WO2007021343A3 - Pharmacokinetic-based culture system with biological barriers - Google Patents
Pharmacokinetic-based culture system with biological barriers Download PDFInfo
- Publication number
- WO2007021343A3 WO2007021343A3 PCT/US2006/018951 US2006018951W WO2007021343A3 WO 2007021343 A3 WO2007021343 A3 WO 2007021343A3 US 2006018951 W US2006018951 W US 2006018951W WO 2007021343 A3 WO2007021343 A3 WO 2007021343A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- microscale
- flow
- simulated
- interactions
- systems
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/16—Microfluidic devices; Capillary tubes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/44—Multiple separable units; Modules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002607965A CA2607965A1 (en) | 2005-05-18 | 2006-05-17 | Pharmacokinetic-based culture system with biological barriers |
JP2008512445A JP2008539787A (en) | 2005-05-18 | 2006-05-17 | Pharmacokinetic-based culture system with biological barrier |
EP06813188A EP1891201A4 (en) | 2005-05-18 | 2006-05-17 | Pharmacokinetic-based culture system with biological barriers |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68213105P | 2005-05-18 | 2005-05-18 | |
US60/682,131 | 2005-05-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007021343A2 WO2007021343A2 (en) | 2007-02-22 |
WO2007021343A3 true WO2007021343A3 (en) | 2007-06-21 |
Family
ID=37758004
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/018951 WO2007021343A2 (en) | 2005-05-18 | 2006-05-17 | Pharmacokinetic-based culture system with biological barriers |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1891201A4 (en) |
JP (1) | JP2008539787A (en) |
CN (1) | CN101223268A (en) |
CA (1) | CA2607965A1 (en) |
WO (1) | WO2007021343A2 (en) |
Cited By (15)
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US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
US8871444B2 (en) | 2004-10-08 | 2014-10-28 | Medical Research Council | In vitro evolution in microfluidic systems |
US9012390B2 (en) | 2006-08-07 | 2015-04-21 | Raindance Technologies, Inc. | Fluorocarbon emulsion stabilizing surfactants |
US9150852B2 (en) | 2011-02-18 | 2015-10-06 | Raindance Technologies, Inc. | Compositions and methods for molecular labeling |
US9228229B2 (en) | 2010-02-12 | 2016-01-05 | Raindance Technologies, Inc. | Digital analyte analysis |
US9273308B2 (en) | 2006-05-11 | 2016-03-01 | Raindance Technologies, Inc. | Selection of compartmentalized screening method |
US9328344B2 (en) | 2006-01-11 | 2016-05-03 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
US9364803B2 (en) | 2011-02-11 | 2016-06-14 | Raindance Technologies, Inc. | Methods for forming mixed droplets |
US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
US9440232B2 (en) | 2007-02-06 | 2016-09-13 | Raindance Technologies, Inc. | Manipulation of fluids and reactions in microfluidic systems |
US9448172B2 (en) | 2003-03-31 | 2016-09-20 | Medical Research Council | Selection by compartmentalised screening |
US9498759B2 (en) | 2004-10-12 | 2016-11-22 | President And Fellows Of Harvard College | Compartmentalized screening by microfluidic control |
US9562897B2 (en) | 2010-09-30 | 2017-02-07 | Raindance Technologies, Inc. | Sandwich assays in droplets |
US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
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US7901939B2 (en) | 2002-05-09 | 2011-03-08 | University Of Chicago | Method for performing crystallization and reactions in pressure-driven fluid plugs |
EP2278338B1 (en) | 2002-05-09 | 2020-08-26 | The University of Chicago | Device and method for pressure-driven plug transport and reaction |
GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
WO2008130623A1 (en) | 2007-04-19 | 2008-10-30 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
WO2009015390A2 (en) * | 2007-07-26 | 2009-01-29 | University Of Chicago | Co-incuating confined microbial communities |
WO2009039378A2 (en) | 2007-09-19 | 2009-03-26 | The Charles Stark Draper Laboratory, Inc. | Microfluidic structures for biomedical applications |
CN101939644B (en) * | 2008-01-10 | 2014-06-11 | 休雷尔公司 | Immune system modeling devices and methods |
WO2009149257A1 (en) | 2008-06-04 | 2009-12-10 | The University Of Chicago | The chemistrode: a plug-based microfluidic device and method for stimulation and sampling with high temporal, spatial, and chemical resolution |
EP3778858A1 (en) | 2008-07-16 | 2021-02-17 | Children's Medical Center Corporation | Device with microchannels and method of use |
WO2010009365A1 (en) | 2008-07-18 | 2010-01-21 | Raindance Technologies, Inc. | Droplet libraries |
WO2010111231A1 (en) | 2009-03-23 | 2010-09-30 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
US10196700B2 (en) | 2009-03-24 | 2019-02-05 | University Of Chicago | Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes |
KR101702154B1 (en) | 2009-03-24 | 2017-02-03 | 유니버시티 오브 시카고 | Device for carrying out a reaction |
US9464319B2 (en) | 2009-03-24 | 2016-10-11 | California Institute Of Technology | Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes |
US9447461B2 (en) | 2009-03-24 | 2016-09-20 | California Institute Of Technology | Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes |
EP2471908B1 (en) | 2009-08-26 | 2016-10-05 | The University of Tokyo | Method for culture of hepatocytes |
US20110082563A1 (en) * | 2009-10-05 | 2011-04-07 | The Charles Stark Draper Laboratory, Inc. | Microscale multiple-fluid-stream bioreactor for cell culture |
WO2011042564A1 (en) | 2009-10-09 | 2011-04-14 | Universite De Strasbourg | Labelled silica-based nanomaterial with enhanced properties and uses thereof |
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US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
JP6122388B2 (en) * | 2011-02-28 | 2017-04-26 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | Cell culture system |
DE202012013668U1 (en) | 2011-06-02 | 2019-04-18 | Raindance Technologies, Inc. | enzyme quantification |
US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
WO2013086486A1 (en) | 2011-12-09 | 2013-06-13 | President And Fellows Of Harvard College | Integrated human organ-on-chip microphysiological systems |
CN102643742B (en) * | 2012-04-18 | 2013-06-05 | 西安建筑科技大学 | Autotrophic bacteria kinetic parameter measurement device and method |
US9528082B2 (en) | 2012-07-25 | 2016-12-27 | The Charles Stark Draper Laboratory, Inc. | Modular platform for multi-tissue integrated cell culture |
US9249387B2 (en) | 2013-01-29 | 2016-02-02 | The Charles Stark Draper Laboratory, Inc. | Modular platform for multi-tissue integrated cell culture |
US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
WO2015103367A1 (en) | 2013-12-31 | 2015-07-09 | Raindance Technologies, Inc. | System and method for detection of rna species |
JP2018516065A (en) | 2015-02-04 | 2018-06-21 | ザ チャールズ スターク ドレイパー ラボラトリー インク | Actuating valves or pumps for microfluidic devices |
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US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
CN105385598B (en) * | 2015-11-30 | 2017-12-29 | 赵明光 | Human cerebral arteriovenous malformations biomechanical model and its vitro construction method |
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WO2019043130A1 (en) * | 2017-08-31 | 2019-03-07 | Philip Morris Products S.A. | Cell culture plate, devices and methods for in vitro exposure |
Citations (2)
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US5043260A (en) * | 1987-11-02 | 1991-08-27 | Rhode Island Hospital | Perfusion device with hepatocytes |
US20030080795A1 (en) * | 2001-10-29 | 2003-05-01 | Mitsubishi Denki Kabushiki Kaisha | Semiconductor device |
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US6001585A (en) * | 1997-11-14 | 1999-12-14 | Cellex Biosciences, Inc. | Micro hollow fiber bioreactor |
DE69903800T2 (en) * | 1998-03-18 | 2003-10-02 | Massachusetts Inst Technology | VASCULARIZED PERFUNDED ARRANGEMENTS FOR MICRO TISSUE AND MICROORGANES |
DK1392814T3 (en) * | 2001-04-25 | 2007-09-24 | Cornell Res Foundation Inc | Devices and Methods for Pharmacokinetic Based Cell Culture System |
US20040077075A1 (en) * | 2002-05-01 | 2004-04-22 | Massachusetts Institute Of Technology | Microfermentors for rapid screening and analysis of biochemical processes |
JP4370082B2 (en) * | 2002-08-26 | 2009-11-25 | 独立行政法人科学技術振興機構 | Neuron culture microchamber |
JP4118102B2 (en) * | 2002-08-26 | 2008-07-16 | 独立行政法人科学技術振興機構 | Cell culture microchamber with semipermeable membrane |
JP4607432B2 (en) * | 2003-05-12 | 2011-01-05 | 高木産業株式会社 | Cell or tissue culture device |
WO2005033263A1 (en) * | 2003-10-01 | 2005-04-14 | Athena Capital Partners, Llc | Circulating flow device for assays of cell cultures, cellular components and cell products |
-
2006
- 2006-05-17 CN CN 200680025975 patent/CN101223268A/en active Pending
- 2006-05-17 WO PCT/US2006/018951 patent/WO2007021343A2/en active Application Filing
- 2006-05-17 EP EP06813188A patent/EP1891201A4/en not_active Withdrawn
- 2006-05-17 JP JP2008512445A patent/JP2008539787A/en active Pending
- 2006-05-17 CA CA002607965A patent/CA2607965A1/en not_active Abandoned
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US5043260A (en) * | 1987-11-02 | 1991-08-27 | Rhode Island Hospital | Perfusion device with hepatocytes |
US20030080795A1 (en) * | 2001-10-29 | 2003-05-01 | Mitsubishi Denki Kabushiki Kaisha | Semiconductor device |
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See also references of EP1891201A4 * |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9448172B2 (en) | 2003-03-31 | 2016-09-20 | Medical Research Council | Selection by compartmentalised screening |
US8871444B2 (en) | 2004-10-08 | 2014-10-28 | Medical Research Council | In vitro evolution in microfluidic systems |
US9186643B2 (en) | 2004-10-08 | 2015-11-17 | Medical Research Council | In vitro evolution in microfluidic systems |
US9498759B2 (en) | 2004-10-12 | 2016-11-22 | President And Fellows Of Harvard College | Compartmentalized screening by microfluidic control |
US9534216B2 (en) | 2006-01-11 | 2017-01-03 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
US9328344B2 (en) | 2006-01-11 | 2016-05-03 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
US9410151B2 (en) | 2006-01-11 | 2016-08-09 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
US9273308B2 (en) | 2006-05-11 | 2016-03-01 | Raindance Technologies, Inc. | Selection of compartmentalized screening method |
US9012390B2 (en) | 2006-08-07 | 2015-04-21 | Raindance Technologies, Inc. | Fluorocarbon emulsion stabilizing surfactants |
US9498761B2 (en) | 2006-08-07 | 2016-11-22 | Raindance Technologies, Inc. | Fluorocarbon emulsion stabilizing surfactants |
US9440232B2 (en) | 2007-02-06 | 2016-09-13 | Raindance Technologies, Inc. | Manipulation of fluids and reactions in microfluidic systems |
US9228229B2 (en) | 2010-02-12 | 2016-01-05 | Raindance Technologies, Inc. | Digital analyte analysis |
US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
US9562897B2 (en) | 2010-09-30 | 2017-02-07 | Raindance Technologies, Inc. | Sandwich assays in droplets |
US9364803B2 (en) | 2011-02-11 | 2016-06-14 | Raindance Technologies, Inc. | Methods for forming mixed droplets |
US9150852B2 (en) | 2011-02-18 | 2015-10-06 | Raindance Technologies, Inc. | Compositions and methods for molecular labeling |
US11965877B2 (en) | 2011-02-18 | 2024-04-23 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
Also Published As
Publication number | Publication date |
---|---|
WO2007021343A2 (en) | 2007-02-22 |
EP1891201A2 (en) | 2008-02-27 |
EP1891201A4 (en) | 2011-11-09 |
CN101223268A (en) | 2008-07-16 |
JP2008539787A (en) | 2008-11-20 |
CA2607965A1 (en) | 2007-02-22 |
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