WO2008015383A3 - Bmp-9 and bmp-10 and their use in breast and prostate cancer therapies - Google Patents

Bmp-9 and bmp-10 and their use in breast and prostate cancer therapies Download PDF

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Publication number
WO2008015383A3
WO2008015383A3 PCT/GB2007/002755 GB2007002755W WO2008015383A3 WO 2008015383 A3 WO2008015383 A3 WO 2008015383A3 GB 2007002755 W GB2007002755 W GB 2007002755W WO 2008015383 A3 WO2008015383 A3 WO 2008015383A3
Authority
WO
WIPO (PCT)
Prior art keywords
bmp
breast
prostate cancer
cancer therapies
therapies
Prior art date
Application number
PCT/GB2007/002755
Other languages
French (fr)
Other versions
WO2008015383A8 (en
WO2008015383A2 (en
Inventor
Wen Guo Jiang
Original Assignee
Univ Cardiff
Wen Guo Jiang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cardiff, Wen Guo Jiang filed Critical Univ Cardiff
Publication of WO2008015383A2 publication Critical patent/WO2008015383A2/en
Publication of WO2008015383A3 publication Critical patent/WO2008015383A3/en
Publication of WO2008015383A8 publication Critical patent/WO2008015383A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention relates to the role of BMP-9 and/or BMP-10 in the treatment of breast or prostate cancer.
PCT/GB2007/002755 2006-07-29 2007-07-20 Bmp-9 and bmp-10 and their use in breast and prostate cancer therapies WO2008015383A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0615129.4 2006-07-29
GBGB0615129.4A GB0615129D0 (en) 2006-07-29 2006-07-29 Anti-cancer activity of BMP-9 and BMP-10 and their use in cancer therapies

Publications (3)

Publication Number Publication Date
WO2008015383A2 WO2008015383A2 (en) 2008-02-07
WO2008015383A3 true WO2008015383A3 (en) 2008-08-14
WO2008015383A8 WO2008015383A8 (en) 2009-07-16

Family

ID=37006438

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/002755 WO2008015383A2 (en) 2006-07-29 2007-07-20 Bmp-9 and bmp-10 and their use in breast and prostate cancer therapies

Country Status (2)

Country Link
GB (1) GB0615129D0 (en)
WO (1) WO2008015383A2 (en)

Families Citing this family (26)

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Publication number Priority date Publication date Assignee Title
ES2561048T3 (en) 2004-07-23 2016-02-24 Acceleron Pharma Inc. ActRII receptor polypeptides
KR20160137665A (en) 2005-11-23 2016-11-30 악셀레론 파마 인코포레이티드 Activin-actrπa antagonists and uses for promoting bone growth
US8128933B2 (en) 2005-11-23 2012-03-06 Acceleron Pharma, Inc. Method of promoting bone growth by an anti-activin B antibody
US8895016B2 (en) 2006-12-18 2014-11-25 Acceleron Pharma, Inc. Antagonists of activin-actriia and uses for increasing red blood cell levels
AU2008211007B2 (en) 2007-02-01 2013-09-19 Acceleron Pharma Inc. Activin-ActRIIa antagonists and uses for treating or preventing breast cancer
TW202021980A (en) 2007-02-02 2020-06-16 美商艾瑟勒朗法瑪公司 Variants derived from actriib and uses therefor
CA3039330C (en) 2007-02-09 2021-11-09 Acceleron Pharma Inc. Activin-actriia antagonists and uses for promoting bone growth in cancer patients
CN107412734A (en) 2007-09-18 2017-12-01 阿塞勒隆制药公司 Activin A CTRIIA antagonists and the purposes for reducing or suppressing FSH secretions
WO2009084739A1 (en) * 2007-12-28 2009-07-09 Kyowa Hakko Kirin Co., Ltd. Method and pharmaceutical composition for treatment of cancer using bmp10 protein,
WO2009084738A1 (en) * 2007-12-28 2009-07-09 Kyowa Hakko Kirin Co., Ltd. Method and pharmaceutical composition for treatment of cancer using bmp9 protein
JP5922928B2 (en) 2008-08-14 2016-05-24 アクセルロン ファーマ， インコーポレイテッド Use of GDF traps to increase red blood cell levels
US8216997B2 (en) 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
EP2387412A4 (en) 2009-01-13 2013-04-03 Acceleron Pharma Inc Methods for increasing adiponectin
EP2440576A4 (en) 2009-06-08 2013-11-20 Acceleron Pharma Inc Methods for increasing thermogenic adipocytes
AU2010263182B2 (en) 2009-06-12 2016-05-12 Acceleron Pharma Inc. Truncated ActRIIB-Fc fusion proteins
CA2781152A1 (en) 2009-11-17 2011-05-26 Acceleron Pharma Inc. Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy
CA2817008A1 (en) 2010-11-08 2012-05-18 Acceleron Pharma Inc. Actriia binding agents and uses thereof
US9809636B2 (en) 2012-04-06 2017-11-07 Acceleron Pharma Inc. Methods for increasing red blood cell levels comprising administering BMP9
ES2884095T3 (en) 2012-11-02 2021-12-10 Celgene Corp Activin-actrii antagonists and uses for treating bone and other disorders
BR122023023170A2 (en) 2014-06-13 2024-02-20 Acceleron Pharma Inc. USE OF AN ACTRII ANTAGONIST IN THE TREATMENT OR PREVENTION OF SKIN ULCERS ASSOCIATED WITH BETA-THALASSEMIA
MA41052A (en) 2014-10-09 2017-08-15 Celgene Corp TREATMENT OF CARDIOVASCULAR DISEASE USING ACTRII LIGAND TRAPS
MD4801C1 (en) 2014-12-03 2022-10-31 Celgene Corporation Activin-ActRII antagonists and uses for treating myelodysplastic syndromes
CA2995310A1 (en) 2015-08-25 2017-03-02 Histide Ag Compounds for inducing tissue formation and uses thereof
ES2862103T3 (en) * 2015-09-17 2021-10-07 Histide Ag Pharmaceutical associations of growth factor receptor agonists and adhesion protein inhibitors for the conversion of neoplastic cells into non-neoplastic cells and their uses
PL3349778T3 (en) * 2015-09-17 2021-12-27 Histide Ag Pharmaceutical association of growth factor receptor agonist and adhesion protein inhibitor for converting a neoplastic cell into a non-neoplastic cell and uses thereof
WO2023069447A1 (en) * 2021-10-18 2023-04-27 The Uab Research Foundation Bmp9 or an agonist thereof and its uses related to reducing metastasis of cancer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1435243A2 (en) * 1998-11-13 2004-07-07 Curis, Inc. Methods of alleviating cancer symtoms
US20060039949A1 (en) * 2004-08-20 2006-02-23 Nycz Jeffrey H Acetabular cup with controlled release of an osteoinductive formulation
WO2006029406A2 (en) * 2004-09-09 2006-03-16 Stryker Corporation Methods for treating bone tumors using bone morphogenic proteins

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1435243A2 (en) * 1998-11-13 2004-07-07 Curis, Inc. Methods of alleviating cancer symtoms
US20060039949A1 (en) * 2004-08-20 2006-02-23 Nycz Jeffrey H Acetabular cup with controlled release of an osteoinductive formulation
WO2006029406A2 (en) * 2004-09-09 2006-03-16 Stryker Corporation Methods for treating bone tumors using bone morphogenic proteins

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 11 March 2004 (2004-03-11), ROSEN C.A. ET AL.: "New albumin fusion proteins useful for preparing a composition for treating diabetes mellitus", XP002474103, retrieved from WWW.EBI.AC.UK accession no. ADH22105 *
SONG J.J. ET AL.: "Bone morphogentic protein-9 binds to liver cells and stimulates proliferation.", ENDOCRINOLOGY, vol. 136, no. 10, 1995, pages 4293 - 4297, XP002474102 *
VARADY P. ET AL.: "Morphologic analysis of BMP-9 gene therapy induced osteogenesis.", HUMAN GENE THERAPY, vol. 12, 10 April 2001 (2001-04-10), pages 697 - 710, XP002474101 *

Also Published As

Publication number Publication date
GB0615129D0 (en) 2006-09-06
WO2008015383A8 (en) 2009-07-16
WO2008015383A2 (en) 2008-02-07

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