WO2009026339A3 - Modular droplet actuator drive - Google Patents
Modular droplet actuator drive Download PDFInfo
- Publication number
- WO2009026339A3 WO2009026339A3 PCT/US2008/073673 US2008073673W WO2009026339A3 WO 2009026339 A3 WO2009026339 A3 WO 2009026339A3 US 2008073673 W US2008073673 W US 2008073673W WO 2009026339 A3 WO2009026339 A3 WO 2009026339A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- droplet actuator
- actuator drive
- circuitry
- detection apparatus
- droplet
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/143—Quality control, feedback systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
- B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
Abstract
The invention provides a droplet actuator drive. In certain embodiments, the droplet actuator drive may include a detection apparatus for sensing a property of a droplet on a droplet actuator; circuitry for controlling the detection apparatus electronically coupled to the detection apparatus; a droplet actuator cartridge connector; circuitry for controlling a droplet actuator coupled to the droplet actuator connector; and/or a means for coupling the droplet actuator circuitry to a processor. Systems, kits and methods of conducting assays are also provided.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/707,081 US8041463B2 (en) | 2006-05-09 | 2010-02-17 | Modular droplet actuator drive |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95677407P | 2007-08-20 | 2007-08-20 | |
US60/956,774 | 2007-08-20 | ||
US98050307P | 2007-10-17 | 2007-10-17 | |
US60/980,503 | 2007-10-17 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/838,388 Continuation-In-Part US7822510B2 (en) | 2006-05-09 | 2007-08-14 | Systems, methods, and products for graphically illustrating and controlling a droplet actuator |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/707,081 Continuation US8041463B2 (en) | 2006-05-09 | 2010-02-17 | Modular droplet actuator drive |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009026339A2 WO2009026339A2 (en) | 2009-02-26 |
WO2009026339A3 true WO2009026339A3 (en) | 2009-05-28 |
Family
ID=40378966
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/073673 WO2009026339A2 (en) | 2006-05-09 | 2008-08-20 | Modular droplet actuator drive |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2009026339A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8637242B2 (en) | 2011-11-07 | 2014-01-28 | Illumina, Inc. | Integrated sequencing apparatuses and methods of use |
Families Citing this family (45)
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---|---|---|---|---|
EP1859330B1 (en) | 2005-01-28 | 2012-07-04 | Duke University | Apparatuses and methods for manipulating droplets on a printed circuit board |
US20140193807A1 (en) | 2006-04-18 | 2014-07-10 | Advanced Liquid Logic, Inc. | Bead manipulation techniques |
US8809068B2 (en) | 2006-04-18 | 2014-08-19 | Advanced Liquid Logic, Inc. | Manipulation of beads in droplets and methods for manipulating droplets |
US7439014B2 (en) | 2006-04-18 | 2008-10-21 | Advanced Liquid Logic, Inc. | Droplet-based surface modification and washing |
US10078078B2 (en) | 2006-04-18 | 2018-09-18 | Advanced Liquid Logic, Inc. | Bead incubation and washing on a droplet actuator |
US8658111B2 (en) | 2006-04-18 | 2014-02-25 | Advanced Liquid Logic, Inc. | Droplet actuators, modified fluids and methods |
US8637324B2 (en) | 2006-04-18 | 2014-01-28 | Advanced Liquid Logic, Inc. | Bead incubation and washing on a droplet actuator |
US8716015B2 (en) | 2006-04-18 | 2014-05-06 | Advanced Liquid Logic, Inc. | Manipulation of cells on a droplet actuator |
WO2009111769A2 (en) | 2008-03-07 | 2009-09-11 | Advanced Liquid Logic, Inc. | Reagent and sample preparation and loading on a fluidic device |
US8685344B2 (en) | 2007-01-22 | 2014-04-01 | Advanced Liquid Logic, Inc. | Surface assisted fluid loading and droplet dispensing |
CN101627308B (en) | 2007-02-09 | 2013-08-14 | 先进流体逻辑公司 | Droplet actuator devices and methods employing magnetic beads |
WO2008101194A2 (en) | 2007-02-15 | 2008-08-21 | Advanced Liquid Logic, Inc. | Capacitance detection in a droplet actuator |
WO2009032863A2 (en) | 2007-09-04 | 2009-03-12 | Advanced Liquid Logic, Inc. | Droplet actuator with improved top substrate |
JP5462183B2 (en) | 2007-12-23 | 2014-04-02 | アドヴァンスト リキッド ロジック インコーポレイテッド | Droplet actuator configuration and method for directing droplet motion |
US8852952B2 (en) | 2008-05-03 | 2014-10-07 | Advanced Liquid Logic, Inc. | Method of loading a droplet actuator |
EP2286228B1 (en) | 2008-05-16 | 2019-04-03 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods for manipulating beads |
US8877512B2 (en) | 2009-01-23 | 2014-11-04 | Advanced Liquid Logic, Inc. | Bubble formation techniques using physical or chemical features to retain a gas bubble within a droplet actuator |
US8926065B2 (en) | 2009-08-14 | 2015-01-06 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods |
WO2011057197A2 (en) | 2009-11-06 | 2011-05-12 | Advanced Liquid Logic, Inc. | Integrated droplet actuator for gel electrophoresis and molecular analysis |
EP2516669B1 (en) | 2009-12-21 | 2016-10-12 | Advanced Liquid Logic, Inc. | Enzyme assays on a droplet actuator |
WO2011126892A2 (en) | 2010-03-30 | 2011-10-13 | Advanced Liquid Logic, Inc. | Droplet operations platform |
US10232374B2 (en) | 2010-05-05 | 2019-03-19 | Miroculus Inc. | Method of processing dried samples using digital microfluidic device |
US9011662B2 (en) | 2010-06-30 | 2015-04-21 | Advanced Liquid Logic, Inc. | Droplet actuator assemblies and methods of making same |
WO2012154745A2 (en) | 2011-05-09 | 2012-11-15 | Advanced Liquid Logic, Inc. | Microfluidic feedback using impedance detection |
EP2707724A4 (en) | 2011-05-10 | 2015-01-21 | Advanced Liquid Logic Inc | Enzyme concentration and assays |
US8901043B2 (en) | 2011-07-06 | 2014-12-02 | Advanced Liquid Logic, Inc. | Systems for and methods of hybrid pyrosequencing |
AU2012279420A1 (en) | 2011-07-06 | 2014-01-30 | Advanced Liquid Logic Inc | Reagent storage on a droplet actuator |
WO2013009927A2 (en) | 2011-07-11 | 2013-01-17 | Advanced Liquid Logic, Inc. | Droplet actuators and techniques for droplet-based assays |
WO2013016413A2 (en) | 2011-07-25 | 2013-01-31 | Advanced Liquid Logic Inc | Droplet actuator apparatus and system |
WO2013078216A1 (en) | 2011-11-21 | 2013-05-30 | Advanced Liquid Logic Inc | Glucose-6-phosphate dehydrogenase assays |
US9223317B2 (en) | 2012-06-14 | 2015-12-29 | Advanced Liquid Logic, Inc. | Droplet actuators that include molecular barrier coatings |
CA2877950C (en) | 2012-06-27 | 2021-06-22 | Advanced Liquid Logic Inc. | Techniques and droplet actuator designs for reducing bubble formation |
WO2014062551A1 (en) | 2012-10-15 | 2014-04-24 | Advanced Liquid Logic, Inc. | Digital microfluidics cartridge and system for operating a flow cell |
GB2512564B (en) | 2013-01-16 | 2020-01-22 | Mast Group Ltd | Modular assay system |
CN108026494A (en) | 2015-06-05 | 2018-05-11 | 米罗库鲁斯公司 | Limitation evaporation and the digital microcurrent-controlled apparatus and method of air matrix of surface scale |
WO2016197106A1 (en) | 2015-06-05 | 2016-12-08 | Miroculus Inc. | Evaporation management in digital microfluidic devices |
US20170300340A1 (en) * | 2016-04-15 | 2017-10-19 | Sunland International, Llc | Secure computer access using removable bootable drives |
JP2020501107A (en) | 2016-08-22 | 2020-01-16 | ミロキュラス インコーポレイテッド | Feedback system for parallel droplet control in digital microfluidic devices |
WO2018126082A1 (en) | 2016-12-28 | 2018-07-05 | Miroculis Inc. | Digital microfluidic devices and methods |
US11623219B2 (en) | 2017-04-04 | 2023-04-11 | Miroculus Inc. | Digital microfluidics apparatuses and methods for manipulating and processing encapsulated droplets |
CN110892258A (en) | 2017-07-24 | 2020-03-17 | 米罗库鲁斯公司 | Digital microfluidic system and method with integrated plasma collection device |
CN115582155A (en) | 2017-09-01 | 2023-01-10 | 米罗库鲁斯公司 | Digital microfluidic device and method of use thereof |
CA3133124A1 (en) | 2019-04-08 | 2020-10-15 | Miroculus Inc. | Multi-cartridge digital microfluidics apparatuses and methods of use |
US11524298B2 (en) | 2019-07-25 | 2022-12-13 | Miroculus Inc. | Digital microfluidics devices and methods of use thereof |
US11857961B2 (en) | 2022-01-12 | 2024-01-02 | Miroculus Inc. | Sequencing by synthesis using mechanical compression |
Citations (5)
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US20020055167A1 (en) * | 1999-06-25 | 2002-05-09 | Cepheid | Device incorporating a microfluidic chip for separating analyte from a sample |
US20020142471A1 (en) * | 2001-03-28 | 2002-10-03 | Kalyan Handique | Methods and systems for moving fluid in a microfluidic device |
US20060078935A1 (en) * | 2001-05-18 | 2006-04-13 | Werner Martin E | Surface assembly for immobilizing DNA capture probes in genetic assays using enzymatic reactions to generate signal in optical bio-discs and methods relating thereto |
US7215425B2 (en) * | 2000-08-02 | 2007-05-08 | Honeywell International Inc. | Optical alignment for flow cytometry |
WO2007073107A1 (en) * | 2005-12-21 | 2007-06-28 | Jae Chern Yoo | Bio memory disc and bio memory disk drive apparatus, and assay method using the same |
-
2008
- 2008-08-20 WO PCT/US2008/073673 patent/WO2009026339A2/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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US20020055167A1 (en) * | 1999-06-25 | 2002-05-09 | Cepheid | Device incorporating a microfluidic chip for separating analyte from a sample |
US7215425B2 (en) * | 2000-08-02 | 2007-05-08 | Honeywell International Inc. | Optical alignment for flow cytometry |
US20020142471A1 (en) * | 2001-03-28 | 2002-10-03 | Kalyan Handique | Methods and systems for moving fluid in a microfluidic device |
US20060078935A1 (en) * | 2001-05-18 | 2006-04-13 | Werner Martin E | Surface assembly for immobilizing DNA capture probes in genetic assays using enzymatic reactions to generate signal in optical bio-discs and methods relating thereto |
WO2007073107A1 (en) * | 2005-12-21 | 2007-06-28 | Jae Chern Yoo | Bio memory disc and bio memory disk drive apparatus, and assay method using the same |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8637242B2 (en) | 2011-11-07 | 2014-01-28 | Illumina, Inc. | Integrated sequencing apparatuses and methods of use |
Also Published As
Publication number | Publication date |
---|---|
WO2009026339A2 (en) | 2009-02-26 |
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