WO2008005676A3 - Injectable collagen material - Google Patents

Injectable collagen material

Info

Publication number
WO2008005676A3
WO2008005676A3 PCT/US2007/071292 US2007071292W WO2008005676A3 WO 2008005676 A3 WO2008005676 A3 WO 2008005676A3 US 2007071292 W US2007071292 W US 2007071292W WO 2008005676 A3 WO2008005676 A3 WO 2008005676A3
Authority
WO
WIPO (PCT)
Prior art keywords
collagen material
particle
injectable collagen
fibers
particles
Prior art date
Application number
PCT/US2007/071292
Other languages
French (fr)
Other versions
WO2008005676A2 (en
Inventor
Hai H Trieu
Sean M Haddock
T Andrew Simonton
Jeffrey M Gross
Keith M Kinnane
Original Assignee
Warsaw Orthopedic Inc
Hai H Trieu
Sean M Haddock
T Andrew Simonton
Jeffrey M Gross
Keith M Kinnane
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warsaw Orthopedic Inc, Hai H Trieu, Sean M Haddock, T Andrew Simonton, Jeffrey M Gross, Keith M Kinnane filed Critical Warsaw Orthopedic Inc
Publication of WO2008005676A2 publication Critical patent/WO2008005676A2/en
Publication of WO2008005676A3 publication Critical patent/WO2008005676A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs

Abstract

A collagen material is disclosed and can include a plurality of particles. Each particle can include an elongated, thin body having one or more arcuate portions and one or more straight portions. Further, each particle can include one or more fibers extending from the body. One or more fibers of one particle can engage the one or more fibers of one or more other particles to establish a matrix of material.
PCT/US2007/071292 2006-06-30 2007-06-15 Injectable collagen material WO2008005676A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/480,067 US8399619B2 (en) 2006-06-30 2006-06-30 Injectable collagen material
US11/480,067 2006-06-30

Publications (2)

Publication Number Publication Date
WO2008005676A2 WO2008005676A2 (en) 2008-01-10
WO2008005676A3 true WO2008005676A3 (en) 2008-02-21

Family

ID=38787069

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/071292 WO2008005676A2 (en) 2006-06-30 2007-06-15 Injectable collagen material

Country Status (2)

Country Link
US (1) US8399619B2 (en)
WO (1) WO2008005676A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008511420A (en) 2004-08-30 2008-04-17 スピネオベイションズ・インコポレーテッド Methods of treatment of spinal disc injury
JP2008511405A (en) 2004-08-30 2008-04-17 アリーン、ネビル Methods of using grafts for treatment of ligaments and tendons
US20080096976A1 (en) * 2006-10-24 2008-04-24 Neville Alleyne Method of treating spinal internal disk derangement
US8469961B2 (en) 2008-03-05 2013-06-25 Neville Alleyne Methods and compositions for minimally invasive capsular augmentation of canine coxofemoral joints
JP2016514030A (en) * 2013-03-14 2016-05-19 ジェンザイム・コーポレーション Thermosensitive bone growth composition
JP7004501B2 (en) * 2013-12-03 2022-01-21 コーネル ユニバーシティー Methods for Repairing the Annulus fibrosus and Collagen Gel Composition
AU2015374114B2 (en) 2014-12-29 2018-07-26 Bioventus, Llc Systems and methods for improved delivery of osteoinductive molecules in bone repair
ES2693579T3 (en) 2015-01-16 2018-12-12 Spineovations, Inc. Method of treatment of the intervertebral disc
DE102015220583A1 (en) * 2015-10-21 2017-04-27 Tetec Tissue Engineering Technologies Ag A medical composition and hydrogel for use in the prevention and / or treatment of facet joint disease and / or for the replacement and / or regeneration of articular cartilage
US11633223B2 (en) * 2018-12-20 2023-04-25 Integrity Implants Inc. Surgical guidance device

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000034556A1 (en) * 1998-12-11 2000-06-15 C.R. Bard, Inc. Collagen hemostatic fibers
US6179872B1 (en) * 1998-03-17 2001-01-30 Tissue Engineering Biopolymer matt for use in tissue repair and reconstruction
WO2003099230A2 (en) * 2002-05-28 2003-12-04 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering
WO2006138098A1 (en) * 2005-06-17 2006-12-28 Ethicon, Inc. Reinforced collagen scaffold
US20070026053A1 (en) * 2005-07-28 2007-02-01 Pedrozo Hugo A Joint resurfacing orthopaedic implant and associated method

Family Cites Families (247)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3551560A (en) 1967-10-02 1970-12-29 Heinrich F Thiele Process of reconstructing tendons,cartilage,nerve sheaths,and products
CA962806A (en) 1970-06-04 1975-02-18 Ontario Research Foundation Surgical prosthetic device
US3875595A (en) 1974-04-15 1975-04-08 Edward C Froning Intervertebral disc prosthesis and instruments for locating same
US4085466A (en) 1974-11-18 1978-04-25 National Research Development Corporation Prosthetic joint device
US4060081A (en) 1975-07-15 1977-11-29 Massachusetts Institute Of Technology Multilayer membrane useful as synthetic skin
GB1515963A (en) 1975-07-15 1978-06-28 Massachusetts Inst Technology Crosslinked collagen-mucopolysaccharide composite materials
US4280954A (en) 1975-07-15 1981-07-28 Massachusetts Institute Of Technology Crosslinked collagen-mucopolysaccharide composite materials
US4185813A (en) 1978-05-17 1980-01-29 Spann Donald C Surgical body positioner
CA1146301A (en) 1980-06-13 1983-05-17 J. David Kuntz Intervertebral disc prosthesis
US4344192A (en) 1980-07-14 1982-08-17 Imbert Jean C Full dual element prosthesis designed for the femoro-patellar joint
US4378224A (en) 1980-09-19 1983-03-29 Nimni Marcel E Coating for bioprosthetic device and method of making same
US4400833A (en) 1981-06-10 1983-08-30 Kurland Kenneth Z Means and method of implanting bioprosthetics
US4350629A (en) 1981-07-29 1982-09-21 Massachusetts Institute Of Technology Procedures for preparing composite materials from collagen and glycosaminoglycan
US4458678A (en) 1981-10-26 1984-07-10 Massachusetts Institute Of Technology Cell-seeding procedures involving fibrous lattices
US4418691A (en) 1981-10-26 1983-12-06 Massachusetts Institute Of Technology Method of promoting the regeneration of tissue at a wound
US4505266A (en) 1981-10-26 1985-03-19 Massachusetts Institute Of Technology Method of using a fibrous lattice
US4424208A (en) 1982-01-11 1984-01-03 Collagen Corporation Collagen implant material and method for augmenting soft tissue
US4582640A (en) 1982-03-08 1986-04-15 Collagen Corporation Injectable cross-linked collagen implant material
US4787900A (en) 1982-04-19 1988-11-29 Massachusetts Institute Of Technology Process for forming multilayer bioreplaceable blood vessel prosthesis
US4544516A (en) 1982-07-28 1985-10-01 Battelle Development Corporation Collagen orientation
US4589881A (en) 1982-08-04 1986-05-20 La Jolla Cancer Research Foundation Polypeptide
US4578079A (en) 1982-08-04 1986-03-25 La Jolla Cancer Research Foundation Tetrapeptide
US4661111A (en) 1982-08-04 1987-04-28 La Jolla Cancer Research Foundation Polypeptide
IL68218A (en) 1983-03-23 1985-12-31 Univ Ramot Compositions for cartilage repair comprising embryonal chondrocytes
US4801299A (en) 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
US4448718A (en) 1983-09-13 1984-05-15 Massachusetts Institute Of Technology Method for the preparation of collagen-glycosaminoglycan composite materials
GB2148901A (en) 1983-10-04 1985-06-05 Johnson & Johnson Protein/polysaccharide complexes
US4837285A (en) 1984-03-27 1989-06-06 Medimatrix Collagen matrix beads for soft tissue repair
CA1295796C (en) 1984-03-27 1992-02-18 Conrad Whyne Biodegradable matrix and methods for producing same
US4879135A (en) 1984-07-23 1989-11-07 University Of Medicine And Dentistry Of New Jersey Drug bonded prosthesis and process for producing same
US4642117A (en) 1985-03-22 1987-02-10 Collagen Corporation Mechanically sheared collagen implant material and method
US4627853A (en) 1985-05-29 1986-12-09 American Hospital Supply Corporation Method of producing prostheses for replacement of articular cartilage and prostheses so produced
US4803075A (en) 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
DE3631469A1 (en) 1986-09-16 1988-03-17 Merck Patent Gmbh METAL ORGANIC COMPOUNDS
NL8700113A (en) 1987-01-19 1988-08-16 Groningen Science Park INK, SUITABLE FOR TREATMENT BY RECONSTRUCTIVE SURGERY, WITH TISSUE-SPECIFIC POROSITY, AND METHOD FOR MANUFACTURING THE ENTAGMENT.
US5108438A (en) 1989-03-02 1992-04-28 Regen Corporation Prosthetic intervertebral disc
US5007934A (en) 1987-07-20 1991-04-16 Regen Corporation Prosthetic meniscus
US5258043A (en) 1987-07-20 1993-11-02 Regen Corporation Method for making a prosthetic intervertebral disc
US4772287A (en) 1987-08-20 1988-09-20 Cedar Surgical, Inc. Prosthetic disc and method of implanting
US4758569A (en) 1987-08-26 1988-07-19 Pfizer Inc. Doxazosin as an anti-atherosclerosis agent
US4976733A (en) 1988-02-03 1990-12-11 Biomedical Design, Inc. Prevention of prosthesis calcification
US4955893A (en) 1988-05-09 1990-09-11 Massachusetts Institute Of Technologh Prosthesis for promotion of nerve regeneration
US5110604A (en) * 1988-06-30 1992-05-05 Collagen Corporation Processes for producing collagen matrixes and methods of using same
US5067962A (en) 1989-04-18 1991-11-26 Baxter International Inc. Bioprosthetic ligament
US4946792A (en) 1989-08-18 1990-08-07 Osteotech, Inc. Process for debriding bone
US5106949A (en) 1989-09-15 1992-04-21 Organogenesis, Inc. Collagen compositions and methods for preparation thereof
JPH03124800A (en) * 1989-10-06 1991-05-28 Showa Denko Kk Agent for forming leather-like surface layer
US5229497A (en) 1990-10-03 1993-07-20 Teepak, Inc. Process for recovering collagen
US5137514A (en) 1990-11-01 1992-08-11 Accumed Systems, Inc. Inflation syringe assembly for percutaneous transluminal angioplasty
US5192326A (en) 1990-12-21 1993-03-09 Pfizer Hospital Products Group, Inc. Hydrogel bead intervertebral disc nucleus
US5605938A (en) 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
US5507810A (en) 1991-10-07 1996-04-16 Osteotech, Inc. Processing of fibrous connective tissue
US5391203A (en) 1992-04-13 1995-02-21 Scott P. Bartlett Method of draining and filling soft tissue implant
US5478739A (en) 1992-10-23 1995-12-26 Advanced Tissue Sciences, Inc. Three-dimensional stromal cell and tissue culture system
US5397352A (en) 1993-08-27 1995-03-14 Burres; Steven Method of recollagenation
US6716216B1 (en) 1998-08-14 2004-04-06 Kyphon Inc. Systems and methods for treating vertebral bodies
KR100355207B1 (en) 1994-01-26 2003-01-24 마크 에이 레일리 Improved inflatable device for use in surgical protocol relating to fixation of bone
US7166121B2 (en) 1994-01-26 2007-01-23 Kyphon Inc. Systems and methods using expandable bodies to push apart cortical bone surfaces
US6248110B1 (en) 1994-01-26 2001-06-19 Kyphon, Inc. Systems and methods for treating fractured or diseased bone using expandable bodies
NZ279442A (en) 1994-01-26 1998-02-26 Mark A Reiley Bone treatment device; inflatable balloon for insertion into a bone; balloon details
US6140452A (en) 1994-05-06 2000-10-31 Advanced Bio Surfaces, Inc. Biomaterial for in situ tissue repair
US5888220A (en) 1994-05-06 1999-03-30 Advanced Bio Surfaces, Inc. Articulating joint repair
US6248131B1 (en) 1994-05-06 2001-06-19 Advanced Bio Surfaces, Inc. Articulating joint repair
US5571189A (en) 1994-05-20 1996-11-05 Kuslich; Stephen D. Expandable fabric implant for stabilizing the spinal motion segment
US5906827A (en) 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
SE9402528D0 (en) 1994-07-19 1994-07-19 Astra Ab Hard tissue stimulant with electricity
US5935849A (en) 1994-07-20 1999-08-10 Cytotherapeutics, Inc. Methods and compositions of growth control for cells encapsulated within bioartificial organs
US5776747A (en) 1994-07-20 1998-07-07 Cytotherapeutics, Inc. Method for controlling the distribution of cells within a bioartificial organ using polycthylene oxide-poly (dimethylsiloxane) copolymer
EP0700671B1 (en) 1994-09-08 2001-08-08 Stryker Technologies Corporation Hydrogel intervertebral disc nucleus
CA2201607C (en) 1994-10-17 2001-02-13 Charles D. Ray Prosthetic spinal disc nucleus
US5562736A (en) 1994-10-17 1996-10-08 Raymedica, Inc. Method for surgical implantation of a prosthetic spinal disc nucleus
EP0713707A1 (en) 1994-11-23 1996-05-29 Collagen Corporation In situ crosslinkable, injectable collagen composition for tissue augmention
US6080194A (en) 1995-02-10 2000-06-27 The Hospital For Joint Disease Orthopaedic Institute Multi-stage collagen-based template or implant for use in the repair of cartilage lesions
US20050186673A1 (en) 1995-02-22 2005-08-25 Ed. Geistlich Soehne Ag Fuer Chemistrie Industrie Collagen carrier of therapeutic genetic material, and method
US5733337A (en) 1995-04-07 1998-03-31 Organogenesis, Inc. Tissue repair fabric
US20020095218A1 (en) 1996-03-12 2002-07-18 Carr Robert M. Tissue repair fabric
US6046379A (en) 1995-06-07 2000-04-04 Stone; Kevin R. Meniscal xenografts
CA2172917A1 (en) 1995-06-07 1996-12-08 Hugh R. Mcmullin Moldable collagen compositions for hard tissue repair and augmentation
US6095149A (en) 1996-08-13 2000-08-01 Oratec Interventions, Inc. Method for treating intervertebral disc degeneration
US6007570A (en) 1996-08-13 1999-12-28 Oratec Interventions, Inc. Apparatus with functional element for performing function upon intervertebral discs
US6048964A (en) 1995-12-12 2000-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
JP4193917B2 (en) 1995-12-18 2008-12-10 アンジオデバイス インターナショナル ゲーエムベーハー Crosslinked polymer composition and method of use thereof
US6322786B1 (en) 1996-02-15 2001-11-27 Kansas University Medical Center Research Institute, Inc. Method of producing bone-inducing agent
US6352558B1 (en) 1996-02-22 2002-03-05 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method for promoting regeneration of surface cartilage in a damage joint
US5607478A (en) 1996-03-14 1997-03-04 Meadox Medicals Inc. Yarn wrapped PTFE tubular prosthesis
US5788625A (en) 1996-04-05 1998-08-04 Depuy Orthopaedics, Inc. Method of making reconstructive SIS structure for cartilaginous elements in situ
AU2759397A (en) 1996-05-28 1998-01-05 1218122 Ontario Inc. Resorbable implant biomaterial made of condensed calcium phosphate particles
US6620155B2 (en) 1996-07-16 2003-09-16 Arthrocare Corp. System and methods for electrosurgical tissue contraction within the spine
US5964807A (en) 1996-08-08 1999-10-12 Trustees Of The University Of Pennsylvania Compositions and methods for intervertebral disc reformation
US6126682A (en) 1996-08-13 2000-10-03 Oratec Interventions, Inc. Method for treating annular fissures in intervertebral discs
EP0873145A2 (en) 1996-11-15 1998-10-28 Advanced Bio Surfaces, Inc. Biomaterial system for in situ tissue repair
GB9704749D0 (en) 1997-03-07 1997-04-23 Univ London Tissue Implant
US6022376A (en) 1997-06-06 2000-02-08 Raymedica, Inc. Percutaneous prosthetic spinal disc nucleus and method of manufacture
FR2764514B1 (en) 1997-06-13 1999-09-03 Biopharmex Holding Sa IMPLANT INJECTED IN SUBCUTANEOUS OR INTRADERMAL WITH CONTROLLED BIORESORBABILITY FOR REPAIR OR PLASTIC SURGERY AND AESTHETIC DERMATOLOGY
GB9714580D0 (en) 1997-07-10 1997-09-17 Wardlaw Douglas Prosthetic intervertebral disc nucleus
WO1999004720A1 (en) 1997-07-11 1999-02-04 Reprogenesis Inc. Repair of intervertebral disks
US6080579A (en) 1997-11-26 2000-06-27 Charlotte-Mecklenburg Hospital Authority Method for producing human intervertebral disc cells
US6123731A (en) 1998-02-06 2000-09-26 Osteotech, Inc. Osteoimplant and method for its manufacture
EP1056413A4 (en) 1998-02-27 2003-08-20 Bioelastics Res Ltd Injectable implants for tissue augmentation and restoration
EP1098672A4 (en) 1998-05-18 2004-03-17 Vincent Bryan Balloon jack
US6224630B1 (en) 1998-05-29 2001-05-01 Advanced Bio Surfaces, Inc. Implantable tissue repair device
US6132465A (en) 1998-06-04 2000-10-17 Raymedica, Inc. Tapered prosthetic spinal disc nucleus
DE19835538A1 (en) 1998-08-06 2000-02-10 Meissner & Wurst Clean room
WO2000007639A1 (en) * 1998-08-07 2000-02-17 Tissue Engineering, Inc. Bone precursor compositions
SE9803710L (en) 1998-09-25 2000-03-26 A & Science Invest Ab Use of certain substances for the treatment of nerve root damage
US20010055594A1 (en) 1998-09-25 2001-12-27 Kjell Olmarker Use of certain drugs for treating nerve root injury
US6958149B2 (en) 1998-10-06 2005-10-25 Stryker Corporation Repair of larynx, trachea, and other fibrocartilaginous tissues
US6025538A (en) 1998-11-20 2000-02-15 Musculoskeletal Transplant Foundation Compound bone structure fabricated from allograft tissue
US20010006948A1 (en) 1998-11-25 2001-07-05 James D. Kang Gene transfer to intervertebral disc cells
JP2002531181A (en) 1998-12-01 2002-09-24 クック・バイオテック・インコーポレーテッド Polymorphic collagen biomaterial medical device
US6146422A (en) 1999-01-25 2000-11-14 Lawson; Kevin Jon Prosthetic nucleus replacement for surgical reconstruction of intervertebral discs and treatment method
US6264659B1 (en) 1999-02-22 2001-07-24 Anthony C. Ross Method of treating an intervertebral disk
US6419944B2 (en) 1999-02-24 2002-07-16 Edward L. Tobinick Cytokine antagonists for the treatment of localized disorders
US6197061B1 (en) 1999-03-01 2001-03-06 Koichi Masuda In vitro production of transplantable cartilage tissue cohesive cartilage produced thereby, and method for the surgical repair of cartilage damage
US6662805B2 (en) 1999-03-24 2003-12-16 The Johns Hopkins University Method for composite cell-based implants
US6428576B1 (en) 1999-04-16 2002-08-06 Endospine, Ltd. System for repairing inter-vertebral discs
US6340369B1 (en) 1999-08-13 2002-01-22 Bret A. Ferree Treating degenerative disc disease with harvested disc cells and analogues of the extracellular matrix
US6419702B1 (en) 1999-08-13 2002-07-16 Bret A. Ferree Treating degenerative disc disease through transplantation of the nucleus pulposis
US6969404B2 (en) 1999-10-08 2005-11-29 Ferree Bret A Annulus fibrosis augmentation methods and apparatus
SE9902155L (en) 1999-06-09 2000-12-10 Bjoern Rydevik Serum antibodies
FR2797179B1 (en) 1999-08-03 2002-03-08 Michel Gau INTERVERTEBRAL NUCLEAR PROSTHESIS AND SURGICAL IMPLANTATION METHOD
US6648918B2 (en) 1999-08-13 2003-11-18 Bret A. Ferree Treating degenerative disc disease through the transplantation of dehydrated tissue
US6793677B2 (en) 1999-08-13 2004-09-21 Bret A. Ferree Method of providing cells and other biologic materials for transplantation
US6344058B1 (en) 1999-08-13 2002-02-05 Bret A. Ferree Treating degenerative disc disease through transplantation of allograft disc and vertebral endplates
US6352557B1 (en) 1999-08-13 2002-03-05 Bret A. Ferree Treating degenerative disc disease through transplantion of extracellular nucleus pulposus matrix and autograft nucleus pulposus cells
US6936072B2 (en) 1999-08-18 2005-08-30 Intrinsic Therapeutics, Inc. Encapsulated intervertebral disc prosthesis and methods of manufacture
US6425919B1 (en) 1999-08-18 2002-07-30 Intrinsic Orthopedics, Inc. Devices and methods of vertebral disc augmentation
US7553329B2 (en) 1999-08-18 2009-06-30 Intrinsic Therapeutics, Inc. Stabilized intervertebral disc barrier
WO2002054978A2 (en) 1999-08-18 2002-07-18 Intrinsic Orthopedics Inc Devices and method for nucleus pulposus augmentation and retention
US6783546B2 (en) 1999-09-13 2004-08-31 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US6264695B1 (en) 1999-09-30 2001-07-24 Replication Medical, Inc. Spinal nucleus implant
US6436119B1 (en) 1999-09-30 2002-08-20 Raymedica, Inc. Adjustable surgical dilator
US6939329B1 (en) 1999-10-08 2005-09-06 Harvest Technologies Corporation Apparatus for holding and operating one or more syringes
US6878167B2 (en) 2002-04-24 2005-04-12 Bret A. Ferree Methods and apparatus for placing intradiscal devices
US6592625B2 (en) 1999-10-20 2003-07-15 Anulex Technologies, Inc. Spinal disc annulus reconstruction method and spinal disc annulus stent
DK1244388T3 (en) 1999-12-06 2007-05-14 Warsaw Orthopedic Inc Device for treating intervertebral discs
DE19959975A1 (en) 1999-12-13 2001-07-26 Efmt Entwicklungs Und Forschun Cannula serving as a passage for a medical instrument or a substance comprises an end section with a shape memory which is activated when a given transition temperature is reached
US6623963B1 (en) 1999-12-20 2003-09-23 Verigen Ag Cellular matrix
US6558390B2 (en) 2000-02-16 2003-05-06 Axiamed, Inc. Methods and apparatus for performing therapeutic procedures in the spine
US7014633B2 (en) 2000-02-16 2006-03-21 Trans1, Inc. Methods of performing procedures in the spine
CN1427700B (en) 2000-04-05 2010-04-21 科丰有限公司 Method and device for treating fractured and/or diseased bone
US6723335B1 (en) 2000-04-07 2004-04-20 Jeffrey William Moehlenbruck Methods and compositions for treating intervertebral disc degeneration
NZ521800A (en) 2000-04-07 2004-06-25 Kyphon Inc Insertion devices and directing the expansion of an expandable structure of the device within a bone
US6324710B1 (en) 2000-04-14 2001-12-04 Arthur S. Hernandez Prone support apparatus for spinal procedures
US6749614B2 (en) 2000-06-23 2004-06-15 Vertelink Corporation Formable orthopedic fixation system with cross linking
EP1297107B1 (en) 2000-06-29 2010-04-28 Mount Sinai Hospital Intervertebral disc
US20020032155A1 (en) 2000-06-30 2002-03-14 Ferree Bret A. Method of treating disc herniation and disc degeneration with concentrated growth and differentiation factors
CA2415389C (en) 2000-07-14 2009-02-17 Kyphon Inc. Systems and methods for treating vertebral bodies
ES2341641T3 (en) 2000-07-21 2010-06-24 The Spineology Group, Llc AN EXPANSIBLE POROUS MESH BAG DEVICE AND ITS USE FOR OSEA SURGERY.
CN1192750C (en) 2000-08-28 2005-03-16 迪斯科动力学公司 Prosthesis of vertebral disc
US20020026244A1 (en) 2000-08-30 2002-02-28 Trieu Hai H. Intervertebral disc nucleus implants and methods
US20050154463A1 (en) 2000-08-30 2005-07-14 Trieu Hal H. Spinal nucleus replacement implants and methods
ES2252281T3 (en) 2000-08-30 2006-05-16 Sdgi Holdings, Inc. IMPLANTS OF INTERVERTEBRAL DISC NUCLEUS.
DE60020171T2 (en) 2000-09-07 2006-01-26 Sherwood Services Ag DEVICE FOR TREATING DISCS
US20020045942A1 (en) 2000-10-16 2002-04-18 Ham Michael J. Procedure for repairing damaged discs
AU1538702A (en) 2000-10-24 2002-05-06 Cryolife Inc In situ bioprosthetic filler and methods, particularly for the in situ formationof vertebral disc bioprosthetics
JP4130126B2 (en) 2000-10-27 2008-08-06 ウォーソー・オーソペディック・インコーポレーテッド Annulus repair system and method
US6613044B2 (en) 2000-10-30 2003-09-02 Allen Carl Selective delivery of cryogenic energy to intervertebral disc tissue and related methods of intradiscal hypothermia therapy
US20040091540A1 (en) 2000-11-15 2004-05-13 Desrosiers Eric Andre Method for restoring a damaged or degenerated intervertebral disc
AU2002246690B2 (en) 2000-12-15 2006-02-02 Spineology, Inc. Annulus- reinforcing band
US20020176893A1 (en) 2001-02-02 2002-11-28 Wironen John F. Compositions, implants, methods, and kits for closure of lumen openings, repair of ruptured tissue, and for bulking of tissue
US20050240201A1 (en) 2001-02-13 2005-10-27 Yeung Jeffrey E Disc shunt delivery devices
US7544196B2 (en) 2001-02-20 2009-06-09 Orthovita, Inc. System and kit for delivery of restorative materials
US20020115742A1 (en) 2001-02-22 2002-08-22 Trieu Hai H. Bioactive nanocomposites and methods for their use
US6776800B2 (en) 2001-02-28 2004-08-17 Synthes (U.S.A.) Implants formed with demineralized bone
US20040083002A1 (en) 2001-04-06 2004-04-29 Belef William Martin Methods for treating spinal discs
US6632235B2 (en) 2001-04-19 2003-10-14 Synthes (U.S.A.) Inflatable device and method for reducing fractures in bone and in treating the spine
US20030008817A1 (en) 2001-07-03 2003-01-09 Tom Sander Cross-link reversing agent
JP4198591B2 (en) 2001-07-31 2008-12-17 アヌレックス テクノロジーズ，インコーポレーテッド Disc regeneration device
US7153518B2 (en) 2001-08-27 2006-12-26 Regeneration Technologies, Inc. Processed soft tissue for topical or internal application
US6736815B2 (en) 2001-09-06 2004-05-18 Core Medical, Inc. Apparatus and methods for treating spinal discs
WO2003020327A2 (en) 2001-09-06 2003-03-13 Bone Sa A cross-linked collagenous biomaterial
AU2002336694A1 (en) 2001-11-01 2003-05-12 Lawrence M. Boyd Devices and methods for the restoration of a spinal disc
CA2468908C (en) 2001-12-05 2009-03-31 Mathys Medizinaltechnik Ag Intervertebral disk prosthesis or nucleus replacement prosthesis
US20040010251A1 (en) 2001-12-10 2004-01-15 Shahar Pitaru Methods, devices, and preparations for intervertebral disc treatment
WO2003066120A1 (en) 2002-02-04 2003-08-14 Ferree Bret A Treating degenerative disc disease through transplantation of allograft disc
JP2005521516A (en) 2002-04-04 2005-07-21 マシーズ メディツィナルテヒニク アクチエンゲゼルシャフト Intervertebral disc prosthesis or nuclear replacement prosthesis
US20030195630A1 (en) 2002-04-10 2003-10-16 Ferree Bret A. Disc augmentation using materials that expand in situ
DE10223332A1 (en) 2002-05-25 2003-12-04 Efmt Entwicklungs Und Forschun Medical implant
US7166133B2 (en) 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
ITVI20020140A1 (en) 2002-06-26 2003-12-29 Tecres Spa DEVICE FOR THE MANUAL DOSING OF A MEDICAL FLUID, PARTICULARLY BONE CEMENT
CA2390364C (en) * 2002-07-03 2010-06-08 Leonard Arthur Jubinville Post with integral hammer and anvil
US20040116922A1 (en) 2002-09-05 2004-06-17 Arthrocare Corporation Methods and apparatus for treating intervertebral discs
US20040054413A1 (en) 2002-09-16 2004-03-18 Howmedica Osteonics Corp. Radiovisible hydrogel intervertebral disc nucleus
US7744651B2 (en) 2002-09-18 2010-06-29 Warsaw Orthopedic, Inc Compositions and methods for treating intervertebral discs with collagen-based materials
US20040054414A1 (en) 2002-09-18 2004-03-18 Trieu Hai H. Collagen-based materials and methods for augmenting intervertebral discs
CA2499116A1 (en) 2002-09-18 2004-04-01 Sdgi Holdings, Inc. Natural tissue devices and methods of implantation
US6932843B2 (en) 2002-09-25 2005-08-23 Medicinelodge, Inc. Apparatus and method for the in-situ formation of a structural prosthesis
US6827716B2 (en) 2002-09-30 2004-12-07 Depuy Spine, Inc. Method of identifying and treating a pathologic region of an intervertebral disc
US20040068234A1 (en) 2002-10-03 2004-04-08 Jeff Martin Bone graft particle delivery apparatus and method
US7135027B2 (en) 2002-10-04 2006-11-14 Baxter International, Inc. Devices and methods for mixing and extruding medically useful compositions
CA2504591C (en) 2002-11-05 2011-09-13 Spineology Inc. A semi-biological intervertebral disc replacement system
EP1567069A4 (en) 2002-11-08 2008-11-12 Warsaw Orthopedic Inc Transpedicular intervertebral disk access methods and devices
AU2003279506A1 (en) 2002-11-12 2004-06-03 Regenex Ltd. Expandable devices and methods for tissue expansion, regenerationand fixation
US20040101959A1 (en) 2002-11-21 2004-05-27 Olga Marko Treatment of tissue with undifferentiated mesenchymal cells
NL1022023C2 (en) 2002-11-29 2004-06-03 Dsm Nv Artificial intervertebral disc.
US20040186471A1 (en) 2002-12-07 2004-09-23 Sdgi Holdings, Inc. Method and apparatus for intervertebral disc expansion
US20040192658A1 (en) 2002-12-27 2004-09-30 Angiotech International Ag Compositions and methods of using collajolie
US20070173943A1 (en) 2003-01-17 2007-07-26 Dulak Gary R Artificial nucleus pulposus and method of injecting same
FR2850009B1 (en) 2003-01-20 2005-12-23 Spine Next Sa TREATMENT ASSEMBLY FOR THE DEGENERATION OF AN INTERVERTEBRAL DISC
AU2004208821B2 (en) 2003-01-31 2009-01-15 Zimmer Orthobiologics Inc. Hydrogel compositions comprising nucleus pulposus tissue
CN1774220A (en) 2003-02-14 2006-05-17 德普伊斯派尔公司 In-situ formed intervertebral fusion device and method
US20040193274A1 (en) 2003-03-28 2004-09-30 Trieu Hai H. Materials and methods for augmenting and/or repairing intervertebral discs
US6969405B2 (en) 2003-04-23 2005-11-29 Loubert Suddaby Inflatable intervertebral disc replacement prosthesis
US8273347B2 (en) 2003-05-13 2012-09-25 Depuy Spine, Inc. Autologous treatment of degenerated disc with cells
KR20060014048A (en) 2003-05-13 2006-02-14 디퍼이 스파인 인코포레이티드 A method of treating degenerative disc disease
US6958077B2 (en) 2003-07-29 2005-10-25 Loubert Suddaby Inflatable nuclear prosthesis
US20050100538A1 (en) 2003-07-31 2005-05-12 Attawia Mohamed Intradiscal injection of anti-oxidants
US7613472B2 (en) * 2003-09-17 2009-11-03 Sony Ericsson Mobile Communications Ab System and method of sharing a contact list among mobile phones
WO2005030034A2 (en) 2003-09-26 2005-04-07 Depuy Spine, Inc. Device for delivering viscous material
TW200511970A (en) 2003-09-29 2005-04-01 Kwan-Ku Lin A spine wrapping and filling apparatus
US7632294B2 (en) 2003-09-29 2009-12-15 Promethean Surgical Devices, Llc Devices and methods for spine repair
US7879102B2 (en) 2003-09-30 2011-02-01 Depuy Acromed, Inc. Method for treatment of defects in the intervertebral disc
US20050071012A1 (en) 2003-09-30 2005-03-31 Hassan Serhan Methods and devices to replace spinal disc nucleus pulposus
CA2481663A1 (en) 2003-10-01 2005-04-01 Biomet Deutschland Gmbh Device for the mixing and discharge of liquid and pulverulent materials for medical use
WO2005034800A2 (en) 2003-10-03 2005-04-21 Acker David E Prosthetic spinal disc nucleus
JP4050215B2 (en) 2003-10-20 2008-02-20 ペンタックス株式会社 Paste bone filler injector
WO2005041813A2 (en) 2003-10-22 2005-05-12 Intrinsic Therapeutics, Inc. Stabilized intervertebral disc barrier
GB2407580B (en) 2003-10-28 2009-02-25 Univ Cambridge Tech Biomaterial
EP1682196A2 (en) 2003-11-10 2006-07-26 Angiotech International Ag Medical implants and anti-scarring agents
JP2005152501A (en) 2003-11-28 2005-06-16 Kyocera Corp Artificial nucleus pulposus and manufacturing method thereof
US20050125066A1 (en) 2003-12-08 2005-06-09 Innovative Spinal Technologies Nucleus replacement securing device and method
US7763077B2 (en) 2003-12-24 2010-07-27 Biomerix Corporation Repair of spinal annular defects and annulo-nucleoplasty regeneration
WO2005063316A1 (en) 2003-12-26 2005-07-14 Cardio Incorporated Transplantable biomaterial and method of preparing the same
EP1729672A2 (en) 2004-01-08 2006-12-13 Spine Wave, Inc. Apparatus and method for injecting fluent material at a distracted tissue site
WO2005070439A1 (en) 2004-01-09 2005-08-04 Regeneration Technologies Inc. Implant comprising a human muscle tissue matrix
US7488322B2 (en) 2004-02-11 2009-02-10 Medtronic, Inc. High speed surgical cutting instrument
ATE553186T1 (en) 2004-02-20 2012-04-15 Isto Technologies Inc DISC REPAIR AND METHOD THEREOF
US20050187556A1 (en) 2004-02-25 2005-08-25 Synecor, Llc Universal percutaneous spinal access system
US8784421B2 (en) 2004-03-03 2014-07-22 Boston Scientific Scimed, Inc. Apparatus and methods for removing vertebral bone and disc tissue
US20050203537A1 (en) 2004-03-09 2005-09-15 Wiley Roy C. Orthopaedic injection restrictor apparatus and method
US8945223B2 (en) 2004-03-12 2015-02-03 Warsaw Orthopedic, Inc. In-situ formable nucleus pulposus implant with water absorption and swelling capability
US8029511B2 (en) 2004-03-22 2011-10-04 Disc Dynamics, Inc. Multi-stage biomaterial injection system for spinal implants
JP2007530120A (en) 2004-03-26 2007-11-01 ヌヴァシヴ インコーポレイテッド Porous implant for spinal disc nucleus pulposus replacement
US20050222538A1 (en) 2004-03-30 2005-10-06 Sdgi Holdings, Inc. Surgical system for delivery of viscous fluids
US20050234493A1 (en) 2004-03-31 2005-10-20 Carr John P Methods and devices for cavity creation in mammalian bone tissue
US7282065B2 (en) 2004-04-09 2007-10-16 X-Spine Systems, Inc. Disk augmentation system and method
US7452351B2 (en) 2004-04-16 2008-11-18 Kyphon Sarl Spinal diagnostic methods and apparatus
JP5001833B2 (en) 2004-04-23 2012-08-15 フォレスト，レナード・エドワード Apparatus and method for treatment or removal of an intervertebral disc
EP1591133A1 (en) 2004-04-30 2005-11-02 Synthes Biologically active implants
JP4722837B2 (en) 2004-05-07 2011-07-13 生化学工業株式会社 Nucleus pulposus filler
WO2005113032A2 (en) 2004-05-21 2005-12-01 Synthes (U.S.A.) Replacement of nucleus pulposus using a hydrogel
FR2870718B1 (en) 2004-05-25 2006-09-22 Spine Next Sa TREATMENT ASSEMBLY FOR THE DEGENERATION OF AN INTERVERTEBRAL DISC
US20050277996A1 (en) 2004-05-28 2005-12-15 Podhajsky Ronald J Method of reducing pressure in a nucleus pulposus
US20050273093A1 (en) 2004-06-04 2005-12-08 Scimed Life Systems, Inc. Method of treating herniated intervertebral discs using cooled ablation
US20060019869A1 (en) 2004-07-23 2006-01-26 Thomas Dimauro M Intradiscal anti-inflammatory therapy involving autologous adiponectin
JP4972288B2 (en) * 2004-08-30 2012-07-11 富士フイルム株式会社 Image sensor

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6179872B1 (en) * 1998-03-17 2001-01-30 Tissue Engineering Biopolymer matt for use in tissue repair and reconstruction
WO2000034556A1 (en) * 1998-12-11 2000-06-15 C.R. Bard, Inc. Collagen hemostatic fibers
WO2003099230A2 (en) * 2002-05-28 2003-12-04 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering
WO2006138098A1 (en) * 2005-06-17 2006-12-28 Ethicon, Inc. Reinforced collagen scaffold
US20070026053A1 (en) * 2005-07-28 2007-02-01 Pedrozo Hugo A Joint resurfacing orthopaedic implant and associated method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TAY B K-B ET AL: "USE OF A COLLAGEN-HYDROXYAPATITE MATRIX IN SPINAL FUSION A RABBIT MODEL", SPINE, PHILADELPHIA, PA, US, vol. 23, no. 21, 1998, pages 2276 - 2281, XP002906686, ISSN: 0362-2436 *

Also Published As

Publication number Publication date
WO2008005676A2 (en) 2008-01-10
US20080004214A1 (en) 2008-01-03
US8399619B2 (en) 2013-03-19

Similar Documents

Publication Publication Date Title
WO2008005676A3 (en) Injectable collagen material
AP2009004939A0 (en) Material and/or fuel produced from biomas
EP2074140B8 (en) Fibrillation-resistant insulin and insulin analogues
IL194336A (en) Fluid manager having a chassis-mounted actuator and a battery including the same
WO2008035088A3 (en) Degradable composite
WO2008046642A3 (en) Coated implant
EP2032083B8 (en) Assembly between a part made of pyrolytic carbon and another part
EP2171227B8 (en) Erosion resistant mounting material and method of making and using the same
EP2041639A4 (en) Systems, methods, and computer program products for the creation, monetization, distribution, and consumption of metacontent
EP2084605B8 (en) Control and management of virtual systems
ME02268B (en) Process for the preparation of modified electrodes, electrodes prepared with said process, and enzymatic biosensors comprising said electrodes
EP2039705A4 (en) Modified diene rubber and rubber composition containing the same
EG26626A (en) Preparations with improved urease-inhibitory effect, and urea-comprising fertilizers comprising them
SG10201606508VA (en) Patient-specific bin systems, methods and devices
WO2006107677A3 (en) Medical devices including composites
WO2008021455A3 (en) Composites for sound control applications
HUE043436T2 (en) Fibrous materials and electrodes therefrom
WO2007101799A3 (en) Composite metal-aerogel material
WO2007112279A3 (en) Resonators
AU2007328296A8 (en) Construction panels and construction systems, and methods
EP2093301A4 (en) Superhard tip and process for producing the same
IL186094A0 (en) Wet gypsum accelerator and methods, composition, and product relating thereto
PL2122067T3 (en) Integral polyethylene terephthalate grids, the method of manufacture, and uses thereof
GB0411192D0 (en) A filament or fibre
WO2009078931A9 (en) Irf as a tumor suppressor and uses thereof

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07798608

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

NENP Non-entry into the national phase

Ref country code: RU

122 Ep: pct application non-entry in european phase

Ref document number: 07798608

Country of ref document: EP

Kind code of ref document: A2