WO2009003010A3 - Methods for evaluating the aggregation of a protein in a suspension including organopolysiloxane and medical articles coated with organopolysiloxane containing a protein solution - Google Patents
Methods for evaluating the aggregation of a protein in a suspension including organopolysiloxane and medical articles coated with organopolysiloxane containing a protein solution Download PDFInfo
- Publication number
- WO2009003010A3 WO2009003010A3 PCT/US2008/068136 US2008068136W WO2009003010A3 WO 2009003010 A3 WO2009003010 A3 WO 2009003010A3 US 2008068136 W US2008068136 W US 2008068136W WO 2009003010 A3 WO2009003010 A3 WO 2009003010A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- organopolysiloxane
- protein
- aggregation
- evaluating
- methods
- Prior art date
Links
- 229920001296 polysiloxane Polymers 0.000 title abstract 4
- 238000004220 aggregation Methods 0.000 title abstract 2
- 230000002776 aggregation Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000012460 protein solution Substances 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 239000000725 suspension Substances 0.000 title 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000002736 nonionic surfactant Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/80—Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/82—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a precipitate or turbidity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- G01N15/149—
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N2015/0092—Monitoring flocculation or agglomeration
Abstract
This invention relates to methods for evaluating or inhibiting the aggregation of a protein in an aqueous suspension including organopolysiloxane and medical articles coated with organopolysiloxane containing a protein solution including sugar and non-ionic surfactant.
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08841038.6A EP2201380B1 (en) | 2007-10-22 | 2008-10-22 | Methods for evaluating the aggregation of a protein in a suspension including organopolysiloxane and medical articles coated with organopolysiloxane containing a protein solution |
EP20100164045 EP2237038B1 (en) | 2007-10-22 | 2008-10-22 | Medical articles coated with organopolysiloxane containing a protein solution and non-ionic surfactant |
CN200880119613XA CN101889209A (en) | 2007-10-22 | 2008-10-22 | The method of evaluation protein aggregation in containing the suspending liquid of organic based polysiloxane and the medical article that is coated with the organopolysiloxane that contains protein solution |
CN201610529593.XA CN106443002A (en) | 2007-10-22 | 2008-10-22 | Methods for evaluating the aggregation of a protein in a suspension including organic polysiloxane |
US12/739,009 US8633034B2 (en) | 2007-06-25 | 2008-10-22 | Methods for evaluating the aggregation of a protein in a suspension including organopolysiloxane and medical articles coated with organopolysiloxane containing a protein solution |
JP2010531196A JP5081976B2 (en) | 2007-10-22 | 2008-10-22 | Method for assessing protein aggregation in suspensions containing organopolysiloxanes |
ES10164045.6T ES2543735T3 (en) | 2007-10-22 | 2008-10-22 | Medical articles coated with organopolysiloxane containing a protein solution and a non-ionic surfactant |
PCT/US2008/080721 WO2009055427A2 (en) | 2007-10-22 | 2008-10-22 | Methods for evaluating the aggregation of a protein in a suspension including organopolysiloxane and medical articles coated with organopolysiloxane containing a protein solution |
JP2012154844A JP5978034B2 (en) | 2007-10-22 | 2012-07-10 | Method for assessing protein aggregation in a suspension comprising an organopolysiloxane and a medical article coated with an organopolysiloxane containing a protein solution |
US14/139,604 US20140110297A1 (en) | 2007-06-25 | 2013-12-23 | "Medical Articles Coated With Organopolysiloxane Containing a Protein Solution" |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93717907P | 2007-06-25 | 2007-06-25 | |
US60/937,179 | 2007-06-25 |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/739,009 Division US8633034B2 (en) | 2007-06-25 | 2008-10-22 | Methods for evaluating the aggregation of a protein in a suspension including organopolysiloxane and medical articles coated with organopolysiloxane containing a protein solution |
US12/739,009 Continuation-In-Part US8633034B2 (en) | 2007-06-25 | 2008-10-22 | Methods for evaluating the aggregation of a protein in a suspension including organopolysiloxane and medical articles coated with organopolysiloxane containing a protein solution |
PCT/US2008/080721 Continuation-In-Part WO2009055427A2 (en) | 2007-06-25 | 2008-10-22 | Methods for evaluating the aggregation of a protein in a suspension including organopolysiloxane and medical articles coated with organopolysiloxane containing a protein solution |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009003010A2 WO2009003010A2 (en) | 2008-12-31 |
WO2009003010A3 true WO2009003010A3 (en) | 2009-02-12 |
Family
ID=40186268
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/068136 WO2009003010A2 (en) | 2007-06-25 | 2008-06-25 | Methods for evaluating the aggregation of a protein in a suspension including organopolysiloxane and medical articles coated with organopolysiloxane containing a protein solution |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2009003010A2 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101889209A (en) | 2007-10-22 | 2010-11-17 | 贝克顿·迪金森公司 | The method of evaluation protein aggregation in containing the suspending liquid of organic based polysiloxane and the medical article that is coated with the organopolysiloxane that contains protein solution |
US8802603B2 (en) | 2010-06-17 | 2014-08-12 | Becton, Dickinson And Company | Medical components having coated surfaces exhibiting low friction and low reactivity |
TWI669129B (en) | 2014-12-23 | 2019-08-21 | 德商梅茲製藥有限兩合公司 | Refilled glass container, a kit comprising the same and, a use thereof |
RU2722290C2 (en) | 2015-02-03 | 2020-05-28 | Мерц Фарма Гмбх Унд Ко. Кгаа | Container pre-filled with botulinum toxin |
CN107063940B (en) | 2016-02-10 | 2019-10-18 | 贝克顿迪金森法国公司 | Method for evaluating the stability of the preparation based on protein |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6525084B2 (en) * | 1998-07-23 | 2003-02-25 | Novo Nordisk A/S | Stable pharmaceutical formulation |
US20030072807A1 (en) * | 2000-12-22 | 2003-04-17 | Wong Joseph Chung-Tak | Solid particulate antifungal compositions for pharmaceutical use |
US6638519B1 (en) * | 1999-11-08 | 2003-10-28 | L'oreal | Composition for topical application comprising a sugar and its cosmetic uses |
US20050053598A1 (en) * | 2003-02-10 | 2005-03-10 | Burke David J. | Immunoglobulin formulation and method of preparation thereof |
US20050123947A1 (en) * | 1997-09-23 | 2005-06-09 | California Institute Of Technology | Methods and systems for molecular fingerprinting |
US20060051353A1 (en) * | 2004-05-14 | 2006-03-09 | Jean-Frederic Colombel | Methods and compositions to evaluate antibody treatment response |
-
2008
- 2008-06-25 WO PCT/US2008/068136 patent/WO2009003010A2/en active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050123947A1 (en) * | 1997-09-23 | 2005-06-09 | California Institute Of Technology | Methods and systems for molecular fingerprinting |
US6525084B2 (en) * | 1998-07-23 | 2003-02-25 | Novo Nordisk A/S | Stable pharmaceutical formulation |
US6638519B1 (en) * | 1999-11-08 | 2003-10-28 | L'oreal | Composition for topical application comprising a sugar and its cosmetic uses |
US20030072807A1 (en) * | 2000-12-22 | 2003-04-17 | Wong Joseph Chung-Tak | Solid particulate antifungal compositions for pharmaceutical use |
US20050053598A1 (en) * | 2003-02-10 | 2005-03-10 | Burke David J. | Immunoglobulin formulation and method of preparation thereof |
US20060051353A1 (en) * | 2004-05-14 | 2006-03-09 | Jean-Frederic Colombel | Methods and compositions to evaluate antibody treatment response |
Also Published As
Publication number | Publication date |
---|---|
WO2009003010A2 (en) | 2008-12-31 |
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