WO2007022248A3 - Methods of detection of cancer using peptide profiles - Google Patents

Methods of detection of cancer using peptide profiles Download PDF

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Publication number
WO2007022248A3
WO2007022248A3 PCT/US2006/031957 US2006031957W WO2007022248A3 WO 2007022248 A3 WO2007022248 A3 WO 2007022248A3 US 2006031957 W US2006031957 W US 2006031957W WO 2007022248 A3 WO2007022248 A3 WO 2007022248A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
detection
profiles
methods
peptide profiles
Prior art date
Application number
PCT/US2006/031957
Other languages
French (fr)
Other versions
WO2007022248A2 (en
Inventor
Paul Tempst
Josep Villanueva
Original Assignee
Sloan Kettering Inst Cancer
Paul Tempst
Josep Villanueva
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sloan Kettering Inst Cancer, Paul Tempst, Josep Villanueva filed Critical Sloan Kettering Inst Cancer
Priority to US12/063,968 priority Critical patent/US7972770B2/en
Publication of WO2007022248A2 publication Critical patent/WO2007022248A2/en
Publication of WO2007022248A3 publication Critical patent/WO2007022248A3/en
Priority to US13/116,956 priority patent/US20110312522A1/en
Priority to US14/031,712 priority patent/US20140234880A1/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen

Abstract

The disclosed methods address the identification and monitoring of cancer in a subject using serum peptide profiles. Such profiles allow the detection of the differential presence of certain serum peptide markers in comparison with controls. The profiles can be determined employing mass spectrometry.
PCT/US2006/031957 2005-08-16 2006-08-16 Methods of detection of cancer using peptide profiles WO2007022248A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/063,968 US7972770B2 (en) 2005-08-16 2006-08-16 Methods of detection of cancer using peptide profiles
US13/116,956 US20110312522A1 (en) 2005-08-16 2011-05-26 Methods of detection of cancer using peptide profiles
US14/031,712 US20140234880A1 (en) 2005-08-16 2013-09-19 Methods of detection of cancer using peptide profiles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70867605P 2005-08-16 2005-08-16
US60/708,676 2005-08-16

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/063,968 A-371-Of-International US7972770B2 (en) 2005-08-16 2006-08-16 Methods of detection of cancer using peptide profiles
US13/116,956 Division US20110312522A1 (en) 2005-08-16 2011-05-26 Methods of detection of cancer using peptide profiles

Publications (2)

Publication Number Publication Date
WO2007022248A2 WO2007022248A2 (en) 2007-02-22
WO2007022248A3 true WO2007022248A3 (en) 2009-05-14

Family

ID=37758335

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/031957 WO2007022248A2 (en) 2005-08-16 2006-08-16 Methods of detection of cancer using peptide profiles

Country Status (2)

Country Link
US (3) US7972770B2 (en)
WO (1) WO2007022248A2 (en)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5376948B2 (en) 2005-09-13 2013-12-25 ナショナル リサーチ カウンシル オブ カナダ Methods and compositions for modulating tumor cell activity
CN101310185A (en) * 2005-09-19 2008-11-19 约翰·霍普金斯大学 Biomarker for prostate cancer
US8637325B2 (en) * 2009-02-16 2014-01-28 University Of Wyoming Method and apparatus for pyrolysis-induced cleavage in peptides and proteins
CN101153054B (en) 2006-09-30 2012-02-22 北京市肿瘤防治研究所 Peptide for treatment of vascellum generation and uses thereof
US10247736B2 (en) 2007-07-20 2019-04-02 Brigham Young University Identification and quantification of biomarkers for evaluating the risk of preterm birth
US8039227B2 (en) 2007-09-20 2011-10-18 University Of Louisville Research Foundation, Inc. Peptide biomarkers predictive of renal function decline and kidney disease
WO2009051259A1 (en) * 2007-10-18 2009-04-23 Miyazaki Prefectural Industrial Support Foundation Biomarker for diagnosis of liver disease
EP2409155A1 (en) 2009-03-15 2012-01-25 Technion Research and Development Foundation, Ltd. Soluble hla complexes for use in disease diagnosis
EP2440922B1 (en) 2009-06-12 2016-08-10 Vaccine Technologies, Incorporated Methods for diagnostic assays for measuring cell mediated immune response
US8464171B2 (en) * 2009-06-26 2013-06-11 Eppendorf Ag Device for displaying a function chart
AU2010324506B2 (en) 2009-11-24 2015-02-26 Alethia Biotherapeutics Inc. Anti-clusterin antibodies and antigen binding fragments and their use to reduce tumor volume
GB201009798D0 (en) 2010-06-11 2010-07-21 Immunovia Ab Method,array and use thereof
US9057731B2 (en) * 2010-06-23 2015-06-16 University Of Louisville Research Foundation, Inc. Methods and kits for predicting a response to an erythropoietic agent
CA2810473C (en) * 2010-09-15 2018-06-26 Dh Technologies Development Pte. Ltd. Data independent acquisition of product ion spectra and reference spectra library matching
CN102062780A (en) * 2010-11-23 2011-05-18 北京正旦国际科技有限责任公司 Polypeptide immunoassay kit and detection method thereof
CN102507939B (en) * 2011-10-21 2014-03-12 北京正旦国际科技有限责任公司 Enzyme-linked immuno sorbent assay (ELISA) kit for cirrhosis
CN102507941B (en) * 2011-10-25 2014-04-30 北京正旦国际科技有限责任公司 Hepatocirrhosis immuno-mass spectrometric detection reagent kit
EP2592421B1 (en) * 2011-11-14 2017-08-30 Universitätsklinikum Jena Diagnosis of sepsis and systemic inflammatory response syndrome
JP6285865B2 (en) 2011-11-14 2018-02-28 アルファシグマ ソシエタ ペル アチオニ Assays and methods for selecting treatment regimens for subjects with depression
SG10201605361RA (en) 2012-01-05 2016-08-30 Boston Medical Ct Corp Slit-Robo Signaling for Diagnosis and Treatment of Kidney Disease
EA201491568A1 (en) 2012-02-22 2014-11-28 Алетиа Байотерапьютикс Инк. JOINT APPLICATION OF CLUSTERIN INHIBITOR AND EGFR INHIBITOR FOR CANCER TREATMENT
CN102643334B (en) * 2012-03-29 2014-03-12 西安交通大学 Polypeptide molecule for serum in gastric cancer and application
KR20150015531A (en) 2012-05-29 2015-02-10 바이오디식스, 인크. Deep-MALDI TOF mass spectrometry of complex biological samples, e.g., serum, and uses thereof
BR112015010276A2 (en) * 2012-11-06 2019-10-15 Hoffmann La Roche mimetic peptides
CN103304658B (en) * 2013-05-30 2015-02-04 北京正旦国际科技有限责任公司 Radiosensitive polypeptide mark SPG01 for nasopharynx cancer and ELISA (Enzyme-Linked Immuno Sorbent Assay) kit thereof
GB2515334A (en) * 2013-06-20 2014-12-24 Neuro Bio Ltd Biomarkers for alzheimer's Disease
WO2015069187A1 (en) * 2013-11-05 2015-05-14 Agency For Science, Technology And Research Bladder Carcinoma Biomarkers
WO2015069827A2 (en) * 2013-11-06 2015-05-14 H. Lee Moffitt Cancer Center And Research Institute, Inc. Pathology case review, analysis and prediction
JP6079587B2 (en) * 2013-11-27 2017-02-15 株式会社島津製作所 Glycopeptide analyzer
GB201322800D0 (en) 2013-12-20 2014-02-05 Univ Dublin Prostate cancer biomarkers
CN103940934B (en) * 2014-03-25 2016-04-27 张华俊 A kind of method of analysis of mixtures composition
CN104316695B (en) * 2014-08-22 2016-08-24 北京蛋白质组研究中心 For detecting the double-antibody sandwich test kit of hepatocarcinoma and liver cirrhosis related polypeptide-box-like mark of protein groups
ES2568702B1 (en) * 2014-10-01 2017-02-13 Servizo Galego De Saude (Sergas) METHOD FOR THE DIAGNOSIS OF ARTROSIS
WO2016054031A1 (en) 2014-10-02 2016-04-07 Biodesix, Inc. Predictive test for aggressiveness or indolence of prostate cancer from mass spectrometry of blood-based sample
US10392665B2 (en) 2015-06-19 2019-08-27 Sera Prognostics, Inc. Biomarker pairs for predicting preterm birth
CN105384805B (en) * 2015-10-16 2018-05-04 上海市肺科医院 A kind of diagnosis polypeptide and its application
WO2018039137A1 (en) * 2016-08-22 2018-03-01 Jo Eung Joon Database management using a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer
TWI592810B (en) 2016-08-30 2017-07-21 力晶科技股份有限公司 Nonparametric method for measuring clustered level of time rank in binary data
WO2018081691A1 (en) * 2016-10-28 2018-05-03 Frontier Diagnostics, Llc Imaging mass spectrometry and uses thereof
CA3073192A1 (en) 2017-08-18 2019-02-21 Sera Prognostics, Inc Pregnancy clock proteins for predicting due date and time to birth
CN108169184B (en) * 2017-09-05 2021-01-05 哈尔滨工业大学 Establishment method and application of tumor classification identification model
US10692605B2 (en) 2018-01-08 2020-06-23 International Business Machines Corporation Library screening for cancer probability
JP7336097B2 (en) 2019-07-19 2023-08-31 京都府公立大学法人 Peptide markers for breast cancer
JP7334671B2 (en) 2020-04-21 2023-08-29 株式会社島津製作所 Theoretical mass table display system
JP7310692B2 (en) 2020-04-21 2023-07-19 株式会社島津製作所 Theoretical mass table display system

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050059013A1 (en) * 2002-08-06 2005-03-17 The Johns Hopkins University Use of biomarkers for detecting ovarian cancer
WO2006034032A2 (en) * 2004-09-17 2006-03-30 The Johns Hopkins University Biomarkers for breast cancer
WO2006099126A2 (en) * 2005-03-11 2006-09-21 Ciphergen Biosystems, Inc. Biomarkers for ovarian cancer and endometrial cancer: hepcidin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20040098A1 (en) * 2004-02-25 2004-05-25 Univ Roma OLIGOCLONAL ANTI-CLASTERINE ANTIBODIES FOR THE DIAGNOSIS OF NEOPLASIE AND THE PREDICTION OF THEIR DEGREE OF MALIGNITY, DIAGNOSTIC METHOD AND RELATED KITS.
WO2006044666A2 (en) * 2004-10-15 2006-04-27 Northeastern University Detection of disease associated proteolysis by direct mass spectrometry analysis of low molecular weight peptides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050059013A1 (en) * 2002-08-06 2005-03-17 The Johns Hopkins University Use of biomarkers for detecting ovarian cancer
WO2006034032A2 (en) * 2004-09-17 2006-03-30 The Johns Hopkins University Biomarkers for breast cancer
WO2006099126A2 (en) * 2005-03-11 2006-09-21 Ciphergen Biosystems, Inc. Biomarkers for ovarian cancer and endometrial cancer: hepcidin
US20070054329A1 (en) * 2005-03-11 2007-03-08 Ciphergen Biosystems, Inc. Biomarker for ovarian and endometrial cancer: hepcidin

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CAPUTO ET AL.: "Peptide profiling in epithelial tumor plasma by the emerging proteomic techniques.", J OF CHROMATOGRAPHY., vol. 819, May 2005 (2005-05-01), pages 59 - 66, XP002496511, DOI: doi:10.1016/j.jchromb.2005.01.022 *
FUNG ET AL.: "Classification of cancer types by measuring variants of host response proteins using SELDI serum assays.", INT J CANCER., vol. 115, 2005, pages 783 - 789, XP002504152, DOI: doi:10.1002/ijc.20928 *
KOOMEN ET AL.: "Direct tandem mass spectrometry reveals limitations in protein profiling experiments for plasma biomarker discover.", J OF PROTEOME RESEARCH., vol. 4, May 2005 (2005-05-01), pages 972 - 981 *
SONG ET AL.: "Quantification of fragments of human serum inter-alpha-trypsin inhibitor heavy chain 4 by a surface-enhanced laser desorption/ionization-based immunoassay.", CLINICAL CHEMISTRY, vol. 52, June 2006 (2006-06-01), pages 1045 - 1053, XP002584414, DOI: doi:10.1373/clinchem.2005.065722 *
VILLANUEVA ET AL.: "Differential exoprotease activities confer tumor-specific serum peptidome pattems.", J OF CLINICAL INVESTIGATION., vol. 116, January 2006 (2006-01-01), pages 271 - 284, XP002434651, DOI: doi:10.1172/JCI26022 *

Also Published As

Publication number Publication date
US20110312522A1 (en) 2011-12-22
WO2007022248A2 (en) 2007-02-22
US7972770B2 (en) 2011-07-05
US20090208921A1 (en) 2009-08-20
US20140234880A1 (en) 2014-08-21

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