WO2009134820A3 - Accurate quantification of magnetic susceptibility in molecular mri - Google Patents

Accurate quantification of magnetic susceptibility in molecular mri Download PDF

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Publication number
WO2009134820A3
WO2009134820A3 PCT/US2009/042005 US2009042005W WO2009134820A3 WO 2009134820 A3 WO2009134820 A3 WO 2009134820A3 US 2009042005 W US2009042005 W US 2009042005W WO 2009134820 A3 WO2009134820 A3 WO 2009134820A3
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WO
WIPO (PCT)
Prior art keywords
additional information
image
signals
magnetic
collected
Prior art date
Application number
PCT/US2009/042005
Other languages
French (fr)
Other versions
WO2009134820A2 (en
Inventor
Yi Wang
Ludovic De Rochefort
Bryan Kressler
Tian LIU
Pascal Spincemaille
Original Assignee
Cornell University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell University filed Critical Cornell University
Priority to US12/990,148 priority Critical patent/US8781197B2/en
Priority to CN201510026527.6A priority patent/CN105182263A/en
Priority to CN200980124813.9A priority patent/CN102077108B/en
Priority to EP09739622.0A priority patent/EP2283373B1/en
Publication of WO2009134820A2 publication Critical patent/WO2009134820A2/en
Publication of WO2009134820A3 publication Critical patent/WO2009134820A3/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/563—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution of moving material, e.g. flow contrast angiography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5608—Data processing and visualization specially adapted for MR, e.g. for feature analysis and pattern recognition on the basis of measured MR data, segmentation of measured MR data, edge contour detection on the basis of measured MR data, for enhancing measured MR data in terms of signal-to-noise ratio by means of noise filtering or apodization, for enhancing measured MR data in terms of resolution by means for deblurring, windowing, zero filling, or generation of gray-scaled images, colour-coded images or images displaying vectors instead of pixels

Abstract

A method and apparatus is provided for magnetic source magnetic resonance imaging. The method includes collecting energy signals from an object, providing additional information of characteristics of the object, and generating the image of the object from the energy signals and from the additional information such that the image includes a representation of a quantitative estimation of the characteristics, e.g a quantitative estimation of magnetic susceptibility. The additional information may comprise predetermined characteristics of the object, a magnitude image generated from the object, or magnetic signals collected from different relative orientations between the object and the imaging system. The image is generated by an inversion operation based on the collected signals and the additional information. The inversion operation minimizes a cost function obtained by combining the data extracted from the collected signals and the additional information of the object. Additionally, the image is used to detect a number of diagnostic features including microbleeds, contract agents and the like.
PCT/US2009/042005 2008-04-28 2009-04-28 Tool for accurate quantification in molecular mri WO2009134820A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US12/990,148 US8781197B2 (en) 2008-04-28 2009-04-28 Tool for accurate quantification in molecular MRI
CN201510026527.6A CN105182263A (en) 2008-04-28 2009-04-28 Accurate quantification of magnetic suceptibility in molecular mri
CN200980124813.9A CN102077108B (en) 2008-04-28 2009-04-28 Tool for accurate quantification of magnet susceptibility in molecular MRI
EP09739622.0A EP2283373B1 (en) 2008-04-28 2009-04-28 Accurate quantification of magnetic susceptibility in molecular mri

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US12570908P 2008-04-28 2008-04-28
US12571008P 2008-04-28 2008-04-28
US12571308P 2008-04-28 2008-04-28
US12570408P 2008-04-28 2008-04-28
US12575208P 2008-04-28 2008-04-28
US12572708P 2008-04-28 2008-04-28
US61/125,704 2008-04-28
US61/125,713 2008-04-28
US61/125,709 2008-04-28
US61/125,710 2008-04-28
US61/125,727 2008-04-28
US61/125,752 2008-04-28

Publications (2)

Publication Number Publication Date
WO2009134820A2 WO2009134820A2 (en) 2009-11-05
WO2009134820A3 true WO2009134820A3 (en) 2009-12-23

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PCT/US2009/042005 WO2009134820A2 (en) 2008-04-28 2009-04-28 Tool for accurate quantification in molecular mri

Country Status (4)

Country Link
US (1) US8781197B2 (en)
EP (1) EP2283373B1 (en)
CN (2) CN102077108B (en)
WO (1) WO2009134820A2 (en)

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