WO2010008478A3 - Improved techniques for magnetic particle imaging - Google Patents

Improved techniques for magnetic particle imaging Download PDF

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Publication number
WO2010008478A3
WO2010008478A3 PCT/US2009/003764 US2009003764W WO2010008478A3 WO 2010008478 A3 WO2010008478 A3 WO 2010008478A3 US 2009003764 W US2009003764 W US 2009003764W WO 2010008478 A3 WO2010008478 A3 WO 2010008478A3
Authority
WO
WIPO (PCT)
Prior art keywords
field
magnetic
free region
produce
region
Prior art date
Application number
PCT/US2009/003764
Other languages
French (fr)
Other versions
WO2010008478A2 (en
Inventor
Steven M. Conolly
Patrick W. Goodwill
Original Assignee
The Regents Of The University Of California, Berkeley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of California, Berkeley filed Critical The Regents Of The University Of California, Berkeley
Priority to EP23177832.5A priority Critical patent/EP4270143A3/en
Priority to EP09798250.8A priority patent/EP2317916B1/en
Priority to US12/737,214 priority patent/US8847592B2/en
Publication of WO2010008478A2 publication Critical patent/WO2010008478A2/en
Publication of WO2010008478A3 publication Critical patent/WO2010008478A3/en
Priority to US13/050,779 priority patent/US8884617B2/en
Priority to US14/328,560 priority patent/US10048224B2/en
Priority to US14/328,549 priority patent/US9274084B2/en
Priority to US14/971,768 priority patent/US9763594B2/en
Priority to US15/674,234 priority patent/US10667716B2/en
Priority to US16/040,801 priority patent/US11054392B2/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/0515—Magnetic particle imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/02—Measuring direction or magnitude of magnetic fields or magnetic flux
    • G01R33/0213—Measuring direction or magnitude of magnetic fields or magnetic flux using deviation of charged particles by the magnetic field
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/02—Measuring direction or magnitude of magnetic fields or magnetic flux
    • G01R33/10—Plotting field distribution ; Measuring field distribution
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/12—Measuring magnetic properties of articles or specimens of solids or fluids
    • G01R33/1269—Measuring magnetic properties of articles or specimens of solids or fluids of molecules labeled with magnetic beads
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/12—Measuring magnetic properties of articles or specimens of solids or fluids
    • G01R33/1276—Measuring magnetic properties of articles or specimens of solids or fluids of magnetic particles, e.g. imaging of magnetic nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7253—Details of waveform analysis characterised by using transforms
    • A61B5/7257—Details of waveform analysis characterised by using transforms using Fourier transforms

Abstract

A magnetic particle imaging apparatus includes magnets [106,107] that produce a gradient magnetic field having a field free region (FFR), excitation field electromagnets [102,114] that produce a radiofrequency magnetic field within the field free region, high-Q receiving coils [112] that detect a response of magnetic particles in the field free region to the excitation field. Field translation electromagnets create a homogeneous magnetic field displacing the field-free region through the field of view (FOV) allowing the imaging region to be scanned to optimize scan time, scanning power, amplifier heating, SAR, dB/dt, and/or slew rate. Efficient multi-resolution scanning techniques are also provided. Intermodulated low and radio-frequency excitation signals are processed to produce an image of a distribution of the magnetic nanoparticles within the imaging region. A single composite image is computed using deconvolution of multiple signals at different harmonics.
PCT/US2009/003764 2008-06-23 2009-06-23 Improved techniques for magnetic particle imaging WO2010008478A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
EP23177832.5A EP4270143A3 (en) 2008-06-23 2009-06-23 Improved techniques for magnetic particle imaging
EP09798250.8A EP2317916B1 (en) 2008-06-23 2009-06-23 Improved techniques for magnetic particle imaging
US12/737,214 US8847592B2 (en) 2008-06-23 2009-06-23 Techniques for magnetic particle imaging
US13/050,779 US8884617B2 (en) 2008-06-23 2011-03-17 Magnetic particle imaging devices and methods
US14/328,560 US10048224B2 (en) 2008-06-23 2014-07-10 Techniques for magnetic particle imaging
US14/328,549 US9274084B2 (en) 2008-06-23 2014-07-10 Magnetic particle imaging devices and methods
US14/971,768 US9763594B2 (en) 2008-06-23 2015-12-16 Magnetic particle imaging devices and methods
US15/674,234 US10667716B2 (en) 2008-06-23 2017-08-10 Magnetic particle imaging devices and methods
US16/040,801 US11054392B2 (en) 2008-06-23 2018-07-20 Techniques for magnetic particle imaging

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7493108P 2008-06-23 2008-06-23
US61/074,931 2008-06-23

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US12/737,214 A-371-Of-International US8847592B2 (en) 2008-06-23 2009-06-23 Techniques for magnetic particle imaging
US13/050,779 Continuation-In-Part US8884617B2 (en) 2008-06-23 2011-03-17 Magnetic particle imaging devices and methods
US14/328,560 Division US10048224B2 (en) 2008-06-23 2014-07-10 Techniques for magnetic particle imaging

Publications (2)

Publication Number Publication Date
WO2010008478A2 WO2010008478A2 (en) 2010-01-21
WO2010008478A3 true WO2010008478A3 (en) 2010-03-11

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Family Applications (1)

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PCT/US2009/003764 WO2010008478A2 (en) 2008-06-23 2009-06-23 Improved techniques for magnetic particle imaging

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US (3) US8847592B2 (en)
EP (2) EP4270143A3 (en)
WO (1) WO2010008478A2 (en)

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Also Published As

Publication number Publication date
US20190212298A1 (en) 2019-07-11
EP2317916B1 (en) 2023-06-07
US20150008910A1 (en) 2015-01-08
WO2010008478A2 (en) 2010-01-21
EP2317916A4 (en) 2015-08-26
US10048224B2 (en) 2018-08-14
US20110089942A1 (en) 2011-04-21
EP4270143A3 (en) 2023-12-27
US11054392B2 (en) 2021-07-06
EP4270143A2 (en) 2023-11-01
US8847592B2 (en) 2014-09-30
EP2317916A2 (en) 2011-05-11

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