WO2008143682A1 - Colored esmolol concentrate - Google Patents
Colored esmolol concentrate Download PDFInfo
- Publication number
- WO2008143682A1 WO2008143682A1 PCT/US2007/075069 US2007075069W WO2008143682A1 WO 2008143682 A1 WO2008143682 A1 WO 2008143682A1 US 2007075069 W US2007075069 W US 2007075069W WO 2008143682 A1 WO2008143682 A1 WO 2008143682A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- esmolol
- formulation
- concentrated
- propylene glycol
- colored
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2007800530913A CN101678111B (en) | 2007-05-22 | 2007-08-02 | Colored esmolol concentrate |
MX2009012620A MX2009012620A (en) | 2007-05-22 | 2007-08-02 | Colored esmolol concentrate. |
CA002686488A CA2686488A1 (en) | 2007-05-22 | 2007-08-02 | Colored esmolol concentrate |
EP07813699A EP2162154B1 (en) | 2007-05-22 | 2007-08-02 | Colored esmolol concentrate |
AU2007353795A AU2007353795B2 (en) | 2007-05-22 | 2007-08-02 | Colored esmolol concentrate |
AT07813699T ATE512673T1 (en) | 2007-05-22 | 2007-08-02 | COLORED ESMOLOL CONCENTRATES |
JP2010509321A JP5825785B2 (en) | 2007-05-22 | 2007-08-02 | Colored esmolol concentrate |
BRPI0721681-5A BRPI0721681A2 (en) | 2007-05-22 | 2007-08-02 | FORMULATION OF COLORED CONCRETE ALMS, MEDICAL PRODUCT, AND METHOD FOR ALLOWING EASY IDENTIFICATION OF A CONCRETE ALMS FORMULATION. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/752,086 US8426467B2 (en) | 2007-05-22 | 2007-05-22 | Colored esmolol concentrate |
US11/752,086 | 2007-05-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008143682A1 true WO2008143682A1 (en) | 2008-11-27 |
Family
ID=39232832
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/075069 WO2008143682A1 (en) | 2007-05-22 | 2007-08-02 | Colored esmolol concentrate |
Country Status (11)
Country | Link |
---|---|
US (1) | US8426467B2 (en) |
EP (1) | EP2162154B1 (en) |
JP (1) | JP5825785B2 (en) |
KR (1) | KR20100022991A (en) |
CN (1) | CN101678111B (en) |
AT (1) | ATE512673T1 (en) |
AU (1) | AU2007353795B2 (en) |
BR (1) | BRPI0721681A2 (en) |
CA (1) | CA2686488A1 (en) |
MX (1) | MX2009012620A (en) |
WO (1) | WO2008143682A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6081241B2 (en) * | 2013-03-13 | 2017-02-15 | テルモ株式会社 | Remifentanil injection preparation containing colorant |
US8835505B1 (en) * | 2013-03-15 | 2014-09-16 | Welgrace Research Group | Ready-to-use co-solvents pharmaceutical composition in modified flexible plastic container |
EP3192508B1 (en) * | 2014-09-12 | 2019-05-08 | Terumo Kabushiki Kaisha | Remifentanil injection containing coloring agent |
US10265312B1 (en) * | 2018-02-01 | 2019-04-23 | Jason Ahee | Antibiotic solution and method of injection to prevent ophthalmic infections |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4857552A (en) * | 1988-06-08 | 1989-08-15 | E. I. Du Pont De Nemours And Co. | Stable pharmaceutical composition |
US6310094B1 (en) * | 2001-01-12 | 2001-10-30 | Baxter International Inc. | Ready-to-use esmolol solution |
EP1417962A1 (en) * | 2002-11-06 | 2004-05-12 | AOP Orphan Pharmaceuticals AG | Method for the manufacture of a medicament comprising esmolol |
Family Cites Families (218)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2525071A (en) | 1945-11-30 | 1950-10-10 | Standard Oil Dev Co | Laminated sheet material and compositions |
BE515475A (en) | 1951-11-13 | |||
US2745785A (en) | 1952-10-29 | 1956-05-15 | American Home Prod | Therapeutic composition comprising tabular nu, nu'-dibenzylethylenediamine di-penicillin, and process for preparing same |
US3685261A (en) | 1971-02-16 | 1972-08-22 | Environeering | Wet scrubber for contaminated gas |
US4798846A (en) | 1974-03-28 | 1989-01-17 | Imperial Chemical Industries Plc | Pharmaceutical compositions |
GB1472793A (en) | 1974-03-28 | 1977-05-04 | Ici Ltd | Pharmaceutical compositions |
US4073943A (en) | 1974-09-11 | 1978-02-14 | Apoteksvarucentralen Vitrum Ab | Method of enhancing the administration of pharmalogically active agents |
JPS597693B2 (en) | 1978-01-07 | 1984-02-20 | 株式会社ミドリ十字 | Antithrombin preparation and its manufacturing method |
DE3013839A1 (en) | 1979-04-13 | 1980-10-30 | Freunt Ind Co Ltd | METHOD FOR PRODUCING AN ACTIVATED PHARMACEUTICAL COMPOSITION |
US4593119A (en) | 1980-11-28 | 1986-06-03 | American Hospital Supply Corporation | Method for treatment or prophylaxis of cardiac disorders |
US4387103A (en) | 1980-11-28 | 1983-06-07 | American Hospital Supply Corporation | Method for treatment or prophylaxis of cardiac disorders |
US4622219A (en) | 1983-06-17 | 1986-11-11 | Haynes Duncan H | Method of inducing local anesthesia using microdroplets of a general anesthetic |
US4725442A (en) | 1983-06-17 | 1988-02-16 | Haynes Duncan H | Microdroplets of water-insoluble drugs and injectable formulations containing same |
US4606939A (en) | 1983-06-22 | 1986-08-19 | The Ohio State University Research Foundation | Small particle formation |
US4608278A (en) | 1983-06-22 | 1986-08-26 | The Ohio State University Research Foundation | Small particule formation and encapsulation |
JPH0720861B2 (en) | 1984-04-09 | 1995-03-08 | ザ デュポン マーク ファーマソウテイカル カンパニー | Pharmaceutical compositions and methods for the treatment or prevention of heart disorders |
US4826689A (en) | 1984-05-21 | 1989-05-02 | University Of Rochester | Method for making uniformly sized particles from water-insoluble organic compounds |
CA1282405C (en) | 1984-05-21 | 1991-04-02 | Michael R. Violante | Method for making uniformly sized particles from water-insoluble organic compounds |
US4606940A (en) | 1984-12-21 | 1986-08-19 | The Ohio State University Research Foundation | Small particle formation and encapsulation |
US5354563A (en) | 1985-07-15 | 1994-10-11 | Research Development Corp. Of Japan | Water dispersion containing ultrafine particles of organic compounds |
US5023271A (en) | 1985-08-13 | 1991-06-11 | California Biotechnology Inc. | Pharmaceutical microemulsions |
US5171566A (en) | 1986-05-16 | 1992-12-15 | The Green Cross Corporation | Flurbiprofen derivative ophthalmic preparation |
GB8618846D0 (en) | 1986-08-01 | 1986-09-10 | Smithkline Beckman Corp | Chemical process |
CA1338736C (en) | 1986-12-05 | 1996-11-26 | Roger Baurain | Microcrystals containing an active ingredient with affinity for phospholipids and at least one phospholipid; process for preparing the same |
FR2608988B1 (en) | 1986-12-31 | 1991-01-11 | Centre Nat Rech Scient | PROCESS FOR THE PREPARATION OF COLLOIDAL DISPERSIBLE SYSTEMS OF A SUBSTANCE, IN THE FORM OF NANOPARTICLES |
FR2634397B2 (en) | 1986-12-31 | 1991-04-19 | Centre Nat Rech Scient | PROCESS FOR THE PREPARATION OF DISPERSIBLE COLLOIDAL SYSTEMS OF A PROTEIN IN THE FORM OF NANOPARTICLES |
FR2608942B1 (en) | 1986-12-31 | 1991-01-11 | Centre Nat Rech Scient | PROCESS FOR THE PREPARATION OF COLLOIDAL DISPERSIBLE SYSTEMS OF A SUBSTANCE, IN THE FORM OF NANOCAPSULES |
US5174930A (en) | 1986-12-31 | 1992-12-29 | Centre National De La Recherche Scientifique (Cnrs) | Process for the preparation of dispersible colloidal systems of amphiphilic lipids in the form of oligolamellar liposomes of submicron dimensions |
IL86211A (en) | 1987-05-04 | 1992-03-29 | Ciba Geigy Ag | Oral forms of administration for carbamazepine in the forms of stable aqueous suspension with delayed release and their preparation |
GB8901254D0 (en) | 1989-01-20 | 1989-03-15 | Allied Colloids Ltd | Particulate materials and their production |
FR2631826B1 (en) | 1988-05-27 | 1992-06-19 | Centre Nat Rech Scient | PARTICULATE VECTOR USEFUL IN PARTICULAR FOR THE TRANSPORT OF BIOLOGICALLY ACTIVATED MOLECULES AND METHOD FOR THE PREPARATION THEREOF |
IL90561A (en) | 1988-06-08 | 1993-08-18 | Fountain Pharm Inc | Method for making solvent dilution microcarriers |
US5269979A (en) | 1988-06-08 | 1993-12-14 | Fountain Pharmaceuticals, Inc. | Method for making solvent dilution microcarriers |
DE68904483T2 (en) | 1988-06-30 | 1993-05-19 | Centre Nat Rech Scient | METHOD FOR PRODUCING COLLOIDAL DISPERSIBLE PROTEIN SYSTEMS, LIKE NANOPARTICLES. |
US5707634A (en) | 1988-10-05 | 1998-01-13 | Pharmacia & Upjohn Company | Finely divided solid crystalline powders via precipitation into an anti-solvent |
US5474989A (en) | 1988-11-11 | 1995-12-12 | Kurita Water Industries, Ltd. | Drug composition |
IL92344A0 (en) | 1989-01-04 | 1990-07-26 | Gist Brocades Nv | Microencapsulation of bioactive substances in biocompatible polymers,microcapsules obtained and pharmaceutical preparation comprising said microcapsules |
CH677886A5 (en) | 1989-06-26 | 1991-07-15 | Hans Georg Prof Dr Weder | |
FR2651680B1 (en) | 1989-09-14 | 1991-12-27 | Medgenix Group Sa | NOVEL PROCESS FOR THE PREPARATION OF LIPID MICROPARTICLES. |
JP2602964B2 (en) | 1989-10-16 | 1997-04-23 | 裕 水島 | Prostaglandin analogs and their fat emulsions |
US5188837A (en) | 1989-11-13 | 1993-02-23 | Nova Pharmaceutical Corporation | Lipsopheres for controlled delivery of substances |
US5078994A (en) | 1990-04-12 | 1992-01-07 | Eastman Kodak Company | Microgel drug delivery system |
US5091188A (en) | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
US5091187A (en) | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
US5246707A (en) | 1990-04-26 | 1993-09-21 | Haynes Duncan H | Sustained release delivery of water-soluble bio-molecules and drugs using phospholipid-coated microcrystals, microdroplets and high-concentration liposomes |
EP0461930B1 (en) | 1990-06-15 | 1995-09-13 | Merck & Co. Inc. | A crystallization method to improve crystal structure and size |
CA2046830C (en) | 1990-07-19 | 1999-12-14 | Patrick P. Deluca | Drug delivery system involving inter-action between protein or polypeptide and hydrophobic biodegradable polymer |
AU642066B2 (en) | 1991-01-25 | 1993-10-07 | Nanosystems L.L.C. | X-ray contrast compositions useful in medical imaging |
US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
US5552160A (en) | 1991-01-25 | 1996-09-03 | Nanosystems L.L.C. | Surface modified NSAID nanoparticles |
US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
US5306519A (en) | 1991-05-23 | 1994-04-26 | Universal Foods Corporation | Syrup for confections and methods for using same |
IT1247472B (en) | 1991-05-31 | 1994-12-17 | Fidia Spa | PROCESS FOR THE PREPARATION OF MICROSPHERES CONTAINING BIOLOGICALLY ACTIVE COMPONENTS. |
US5766635A (en) | 1991-06-28 | 1998-06-16 | Rhone-Poulenc Rorer S.A. | Process for preparing nanoparticles |
CH683149A5 (en) | 1991-07-22 | 1994-01-31 | Debio Rech Pharma Sa | Process for the preparation of microspheres of a biodegradable polymeric material. |
US5250236A (en) | 1991-08-05 | 1993-10-05 | Gasco Maria R | Method for producing solid lipid microspheres having a narrow size distribution |
CA2078388A1 (en) | 1991-10-02 | 1993-04-03 | Mridula Nair | Biocompatible emulsion particles |
US6063910A (en) | 1991-11-14 | 2000-05-16 | The Trustees Of Princeton University | Preparation of protein microparticles by supercritical fluid precipitation |
US5298483A (en) | 1992-03-30 | 1994-03-29 | Tropicana Products, Inc. | New matter of composition and method for using the same as plant bioregulators |
US5389263A (en) | 1992-05-20 | 1995-02-14 | Phasex Corporation | Gas anti-solvent recrystallization and application for the separation and subsequent processing of RDX and HMX |
DK0644755T3 (en) | 1992-06-10 | 1997-09-22 | Nanosystems Llc | Surface Modified NSAID Nanoparticles |
JP3961029B2 (en) | 1992-06-24 | 2007-08-15 | 博 木戸 | Influenza virus infection inhibitor |
SE9202128D0 (en) | 1992-07-09 | 1992-07-09 | Astra Ab | PRECIPITATION OF ONE OR MORE ACTIVE COMPOUNDS IN SITU |
US5417956A (en) | 1992-08-18 | 1995-05-23 | Worcester Polytechnic Institute | Preparation of nanophase solid state materials |
US5466646A (en) | 1992-08-18 | 1995-11-14 | Worcester Polytechnic Institute | Process for the preparation of solid state materials and said materials |
AU660852B2 (en) | 1992-11-25 | 1995-07-06 | Elan Pharma International Limited | Method of grinding pharmaceutical substances |
US5346702A (en) | 1992-12-04 | 1994-09-13 | Sterling Winthrop Inc. | Use of non-ionic cloud point modifiers to minimize nanoparticle aggregation during sterilization |
US5298262A (en) | 1992-12-04 | 1994-03-29 | Sterling Winthrop Inc. | Use of ionic cloud point modifiers to prevent particle aggregation during sterilization |
US5302401A (en) | 1992-12-09 | 1994-04-12 | Sterling Winthrop Inc. | Method to reduce particle size growth during lyophilization |
US5340564A (en) | 1992-12-10 | 1994-08-23 | Sterling Winthrop Inc. | Formulations comprising olin 10-G to prevent particle aggregation and increase stability |
US5336507A (en) | 1992-12-11 | 1994-08-09 | Sterling Winthrop Inc. | Use of charged phospholipids to reduce nanoparticle aggregation |
US5429824A (en) | 1992-12-15 | 1995-07-04 | Eastman Kodak Company | Use of tyloxapole as a nanoparticle stabilizer and dispersant |
US5352459A (en) | 1992-12-16 | 1994-10-04 | Sterling Winthrop Inc. | Use of purified surface modifiers to prevent particle aggregation during sterilization |
US5326552A (en) | 1992-12-17 | 1994-07-05 | Sterling Winthrop Inc. | Formulations for nanoparticulate x-ray blood pool contrast agents using high molecular weight nonionic surfactants |
DE4305003A1 (en) | 1993-02-18 | 1994-08-25 | Knoll Ag | Process for the preparation of colloidal aqueous solutions of poorly soluble active substances |
US5916596A (en) | 1993-02-22 | 1999-06-29 | Vivorx Pharmaceuticals, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
US5665383A (en) | 1993-02-22 | 1997-09-09 | Vivorx Pharmaceuticals, Inc. | Methods for the preparation of immunostimulating agents for in vivo delivery |
US5439686A (en) | 1993-02-22 | 1995-08-08 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor |
US5885486A (en) | 1993-03-05 | 1999-03-23 | Pharmaciaand Upjohn Ab | Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof |
US6090925A (en) | 1993-03-09 | 2000-07-18 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
US5981719A (en) | 1993-03-09 | 1999-11-09 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
FR2703927B1 (en) | 1993-04-13 | 1995-07-13 | Coletica | Use of a transacylation reaction between an esterified polysaccharide and a polyamine to form in an aqueous medium a membrane at least on the surface of gelled particles. |
US5576016A (en) | 1993-05-18 | 1996-11-19 | Pharmos Corporation | Solid fat nanoemulsions as drug delivery vehicles |
US5565215A (en) | 1993-07-23 | 1996-10-15 | Massachusettes Institute Of Technology | Biodegradable injectable particles for imaging |
US6596260B1 (en) | 1993-08-27 | 2003-07-22 | Novartis Corporation | Aerosol container and a method for storage and administration of a predetermined amount of a pharmaceutically active aerosol |
US5500161A (en) | 1993-09-21 | 1996-03-19 | Massachusetts Institute Of Technology And Virus Research Institute | Method for making hydrophobic polymeric microparticles |
ES2170102T3 (en) | 1993-09-24 | 2002-08-01 | Univ British Columbia | AMINOCICLOHEXILESTERES AND USE OF THE SAME. |
SE9303574D0 (en) | 1993-11-01 | 1993-11-01 | Kabi Pharmacia Ab | Composition for drug delivery and method of manufacturing thereof |
SI9420069A (en) | 1993-11-15 | 1996-12-31 | Zeneca Ltd | Microcapsules containing suspensions of biologically active compounds |
US5468224A (en) | 1993-11-30 | 1995-11-21 | Souryal; Tarek O. | Methods of color coding injectable medications |
JP2699839B2 (en) | 1993-12-03 | 1998-01-19 | 日本電気株式会社 | Method for manufacturing semiconductor device |
IE940292A1 (en) | 1994-04-06 | 1995-10-18 | Elan Corp Plc | Biodegradable microcapsules and method for their manufacture |
JP2865554B2 (en) | 1994-04-08 | 1999-03-08 | セントラル硝子株式会社 | Gas chromatographic analysis of fluoromethyl-1,1,1,3,3,3-hexafluoroisopropyl ether |
TW384224B (en) | 1994-05-25 | 2000-03-11 | Nano Sys Llc | Method of preparing submicron particles of a therapeutic or diagnostic agent |
FR2721510B1 (en) | 1994-06-22 | 1996-07-26 | Rhone Poulenc Rorer Sa | Nanoparticles filterable under sterile conditions. |
US5587143A (en) | 1994-06-28 | 1996-12-24 | Nanosystems L.L.C. | Butylene oxide-ethylene oxide block copolymer surfactants as stabilizer coatings for nanoparticle compositions |
GB9413202D0 (en) | 1994-06-30 | 1994-08-24 | Univ Bradford | Method and apparatus for the formation of particles |
US6007845A (en) | 1994-07-22 | 1999-12-28 | Massachusetts Institute Of Technology | Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers |
ES2139097T3 (en) | 1994-09-27 | 2000-02-01 | Nycomed Imaging As | CONTRAST AGENT. |
US5720551A (en) | 1994-10-28 | 1998-02-24 | Shechter; Tal | Forming emulsions |
SE9403846D0 (en) | 1994-11-09 | 1994-11-09 | Univ Ohio State Res Found | Small particle formation |
DE4440337A1 (en) | 1994-11-11 | 1996-05-15 | Dds Drug Delivery Services Ges | Pharmaceutical nanosuspensions for drug application as systems with increased saturation solubility and dissolution rate |
US5662883A (en) | 1995-01-10 | 1997-09-02 | Nanosystems L.L.C. | Microprecipitation of micro-nanoparticulate pharmaceutical agents |
US5665331A (en) | 1995-01-10 | 1997-09-09 | Nanosystems L.L.C. | Co-microprecipitation of nanoparticulate pharmaceutical agents with crystal growth modifiers |
US5560932A (en) | 1995-01-10 | 1996-10-01 | Nano Systems L.L.C. | Microprecipitation of nanoparticulate pharmaceutical agents |
US5716642A (en) | 1995-01-10 | 1998-02-10 | Nano Systems L.L.C. | Microprecipitation of nanoparticulate pharmaceutical agents using surface active material derived from similar pharmaceutical agents |
US5569448A (en) | 1995-01-24 | 1996-10-29 | Nano Systems L.L.C. | Sulfated nonionic block copolymer surfactants as stabilizer coatings for nanoparticle compositions |
WO1996024332A1 (en) | 1995-02-06 | 1996-08-15 | Nanosystems L.L.C. | Formulations of compounds as nanoparticulate dispersions in digestible oils or fatty acids |
US5518738A (en) | 1995-02-09 | 1996-05-21 | Nanosystem L.L.C. | Nanoparticulate nsaid compositions |
US5534270A (en) | 1995-02-09 | 1996-07-09 | Nanosystems Llc | Method of preparing stable drug nanoparticles |
US5591456A (en) | 1995-02-10 | 1997-01-07 | Nanosystems L.L.C. | Milled naproxen with hydroxypropyl cellulose as a dispersion stabilizer |
US5573783A (en) | 1995-02-13 | 1996-11-12 | Nano Systems L.L.C. | Redispersible nanoparticulate film matrices with protective overcoats |
US5543133A (en) | 1995-02-14 | 1996-08-06 | Nanosystems L.L.C. | Process of preparing x-ray contrast compositions containing nanoparticles |
US5510118A (en) | 1995-02-14 | 1996-04-23 | Nanosystems Llc | Process for preparing therapeutic compositions containing nanoparticles |
US5580579A (en) | 1995-02-15 | 1996-12-03 | Nano Systems L.L.C. | Site-specific adhesion within the GI tract using nanoparticles stabilized by high molecular weight, linear poly (ethylene oxide) polymers |
WO1996025918A1 (en) | 1995-02-24 | 1996-08-29 | Nanosystems L.L.C. | Aerosols containing nanoparticle dispersions |
US5605785A (en) | 1995-03-28 | 1997-02-25 | Eastman Kodak Company | Annealing processes for nanocrystallization of amorphous dispersions |
AU695207B2 (en) | 1995-03-28 | 1998-08-06 | Fidia Farmaceutici S.P.A. | Nanospheres comprising a biocompatible polysaccharide |
IE75744B1 (en) | 1995-04-03 | 1997-09-24 | Elan Corp Plc | Controlled release biodegradable micro- and nanospheres containing cyclosporin |
IE80468B1 (en) | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
SE9501384D0 (en) | 1995-04-13 | 1995-04-13 | Astra Ab | Process for the preparation of respirable particles |
GB9511220D0 (en) | 1995-06-02 | 1995-07-26 | Glaxo Group Ltd | Solid dispersions |
US5667809A (en) | 1995-06-07 | 1997-09-16 | Alliance Pharmaceutical Corp. | Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents |
FR2735978B1 (en) | 1995-06-30 | 1997-09-19 | Sanofi Sa | PHARMACEUTICAL COMPOSITION OF AMIODARONE FOR PARENTERAL ADMINISTRATION |
ES2177592T3 (en) | 1995-07-05 | 2002-12-16 | Europ Economic Community | BIOCOMPATIBLE AND BIODEGRADABLE NANOPARTICLES FOR THE ABSORPTION AND ADMINISTRATION OF PROTEINIC MEDICINES. |
US6143211A (en) | 1995-07-21 | 2000-11-07 | Brown University Foundation | Process for preparing microparticles through phase inversion phenomena |
TW487582B (en) | 1995-08-11 | 2002-05-21 | Nissan Chemical Ind Ltd | Method for converting sparingly water-soluble medical substance to amorphous state |
EP0857484A4 (en) | 1995-09-13 | 2000-12-06 | Nippon Shinyaku Co Ltd | Pge1- containing freeze-dried preparation and process for the production thereof |
DE19545257A1 (en) | 1995-11-24 | 1997-06-19 | Schering Ag | Process for the production of morphologically uniform microcapsules and microcapsules produced by this process |
FR2742357B1 (en) | 1995-12-19 | 1998-01-09 | Rhone Poulenc Rorer Sa | STABILIZED AND FILTRABLE NANOPARTICLES UNDER STERILE CONDITIONS |
US6245349B1 (en) | 1996-02-23 | 2001-06-12 | éLAN CORPORATION PLC | Drug delivery compositions suitable for intravenous injection |
US5833891A (en) | 1996-10-09 | 1998-11-10 | The University Of Kansas | Methods for a particle precipitation and coating using near-critical and supercritical antisolvents |
US5637625A (en) | 1996-03-19 | 1997-06-10 | Research Triangle Pharmaceuticals Ltd. | Propofol microdroplet formulations |
IL117773A (en) | 1996-04-02 | 2000-10-31 | Pharmos Ltd | Solid lipid compositions of coenzyme Q10 for enhanced oral bioavailability |
US5660858A (en) | 1996-04-03 | 1997-08-26 | Research Triangle Pharmaceuticals | Cyclosporin emulsions |
CN1220598A (en) | 1996-05-02 | 1999-06-23 | 大正制药株式会社 | Suspension of spraingly water-soluble acidic drug |
ATE357218T1 (en) | 1996-05-07 | 2007-04-15 | Alkermes Inc | MICROPARTICLES |
NZ330739A (en) | 1996-05-20 | 1999-06-29 | Janssen Pharmaceutica Nv | Particulate solid dispersion of itraconazole and a water soluble polymer |
WO1998007414A1 (en) | 1996-08-22 | 1998-02-26 | Research Triangle Pharmaceuticals Ltd. | Compositions comprising microparticles of water-insoluble substances and method for preparing same |
US6344271B1 (en) | 1998-11-06 | 2002-02-05 | Nanoenergy Corporation | Materials and products using nanostructured non-stoichiometric substances |
DE19637517A1 (en) | 1996-09-13 | 1998-03-19 | Basf Ag | Production of powdered, cold water dispersible carotenoid preparations and the use of the new carotenoid preparations |
ES2212083T3 (en) | 1996-10-03 | 2004-07-16 | Hermes Biosciences, Inc. | HYDROPHILE MICROPARTICLES AND PROCEDURE TO PREPARE THEM. |
US6261537B1 (en) | 1996-10-28 | 2001-07-17 | Nycomed Imaging As | Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors |
KR20000069513A (en) | 1996-12-17 | 2000-11-25 | 알. 로버트 해리스 | Salting-out process of crystallizing 2,4,6,8,10,12-hexanitro-2,4,8,10,12-hexaazatetracyclo[5.5.0.05,903,11]-dodecane |
US5874111A (en) | 1997-01-07 | 1999-02-23 | Maitra; Amarnath | Process for the preparation of highly monodispersed polymeric hydrophilic nanoparticles |
US6458373B1 (en) | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
WO1998035666A1 (en) | 1997-02-13 | 1998-08-20 | Nanosystems Llc | Formulations of nanoparticle naproxen tablets |
US6045829A (en) | 1997-02-13 | 2000-04-04 | Elan Pharma International Limited | Nanocrystalline formulations of human immunodeficiency virus (HIV) protease inhibitors using cellulosic surface stabilizers |
IT1292142B1 (en) | 1997-06-12 | 1999-01-25 | Maria Rosa Gasco | PHARMACEUTICAL COMPOSITION IN THE FORM OF SOLID LIPID MICROPARTICLES SUITABLE FOR PARENTERAL ADMINISTRATION |
KR19990001564A (en) | 1997-06-16 | 1999-01-15 | 유충식 | Azole antifungal agents with improved solubility and preparations containing them |
US6217886B1 (en) | 1997-07-14 | 2001-04-17 | The Board Of Trustees Of The University Of Illinois | Materials and methods for making improved micelle compositions |
EP1011856B1 (en) | 1997-08-05 | 2003-04-09 | Microfluidics International Corporation | Multiple stream high pressure mixer/reactor |
DE19737481A1 (en) | 1997-08-28 | 1999-03-04 | Hoechst Ag | Microparticles containing spherical linear polysaccharides |
US6281175B1 (en) | 1997-09-23 | 2001-08-28 | Scimed Life Systems, Inc. | Medical emulsion for lubrication and delivery of drugs |
US5886239A (en) | 1997-11-21 | 1999-03-23 | Baxter International Inc. | Method of preparing monofluoromethyl ethers |
US6083514A (en) | 1998-01-09 | 2000-07-04 | Abbott Laboratories | Polymethylpentene container for an inhalation anesthetic |
US6086376A (en) | 1998-01-30 | 2000-07-11 | Rtp Pharma Inc. | Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant |
US6337092B1 (en) | 1998-03-30 | 2002-01-08 | Rtp Pharma Inc. | Composition and method of preparing microparticles of water-insoluble substances |
ES2257041T3 (en) | 1998-03-30 | 2006-07-16 | Jagotec Ag | COMPOSITION AND METHOD FOR PREPARING MICROPARTICLES OF INSOLUBLE SUBSTANCES IN WATER. |
ES2272066T3 (en) | 1998-04-09 | 2007-04-16 | F. Hoffmann-La Roche Ag | PROCESS FOR MANUFACTURE OF PARTICLES WITH SIZE OF (SUB) MICROS BY DISSOLUTION OF COMPRESSED GAS AND SURFACTANTS. |
FR2777193B1 (en) | 1998-04-14 | 2001-06-08 | Coletica | PARTICLE WITH A CHELATING HYDROXAMIC GROUP OF METAL IONS AND THEIR USE IN COSMETICS OR PHARMACY |
WO1999059535A1 (en) | 1998-05-15 | 1999-11-25 | Unilever Plc | Oral composition comprising capsules |
US6696019B2 (en) | 1998-06-15 | 2004-02-24 | Bbi Bioseq, Inc. | Rapid cryobaric sterilization and vaccine preparation |
CA2335472C (en) | 1998-06-19 | 2008-10-28 | Rtp Pharma Inc. | Processes to generate submicron particles of water-insoluble compounds |
FR2780901B1 (en) | 1998-07-09 | 2000-09-29 | Coletica | PARTICLES, IN PARTICULAR MICRO- OR NANOPARTICLES OF CROSSLINKED MONOSACCHARIDES AND OLIGOSACCHARIDES, THEIR PREPARATION METHODS AND COSMETIC, PHARMACEUTICAL OR FOOD COMPOSITIONS CONTAINING THE SAME |
US6153225A (en) | 1998-08-13 | 2000-11-28 | Elan Pharma International Limited | Injectable formulations of nanoparticulate naproxen |
US6238677B1 (en) | 1998-08-18 | 2001-05-29 | The United States Of America As Represented By The Secretary Of Agriculture | Starch microcapsules for delivery of active agents |
US6165506A (en) | 1998-09-04 | 2000-12-26 | Elan Pharma International Ltd. | Solid dose form of nanoparticulate naproxen |
US6350786B1 (en) | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
US8293277B2 (en) | 1998-10-01 | 2012-10-23 | Alkermes Pharma Ireland Limited | Controlled-release nanoparticulate compositions |
US6375986B1 (en) | 2000-09-21 | 2002-04-23 | Elan Pharma International Ltd. | Solid dose nanoparticulate compositions comprising a synergistic combination of a polymeric surface stabilizer and dioctyl sodium sulfosuccinate |
US6428814B1 (en) | 1999-10-08 | 2002-08-06 | Elan Pharma International Ltd. | Bioadhesive nanoparticulate compositions having cationic surface stabilizers |
SE9804001D0 (en) | 1998-11-23 | 1998-11-23 | Astra Ab | New process |
US6365191B1 (en) | 1999-02-17 | 2002-04-02 | Dabur Research Foundation | Formulations of paclitaxel, its derivatives or its analogs entrapped into nanoparticles of polymeric micelles, process for preparing same and the use thereof |
US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
US6270806B1 (en) | 1999-03-03 | 2001-08-07 | Elan Pharma International Limited | Use of peg-derivatized lipids as surface stabilizers for nanoparticulate compositions |
US6267989B1 (en) | 1999-03-08 | 2001-07-31 | Klan Pharma International Ltd. | Methods for preventing crystal growth and particle aggregation in nanoparticulate compositions |
US6045826A (en) | 1999-04-02 | 2000-04-04 | National Research Council Of Canada | Water-soluble compositions of bioactive lipophilic compounds |
US6632443B2 (en) | 2000-02-23 | 2003-10-14 | National Research Council Of Canada | Water-soluble compositions of bioactive lipophilic compounds |
US6100302A (en) | 1999-04-05 | 2000-08-08 | Baxter International Inc. | Propofol formulation with enhanced microbial characteristics |
US6610317B2 (en) | 1999-05-27 | 2003-08-26 | Acusphere, Inc. | Porous paclitaxel matrices and methods of manufacture thereof |
US6395300B1 (en) | 1999-05-27 | 2002-05-28 | Acusphere, Inc. | Porous drug matrices and methods of manufacture thereof |
KR100331529B1 (en) | 1999-06-16 | 2002-04-06 | 민경윤 | Composition for Oral Administration of Hardly Soluble Antifungal Agent and Process for the Preparation Thereof |
US6458387B1 (en) | 1999-10-18 | 2002-10-01 | Epic Therapeutics, Inc. | Sustained release microspheres |
WO2001051919A2 (en) | 2000-01-07 | 2001-07-19 | Transform Pharmaceuticals, Inc. | High-throughput formation, identification, and analysis of diverse solid-forms |
US7338657B2 (en) | 2001-03-15 | 2008-03-04 | Biosphere Medical, Inc. | Injectable microspheres for tissue construction |
US6682761B2 (en) | 2000-04-20 | 2004-01-27 | Rtp Pharma, Inc. | Water-insoluble drug particle process |
JP3412606B2 (en) | 2000-08-04 | 2003-06-03 | 株式会社島津製作所 | Laser diffraction / scattering particle size distribution analyzer |
WO2002013786A2 (en) | 2000-08-15 | 2002-02-21 | Board Of Trustees Of The University Of Illinois | Method of forming microparticles |
US6635223B2 (en) | 2000-10-25 | 2003-10-21 | Andreas Maerz | Method for inactivating micro-organisms using high pressure processing |
DE60138641D1 (en) | 2000-10-27 | 2009-06-18 | Baxter Healthcare Sa | PREPARATION OF MICRO BEADS |
US7105176B2 (en) | 2000-11-29 | 2006-09-12 | Basf Aktiengesellschaft | Production of solid preparations of water-soluble, sparingly water-soluble or water-insoluble active compounds |
FR2817478A1 (en) | 2000-12-04 | 2002-06-07 | Oreal | Aqueous suspension of nanospheres useful in cosmetic compositions, comprises an amorphous lipophilic active ingredient stabilized with a surfactant |
DE10063712C1 (en) * | 2000-12-20 | 2002-08-29 | Stiftung A Wegener Inst Polar | Microbiological process for the biosynthesis of the natural blue-violet dyes violacein and deoxyviolacein and their use |
US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
US6951656B2 (en) | 2000-12-22 | 2005-10-04 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
US20030096013A1 (en) | 2000-12-22 | 2003-05-22 | Jane Werling | Preparation of submicron sized particles with polymorph control |
US6884436B2 (en) | 2000-12-22 | 2005-04-26 | Baxter International Inc. | Method for preparing submicron particle suspensions |
US7193084B2 (en) | 2000-12-22 | 2007-03-20 | Baxter International Inc. | Polymorphic form of itraconazole |
US20040022862A1 (en) | 2000-12-22 | 2004-02-05 | Kipp James E. | Method for preparing small particles |
US20040256749A1 (en) | 2000-12-22 | 2004-12-23 | Mahesh Chaubal | Process for production of essentially solvent-free small particles |
US7037528B2 (en) | 2000-12-22 | 2006-05-02 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
US6977085B2 (en) | 2000-12-22 | 2005-12-20 | Baxter International Inc. | Method for preparing submicron suspensions with polymorph control |
US20030072807A1 (en) | 2000-12-22 | 2003-04-17 | Wong Joseph Chung-Tak | Solid particulate antifungal compositions for pharmaceutical use |
TWI277414B (en) * | 2001-01-12 | 2007-04-01 | Baxter Int | Esmolol formulation |
US20040022861A1 (en) | 2001-01-30 | 2004-02-05 | Williams Robert O. | Process for production of nanoparticles and microparticles by spray freezing into liquid |
US20030054042A1 (en) | 2001-09-14 | 2003-03-20 | Elaine Liversidge | Stabilization of chemical compounds using nanoparticulate formulations |
US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
CA2461349C (en) | 2001-09-26 | 2011-11-29 | Baxter International Inc. | Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal |
US7112340B2 (en) | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
GB0204772D0 (en) * | 2002-02-28 | 2002-04-17 | Phoqus Ltd | Pharmaceutical dosage forms |
FR2838969B1 (en) | 2002-04-30 | 2006-05-19 | Ellipse Pharmaceuticals | METHOD FOR HIGH-PRESSURE STERILIZATION OF PHARMACEUTICAL COMPOSITIONS IN THE MICRO OR NANODISPERSEE FORM AND COMPOSITIONS THUS OBTAINED |
SE523535C2 (en) | 2002-12-20 | 2004-04-27 | Tetra Laval Holdings & Finance | Heat-treatment method for package made from paper-based packaging laminate, involves supplying heating medium to packages and products before the pressure in retort is increased |
US20040229901A1 (en) | 2003-02-24 | 2004-11-18 | Lauren Otsuki | Method of treatment of disease using an adenosine A1 receptor antagonist |
EP1628641A2 (en) | 2003-05-19 | 2006-03-01 | Baxter International Inc. | Solid particles comprising an anticonvulsant or an immunosuppressive coated with one or more surface modifiers |
EP1652533B2 (en) | 2003-08-08 | 2014-11-19 | Ono Pharmaceutical Co., Ltd. | Heart-slowing drug containing short-acting beta-blocker as the active ingredient |
CN100479812C (en) * | 2004-02-13 | 2009-04-22 | 生物药效率有限公司 | A microemulsion preparation of high concentration propofol for anesthetic uses |
EE05278B1 (en) * | 2004-03-23 | 2010-02-15 | As Laser Diagnostic Instruments | Method for Automatic Marking and Subsequent Identification of Liquids |
-
2007
- 2007-05-22 US US11/752,086 patent/US8426467B2/en active Active
- 2007-08-02 AT AT07813699T patent/ATE512673T1/en active
- 2007-08-02 MX MX2009012620A patent/MX2009012620A/en active IP Right Grant
- 2007-08-02 CA CA002686488A patent/CA2686488A1/en not_active Abandoned
- 2007-08-02 WO PCT/US2007/075069 patent/WO2008143682A1/en active Application Filing
- 2007-08-02 EP EP07813699A patent/EP2162154B1/en not_active Not-in-force
- 2007-08-02 JP JP2010509321A patent/JP5825785B2/en not_active Expired - Fee Related
- 2007-08-02 AU AU2007353795A patent/AU2007353795B2/en not_active Ceased
- 2007-08-02 CN CN2007800530913A patent/CN101678111B/en not_active Expired - Fee Related
- 2007-08-02 BR BRPI0721681-5A patent/BRPI0721681A2/en not_active IP Right Cessation
- 2007-08-02 KR KR1020097026609A patent/KR20100022991A/en not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4857552A (en) * | 1988-06-08 | 1989-08-15 | E. I. Du Pont De Nemours And Co. | Stable pharmaceutical composition |
US6310094B1 (en) * | 2001-01-12 | 2001-10-30 | Baxter International Inc. | Ready-to-use esmolol solution |
EP1417962A1 (en) * | 2002-11-06 | 2004-05-12 | AOP Orphan Pharmaceuticals AG | Method for the manufacture of a medicament comprising esmolol |
Non-Patent Citations (2)
Title |
---|
ANESTHESIOLOGY ABSTRACTS OF SCIENTIFIC PAPERS ANNUAL MEETING, no. 2002, 2002, 2002 ANNUAL MEETING OF THE AMERICAN SOCIETY OF ANESTHESIOLOGISTS; ORLANDO, FL, USA; OCTOBER 12-16, 2002, pages Abstract No. A - 1153 URL * |
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2002, VASDEV GURINDER ET AL: "Analysis of Systems Failure Leading to Medication Errors: The role of Sentinel Events for Anesthesiologists.", XP002475538, Database accession no. PREV200300100453 * |
Also Published As
Publication number | Publication date |
---|---|
US8426467B2 (en) | 2013-04-23 |
CA2686488A1 (en) | 2008-11-27 |
US20080292558A1 (en) | 2008-11-27 |
MX2009012620A (en) | 2009-12-11 |
EP2162154A1 (en) | 2010-03-17 |
CN101678111B (en) | 2013-01-02 |
EP2162154B1 (en) | 2011-06-15 |
JP5825785B2 (en) | 2015-12-02 |
CN101678111A (en) | 2010-03-24 |
AU2007353795A1 (en) | 2008-11-27 |
KR20100022991A (en) | 2010-03-03 |
JP2010528001A (en) | 2010-08-19 |
ATE512673T1 (en) | 2011-07-15 |
AU2007353795B2 (en) | 2012-09-13 |
BRPI0721681A2 (en) | 2014-02-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5778384B2 (en) | Esmolol formulation | |
CA2410446C (en) | Esmolol formulation | |
US20150005376A1 (en) | Concentrate esmolol | |
AU2007353795B2 (en) | Colored esmolol concentrate | |
AU2008256949B2 (en) | Multi-dose concentrate esmolol with benzyl alcohol | |
AU2014203121B2 (en) | Concentrate esmolol |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 200780053091.3 Country of ref document: CN |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 07813699 Country of ref document: EP Kind code of ref document: A1 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2686488 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007353795 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2010509321 Country of ref document: JP Ref document number: MX/A/2009/012620 Country of ref document: MX |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: 2007353795 Country of ref document: AU Date of ref document: 20070802 Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 8262/DELNP/2009 Country of ref document: IN |
|
ENP | Entry into the national phase |
Ref document number: 20097026609 Country of ref document: KR Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007813699 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: PI0721681 Country of ref document: BR Kind code of ref document: A2 Effective date: 20091119 |