WO2009144272A1 - Reservoir filling device - Google Patents

Reservoir filling device Download PDF

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Publication number
WO2009144272A1
WO2009144272A1 PCT/EP2009/056533 EP2009056533W WO2009144272A1 WO 2009144272 A1 WO2009144272 A1 WO 2009144272A1 EP 2009056533 W EP2009056533 W EP 2009056533W WO 2009144272 A1 WO2009144272 A1 WO 2009144272A1
Authority
WO
WIPO (PCT)
Prior art keywords
cartridge
housing
filling device
venting
reservoir
Prior art date
Application number
PCT/EP2009/056533
Other languages
French (fr)
Inventor
Claus Jakobsen
Bo Justesen
Elo HØRDUM
Original Assignee
Unomedical A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unomedical A/S filed Critical Unomedical A/S
Priority to CN2009801244405A priority Critical patent/CN102202636A/en
Priority to EP20090753927 priority patent/EP2303220A1/en
Priority to MX2010013084A priority patent/MX2010013084A/en
Priority to US12/994,234 priority patent/US20110168294A1/en
Publication of WO2009144272A1 publication Critical patent/WO2009144272A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2017—Piercing means having three or more piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2072—Venting means for internal venting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2075—Venting means for external venting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2082—Filtering means for gas filtration

Definitions

  • the invention relates to a filling device for a reservoir which reservoir is to be filled from a cartridge such as cartridges having rigid walls e.g. made of glass and provided with a membrane which can be penetrated by a needle for protection of the entrance.
  • a cartridge such as cartridges having rigid walls e.g. made of glass and provided with a membrane which can be penetrated by a needle for protection of the entrance.
  • a problem which arises when manufacturing such filling devices is how to place the venting channel in order not to hamper the filling process or to contaminate the filling liquid which will normally be some kind of medication.
  • US 4.296.786 discloses a transfer device for use in mixing substances in different containers which containers each are closed by a stopper of resilient material having a puncturable diaphragm.
  • the transfer device consists of a central body portion and a pair of aligned spikes or cannulas projecting from opposite sides of this central body portion. This device is not provided with a venting needle moving independently of the filling needle, and therefore the joined spikes or cannulas according to this document have a relatively large diameter.
  • the object of the invention is to provide a filling device which is easy to handle for the user, simple and non-expensive to manufacture and where the risk of breaking the venting needle during the filling process has been eliminated.
  • the invention concerns a filling device which comprising - a housing comprising - a first position means adapted to receive a reservoir for receiving liquid,
  • a second position means adapted to receive a cartridge containing a liquid
  • venting unit providing access of gas to the cartridge during emptying of the cartridge
  • at least a part of the venting unit is placed off the rotational centre (r c ) of the housing and is attached to a part.
  • the invention is characterized in that this part can rotate relative to the housing and relative to the unit providing a flow path.
  • the unit providing the flow path between the reservoir and the cartridge when they are at their positions comprises a needle having two pointy ends.
  • the needle can be made of any kind of material which can penetrate the membranes protecting the access to respectively the cartridge and the reservoir, and the needle could be blunt at one end and pointed at the other end.
  • the unit providing the flow path is placed along the rotational centre of the housing.
  • the unit is fastened unreleasably to or is a part of a wall in the housing which wall separates the first position means adapted to receive the reservoir from the second position means adapted to receive the cartridge.
  • the part which can rotate relative to the housing is formed as a circular plate which periphery is in proximity of or in slidable contact with walls of the housing.
  • the circular plate can move in a track formed in the walls of the housing.
  • the formation of a "track” prevents the circular plate from moving in a direction parallel to the rotational axis r c of the housing.
  • the periphery of the circular plate is provided with a track formed along the periphery which track corresponds to one or more protruding part(s) of the housing.
  • the circular plate can be provided with a friction layer which friction layer prevents that the cartridge moves in relation to the cartridge i.e. when the cartridge is pushed into the fitted second position means of the filling device housing and the venting unit has penetrated to the inner room of the cartridge then the friction layer will reduce the risk of any displacement of the cartridge relative to the rotary part.
  • the venting unit comprises a venting needle which venting needle provides access from outside the cartridge to the inner room of the cartridge.
  • the venting unit (5) can further comprise a venting valve (5b) which venting valve (5b) provides a one-way passage of clean gas into a room wherefrom the venting needle (5a) is provided with clean gas.
  • "Clean gas” is considered to be gas of a quality as defined as necessary by the user or by the manufacturer of the device. It can be sterile gas but might be gas of a more inferior quality. Normally the gas will be atmospheric air.
  • the venting needle is attached to the rotary part providing a flow path for clean gas from one side of the rotary part to the other and the venting valve can be attached to the open end of the venting needle pointing away from the cartridge.
  • the venting valve can be attached to a wall of the housing proving access of clean gas from outside wall of the housing to the inside of the wall of the housing.
  • the invention also relates to a kit combining a cartridge filling device according to any of the claims 1 -1 1 and a cartridge containing liquid which filling device can be either for single use and thereby permanently joined to the cartridge or for multiple use and thereby can be connected and disconnected to the cartridge.
  • FIG. 1 shows a cut-through view of a filling device housing where a reservoir to be filled is half-way in position and a cartridge containing liquid is also half-way in position;
  • Fig. 2 shows a cut-through view of a filling device housing where the venting valve is placed away from the venting needle.
  • the embodiment of the reservoir filling device of fig. 1 is shown in a state where liquid cannot be transferred from the liquid containing cartridge 3 to the reservoir.
  • the embodiment of the filling device comprises a housing 1 having cylindrical outer walls and a separating wall 8 dividing the housing into two positions, a first position for the reservoir 2 to be filled and a second position for the cartridge 3 to be emptied.
  • Each position is either provided by the walls of the housing 1 thereby providing a close fit for the device to be placed there or is provided with guiding means assuring a well-defined final position of the device to be placed.
  • both or one of the positions only comprise a central portion in form of the separating wall 8 having no outer walls.
  • the positions including the guiding means are referred to as position means.
  • the embodiment of the filling device further comprises a filling needle 4 which filing needle 4 provides a flow path for liquid flowing from the cartridge 3 to the reservoir 2.
  • Both the cartridge 3 and the reservoir are in the embodiments of fig. 1 each provided with a membrane 6 and 10 which have to be penetrated by the filling needle 4 in order to create a flow path between the two units.
  • the filling needle 4 is unreleasably attached to the separating walls 8 and kept in a stationary position relative to the housing 1 along the central axis of the housing 1 .
  • the filling device is also provided with a rotary part 7 which according to this embodiment is formed as a turntable provided with a folding at the periphery.
  • the folding provides a contact surface which can slide along the inner surface of the housing 1 wall.
  • the rotary part 7 can rotate around the filling needle 4 which according to this embodiment is stationary relative to the housing 1 .
  • the rotary part 7 is prevented from moving in the longitudinal direction by one or more protruding parts 12 preventing the rotary part 7 from moving towards the cartridge and the separating wall 8 preventing the rotary part 7 from moving towards the reservoir 2.
  • Gas can pass from one side of the rotary part to the other through the venting needle 5 which according to this embodiment is constructed of a penetrating member 5a and a valve member 5b which two parts are joined.
  • the penetrating member 5a is unreleasably attached to the rotary part 7 and provides a flow path for gas through the rotary part 7 and into the clean inner room 1 1 of the cartridge 3.
  • the penetrating member 5a will normally be provided with a pointed end towards the cartridge in order for it to be able to cut through the membrane layer 6 protecting the entrance of the cartridge 3.
  • the venting valve 5b is attached to the open end of the penetrating member 5a turned towards the reservoir 2 and the valve 5b allows for gas/air to pass from the room between the rotary part 7 and the separating wall 8 into the inner room 1 1 of the cartridge 3 when the penetrating member 5a has penetrated the membrane 6 and been inserted into this room.
  • the valve 5b prevents micro organisms from accessing the clean inner room 1 1 of the cartridge 3.
  • the rotary part 7 is according to this embodiment provided with one or more friction layers 9 on the side turned toward the cartridge 3.
  • the friction layers 9 correspond to contact surfaces 13 on the cartridge 3 and when the friction layers 9 and the contact surfaces make contact the two units are "locked" relative to each other and move together.
  • Fig. 1 also shows the reservoir 2 when this is pushed half-way into the position of the housing 1 , in this half-way position the filling needle 4 does not penetrate the septum or membrane 10 which is protecting the entrance of the reservoir 2.
  • the reservoir 2 according to this embodiment is also provided with an illustrative piston with which liquid has been pushed out of the reservoir 2 during use and emptying of the reservoir 2.
  • Fig. 2 shows another embodiment of a filling device according to the present invention.
  • the penetrating member 5a and the venting valve 5b are separated from each other.
  • the venting valve 5a transfers gas or air from the outside of the housing 1 into the clean room 1 1 between the rotary part 7 and the separating wall 8.
  • the rotary part 7 must provide an airtight seal against the walls of the housing 1 .
  • the penetrating member 5a has a blunt end turned toward the reservoir 2 and a pointed end turned toward the membrane of the cartridge 3.
  • the penetrating member 5a When the cartridge 3 is pushed into position the penetrating member 5a will penetrate the membrane 6 and provide a flow path for clean gas/air between the clean room 1 1 formed between the rotary part 7 and the separating wall 8 and the inner clean room 1 1 of the cartridge 3. Gas will flow through this flow path when the pressure is reduced in the reservoir 2 as the piston 14 is pulled back.
  • the filling needle 4 is provided with two pointed ends respectively penetrating the membrane 6 of the cartridge 3 and the membrane 10 of the reservoir 2 when these two devices are pushed into each their position.
  • the housing 1 of the filling device according to the present invention need not be cylindrical or have a round profile but it should be able to provide a close fit between the rotary part 7 and the inner surface of the housing 1 especially according to the embodiment of fig. 2 where it is necessary to have clean atmosphere in the room between the rotary part 7 and the separating walls 8. If the inner surface of the housing at this position is not round it could be provided with a round track e.g. formed in a protruding part of the inner surface of the walls of the housing 1 .
  • the liquid contained in the cartridge will often be a kind of medication which advantageously can be continuously administrated to a patient.
  • This medication could e.g. be insulin which can be continuously administered to patients with diabetes.
  • the cartridge 3 could be a glass ampoule containing an apportioned amount of insulin.

Abstract

The invention relates to a filling device for a reservoir which reservoir is to be filled from a cartridge such as cartridges having rigid walls e.g. made of glass and provided with a membrane which can be penetrated by a needle for protection of the entrance. According to the present invention the filling device comprises - a housing (1 ) which housing (1 ) comprises - a first position means adapted to receive a reservoir (2) for a delivering device, - a second position means adapted to receive a cartridge (3) containing a liquid, - a unit (4) providing a flow path when both the reservoir (2) and the cartridge are received respectively by the first and second positions means, - a venting unit (5, 5a, 5b) providing access of gas to the cartridge (3) during emptying of the cartridge (3). The filling device is characterized in that at least a part of the venting unit (5) is placed off the rotational centre (rc) of the housing and is attached to a part (7) which part (7) can rotate relative to the housing (1 ).

Description

Reservoir filling device
Technical field
The invention relates to a filling device for a reservoir which reservoir is to be filled from a cartridge such as cartridges having rigid walls e.g. made of glass and provided with a membrane which can be penetrated by a needle for protection of the entrance.
Background of the invention Filling devices for reservoirs are known and it is recognized that it can be necessary to vent the container which is to be emptied for filling liquid in order to reduce the costs for filling or refilling of reservoirs.
A problem which arises when manufacturing such filling devices is how to place the venting channel in order not to hamper the filling process or to contaminate the filling liquid which will normally be some kind of medication.
US 4.296.786 discloses a transfer device for use in mixing substances in different containers which containers each are closed by a stopper of resilient material having a puncturable diaphragm. The transfer device consists of a central body portion and a pair of aligned spikes or cannulas projecting from opposite sides of this central body portion. This device is not provided with a venting needle moving independently of the filling needle, and therefore the joined spikes or cannulas according to this document have a relatively large diameter.
Description of invention
The object of the invention is to provide a filling device which is easy to handle for the user, simple and non-expensive to manufacture and where the risk of breaking the venting needle during the filling process has been eliminated.
The invention concerns a filling device which comprising - a housing comprising - a first position means adapted to receive a reservoir for receiving liquid,
- a second position means adapted to receive a cartridge containing a liquid,
- a unit unreleasably attached to the housing and providing a flow path when both the reservoir and the cartridge are received respectively by the first and second positions means,
- a venting unit providing access of gas to the cartridge during emptying of the cartridge, and at least a part of the venting unit is placed off the rotational centre (rc) of the housing and is attached to a part. The invention is characterized in that this part can rotate relative to the housing and relative to the unit providing a flow path.
According to one embodiment of the invention the unit providing the flow path between the reservoir and the cartridge when they are at their positions comprises a needle having two pointy ends. The needle can be made of any kind of material which can penetrate the membranes protecting the access to respectively the cartridge and the reservoir, and the needle could be blunt at one end and pointed at the other end.
According to one embodiment of the invention the unit providing the flow path is placed along the rotational centre of the housing.
According to the above embodiment of the invention the unit is fastened unreleasably to or is a part of a wall in the housing which wall separates the first position means adapted to receive the reservoir from the second position means adapted to receive the cartridge.
According to one embodiment of the invention the part which can rotate relative to the housing is formed as a circular plate which periphery is in proximity of or in slidable contact with walls of the housing. E.g. the circular plate can move in a track formed in the walls of the housing. The formation of a "track" prevents the circular plate from moving in a direction parallel to the rotational axis rc of the housing. Alternatively the periphery of the circular plate is provided with a track formed along the periphery which track corresponds to one or more protruding part(s) of the housing.
According to one embodiment of the invention the circular plate can be provided with a friction layer which friction layer prevents that the cartridge moves in relation to the cartridge i.e. when the cartridge is pushed into the fitted second position means of the filling device housing and the venting unit has penetrated to the inner room of the cartridge then the friction layer will reduce the risk of any displacement of the cartridge relative to the rotary part.
According to one embodiment of the invention the venting unit comprises a venting needle which venting needle provides access from outside the cartridge to the inner room of the cartridge. The venting unit (5) can further comprise a venting valve (5b) which venting valve (5b) provides a one-way passage of clean gas into a room wherefrom the venting needle (5a) is provided with clean gas. "Clean gas" is considered to be gas of a quality as defined as necessary by the user or by the manufacturer of the device. It can be sterile gas but might be gas of a more inferior quality. Normally the gas will be atmospheric air.
According to this embodiment the venting needle is attached to the rotary part providing a flow path for clean gas from one side of the rotary part to the other and the venting valve can be attached to the open end of the venting needle pointing away from the cartridge. Alternatively the venting valve can be attached to a wall of the housing proving access of clean gas from outside wall of the housing to the inside of the wall of the housing.
The invention also relates to a kit combining a cartridge filling device according to any of the claims 1 -1 1 and a cartridge containing liquid which filling device can be either for single use and thereby permanently joined to the cartridge or for multiple use and thereby can be connected and disconnected to the cartridge. Description of the drawings
The invention is explained in greater detail below with reference to the accompanying drawings wherein two preferred embodiments of the invention are shown. Fig. 1 shows a cut-through view of a filling device housing where a reservoir to be filled is half-way in position and a cartridge containing liquid is also half-way in position;
Fig. 2 shows a cut-through view of a filling device housing where the venting valve is placed away from the venting needle.
The embodiment of the reservoir filling device of fig. 1 is shown in a state where liquid cannot be transferred from the liquid containing cartridge 3 to the reservoir. The embodiment of the filling device comprises a housing 1 having cylindrical outer walls and a separating wall 8 dividing the housing into two positions, a first position for the reservoir 2 to be filled and a second position for the cartridge 3 to be emptied. Each position is either provided by the walls of the housing 1 thereby providing a close fit for the device to be placed there or is provided with guiding means assuring a well-defined final position of the device to be placed. In the most simple form both or one of the positions only comprise a central portion in form of the separating wall 8 having no outer walls. The positions including the guiding means are referred to as position means.
The embodiment of the filling device further comprises a filling needle 4 which filing needle 4 provides a flow path for liquid flowing from the cartridge 3 to the reservoir 2. Both the cartridge 3 and the reservoir are in the embodiments of fig. 1 each provided with a membrane 6 and 10 which have to be penetrated by the filling needle 4 in order to create a flow path between the two units. The filling needle 4 is unreleasably attached to the separating walls 8 and kept in a stationary position relative to the housing 1 along the central axis of the housing 1 .
The filling device is also provided with a rotary part 7 which according to this embodiment is formed as a turntable provided with a folding at the periphery. The folding provides a contact surface which can slide along the inner surface of the housing 1 wall. The rotary part 7 can rotate around the filling needle 4 which according to this embodiment is stationary relative to the housing 1 .
The rotary part 7 is prevented from moving in the longitudinal direction by one or more protruding parts 12 preventing the rotary part 7 from moving towards the cartridge and the separating wall 8 preventing the rotary part 7 from moving towards the reservoir 2.
Gas can pass from one side of the rotary part to the other through the venting needle 5 which according to this embodiment is constructed of a penetrating member 5a and a valve member 5b which two parts are joined. The penetrating member 5a is unreleasably attached to the rotary part 7 and provides a flow path for gas through the rotary part 7 and into the clean inner room 1 1 of the cartridge 3. The penetrating member 5a will normally be provided with a pointed end towards the cartridge in order for it to be able to cut through the membrane layer 6 protecting the entrance of the cartridge 3.
The venting valve 5b is attached to the open end of the penetrating member 5a turned towards the reservoir 2 and the valve 5b allows for gas/air to pass from the room between the rotary part 7 and the separating wall 8 into the inner room 1 1 of the cartridge 3 when the penetrating member 5a has penetrated the membrane 6 and been inserted into this room. The valve 5b prevents micro organisms from accessing the clean inner room 1 1 of the cartridge 3.
The rotary part 7 is according to this embodiment provided with one or more friction layers 9 on the side turned toward the cartridge 3. The friction layers 9 correspond to contact surfaces 13 on the cartridge 3 and when the friction layers 9 and the contact surfaces make contact the two units are "locked" relative to each other and move together. Fig. 1 also shows the reservoir 2 when this is pushed half-way into the position of the housing 1 , in this half-way position the filling needle 4 does not penetrate the septum or membrane 10 which is protecting the entrance of the reservoir 2. The reservoir 2 according to this embodiment is also provided with an illustrative piston with which liquid has been pushed out of the reservoir 2 during use and emptying of the reservoir 2. When filling the reservoir with liquid from the cartridge 3 the piston 14 is pulled back causing a reduced pressure in the reservoir 2 and this reduced pressure will transport liquid contained in the cartridge via the flow path provided by the filling needle 4 into the reservoir 2. The removal of liquid from the cartridge 2, which is a closed container with rigid walls, will reduce the pressure in the cartridge 3 and if air or other gas is not let into the inner room of the cartridge 3 then it will be necessary to assure that the piston 14 seal tightly toward the inner walls of the reservoir 2 in order to be able to provide a reduced pressure which can overcome the low pressure in the cartridge 3.
Instead of increasing the quality of the reservoir piston 2 it can be more convenient to prevent the pressure inside the cartridge 3 to drop to low and this can be done e.g. as suggested according to the present embodiment of the filling device by letting air or other gas into the cartridge through the venting needle 5.
Fig. 2 shows another embodiment of a filling device according to the present invention. According to this embodiment the penetrating member 5a and the venting valve 5b are separated from each other. The venting valve 5a transfers gas or air from the outside of the housing 1 into the clean room 1 1 between the rotary part 7 and the separating wall 8. According to this embodiment the rotary part 7 must provide an airtight seal against the walls of the housing 1 . The penetrating member 5a has a blunt end turned toward the reservoir 2 and a pointed end turned toward the membrane of the cartridge 3. When the cartridge 3 is pushed into position the penetrating member 5a will penetrate the membrane 6 and provide a flow path for clean gas/air between the clean room 1 1 formed between the rotary part 7 and the separating wall 8 and the inner clean room 1 1 of the cartridge 3. Gas will flow through this flow path when the pressure is reduced in the reservoir 2 as the piston 14 is pulled back.
As in the embodiment of fig. 1 the filling needle 4 is provided with two pointed ends respectively penetrating the membrane 6 of the cartridge 3 and the membrane 10 of the reservoir 2 when these two devices are pushed into each their position.
The housing 1 of the filling device according to the present invention need not be cylindrical or have a round profile but it should be able to provide a close fit between the rotary part 7 and the inner surface of the housing 1 especially according to the embodiment of fig. 2 where it is necessary to have clean atmosphere in the room between the rotary part 7 and the separating walls 8. If the inner surface of the housing at this position is not round it could be provided with a round track e.g. formed in a protruding part of the inner surface of the walls of the housing 1 .
The liquid contained in the cartridge will often be a kind of medication which advantageously can be continuously administrated to a patient. This medication could e.g. be insulin which can be continuously administered to patients with diabetes. In this case the cartridge 3 could be a glass ampoule containing an apportioned amount of insulin.

Claims

Claims
1 . Filling device comprising
- a housing (1 ) comprising
- first position means adapted to receive a reservoir (2) for receiving liquid,
- second position means adapted to receive a cartridge (3) containing a liquid,
- a unit (4) unreleasably attached to the housing (1 ) and providing a flow path when both the reservoir (2) and the cartridge are received respectively by the first and second positions means,
- a venting unit (5, 5a, 5b) providing access of gas to the cartridge (3) during emptying of the cartridge (3), and at least a part of the venting unit (5) is placed off the rotational centre (rc) of the housing and is attached to a part (7) characterized in that this part (7) can rotate relative to the housing (1 ) and relative to the unit (4) providing a flow path.
2. Filling device according to claim 1 , wherein the unit (4) providing the flow path between the reservoir (2) and the cartridge, when the cartridge is placed according to the second position means, comprises a needle having two pointy ends.
3. Filling device according to claim 1 or 2, wherein the unit (4) providing the flow path is placed along the rotational centre of the housing (1 ).
4. Filling device according to claim 3, wherein the unit (4) is fastened unreleasably to or is a part of a wall (7) in the housing (1 ) which wall (7) separates the first position means adapted to receive the reservoir (2) from the second position means adapted to receive the cartridge (3).
5. Filling device according to any preceding claim, wherein the part (7) which can rotate relative to the housing (1 ) is formed as a circular plate which periphery is in proximity of or in slidable contact with walls of the housing (1 ).
6. Filling device according to claim 5, wherein the circular plate moves in a track formed in the walls of the housing (1 ).
7. Filling device according to claim 5, wherein the periphery of the circular plate (7) is provided with a track formed along the periphery which track corresponds to one or more protruding part(s) of the housing (1 ).
8. Filling device according to any of the claims 5-7, wherein the circular plate (7) is provided with a friction layer (9) which friction layer (9) prevents the cartridge (3) from moving relative to the circular plate (7).
9. Filling device according to any preceding claim, wherein the venting unit (5) comprises a venting needle (5a) providing access from outside the cartridge (3) to the inner room of the cartridge (3) during use.
10. Filling device according claim 9, wherein the venting unit (5) comprises a venting valve (5b) providing a one-way passage of clean gas into a room wherefrom the venting needle (5a) is provided with clean gas.
1 1 . Filling device according to claim 10, wherein the venting needle (5a) is attached to the rotary part (7) providing a flow path for clean gas from one side of the rotary part to the other and the venting valve (5b) is attached to the open end of the venting needle (5a) pointing away from the cartridge (3).
12. Filling device according to claim 10, wherein venting needle (5a) is attached to the rotary part (7) providing a flow path for clean gas from one side of the rotary part to the other and the venting valve (5b) is attached to a wall of the housing (1 ) proving access of clean gas from outside wall of the housing to the inside of the wall of the housing (1 ).
13. Kit combining a filling device according to any of the claims 1 -1 1 and a cartridge (3) containing liquid which filling device can be either for single use and thereby permanently joined to the cartridge (3) or for multiple use and thereby can be connected and disconnected to the cartridge (3).
PCT/EP2009/056533 2008-05-30 2009-05-28 Reservoir filling device WO2009144272A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN2009801244405A CN102202636A (en) 2008-05-30 2009-05-28 Reservoir filling device
EP20090753927 EP2303220A1 (en) 2008-05-30 2009-05-28 Reservoir filling device
MX2010013084A MX2010013084A (en) 2008-05-30 2009-05-28 Reservoir filling device.
US12/994,234 US20110168294A1 (en) 2008-05-30 2009-05-28 Reservoir filling device

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US5758008P 2008-05-30 2008-05-30
US61/057,580 2008-05-30
DKPA200800737 2008-05-30
DKPA200800737 2008-05-30

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WO2009144272A1 true WO2009144272A1 (en) 2009-12-03

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PCT/EP2009/056533 WO2009144272A1 (en) 2008-05-30 2009-05-28 Reservoir filling device

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US (1) US20110168294A1 (en)
EP (1) EP2303220A1 (en)
CN (1) CN102202636A (en)
MX (1) MX2010013084A (en)
WO (1) WO2009144272A1 (en)

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CN102202636A (en) 2011-09-28
EP2303220A1 (en) 2011-04-06
US20110168294A1 (en) 2011-07-14
MX2010013084A (en) 2010-12-20

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