WO2007092909A3 - Molecular interaction sensors - Google Patents

Molecular interaction sensors Download PDF

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Publication number
WO2007092909A3
WO2007092909A3 PCT/US2007/061808 US2007061808W WO2007092909A3 WO 2007092909 A3 WO2007092909 A3 WO 2007092909A3 US 2007061808 W US2007061808 W US 2007061808W WO 2007092909 A3 WO2007092909 A3 WO 2007092909A3
Authority
WO
WIPO (PCT)
Prior art keywords
molecular interaction
linker
coupled
preferred embodiments
detectable label
Prior art date
Application number
PCT/US2007/061808
Other languages
French (fr)
Other versions
WO2007092909A2 (en
WO2007092909A8 (en
Inventor
Mitchell C Sanders
Andrei Rakitin
James C Comolli
Original Assignee
Expressive Constructs Inc
Mitchell C Sanders
Andrei Rakitin
James C Comolli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Expressive Constructs Inc, Mitchell C Sanders, Andrei Rakitin, James C Comolli filed Critical Expressive Constructs Inc
Publication of WO2007092909A2 publication Critical patent/WO2007092909A2/en
Publication of WO2007092909A3 publication Critical patent/WO2007092909A3/en
Publication of WO2007092909A8 publication Critical patent/WO2007092909A8/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6823Release of bound markers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001Enzyme electrodes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/10Libraries containing peptides or polypeptides, or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/12Apparatus specially adapted for use in combinatorial chemistry or with libraries for screening libraries
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326Magnetic particles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346Nanoparticles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

In preferred embodiments, the present invention provides a specific molecular interaction sensor and methods of use thereof, comprising at least one molecular interaction complex comprising a disruptable linker having first and second end, the first end being coupled to a detectable label and the second end being coupled to a surface of a support, wherein the linker is disrupted by a specific predetermined target molecule; a detector adapted to detect the label; and at least one readout device. In preferred embodiments, the detectable label is a superparamagnetic nanoparticle and the detector is a magnetoresistive device.
PCT/US2007/061808 2006-02-07 2007-02-07 Molecular interaction sensors WO2007092909A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77110706P 2006-02-07 2006-02-07
US60/771,107 2006-02-07

Publications (3)

Publication Number Publication Date
WO2007092909A2 WO2007092909A2 (en) 2007-08-16
WO2007092909A3 true WO2007092909A3 (en) 2008-11-13
WO2007092909A8 WO2007092909A8 (en) 2009-07-16

Family

ID=38345949

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/061808 WO2007092909A2 (en) 2006-02-07 2007-02-07 Molecular interaction sensors

Country Status (1)

Country Link
WO (1) WO2007092909A2 (en)

Families Citing this family (27)

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EP1576181B1 (en) 2002-01-31 2013-08-14 Systagenix Wound Management IP Co. BV. Method for detecting pathogenic bacteria in wounds
GB0618524D0 (en) * 2006-09-20 2006-11-01 Isis Innovation Multimeric particles
WO2009102349A2 (en) * 2007-10-28 2009-08-20 Eci Biotech Inc. Sensors for measuring contaminants
DE102007057667A1 (en) 2007-11-30 2009-09-03 Siemens Ag Device for detecting particles in a fluid
US9958442B2 (en) 2009-02-11 2018-05-01 Duke University Sensors incorporating antibodies and methods of making and using the same
US9599591B2 (en) * 2009-03-06 2017-03-21 California Institute Of Technology Low cost, portable sensor for molecular assays
US8993236B2 (en) * 2009-04-17 2015-03-31 California Institute Of Technology Electromagnetic molecular sensors and methods of using same
FR2963106A1 (en) * 2010-07-21 2012-01-27 Ecole Polytechnique Dgar METHOD AND DEVICE FOR ANALYZING MOLECULAR INTERACTIONS, AND USES THEREOF
US8815610B2 (en) * 2010-10-15 2014-08-26 International Business Machines Corporation Magnetic nanoparticle detection across a membrane
JP6158097B2 (en) 2011-03-18 2017-07-05 デューク・ユニヴァーシティ Peptides for inhibiting inflammation
US9303063B2 (en) 2011-03-18 2016-04-05 Duke University Peptide compounds for suppressing inflammation
AU2013204332B2 (en) 2012-04-16 2015-07-16 Commonwealth Scientific And Industrial Research Organisation Methods and systems for detecting an analyte or classifying a sample
WO2015187227A2 (en) 2014-03-13 2015-12-10 Duke University Electronic platform for sensing and control of electrochemical reactions
EP2930497A1 (en) * 2014-04-07 2015-10-14 Institut Pasteur Enzyme-independent photon emission
US20160011182A1 (en) * 2014-07-09 2016-01-14 Zepto Life Technology, LLC Method and system for substance detection with a magnetic sensor
EP2977347A1 (en) * 2014-07-22 2016-01-27 Niklas Anttu Optical molecular nanowire sensor
CN106248944A (en) * 2016-06-30 2016-12-21 深圳市亚辉龙生物科技股份有限公司 A kind of CPn IgG chemiluminescence immune detection reagent kit and preparation method thereof
JP2020510406A (en) * 2016-11-14 2020-04-09 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガナイゼーション Protease sensor molecule
US20200131558A1 (en) * 2017-04-21 2020-04-30 Colorado State University Research Foundation Paper-based assay for antimicrobial resistance
EP3665481B1 (en) 2017-08-08 2023-10-11 PPB Technology Pty Ltd Carbohydrate sensors
WO2020023934A1 (en) * 2018-07-27 2020-01-30 Zepto Life Technology, LLC System and method for processing analyte signals in gmr-based detection of biomarkers
US11291997B2 (en) 2018-08-02 2022-04-05 Colorado State University Research Foundation Rotary manifold for paper-based immunoassays
US20230085052A1 (en) * 2020-01-17 2023-03-16 Zepto Life Technology, LLC Systems and methods for sensing analytes in gmr-based detection of biomarkers
WO2022263523A1 (en) * 2021-06-17 2022-12-22 F. Hoffmann-La Roche Ag Method for immunosensing on a lipid layer
US20220404347A1 (en) * 2021-06-17 2022-12-22 Roche Diagnostics Operations, Inc. Methods for detecting an analyte using structure switching binding agents
WO2022263542A1 (en) * 2021-06-17 2022-12-22 Roche Diagnostics Gmbh Method for immunosensing on a lipid layer using magnetic tunnel junctions ii
CN117501122A (en) * 2021-06-17 2024-02-02 豪夫迈·罗氏有限公司 Method for immunosensing lipid layers using magnetic tunnel junctions

Citations (3)

* Cited by examiner, † Cited by third party
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US20010007022A1 (en) * 1999-12-22 2001-07-05 Dade Behring Marburg Gmbh. Anti-procalcitonin antibodies and the preparation and use thereof
US20040219590A1 (en) * 2000-02-10 2004-11-04 Todd Dickinson Methods of detecting targets on an arrary
US20050100930A1 (en) * 2003-11-12 2005-05-12 Wang Shan X. Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010007022A1 (en) * 1999-12-22 2001-07-05 Dade Behring Marburg Gmbh. Anti-procalcitonin antibodies and the preparation and use thereof
US20040219590A1 (en) * 2000-02-10 2004-11-04 Todd Dickinson Methods of detecting targets on an arrary
US20050100930A1 (en) * 2003-11-12 2005-05-12 Wang Shan X. Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules

Also Published As

Publication number Publication date
WO2007092909A2 (en) 2007-08-16
WO2007092909A8 (en) 2009-07-16

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