WO2008013763A3 - Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation - Google Patents

Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation Download PDF

Info

Publication number
WO2008013763A3
WO2008013763A3 PCT/US2007/016528 US2007016528W WO2008013763A3 WO 2008013763 A3 WO2008013763 A3 WO 2008013763A3 US 2007016528 W US2007016528 W US 2007016528W WO 2008013763 A3 WO2008013763 A3 WO 2008013763A3
Authority
WO
WIPO (PCT)
Prior art keywords
packed
restoration
implantation
replacement
methods
Prior art date
Application number
PCT/US2007/016528
Other languages
French (fr)
Other versions
WO2008013763A2 (en
Inventor
Eric J Semler
Judith I Yannariello-Brown
Morris L Jacobs
Original Assignee
Musculoskeletal Transplant
Eric J Semler
Judith I Yannariello-Brown
Morris L Jacobs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Musculoskeletal Transplant, Eric J Semler, Judith I Yannariello-Brown, Morris L Jacobs filed Critical Musculoskeletal Transplant
Priority to CA002658934A priority Critical patent/CA2658934A1/en
Priority to EP07810682A priority patent/EP2076220A2/en
Publication of WO2008013763A2 publication Critical patent/WO2008013763A2/en
Publication of WO2008013763A3 publication Critical patent/WO2008013763A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/441—Joints for the spine, e.g. vertebrae, spinal discs made of inflatable pockets or chambers filled with fluid, e.g. with hydrogel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/3654—Cartilage, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/3654—Cartilage, e.g. meniscus
    • A61L27/3658—Intervertebral discs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
    • A61F2002/30059—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in bone mineralization, e.g. made from both mineralized and demineralized adjacent parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/3008—Properties of materials and coating materials radio-opaque, e.g. radio-opaque markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30224—Three-dimensional shapes cylindrical
    • A61F2002/30225—Flat cylinders, i.e. discs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30242—Three-dimensional shapes spherical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30261—Three-dimensional shapes parallelepipedal
    • A61F2002/30263—Three-dimensional shapes parallelepipedal cubical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30581—Special structural features of bone or joint prostheses not otherwise provided for having a pocket filled with fluid, e.g. liquid
    • A61F2002/30588—Special structural features of bone or joint prostheses not otherwise provided for having a pocket filled with fluid, e.g. liquid filled with solid particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A61F2002/444—Intervertebral or spinal discs, e.g. resilient for replacing the nucleus pulposus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2002/4495—Joints for the spine, e.g. vertebrae, spinal discs having a fabric structure, e.g. made from wires or fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A61F2002/4649—Bone graft or bone dowel harvest sites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0069—Three-dimensional shapes cylindrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0071—Three-dimensional shapes spherical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0082—Three-dimensional shapes parallelepipedal
    • A61F2230/0084—Three-dimensional shapes parallelepipedal cubical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
    • A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs

Abstract

A composition for spinal disc repair comprising a plurality of uniformly shaped demineralized cancellous bone pieces ranging in size from about 2.0mm to about 4.0mm loaded into a porous mesh container with the cancellous bone pieces being treated so that they are not osteoinductive and are packed in the porous mesh container under compression forces.
PCT/US2007/016528 2006-07-25 2007-07-23 Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation WO2008013763A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002658934A CA2658934A1 (en) 2006-07-25 2007-07-23 Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation
EP07810682A EP2076220A2 (en) 2006-07-25 2007-07-23 Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83295606P 2006-07-25 2006-07-25
US60/832,956 2006-07-25

Publications (2)

Publication Number Publication Date
WO2008013763A2 WO2008013763A2 (en) 2008-01-31
WO2008013763A3 true WO2008013763A3 (en) 2008-06-26

Family

ID=38982002

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/016528 WO2008013763A2 (en) 2006-07-25 2007-07-23 Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation

Country Status (4)

Country Link
US (1) US7959683B2 (en)
EP (1) EP2076220A2 (en)
CA (1) CA2658934A1 (en)
WO (1) WO2008013763A2 (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US7879103B2 (en) 2005-04-15 2011-02-01 Musculoskeletal Transplant Foundation Vertebral disc repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
USRE42208E1 (en) 2003-04-29 2011-03-08 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7959683B2 (en) 2006-07-25 2011-06-14 Musculoskeletal Transplant Foundation Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation
US8292968B2 (en) 2004-10-12 2012-10-23 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
US9492278B2 (en) 2007-07-10 2016-11-15 Warsaw Orthopedic, Inc. Delivery system

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7717961B2 (en) * 1999-08-18 2010-05-18 Intrinsic Therapeutics, Inc. Apparatus delivery in an intervertebral disc
JP4247519B2 (en) 1999-08-18 2009-04-02 イントリンジック セラピューティックス インコーポレイテッド Apparatus and method for nucleus augmentation and retention
WO2009033100A1 (en) 2007-09-07 2009-03-12 Intrinsic Therapeutics, Inc. Bone anchoring systems
US7972337B2 (en) 2005-12-28 2011-07-05 Intrinsic Therapeutics, Inc. Devices and methods for bone anchoring
US8323341B2 (en) 2007-09-07 2012-12-04 Intrinsic Therapeutics, Inc. Impaction grafting for vertebral fusion
WO2004100841A1 (en) 1999-08-18 2004-11-25 Intrinsic Therapeutics, Inc. Devices and method for augmenting a vertebral disc nucleus
CA2504591C (en) * 2002-11-05 2011-09-13 Spineology Inc. A semi-biological intervertebral disc replacement system
US20070231788A1 (en) * 2003-12-31 2007-10-04 Keyvan Behnam Method for In Vitro Assay of Demineralized Bone Matrix
CA2535169A1 (en) 2003-12-31 2005-07-21 Osteotech, Inc. Improved bone matrix compositions and methods
US20080220044A1 (en) * 2007-03-06 2008-09-11 Semler Eric J Cancellous construct with support ring for repair of osteochondral defects
US20090149893A1 (en) * 2007-12-05 2009-06-11 Semler Eric J Cancellous Bone Implant for Cartilage Repair
WO2007035778A2 (en) 2005-09-19 2007-03-29 Histogenics Corporation Cell-support matrix and a method for preparation thereof
CN101365499A (en) * 2005-11-01 2009-02-11 骨骼技术股份有限公司 Bone matrix compositions and methods
WO2008157492A2 (en) 2007-06-15 2008-12-24 Osteotech, Inc. Osteoinductive demineralized cancellous bone
CA2690457C (en) 2007-06-15 2018-02-20 Osteotech, Inc. Bone matrix compositions and methods
US8642061B2 (en) * 2007-06-15 2014-02-04 Warsaw Orthopedic, Inc. Method of treating bone tissue
US9554920B2 (en) * 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
US20110054408A1 (en) * 2007-07-10 2011-03-03 Guobao Wei Delivery systems, devices, tools, and methods of use
US8282681B2 (en) 2007-08-13 2012-10-09 Nuvasive, Inc. Bioresorbable spinal implant and related methods
CN101808596B (en) * 2007-09-14 2014-06-11 普渡研究基金会 Demineralized cancellous bone scaffolds
ES2446544T3 (en) * 2007-10-19 2014-03-10 Warsaw Orthopedic, Inc. Demineralized bone matrix compositions and methods
CN101909534B (en) * 2007-11-16 2013-03-27 新特斯有限责任公司 Porous containment device for stabilization of vertebral compression fractures
WO2009091811A1 (en) 2008-01-14 2009-07-23 Brenzel Michael P Apparatus and methods for fracture repair
US20090242081A1 (en) * 2008-03-26 2009-10-01 Richard Bauer Aluminum Treatment Composition
EP3366318B1 (en) * 2008-03-28 2020-02-05 Warsaw Orthopedic, Inc. Delivery system attachment
US8377135B1 (en) 2008-03-31 2013-02-19 Nuvasive, Inc. Textile-based surgical implant and related methods
US9101475B2 (en) * 2009-02-12 2015-08-11 Warsaw Orthopedic, Inc. Segmented delivery system
US8911497B2 (en) * 2009-04-09 2014-12-16 DePuy Synthes Products, LLC Minimally invasive spine augmentation and stabilization system and method
WO2011088172A1 (en) 2010-01-15 2011-07-21 Brenzel Michael P Rotary-rigid orthopaedic rod
AU2011207550B2 (en) * 2010-01-20 2016-03-10 Conventus Orthopaedics, Inc. Apparatus and methods for bone access and cavity preparation
EP2544608A4 (en) * 2010-03-08 2017-02-22 Conventus Orthopaedics, Inc. Apparatus and methods for securing a bone implant
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
WO2011150376A1 (en) * 2010-05-28 2011-12-01 C.R. Bard, Inc. Apparatus for use with needle insertion guidance system
WO2012061024A1 (en) * 2010-10-25 2012-05-10 Musculoskeletal Transplant Foundation Demineralized cortical bone implants
US20120259425A1 (en) * 2011-01-26 2012-10-11 Dynamic Surgical Solutions Precision Shaped Compressed Demineralized Cancellous Bone Product and Method to Make Same
US20120251609A1 (en) 2011-03-29 2012-10-04 Yen-Chen Huang Demineralized cancellous bone matrix
US20130282121A1 (en) * 2012-03-22 2013-10-24 Ann Prewett Spinal facet augmentation implant and method
US9539041B2 (en) 2013-09-12 2017-01-10 DePuy Synthes Products, Inc. Minimally invasive biomaterial injection system
CN105939677A (en) 2013-12-12 2016-09-14 康文图斯整形外科公司 Tissue displacement tools and methods
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
US10531957B2 (en) 2015-05-21 2020-01-14 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
US10631881B2 (en) 2017-03-09 2020-04-28 Flower Orthopedics Corporation Plating depth gauge and countersink instrument
WO2018232100A1 (en) 2017-06-14 2018-12-20 Osteoagra Llc Stabilization of vertebral bodies with bone particle slurry
US10918426B2 (en) 2017-07-04 2021-02-16 Conventus Orthopaedics, Inc. Apparatus and methods for treatment of a bone

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571189A (en) * 1994-05-20 1996-11-05 Kuslich; Stephen D. Expandable fabric implant for stabilizing the spinal motion segment
US6652593B2 (en) * 2001-02-28 2003-11-25 Synthes (Usa) Demineralized bone implants

Family Cites Families (173)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE391122B (en) * 1971-01-25 1977-02-07 Cutter Lab PROTESTS IN THE FORM OF A SPINE BONIC DISC AND PROCEDURES FOR MANUFACTURE THEREOF
US3875595A (en) * 1974-04-15 1975-04-08 Edward C Froning Intervertebral disc prosthesis and instruments for locating same
CA1146301A (en) * 1980-06-13 1983-05-17 J. David Kuntz Intervertebral disc prosthesis
US4399814A (en) * 1981-04-27 1983-08-23 Massachusetts Institute Of Technology Method and apparatus for pressure-coated bones
US4488549A (en) 1981-08-25 1984-12-18 University Of Exeter Pressurization of cement in bones
US4466435A (en) * 1981-09-04 1984-08-21 Murray William M Bone cement nozzle and method
US4501269A (en) * 1981-12-11 1985-02-26 Washington State University Research Foundation, Inc. Process for fusing bone joints
CH657980A5 (en) * 1982-10-21 1986-10-15 Sulzer Ag DISPOSABLE BONE CEMENT SYRINGE.
US4655777A (en) * 1983-12-19 1987-04-07 Southern Research Institute Method of producing biodegradable prosthesis and products therefrom
US4625722A (en) 1985-05-03 1986-12-02 Murray William M Bone cement system and method
US5053049A (en) 1985-05-29 1991-10-01 Baxter International Flexible prostheses of predetermined shapes and process for making same
US4743260A (en) * 1985-06-10 1988-05-10 Burton Charles V Method for a flexible stabilization system for a vertebral column
US4735625A (en) * 1985-09-11 1988-04-05 Richards Medical Company Bone cement reinforcement and method
US4655749A (en) * 1985-09-30 1987-04-07 Fischione Eugene A Angioplasty pressure controller
US4751921A (en) * 1985-10-21 1988-06-21 University Of Iowa Research Foundation Bone cement syringe
US4755184A (en) * 1986-01-09 1988-07-05 Mark Silverberg Bone augmentation implant
CH671691A5 (en) * 1987-01-08 1989-09-29 Sulzer Ag
US4834757A (en) * 1987-01-22 1989-05-30 Brantigan John W Prosthetic implant
US4865604A (en) * 1987-04-27 1989-09-12 Chaim Rogozinski Prosthetic bone joint
US4863477A (en) * 1987-05-12 1989-09-05 Monson Gary L Synthetic intervertebral disc prosthesis
US5108438A (en) * 1989-03-02 1992-04-28 Regen Corporation Prosthetic intervertebral disc
US5306311A (en) * 1987-07-20 1994-04-26 Regen Corporation Prosthetic articular cartilage
US4772287A (en) * 1987-08-20 1988-09-20 Cedar Surgical, Inc. Prosthetic disc and method of implanting
US4815454A (en) * 1987-11-16 1989-03-28 Dozier Jr John K Apparatus and method for injecting bone cement
FR2625097B1 (en) * 1987-12-23 1990-05-18 Cote Sarl INTER-SPINOUS PROSTHESIS COMPOSED OF SEMI-ELASTIC MATERIAL COMPRISING A TRANSFILING EYE AT ITS END AND INTER-SPINOUS PADS
US5192325A (en) 1988-02-08 1993-03-09 Mitsubishi Kasei Corporation Ceramic implant
US4911718A (en) * 1988-06-10 1990-03-27 University Of Medicine & Dentistry Of N.J. Functional and biocompatible intervertebral disc spacer
AU624627B2 (en) 1988-08-18 1992-06-18 Johnson & Johnson Orthopaedics, Inc. Functional and biocompatible intervertebral disc spacer containing elastomeric material of varying hardness
FR2639823A1 (en) * 1988-12-06 1990-06-08 Garcia Alain Replacement of the nucleus of the intervertebral disc by a polyurethane polymerised in situ
US5015255A (en) * 1989-05-10 1991-05-14 Spine-Tech, Inc. Spinal stabilization method
US5290558A (en) * 1989-09-21 1994-03-01 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
US4936848A (en) * 1989-09-22 1990-06-26 Bagby George W Implant for vertebrae
US4932975A (en) * 1989-10-16 1990-06-12 Vanderbilt University Vertebral prosthesis
DE8912648U1 (en) * 1989-10-23 1990-11-22 Mecron Medizinische Produkte Gmbh, 1000 Berlin, De
US5059193A (en) 1989-11-20 1991-10-22 Spine-Tech, Inc. Expandable spinal implant and surgical method
FR2659226B1 (en) * 1990-03-07 1992-05-29 Jbs Sa PROSTHESIS FOR INTERVERTEBRAL DISCS AND ITS IMPLEMENTATION INSTRUMENTS.
US5071040A (en) 1990-03-09 1991-12-10 Pfizer Hospital Products Group, Inc. Surgical adhesives mixing and dispensing implement
EP0453393B1 (en) 1990-04-20 1993-10-06 SULZER Medizinaltechnik AG Implant, particularly intervertebral prosthesis
FR2662073A1 (en) * 1990-05-18 1991-11-22 Bfl Medical Sarl Implant for spinal ligament correction and reinforcement
US5269785A (en) 1990-06-28 1993-12-14 Bonutti Peter M Apparatus and method for tissue removal
DE9011685U1 (en) * 1990-08-10 1991-12-12 Thera Patent Gmbh & Co. Kg Gesellschaft Fuer Industrielle Schutzrechte, 8031 Seefeld, De
US5047055A (en) * 1990-12-21 1991-09-10 Pfizer Hospital Products Group, Inc. Hydrogel intervertebral disc nucleus
US5192326A (en) * 1990-12-21 1993-03-09 Pfizer Hospital Products Group, Inc. Hydrogel bead intervertebral disc nucleus
CS277533B6 (en) * 1990-12-29 1993-03-17 Krajicek Milan Fixed osteaosynthesis appliance
US5192327A (en) * 1991-03-22 1993-03-09 Brantigan John W Surgical prosthetic implant for vertebrae
JP3007903B2 (en) * 1991-03-29 2000-02-14 京セラ株式会社 Artificial disc
DE4215137A1 (en) 1991-06-04 1992-12-10 Man Ceramics Gmbh IMPLANT FOR SPINE PILLARS
US5306307A (en) * 1991-07-22 1994-04-26 Calcitek, Inc. Spinal disk implant
US5329846A (en) * 1991-08-12 1994-07-19 Bonutti Peter M Tissue press and system
DE4128332A1 (en) * 1991-08-27 1993-03-04 Man Ceramics Gmbh SPINE BONE REPLACEMENT
US5431654A (en) * 1991-09-30 1995-07-11 Stryker Corporation Bone cement injector
GB9126396D0 (en) * 1991-12-12 1992-02-12 Univ Manchester A hollow needle
US5314476A (en) * 1992-02-04 1994-05-24 Osteotech, Inc. Demineralized bone particles and flowable osteogenic composition containing same
GB9204263D0 (en) * 1992-02-28 1992-04-08 Limbs & Things Ltd Artificial spinal disc
US5306309A (en) * 1992-05-04 1994-04-26 Calcitek, Inc. Spinal disk implant and implantation kit
US5324273A (en) * 1992-09-30 1994-06-28 Centrix, Inc. Disposable barrel dental impression material syringe
DE59209723D1 (en) * 1992-11-20 1999-08-12 Sulzer Orthopaedie Ag Body for distributing bone cement for anchoring implants
FR2702368B1 (en) 1993-03-10 1995-06-09 Medinov Sa Tibial implant for knee prosthesis.
EP0621020A1 (en) * 1993-04-21 1994-10-26 SULZER Medizinaltechnik AG Intervertebral prosthesis and method of implanting such a prosthesis
FR2706768B1 (en) * 1993-05-13 1995-12-01 Inoteb
US5443514A (en) * 1993-10-01 1995-08-22 Acromed Corporation Method for using spinal implants
US5507813A (en) 1993-12-09 1996-04-16 Osteotech, Inc. Shaped materials derived from elongate bone particles
US20030032963A1 (en) * 2001-10-24 2003-02-13 Kyphon Inc. Devices and methods using an expandable body with internal restraint for compressing cancellous bone
GB9407135D0 (en) 1994-04-11 1994-06-01 Aberdeen University And Plasma Treatment of osteoporosis
US20050043808A1 (en) * 1994-05-06 2005-02-24 Advanced Bio Surfaces, Inc. Knee joint prosthesis
US5906827A (en) 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
US5697932A (en) 1994-11-09 1997-12-16 Osteonics Corp. Bone graft delivery system and method
US5782919A (en) * 1995-03-27 1998-07-21 Sdgi Holdings, Inc. Interbody fusion device and method for restoration of normal spinal anatomy
US6039762A (en) 1995-06-07 2000-03-21 Sdgi Holdings, Inc. Reinforced bone graft substitutes
US5716413A (en) 1995-10-11 1998-02-10 Osteobiologics, Inc. Moldable, hand-shapable biodegradable implant material
US5989289A (en) 1995-10-16 1999-11-23 Sdgi Holdings, Inc. Bone grafts
US5814084A (en) 1996-01-16 1998-09-29 University Of Florida Tissue Bank, Inc. Diaphysial cortical dowel
US5964807A (en) * 1996-08-08 1999-10-12 Trustees Of The University Of Pennsylvania Compositions and methods for intervertebral disc reformation
CA2269342C (en) 1996-10-23 2006-09-12 Sdgi Holdings, Inc. Spinal spacer
EP1230902A1 (en) 1996-11-15 2002-08-14 Advanced Bio Surfaces, Inc. Biomaterial system for in situ tissue repair
US5718707A (en) * 1997-01-22 1998-02-17 Mikhail; W. E. Michael Method and apparatus for positioning and compacting bone graft
US5842786A (en) 1997-03-07 1998-12-01 Solomon; Alan Method and device for mixing medical compositions
US6554803B1 (en) * 1997-04-02 2003-04-29 Arthur Ashman Combination syringe and aspirator for bone regeneration material and method for using the syringe
US6022376A (en) * 1997-06-06 2000-02-08 Raymedica, Inc. Percutaneous prosthetic spinal disc nucleus and method of manufacture
US5972015A (en) * 1997-08-15 1999-10-26 Kyphon Inc. Expandable, asymetric structures for deployment in interior body regions
US5972368A (en) 1997-06-11 1999-10-26 Sdgi Holdings, Inc. Bone graft composites and spacers
US5910315A (en) 1997-07-18 1999-06-08 Stevenson; Sharon Allograft tissue material for filling spinal fusion cages or related surgical spaces
US6048346A (en) * 1997-08-13 2000-04-11 Kyphon Inc. Systems and methods for injecting flowable materials into bones
WO1999009914A1 (en) 1997-08-27 1999-03-04 University Of Florida Tissue Bank, Inc. Cortical bone cervical smith-robinson fusion implant
US7048762B1 (en) * 1997-08-27 2006-05-23 Regeneration Technologies, Inc. Elongated cortical bone implant
US20020138143A1 (en) 1997-08-27 2002-09-26 Grooms Jamie M. Cortical bone cervical Smith-Robinson fusion implant
US20010031254A1 (en) 1998-11-13 2001-10-18 Bianchi John R. Assembled implant
US6090998A (en) 1997-10-27 2000-07-18 University Of Florida Segmentally demineralized bone implant
US5997581A (en) 1997-12-29 1999-12-07 Johnson & Johnson Professional, Inc. Hip stem cement spacer
US5899939A (en) * 1998-01-21 1999-05-04 Osteotech, Inc. Bone-derived implant for load-supporting applications
US7087082B2 (en) 1998-08-03 2006-08-08 Synthes (Usa) Bone implants with central chambers
US6123731A (en) * 1998-02-06 2000-09-26 Osteotech, Inc. Osteoimplant and method for its manufacture
US6437018B1 (en) * 1998-02-27 2002-08-20 Musculoskeletal Transplant Foundation Malleable paste with high molecular weight buffered carrier for filling bone defects
US5997582A (en) 1998-05-01 1999-12-07 Weiss; James M. Hip replacement methods and apparatus
US6019765A (en) * 1998-05-06 2000-02-01 Johnson & Johnson Professional, Inc. Morsellized bone allograft applicator device
US6004325A (en) 1998-05-11 1999-12-21 Vargas, Iii; Joseph H. Biomedical cement bonding enhancement tube
US6224630B1 (en) 1998-05-29 2001-05-01 Advanced Bio Surfaces, Inc. Implantable tissue repair device
US6132465A (en) 1998-06-04 2000-10-17 Raymedica, Inc. Tapered prosthetic spinal disc nucleus
AU5341999A (en) 1998-08-06 2000-02-28 Sdgi Holdings, Inc. Composited intervertebral bone spacers
US6174311B1 (en) 1998-10-28 2001-01-16 Sdgi Holdings, Inc. Interbody fusion grafts and instrumentation
US6214012B1 (en) * 1998-11-13 2001-04-10 Harrington Arthritis Research Center Method and apparatus for delivering material to a desired location
US6025538A (en) 1998-11-20 2000-02-15 Musculoskeletal Transplant Foundation Compound bone structure fabricated from allograft tissue
US6200347B1 (en) 1999-01-05 2001-03-13 Lifenet Composite bone graft, method of making and using same
US6547823B2 (en) 1999-01-22 2003-04-15 Osteotech, Inc. Intervertebral implant
CA2362049A1 (en) 1999-02-04 2000-08-10 Sdgi Holdings, Inc. Highly-mineralized osteogenic sponge compositions, and uses thereof
US6183518B1 (en) * 1999-02-22 2001-02-06 Anthony C. Ross Method of replacing nucleus pulposus and repairing the intervertebral disk
US6294187B1 (en) 1999-02-23 2001-09-25 Osteotech, Inc. Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same
US6696073B2 (en) 1999-02-23 2004-02-24 Osteotech, Inc. Shaped load-bearing osteoimplant and methods of making same
DE29908794U1 (en) * 1999-05-19 1999-07-22 Medimex Holfeld Gmbh & Co Cannula, especially for insertion into the spinal canal
US6245107B1 (en) 1999-05-28 2001-06-12 Bret A. Ferree Methods and apparatus for treating disc herniation
WO2001087369A2 (en) 2000-05-12 2001-11-22 Osteotech, Inc. Osteoimplant and method for making same
ES2164548B1 (en) * 1999-08-05 2003-03-01 Probitas Pharma Sa DEVICE FOR DOSAGE OF FRAGUABLE MASS FOR VERTEBROPLASTIA AND OTHER SIMILAR OSEOS TREATMENTS.
DE50015178D1 (en) * 1999-08-10 2008-07-10 Zimmer Gmbh Artificial knee joint
US7220281B2 (en) 1999-08-18 2007-05-22 Intrinsic Therapeutics, Inc. Implant for reinforcing and annulus fibrosis
US6620169B1 (en) 1999-08-26 2003-09-16 Spineology Group, Llc. Tools and method for processing and injecting bone graft
US6783546B2 (en) 1999-09-13 2004-08-31 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US7687462B2 (en) 1999-10-05 2010-03-30 The Regents Of The University Of California Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition
US6395034B1 (en) * 1999-11-24 2002-05-28 Loubert Suddaby Intervertebral disc prosthesis
US6458144B1 (en) 1999-12-30 2002-10-01 Osteotech, Inc. Methods for manufacturing skeletal implants
US6379385B1 (en) * 2000-01-06 2002-04-30 Tutogen Medical Gmbh Implant of bone matter
WO2001078798A1 (en) 2000-02-10 2001-10-25 Regeneration Technologies, Inc. Assembled implant
US6740093B2 (en) 2000-02-28 2004-05-25 Stephen Hochschuler Method and apparatus for treating a vertebral body
US6447514B1 (en) 2000-03-07 2002-09-10 Zimmer Polymer filled hip fracture fixation device
AR027685A1 (en) 2000-03-22 2003-04-09 Synthes Ag METHOD AND METHOD FOR CARRYING OUT
EP1272113B1 (en) * 2000-04-07 2012-03-21 Kyphon SÀRL Insertion devices
WO2002000143A1 (en) 2000-06-27 2002-01-03 Kyphon Inc. Systems and methods for injecting flowable materials into bones
US7025771B2 (en) * 2000-06-30 2006-04-11 Spineology, Inc. Tool to direct bone replacement material
TR200400527T4 (en) 2000-07-03 2004-07-21 Osteotech Inc. Bone-derived osteogenic implants
US9387094B2 (en) * 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
DE60141653D1 (en) * 2000-07-21 2010-05-06 Spineology Group Llc A STRONG, POROUS NET BAG DEVICE AND ITS USE IN BONE SURGERY
US6620196B1 (en) * 2000-08-30 2003-09-16 Sdgi Holdings, Inc. Intervertebral disc nucleus implants and methods
US6432436B1 (en) * 2000-10-03 2002-08-13 Musculoskeletal Transplant Foundation Partially demineralized cortical bone constructs
US20020045942A1 (en) * 2000-10-16 2002-04-18 Ham Michael J. Procedure for repairing damaged discs
AU2002243270B2 (en) * 2000-10-25 2006-03-09 Warsaw Orthopedic, Inc. Vertically expanding intervertebral body fusion device
US6692528B2 (en) * 2000-11-09 2004-02-17 The Polymer Technology Group Incorporated Devices that change size/shape via osmotic pressure
DE10057616B4 (en) 2000-11-21 2006-09-14 Stryker Trauma Gmbh Method for mixing and applying flowable bone cement and bone cement mixing device
US6712853B2 (en) * 2000-12-15 2004-03-30 Spineology, Inc. Annulus-reinforcing band
US20020113600A1 (en) * 2000-12-28 2002-08-22 Swank John D. VSWR monitor and alarm
US7931692B2 (en) 2001-02-14 2011-04-26 Osteotech, Inc. Implant derived from bone
US20020147496A1 (en) 2001-04-06 2002-10-10 Integrated Vascular Systems, Inc. Apparatus for treating spinal discs
US7819918B2 (en) 2001-07-16 2010-10-26 Depuy Products, Inc. Implantable tissue repair device
US6599293B2 (en) * 2001-07-16 2003-07-29 Stryker Instruments Delivery device for bone cement
US6620162B2 (en) 2001-07-20 2003-09-16 Spineology, Inc. Device for inserting fill material particles into body cavities
GB2382028B (en) * 2001-11-19 2006-11-01 Aberdeen Orthopaedic Developme Intervertebral disc prosthesis
US6855167B2 (en) * 2001-12-05 2005-02-15 Osteotech, Inc. Spinal intervertebral implant, interconnections for such implant and processes for making
US6991653B2 (en) * 2002-03-21 2006-01-31 Sdgi Holdings, Inc. Vertebral body and disc space replacement devices
US7166133B2 (en) 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
US7744651B2 (en) * 2002-09-18 2010-06-29 Warsaw Orthopedic, Inc Compositions and methods for treating intervertebral discs with collagen-based materials
US7309359B2 (en) 2003-08-21 2007-12-18 Warsaw Orthopedic, Inc. Allogenic/xenogenic implants and methods for augmenting or repairing intervertebral discs
US20040054414A1 (en) 2002-09-18 2004-03-18 Trieu Hai H. Collagen-based materials and methods for augmenting intervertebral discs
US7323011B2 (en) 2002-10-18 2008-01-29 Musculoskeletal Transplant Foundation Cortical and cancellous allograft cervical fusion block
US20080021468A1 (en) * 2002-10-29 2008-01-24 Zucherman James F Interspinous process implants and methods of use
CA2504591C (en) * 2002-11-05 2011-09-13 Spineology Inc. A semi-biological intervertebral disc replacement system
US6761739B2 (en) * 2002-11-25 2004-07-13 Musculoskeletal Transplant Foundation Cortical and cancellous allograft spacer
US7316689B2 (en) 2003-04-23 2008-01-08 The Cleveland Clinic Foundation Apparatus for depositing bone grafting material
US7537617B2 (en) 2003-06-05 2009-05-26 Warsaw Orthopedic, Inc. Bone strip implants and method of making same
US20050131417A1 (en) * 2003-08-22 2005-06-16 Ahern James W. Kit for treating bony defects
DE10340150A1 (en) 2003-08-26 2005-03-31 Aesculap Ag & Co. Kg Implant for closing an opening of the annulus fibrosus
US7226482B2 (en) 2003-09-02 2007-06-05 Synthes (U.S.A.) Multipiece allograft implant
WO2005048897A1 (en) 2003-11-18 2005-06-02 Quantum Orthopedics Osteoconductive integrated spinal cage and method of making same
US7901461B2 (en) 2003-12-05 2011-03-08 Ethicon, Inc. Viable tissue repair implants and methods of use
US20050209602A1 (en) 2004-03-22 2005-09-22 Disc Dynamics, Inc. Multi-stage biomaterial injection system for spinal implants
EP1868539A2 (en) 2005-04-15 2007-12-26 Musculoskeletal Transplant Foundation Vertebral disc repair
US20070067040A1 (en) 2005-09-02 2007-03-22 Anova Corporation Methods and apparatus for reconstructing the anulus fibrosus
US8029575B2 (en) 2005-10-25 2011-10-04 Globus Medical, Inc. Porous and nonporous materials for tissue grafting and repair
US8403985B2 (en) 2005-11-02 2013-03-26 Zimmer, Inc. Joint spacer implant
WO2007130648A2 (en) * 2006-05-05 2007-11-15 Ceramatec, Inc. Fully or partially bioresorbable orthopedic implant
EP2076220A2 (en) 2006-07-25 2009-07-08 Musculoskeletal Transplant Foundation Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation
EP2063808A4 (en) * 2006-09-14 2012-06-13 Spineology Inc Absorbent fabric implant
RS52706B (en) 2006-10-06 2013-08-30 Scil Technology Gmbh Dried reconstituted vesicle formation for pharmaceutical application
US8574825B2 (en) 2007-06-01 2013-11-05 Bacterin International, Inc. Process for demineralization of bone matrix with preservation of natural growth factors
US8685099B2 (en) 2007-08-14 2014-04-01 Warsaw Orthopedic, Inc. Multiple component osteoimplant
US8961571B2 (en) 2007-11-19 2015-02-24 David Lee Method and apparatus for spinal facet joint fusion using irregularly shaped cortical bone implants

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571189A (en) * 1994-05-20 1996-11-05 Kuslich; Stephen D. Expandable fabric implant for stabilizing the spinal motion segment
US6652593B2 (en) * 2001-02-28 2003-11-25 Synthes (Usa) Demineralized bone implants

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE42208E1 (en) 2003-04-29 2011-03-08 Musculoskeletal Transplant Foundation Glue for cartilage repair
USRE43258E1 (en) 2003-04-29 2012-03-20 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US8221500B2 (en) 2003-05-16 2012-07-17 Musculoskeletal Transplant Foundation Cartilage allograft plug
US8292968B2 (en) 2004-10-12 2012-10-23 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US7879103B2 (en) 2005-04-15 2011-02-01 Musculoskeletal Transplant Foundation Vertebral disc repair
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
US7959683B2 (en) 2006-07-25 2011-06-14 Musculoskeletal Transplant Foundation Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US8906110B2 (en) 2007-01-24 2014-12-09 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
US9492278B2 (en) 2007-07-10 2016-11-15 Warsaw Orthopedic, Inc. Delivery system

Also Published As

Publication number Publication date
WO2008013763A2 (en) 2008-01-31
CA2658934A1 (en) 2008-01-31
US20080027546A1 (en) 2008-01-31
US7959683B2 (en) 2011-06-14
EP2076220A2 (en) 2009-07-08

Similar Documents

Publication Publication Date Title
WO2008013763A3 (en) Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation
WO2008033457A3 (en) Variable height vertebral body replacement implant
EP2228041A3 (en) Expandable support device and method of use
Nover et al. Porous titanium bases for osteochondral tissue engineering
WO2006116761A3 (en) Expandable support device and methods of use
WO2007021659A3 (en) Devices and methods for disc nucleus replacement
EP1957012A4 (en) Method and composition for repair and reconstruction of intervertebral discs and other reconstructive surgery
ATE417579T1 (en) ALLOGENE/XENOGENE IMPLANTS FOR REINFORCEMENT OR REPAIR OF INTERVERBAL DISCS
WO2010121149A3 (en) Vertebral endplate connection implant and method
WO2007012070A3 (en) Improvements in and relating to implants
WO2007076049A3 (en) Flexible elongated chain implant
WO2008019024A3 (en) Bone graft composites and methods of treating bone defects
WO2005081870A3 (en) Intervertebral disc repair, methods and devices therefor
WO2008157492A3 (en) Osteoinductive demineralized cancellous bone
WO2005077013A3 (en) Surface directed cellular attachment
WO2006116245A3 (en) Selectively expandable composite structures for spinal arthroplasty
WO2008157495A3 (en) Bone matrix compositions and methods
WO2004093729A3 (en) Expandable implant for partial disc replacement and reinforcement
PT2363080E (en) Bone anchor for intervertebral disc prosthesis
SG152297A1 (en) Composition for stimulating bone growth and differentiation and method for isolating same
EP2465922A3 (en) Mesenchymal stem cells expressing TNF-alpha receptor
WO2007038337A3 (en) Artificial intervertebral disc
IL177172A0 (en) Implant that can be implanted in osseous tissue, method for producing said implant and corresponding implant
WO2005011522A3 (en) Prosthetic spinal disc replacement
WO2006004887A3 (en) Methods for treating defects and injuries of an intervertebral disc

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07810682

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2658934

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2007810682

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: RU