WO2007072491A3 - Sustained release pharmaceutical formulation and treatment of ischemic heart disease by administering the same - Google Patents

Sustained release pharmaceutical formulation and treatment of ischemic heart disease by administering the same Download PDF

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Publication number
WO2007072491A3
WO2007072491A3 PCT/IN2005/000425 IN2005000425W WO2007072491A3 WO 2007072491 A3 WO2007072491 A3 WO 2007072491A3 IN 2005000425 W IN2005000425 W IN 2005000425W WO 2007072491 A3 WO2007072491 A3 WO 2007072491A3
Authority
WO
WIPO (PCT)
Prior art keywords
17beta
estradiol
heart disease
coronary
micro
Prior art date
Application number
PCT/IN2005/000425
Other languages
French (fr)
Other versions
WO2007072491A2 (en
Inventor
Baskaran Chandrasekar
Original Assignee
Baskaran Chandrasekar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baskaran Chandrasekar filed Critical Baskaran Chandrasekar
Priority to PCT/IN2005/000425 priority Critical patent/WO2007072491A2/en
Publication of WO2007072491A2 publication Critical patent/WO2007072491A2/en
Publication of WO2007072491A3 publication Critical patent/WO2007072491A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Abstract

This invention relates to a method of treating ischemic heart disease by stimulating arteriogenesis and angiogenesis. This is achieved by intracoronary administration of a sustained release pharmaceutical formulation containing 17beta-estradiol microencapsulated in biodegradable polymers. A method for stimulation of arteriogenesis and angiogenesis in severe ischemic heart disease by the intra-coronary administration of 17beta-estradiol is described. The 17beta-estradiol is delivered preferably in the form of encapsulated bio-degradable micro-spheres. Intra-coronary delivery of 17beta-estradiol - loaded microspheres can be easily performed during the procedure of cardiac catheterization. The administered 17beta-estradiol - loaded micro-spheres become trapped in the coronary micro-circulation, and undergo gradual degradation producing a sustained concentration of 17beta-estradiol at the level of coronary micro-circulation.
PCT/IN2005/000425 2005-12-21 2005-12-21 Sustained release pharmaceutical formulation and treatment of ischemic heart disease by administering the same WO2007072491A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/IN2005/000425 WO2007072491A2 (en) 2005-12-21 2005-12-21 Sustained release pharmaceutical formulation and treatment of ischemic heart disease by administering the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2005/000425 WO2007072491A2 (en) 2005-12-21 2005-12-21 Sustained release pharmaceutical formulation and treatment of ischemic heart disease by administering the same

Publications (2)

Publication Number Publication Date
WO2007072491A2 WO2007072491A2 (en) 2007-06-28
WO2007072491A3 true WO2007072491A3 (en) 2007-11-08

Family

ID=38189081

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2005/000425 WO2007072491A2 (en) 2005-12-21 2005-12-21 Sustained release pharmaceutical formulation and treatment of ischemic heart disease by administering the same

Country Status (1)

Country Link
WO (1) WO2007072491A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643604A (en) * 1990-06-14 1997-07-01 Aplicaciones Farmaceuticas S.A. De C.V. Parenteral dosage form
US6056972A (en) * 1997-02-26 2000-05-02 Dimera, Llc Method for reducing coronary artery reactivity
US6309669B1 (en) * 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6309669B1 (en) * 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
US5643604A (en) * 1990-06-14 1997-07-01 Aplicaciones Farmaceuticas S.A. De C.V. Parenteral dosage form
US6056972A (en) * 1997-02-26 2000-05-02 Dimera, Llc Method for reducing coronary artery reactivity

Also Published As

Publication number Publication date
WO2007072491A2 (en) 2007-06-28

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