WO2007089564A3 - Microchannel magneto-immunoassay - Google Patents
Microchannel magneto-immunoassay Download PDFInfo
- Publication number
- WO2007089564A3 WO2007089564A3 PCT/US2007/002138 US2007002138W WO2007089564A3 WO 2007089564 A3 WO2007089564 A3 WO 2007089564A3 US 2007002138 W US2007002138 W US 2007002138W WO 2007089564 A3 WO2007089564 A3 WO 2007089564A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- particles
- electromagnets
- immunoassay
- microchannel
- luminescence
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
Abstract
A single microchannel is combined with external electromagnets for performing a fast immunoassay within a very small volume. Magnetic/luminescent nanoparticles serve as carriers for the antibodies and as internal luminescent standard. The immunoreaction is accelerated by applying alternating magnetic field by means of the external electromagnets, thus inducing oscillation of the particles and achieving better diffusion during the incubation steps. Using the electromagnets the particles are held into the channel for washing and luminescence detection steps. The luminescence of the particles serves as an internal calibration for the assay and helps to avoid experimental error from particle loss.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/162,322 US20090227044A1 (en) | 2006-01-26 | 2007-01-26 | Microchannel Magneto-Immunoassay |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76262006P | 2006-01-26 | 2006-01-26 | |
US60/762,620 | 2006-01-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007089564A2 WO2007089564A2 (en) | 2007-08-09 |
WO2007089564A3 true WO2007089564A3 (en) | 2007-12-13 |
Family
ID=38327895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/002138 WO2007089564A2 (en) | 2006-01-26 | 2007-01-26 | Microchannel magneto-immunoassay |
Country Status (2)
Country | Link |
---|---|
US (1) | US20090227044A1 (en) |
WO (1) | WO2007089564A2 (en) |
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Citations (2)
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US20030047028A1 (en) * | 2001-08-08 | 2003-03-13 | Toyoki Kunitake | Nanomaterials of composite metal oxides |
US20050272049A1 (en) * | 2000-06-21 | 2005-12-08 | Sukanta Banerjee | Arrays of magnetic particles |
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US7314763B2 (en) * | 2002-08-27 | 2008-01-01 | Kimberly-Clark Worldwide, Inc. | Fluidics-based assay devices |
WO2005040756A2 (en) * | 2003-10-22 | 2005-05-06 | The Regents Of The University Of California | Methods for preparing and functionalizing nanoparticles |
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US20070037215A1 (en) * | 2005-08-11 | 2007-02-15 | Patton Wayne F | Assay particles and methods of use |
-
2007
- 2007-01-26 WO PCT/US2007/002138 patent/WO2007089564A2/en active Application Filing
- 2007-01-26 US US12/162,322 patent/US20090227044A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050272049A1 (en) * | 2000-06-21 | 2005-12-08 | Sukanta Banerjee | Arrays of magnetic particles |
US20030047028A1 (en) * | 2001-08-08 | 2003-03-13 | Toyoki Kunitake | Nanomaterials of composite metal oxides |
Also Published As
Publication number | Publication date |
---|---|
US20090227044A1 (en) | 2009-09-10 |
WO2007089564A2 (en) | 2007-08-09 |
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