WO2007140391A3 - Methods of making decomposable thin films of polyelectrolytes and uses thereof - Google Patents

Methods of making decomposable thin films of polyelectrolytes and uses thereof Download PDF

Info

Publication number
WO2007140391A3
WO2007140391A3 PCT/US2007/069937 US2007069937W WO2007140391A3 WO 2007140391 A3 WO2007140391 A3 WO 2007140391A3 US 2007069937 W US2007069937 W US 2007069937W WO 2007140391 A3 WO2007140391 A3 WO 2007140391A3
Authority
WO
WIPO (PCT)
Prior art keywords
polyelectrolytes
making
methods
thin films
decomposable thin
Prior art date
Application number
PCT/US2007/069937
Other languages
French (fr)
Other versions
WO2007140391A2 (en
Inventor
Kris C Wood
Helen F Chuang
Robert D Batten
David M Lynn
Paula T Hammond Cunningham
Original Assignee
Massachusetts Inst Technology
Kris C Wood
Helen F Chuang
Robert D Batten
David M Lynn
Paula T Hammond Cunningham
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology, Kris C Wood, Helen F Chuang, Robert D Batten, David M Lynn, Paula T Hammond Cunningham filed Critical Massachusetts Inst Technology
Publication of WO2007140391A2 publication Critical patent/WO2007140391A2/en
Publication of WO2007140391A3 publication Critical patent/WO2007140391A3/en

Links

Classifications

    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01BCABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
    • H01B1/00Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors
    • H01B1/06Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors mainly consisting of other non-metallic substances
    • H01B1/12Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors mainly consisting of other non-metallic substances organic substances
    • H01B1/122Ionic conductors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/68Polyesters containing atoms other than carbon, hydrogen and oxygen
    • C08G63/685Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen
    • C08G63/6854Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/6856Dicarboxylic acids and dihydroxy compounds
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/24Structurally defined web or sheet [e.g., overall dimension, etc.]
    • Y10T428/24942Structurally defined web or sheet [e.g., overall dimension, etc.] including components having same physical characteristic in differing degree
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984Microcapsule with fluid core [includes liposome]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984Microcapsule with fluid core [includes liposome]
    • Y10T428/2985Solid-walled microcapsule from synthetic polymer
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984Microcapsule with fluid core [includes liposome]
    • Y10T428/2985Solid-walled microcapsule from synthetic polymer
    • Y10T428/2987Addition polymer from unsaturated monomers only
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989Microcapsule with solid core [includes liposome]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/31504Composite [nonstructural laminate]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/31504Composite [nonstructural laminate]
    • Y10T428/31551Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/31504Composite [nonstructural laminate]
    • Y10T428/31551Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]
    • Y10T428/31616Next to polyester [e.g., alkyd]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/31504Composite [nonstructural laminate]
    • Y10T428/31678Of metal
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/31504Composite [nonstructural laminate]
    • Y10T428/31725Of polyamide
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/31504Composite [nonstructural laminate]
    • Y10T428/31786Of polyester [e.g., alkyd, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/31504Composite [nonstructural laminate]
    • Y10T428/31786Of polyester [e.g., alkyd, etc.]
    • Y10T428/31797Next to addition polymer from unsaturated monomers

Abstract

A decomposable thin film comprising a plurality of polyelectrolyte layers of alternating charge, wherein decomposition of the thin film is characterized by degradation of at least a portion of the polyelectrolyte layers.
PCT/US2007/069937 2006-05-30 2007-05-30 Methods of making decomposable thin films of polyelectrolytes and uses thereof WO2007140391A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80964006P 2006-05-30 2006-05-30
US60/809,640 2006-05-30
US11/459,979 US8105652B2 (en) 2002-10-24 2006-07-26 Methods of making decomposable thin films of polyelectrolytes and uses thereof
US11/459,979 2006-07-26

Publications (2)

Publication Number Publication Date
WO2007140391A2 WO2007140391A2 (en) 2007-12-06
WO2007140391A3 true WO2007140391A3 (en) 2008-10-30

Family

ID=38779425

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/069937 WO2007140391A2 (en) 2006-05-30 2007-05-30 Methods of making decomposable thin films of polyelectrolytes and uses thereof

Country Status (2)

Country Link
US (1) US8105652B2 (en)
WO (1) WO2007140391A2 (en)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7101575B2 (en) * 1998-03-19 2006-09-05 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Production of nanocapsules and microcapsules by layer-wise polyelectrolyte self-assembly
US7883720B2 (en) * 2003-07-09 2011-02-08 Wisconsin Alumni Research Foundation Charge-dynamic polymers and delivery of anionic compounds
DE102004013637A1 (en) 2004-03-19 2005-10-13 Capsulution Nanoscience Ag Process for the preparation of CS particles and microcapsules using porous templates as well as CS particles and microcapsules
US8734851B2 (en) * 2005-04-29 2014-05-27 Wisconsin Alumni Research Foundation Localized delivery of nucleic acid by polyelectrolyte assemblies
EP3009477B1 (en) 2006-07-20 2024-01-24 Orbusneich Medical Pte. Ltd Bioabsorbable polymeric composition for a medical device
EP2073754A4 (en) 2006-10-20 2012-09-26 Orbusneich Medical Inc Bioabsorbable polymeric composition and medical device background
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
US8834918B2 (en) * 2007-01-22 2014-09-16 Wisconsin Alumni Research Foundation Modified multilayered film
US9254266B2 (en) * 2007-03-21 2016-02-09 Wisconsin Alumni Research Foundation Inhibiting surface enhanced crystallization of amorphous pharmaceuticals with ultrathin coatings
EP2002847A1 (en) * 2007-06-12 2008-12-17 Capsulution Nanoscience AG Drug-releasing polyelectrolyte coating, method for forming a drug-releasing polyelectrolyte coating, and implantable device
EP2162283B1 (en) * 2007-06-14 2015-08-12 Massachusetts Institute of Technology Self assembled films for protein and drug delivery applications
US8133553B2 (en) * 2007-06-18 2012-03-13 Zimmer, Inc. Process for forming a ceramic layer
US8309521B2 (en) 2007-06-19 2012-11-13 Zimmer, Inc. Spacer with a coating thereon for use with an implant device
EP2016957A1 (en) * 2007-07-20 2009-01-21 Capsulution Nanoscience AG Drug-coated catheter and method for forming a drug-coated catherer
US8071210B2 (en) * 2007-10-09 2011-12-06 Wiscousin Alumni Research Foundation Covalent assembly of ultrathin polymeric films
WO2009049100A2 (en) 2007-10-09 2009-04-16 Wisconsin Alumni Research Foundation Ultrathin multilayered films for controlled release of anionic reagents
US8608049B2 (en) * 2007-10-10 2013-12-17 Zimmer, Inc. Method for bonding a tantalum structure to a cobalt-alloy substrate
US20110230973A1 (en) * 2007-10-10 2011-09-22 Zimmer, Inc. Method for bonding a tantalum structure to a cobalt-alloy substrate
US20090187256A1 (en) * 2008-01-21 2009-07-23 Zimmer, Inc. Method for forming an integral porous region in a cast implant
US8283384B2 (en) 2008-01-24 2012-10-09 University Of Utah Research Foundation Adhesive complex coacervates and methods of making and using thereof
US9272069B2 (en) * 2008-01-24 2016-03-01 University Of Utah Research Foundation Adhesive complex coacervates and methods of making and using thereof
US20090198286A1 (en) * 2008-02-05 2009-08-06 Zimmer, Inc. Bone fracture fixation system
US8324333B2 (en) * 2008-06-05 2012-12-04 Wisconsin Alumni Research Foundation Anionic charge-dynamic polymers for release of cationic agents
US9198875B2 (en) * 2008-08-17 2015-12-01 Massachusetts Institute Of Technology Controlled delivery of bioactive agents from decomposable films
CN103025360A (en) 2010-05-24 2013-04-03 犹他大学研究基金会 Reinforced adhesive complex coacervates and methods of making and using thereof
US9173971B2 (en) 2010-11-12 2015-11-03 University Of Utah Research Foundation Simple adhesive coacervates and methods of making and using thereof
CN102836804B (en) * 2011-06-20 2015-02-25 河南大学 Ultrathin biological film preparation method combined spin-coating method and AFM technology
US20130029133A1 (en) * 2011-07-28 2013-01-31 Kiyoshi Itoh Laminates and process for producing laminates
US10278927B2 (en) 2012-04-23 2019-05-07 Massachusetts Institute Of Technology Stable layer-by-layer coated particles
EP2953992B1 (en) 2013-02-06 2021-11-24 3M Innovative Properties Company Polymers, preparation and use thereof
WO2014134029A1 (en) 2013-02-26 2014-09-04 Massachusetts Institute Of Technology Nucleic acid particles, methods and use thereof
WO2014150074A1 (en) 2013-03-15 2014-09-25 Massachusetts Institute Of Technology Compositions and methods for nucleic acid delivery
US20140272232A1 (en) * 2013-03-15 2014-09-18 Bard Access Systems, Inc. Antithrombic coatings and uses thereof
WO2015048315A1 (en) * 2013-09-25 2015-04-02 Massachusetts Institute Of Technology Biodegradable layer-by-layer (lbl) films for cell capture and release
CN103751847A (en) * 2013-11-25 2014-04-30 同济大学 Preparation method of tissue-regeneration-promoting controlled-release multiple-growth-factor self-assembled coating
WO2015191693A2 (en) 2014-06-10 2015-12-17 Massachusetts Institute Of Technology Method for gene editing
AU2015289798B2 (en) 2014-07-14 2019-09-12 University Of Utah Research Foundation In situ solidifying complex coacervates and methods of making and using thereof
US20160066822A1 (en) * 2014-09-08 2016-03-10 iHear Medical, Inc. Hearing test system for non-expert user with built-in calibration and method
US9956323B2 (en) 2014-12-18 2018-05-01 Cook Medical Technologies Llc Medical devices for local bioactive delivery
US20170181981A1 (en) * 2015-12-29 2017-06-29 Massachusetts Institute Of Technology Biodegradable free-standing controlled drug release stickers
WO2017186809A1 (en) * 2016-04-26 2017-11-02 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nano-sized drug delivery structure
US11624151B2 (en) * 2017-03-28 2023-04-11 The Texas A&M University System Coatings for materials
CN109682709A (en) * 2017-10-19 2019-04-26 中国科学院化学研究所 A kind of method of the relaxation behavior of measurement polyelectrolyte brush inside counter ion counterionsl gegenions pair
WO2019089567A1 (en) 2017-10-30 2019-05-09 Massachusetts Institute Of Technology Layer-by-layer nanoparticles for cytokine therapy in cancer treatment
EP3743120A4 (en) 2018-01-26 2021-10-13 Fluidx Medical Technology, LLC Apparatus and method of using in situ solidifying complex coacervates for vascular occlusion
CN113164556A (en) 2018-08-30 2021-07-23 特纳亚治疗股份有限公司 Cardiac cell reprogramming with cardiac myoprotein and ASCL1
EP3714913A1 (en) * 2019-03-29 2020-09-30 Picosun Oy Color coding
EP3997226A1 (en) 2019-07-11 2022-05-18 Tenaya Therapeutics, Inc. Cardiac cell reprogramming with micrornas and other factors

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208111A (en) * 1990-08-25 1993-05-04 Bayer Aktiengesellschaft One- or multi-layered layer elements applied to supports and their production
US5537573A (en) * 1993-05-28 1996-07-16 Rambus, Inc. Cache system and method for prefetching of data
US5837377A (en) * 1994-12-16 1998-11-17 Advanced Surface Technology, Inc. Biomedical articles with ionically bonded polyelectrolyte coatings
US6447887B1 (en) * 1999-09-14 2002-09-10 Virginia Tech Intellectual Properties, Inc. Electrostrictive and piezoelectric thin film assemblies and method of fabrication therefor
US6492096B1 (en) * 1996-11-21 2002-12-10 Virginia Tech Intellectual Properties, Inc. Patterned molecular self-assembly
US20030124368A1 (en) * 2001-10-25 2003-07-03 Lynn David M. Methods of making decomposable thin films of polyelectrolytes and uses thereof
US6743521B2 (en) * 1997-04-21 2004-06-01 California Institute Of Technology Multifunctional polymeric tissue coatings

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO125853B (en) 1966-10-03 1972-11-13 Ford Motor Co
GB1213806A (en) 1966-10-03 1970-11-25 Ford Motor Co Siloxane-modified polycarboxylic acid resins, and paint binder compositions incorporating the same
US3710795A (en) * 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
US3962414A (en) * 1972-04-27 1976-06-08 Alza Corporation Structured bioerodible drug delivery device
US4191811A (en) 1977-03-01 1980-03-04 Ionics, Incorported Ion exchange membranes based upon polyphenylene sulfide and fluorocarbon polymeric binder
US4250029A (en) 1977-04-25 1981-02-10 Rohm And Haas Company Coated membranes
US4191911A (en) * 1978-11-24 1980-03-04 Gerry Martin E AC power generation control system
US5114719A (en) * 1987-04-29 1992-05-19 Sabel Bernhard A Extended drug delivery of small, water-soluble molecules
US5462990A (en) 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
US5364634A (en) 1991-11-08 1994-11-15 Southwest Research Institute Controlled-release PH sensitive capsule and adhesive system and method
CA2117588C (en) 1992-02-28 1998-08-25 Jeffrey A. Hubbell Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5630941A (en) 1992-12-23 1997-05-20 Burger; Wolfgang Permanent hydrophilic modification of fluoropolymers
US5518767A (en) 1993-07-01 1996-05-21 Massachusetts Institute Of Technology Molecular self-assembly of electrically conductive polymers
US5716709A (en) 1994-07-14 1998-02-10 Competitive Technologies, Inc. Multilayered nanostructures comprising alternating organic and inorganic ionic layers
IT1268718B1 (en) 1994-07-26 1997-03-06 Fidia Advanced Biopolymers Srl SYNTHESIS OF CHEMICAL GEL FROM POLYSACCHARIDES POLYELECTROLYTES VIA GAMMA IRRADIATION
GB9623051D0 (en) * 1996-11-06 1997-01-08 Schacht Etienne H Delivery of DNA to target cells in biological systems
US6919373B1 (en) * 1996-11-12 2005-07-19 Alza Corporation Methods and devices for providing prolonged drug therapy
US5904927A (en) * 1997-03-14 1999-05-18 Northeastern University Drug delivery using pH-sensitive semi-interpenetrating network hydrogels
US6451871B1 (en) 1998-11-25 2002-09-17 Novartis Ag Methods of modifying surface characteristics
DE19812083A1 (en) 1998-03-19 1999-09-30 Max Planck Gesellschaft Simple preparation of coated particles, used to prepare systems for slow and/or targeted release of actives including pharmaceuticals, contrast agents, herbicides, pesticides, catalysts and pigments
US7101575B2 (en) * 1998-03-19 2006-09-05 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Production of nanocapsules and microcapsules by layer-wise polyelectrolyte self-assembly
EP1064088B1 (en) 1998-03-19 2002-12-04 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Fabrication of multilayer-coated particles and hollow shells via electrostatic self-assembly of nanocomposite multilayers on decomposable colloidal templates
US5962520A (en) 1998-04-02 1999-10-05 The University Of Akron Hydrolytically unstable, biocompatible polymer
EP1098696B2 (en) 1998-07-15 2010-07-14 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Polyelectrolyte coverings on biological templates
US6402918B1 (en) 1998-11-16 2002-06-11 Joseph B. Schlenoff Apparatus for capillary electrophoresis and associated method
US6497729B1 (en) * 1998-11-20 2002-12-24 The University Of Connecticut Implant coating for control of tissue/implant interactions
DE20023081U1 (en) 1999-06-10 2003-01-16 Max Planck Gesellschaft Encapsulated crystals with multi-layer coating
DE10001172A1 (en) 2000-01-13 2001-07-26 Max Planck Gesellschaft Templating solid particles with polymer multilayers
AR027348A1 (en) 2000-02-04 2003-03-26 Novartis Ag PROCESS TO COVER A SURFACE
AU2001252982A1 (en) * 2000-03-28 2001-10-08 The Board Of Regents For Oklahoma State University Assembly of free-standing films using a layer-by-layer process
DE10027393B4 (en) 2000-06-02 2007-05-16 Wella Ag Poly- and oligoesters of cationic hydroxy acids, process for their preparation and their use
US6860980B2 (en) 2000-09-15 2005-03-01 The United States Of America As Represented By The Secretary Of Commerce Polyelectrolyte derivatization of microfluidic devices
US6998115B2 (en) 2000-10-10 2006-02-14 Massachusetts Institute Of Technology Biodegradable poly(β-amino esters) and uses thereof
WO2002085500A1 (en) * 2001-04-18 2002-10-31 Florida State University Research Foundation, Inc. Method of preparing free polyelectrolyte membranes
US6939564B2 (en) * 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
US7101947B2 (en) 2002-06-14 2006-09-05 Florida State University Research Foundation, Inc. Polyelectrolyte complex films for analytical and membrane separation of chiral compounds
US7364585B2 (en) * 2003-08-11 2008-04-29 Boston Scientific Scimed, Inc. Medical devices comprising drug-loaded capsules for localized drug delivery
US7348399B2 (en) * 2003-08-29 2008-03-25 Louisiana Tech University Foundation, Inc. Nanofabricated polypeptide multilayer films, coatings, and microcapsules
US20050152955A1 (en) * 2003-12-16 2005-07-14 Akhave Jay R. Electrostatically self-assembled antimicrobial coating for medical applications
US7491263B2 (en) * 2004-04-05 2009-02-17 Technology Innovation, Llc Storage assembly
GB0605688D0 (en) * 2006-03-21 2006-05-03 Novartis Ag Organic compounds
US8071210B2 (en) * 2007-10-09 2011-12-06 Wiscousin Alumni Research Foundation Covalent assembly of ultrathin polymeric films
WO2009117473A2 (en) * 2008-03-18 2009-09-24 Massachusetts Institute Of Technology Structures including antimicrobial peptides

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208111A (en) * 1990-08-25 1993-05-04 Bayer Aktiengesellschaft One- or multi-layered layer elements applied to supports and their production
US5537573A (en) * 1993-05-28 1996-07-16 Rambus, Inc. Cache system and method for prefetching of data
US5837377A (en) * 1994-12-16 1998-11-17 Advanced Surface Technology, Inc. Biomedical articles with ionically bonded polyelectrolyte coatings
US6492096B1 (en) * 1996-11-21 2002-12-10 Virginia Tech Intellectual Properties, Inc. Patterned molecular self-assembly
US6743521B2 (en) * 1997-04-21 2004-06-01 California Institute Of Technology Multifunctional polymeric tissue coatings
US6447887B1 (en) * 1999-09-14 2002-09-10 Virginia Tech Intellectual Properties, Inc. Electrostrictive and piezoelectric thin film assemblies and method of fabrication therefor
US20030124368A1 (en) * 2001-10-25 2003-07-03 Lynn David M. Methods of making decomposable thin films of polyelectrolytes and uses thereof
US7112361B2 (en) * 2001-10-25 2006-09-26 Massachusetts Institute Of Technology Methods of making decomposable thin films of polyelectrolytes and uses thereof

Also Published As

Publication number Publication date
US8105652B2 (en) 2012-01-31
US20070020469A1 (en) 2007-01-25
WO2007140391A2 (en) 2007-12-06

Similar Documents

Publication Publication Date Title
WO2007140391A3 (en) Methods of making decomposable thin films of polyelectrolytes and uses thereof
WO2006086391A3 (en) Electrochemically-degradable layer-by-layer thin films
USD814058S1 (en) Trim reveal extrusion
WO2008036357A3 (en) Medical devices having biodegradable polymeric regions with overlying hard, thin layers
WO2008039658A3 (en) Metallized films, articles, and methods of making the same
WO2010088682A3 (en) Composite antimicrobial accessory including a membrane layer and a porous layer
WO2008002905A3 (en) Solid dosage forms of valsartan, amlodipine and hydrochlorothiazide and method of making the same
WO2005070671A3 (en) Multilayer pipe
WO2008046164A3 (en) Method for manufacturing a multi-layered film and film manufactured by said method
WO2009067140A3 (en) Fin-jfet
WO2009117473A3 (en) Structures including antimicrobial peptides
WO2007022113A3 (en) Solid dosage forms of valsartan and amlodipine and method of making the same
WO2007133633A3 (en) Crosslinkable hole-transporting materials for organic light-emitting devices
WO2009017032A1 (en) Substrate having barrier layer, display element and display element manufacturing method
WO2007078972A3 (en) Multi-layer fluoropolymer films
WO2007098019A3 (en) Roofing membranes including fluoropolymer
WO2011034778A3 (en) Memory devices with enhanced isolation of memory cells, systems including same and methods of forming same
GB201015588D0 (en) Micromachined structure and method of making such a structure
WO2009002827A3 (en) Helical and segmented stent-graft
WO2006121890A3 (en) Medical devices and methods of making the same
EP2478127A4 (en) Multilayer coating, method for fabricating a multilayer coating, and uses for the same
WO2009072431A1 (en) Adhesive for laminate
GB2432837B (en) Polymeric compound, thin polymer film, and thin polymer film element including the same
EP1972988B8 (en) Light-transmissive film, method for manufacturing the same, and display apparatus
WO2008099398A3 (en) Biodegradable irrigation pipe

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07762347

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07762347

Country of ref document: EP

Kind code of ref document: A2