordion-like segment, and/or a hinge portion.
PCT/US2006/024491 2005-06-22 2006-06-22 Dynamic fixation device and method of use WO2007002409A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN2006800301055A CN101247764B (en) 2005-06-22 2006-06-22 Dynamic fixation device and method of use
AU2006262057A AU2006262057A1 (en) 2005-06-22 2006-06-22 Dynamic fixation device and method of use
EP06785447.1A EP1898813B9 (en) 2005-06-22 2006-06-22 Dynamic fixation device
JP2008518436A JP5435943B2 (en) 2005-06-22 2006-06-22 Dynamic fixing device
CA002612943A CA2612943A1 (en) 2005-06-22 2006-06-22 Dynamic fixation device and method of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69312605P 2005-06-22 2005-06-22
US60/693,126 2005-06-22

Publications (2)

Publication Number Publication Date
WO2007002409A2 WO2007002409A2 (en) 2007-01-04
WO2007002409A3 true WO2007002409A3 (en) 2007-11-15

Family

ID=37595883

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/024491 WO2007002409A2 (en) 2005-06-22 2006-06-22 Dynamic fixation device and method of use

Country Status (7)

Country Link
EP (1) EP1898813B9 (en)
JP (1) JP5435943B2 (en)
KR (1) KR20080041628A (en)
CN (1) CN101247764B (en)
AU (1) AU2006262057A1 (en)
CA (1) CA2612943A1 (en)
WO (1) WO2007002409A2 (en)

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8845649B2 (en) 2004-09-24 2014-09-30 Roger P. Jackson Spinal fixation tool set and method for rod reduction and fastener insertion
US8852239B2 (en) 2013-02-15 2014-10-07 Roger P Jackson Sagittal angle screw with integral shank and receiver
US8870928B2 (en) 2002-09-06 2014-10-28 Roger P. Jackson Helical guide and advancement flange with radially loaded lip
US8894657B2 (en) 2004-02-27 2014-11-25 Roger P. Jackson Tool system for dynamic spinal implants
US8911478B2 (en) 2012-11-21 2014-12-16 Roger P. Jackson Splay control closure for open bone anchor
US8911477B2 (en) 2007-10-23 2014-12-16 Roger P. Jackson Dynamic stabilization member with end plate support and cable core extension
US8926672B2 (en) 2004-11-10 2015-01-06 Roger P. Jackson Splay control closure for open bone anchor
US8926670B2 (en) 2003-06-18 2015-01-06 Roger P. Jackson Polyaxial bone screw assembly
US8979904B2 (en) 2007-05-01 2015-03-17 Roger P Jackson Connecting member with tensioned cord, low profile rigid sleeve and spacer with torsion control
US8998959B2 (en) 2009-06-15 2015-04-07 Roger P Jackson Polyaxial bone anchors with pop-on shank, fully constrained friction fit retainer and lock and release insert
US8998960B2 (en) 2004-11-10 2015-04-07 Roger P. Jackson Polyaxial bone screw with helically wound capture connection
US9055978B2 (en) 2004-02-27 2015-06-16 Roger P. Jackson Orthopedic implant rod reduction tool set and method
US9168069B2 (en) 2009-06-15 2015-10-27 Roger P. Jackson Polyaxial bone anchor with pop-on shank and winged insert with lower skirt for engaging a friction fit retainer
US9216041B2 (en) 2009-06-15 2015-12-22 Roger P. Jackson Spinal connecting members with tensioned cords and rigid sleeves for engaging compression inserts
US9216039B2 (en) 2004-02-27 2015-12-22 Roger P. Jackson Dynamic spinal stabilization assemblies, tool set and method
US9439683B2 (en) 2007-01-26 2016-09-13 Roger P Jackson Dynamic stabilization member with molded connection
US9451989B2 (en) 2007-01-18 2016-09-27 Roger P Jackson Dynamic stabilization members with elastic and inelastic sections
US9451993B2 (en) 2014-01-09 2016-09-27 Roger P. Jackson Bi-radial pop-on cervical bone anchor
US9504496B2 (en) 2009-06-15 2016-11-29 Roger P. Jackson Polyaxial bone anchor with pop-on shank, friction fit retainer and winged insert
US9532815B2 (en) 2004-02-27 2017-01-03 Roger P. Jackson Spinal fixation tool set and method
US9566092B2 (en) 2013-10-29 2017-02-14 Roger P. Jackson Cervical bone anchor with collet retainer and outer locking sleeve
US9597119B2 (en) 2014-06-04 2017-03-21 Roger P. Jackson Polyaxial bone anchor with polymer sleeve

Families Citing this family (38)

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US10258382B2 (en) 2007-01-18 2019-04-16 Roger P. Jackson Rod-cord dynamic connection assemblies with slidable bone anchor attachment members along the cord
US10729469B2 (en) 2006-01-09 2020-08-04 Roger P. Jackson Flexible spinal stabilization assembly with spacer having off-axis core member
US7621918B2 (en) 2004-11-23 2009-11-24 Jackson Roger P Spinal fixation tool set and method
US7377923B2 (en) 2003-05-22 2008-05-27 Alphatec Spine, Inc. Variable angle spinal screw assembly
US8366753B2 (en) 2003-06-18 2013-02-05 Jackson Roger P Polyaxial bone screw assembly with fixed retaining structure
US7776067B2 (en) 2005-05-27 2010-08-17 Jackson Roger P Polyaxial bone screw with shank articulation pressure insert and method
US7766915B2 (en) 2004-02-27 2010-08-03 Jackson Roger P Dynamic fixation assemblies with inner core and outer coil-like member
US7967850B2 (en) 2003-06-18 2011-06-28 Jackson Roger P Polyaxial bone anchor with helical capture connection, insert and dual locking assembly
US7179261B2 (en) 2003-12-16 2007-02-20 Depuy Spine, Inc. Percutaneous access devices and bone anchor assemblies
US7527638B2 (en) 2003-12-16 2009-05-05 Depuy Spine, Inc. Methods and devices for minimally invasive spinal fixation element placement
US11419642B2 (en) 2003-12-16 2022-08-23 Medos International Sarl Percutaneous access devices and bone anchor assemblies
US7160300B2 (en) 2004-02-27 2007-01-09 Jackson Roger P Orthopedic implant rod reduction tool set and method
US9050148B2 (en) 2004-02-27 2015-06-09 Roger P. Jackson Spinal fixation tool attachment structure
US11241261B2 (en) 2005-09-30 2022-02-08 Roger P Jackson Apparatus and method for soft spinal stabilization using a tensionable cord and releasable end structure
US8475498B2 (en) 2007-01-18 2013-07-02 Roger P. Jackson Dynamic stabilization connecting member with cord connection
US8007519B2 (en) 2007-03-13 2011-08-30 Zimmer Spine, Inc. Dynamic spinal stabilization system and method of using the same
GB0707285D0 (en) * 2007-04-17 2007-05-23 Burke John Implantable apparatus for modulation of skeletal growth
US10383660B2 (en) 2007-05-01 2019-08-20 Roger P. Jackson Soft stabilization assemblies with pretensioned cords
FR2919170B1 (en) * 2007-07-24 2010-09-03 Henry Graf EXTRA-DISCAL ELEMENT OF INTERVERTEBRAL STABILIZATION, GAME OF SUCH ELEMENTS AND CORRESPONDING STABILIZATION ASSEMBLY
FR2930886A1 (en) * 2007-07-24 2009-11-13 Henry Graf EXTRA-DISCAL ASSEMBLY FOR INTERNETEBRAL PROTHERMAL STABILIZATION
CA2739997C (en) 2008-08-01 2013-08-13 Roger P. Jackson Longitudinal connecting member with sleeved tensioned cords
US20120150309A1 (en) * 2009-04-29 2012-06-14 Roelof Marissen Hinge structure
WO2010144458A1 (en) * 2009-06-08 2010-12-16 Reduction Technologies Inc. Systems, methods and devices for correcting spinal deformities
US11229457B2 (en) 2009-06-15 2022-01-25 Roger P. Jackson Pivotal bone anchor assembly with insert tool deployment
US9668771B2 (en) 2009-06-15 2017-06-06 Roger P Jackson Soft stabilization assemblies with off-set connector
EP2757988A4 (en) 2009-06-15 2015-08-19 Jackson Roger P Polyaxial bone anchor with pop-on shank and winged insert with friction fit compressive collet
WO2011127443A1 (en) * 2010-04-08 2011-10-13 Globus Medical, Inc. Jointed rod
CN102869309A (en) * 2010-04-30 2013-01-09 约翰·霍普金斯大学 Intersegmental motion preservation system for use in the spine and methods for use thereof
CN102362816B (en) * 2011-11-17 2013-04-03 瞿玉兴 Dynamic lumbar vertebra fixing system
CN103356275B (en) * 2012-03-29 2016-06-01 董健文 A kind of Micro-movement lumber pedicle screw elastic-fixation system
US10058354B2 (en) 2013-01-28 2018-08-28 Roger P. Jackson Pivotal bone anchor assembly with frictional shank head seating surfaces
US9717533B2 (en) 2013-12-12 2017-08-01 Roger P. Jackson Bone anchor closure pivot-splay control flange form guide and advancement structure
US10064658B2 (en) 2014-06-04 2018-09-04 Roger P. Jackson Polyaxial bone anchor with insert guides
KR101616124B1 (en) * 2014-08-11 2016-04-28 김현성 Dynamic rod
CN104382682A (en) * 2014-12-03 2015-03-04 耿晓鹏 Composite dynamic lumbar vertebra fixing device
CN105816233A (en) * 2015-01-05 2016-08-03 财团法人金属工业研究发展中心 Bone fixing device
CN110538013A (en) * 2019-09-11 2019-12-06 北京爱康宜诚医疗器材有限公司 Spinal fusion prosthesis
CN111643171B (en) * 2020-05-22 2021-06-04 北京市春立正达医疗器械股份有限公司 Multi-stage angle dynamic vertebral body implantation system

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US20030191470A1 (en) * 2002-04-05 2003-10-09 Stephen Ritland Dynamic fixation device and method of use
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Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8870928B2 (en) 2002-09-06 2014-10-28 Roger P. Jackson Helical guide and advancement flange with radially loaded lip
US8936623B2 (en) 2003-06-18 2015-01-20 Roger P. Jackson Polyaxial bone screw assembly
US8926670B2 (en) 2003-06-18 2015-01-06 Roger P. Jackson Polyaxial bone screw assembly
US9532815B2 (en) 2004-02-27 2017-01-03 Roger P. Jackson Spinal fixation tool set and method
US8894657B2 (en) 2004-02-27 2014-11-25 Roger P. Jackson Tool system for dynamic spinal implants
US9216039B2 (en) 2004-02-27 2015-12-22 Roger P. Jackson Dynamic spinal stabilization assemblies, tool set and method
US9055978B2 (en) 2004-02-27 2015-06-16 Roger P. Jackson Orthopedic implant rod reduction tool set and method
US8845649B2 (en) 2004-09-24 2014-09-30 Roger P. Jackson Spinal fixation tool set and method for rod reduction and fastener insertion
US8926672B2 (en) 2004-11-10 2015-01-06 Roger P. Jackson Splay control closure for open bone anchor
US8998960B2 (en) 2004-11-10 2015-04-07 Roger P. Jackson Polyaxial bone screw with helically wound capture connection
US9522021B2 (en) 2004-11-23 2016-12-20 Roger P. Jackson Polyaxial bone anchor with retainer with notch for mono-axial motion
US9451989B2 (en) 2007-01-18 2016-09-27 Roger P Jackson Dynamic stabilization members with elastic and inelastic sections
US9439683B2 (en) 2007-01-26 2016-09-13 Roger P Jackson Dynamic stabilization member with molded connection
US8979904B2 (en) 2007-05-01 2015-03-17 Roger P Jackson Connecting member with tensioned cord, low profile rigid sleeve and spacer with torsion control
US8911477B2 (en) 2007-10-23 2014-12-16 Roger P. Jackson Dynamic stabilization member with end plate support and cable core extension
US9168069B2 (en) 2009-06-15 2015-10-27 Roger P. Jackson Polyaxial bone anchor with pop-on shank and winged insert with lower skirt for engaging a friction fit retainer
US9216041B2 (en) 2009-06-15 2015-12-22 Roger P. Jackson Spinal connecting members with tensioned cords and rigid sleeves for engaging compression inserts
US9393047B2 (en) 2009-06-15 2016-07-19 Roger P. Jackson Polyaxial bone anchor with pop-on shank and friction fit retainer with low profile edge lock
US9504496B2 (en) 2009-06-15 2016-11-29 Roger P. Jackson Polyaxial bone anchor with pop-on shank, friction fit retainer and winged insert
US8998959B2 (en) 2009-06-15 2015-04-07 Roger P Jackson Polyaxial bone anchors with pop-on shank, fully constrained friction fit retainer and lock and release insert
US8911478B2 (en) 2012-11-21 2014-12-16 Roger P. Jackson Splay control closure for open bone anchor
US8852239B2 (en) 2013-02-15 2014-10-07 Roger P Jackson Sagittal angle screw with integral shank and receiver
US9566092B2 (en) 2013-10-29 2017-02-14 Roger P. Jackson Cervical bone anchor with collet retainer and outer locking sleeve
US9451993B2 (en) 2014-01-09 2016-09-27 Roger P. Jackson Bi-radial pop-on cervical bone anchor
US9597119B2 (en) 2014-06-04 2017-03-21 Roger P. Jackson Polyaxial bone anchor with polymer sleeve

Also Published As

Publication number Publication date
WO2007002409A2 (en) 2007-01-04
EP1898813B9 (en) 2013-04-17
KR20080041628A (en) 2008-05-13
CN101247764B (en) 2011-12-28
EP1898813A2 (en) 2008-03-19
EP1898813B1 (en) 2012-10-10
CA2612943A1 (en) 2007-01-04
CN101247764A (en) 2008-08-20
JP2008546487A (en) 2008-12-25
AU2006262057A1 (en) 2007-01-04
JP5435943B2 (en) 2014-03-05
EP1898813A4 (en) 2009-04-22

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