WO2010027993A3 - Systems for stimulation of the cholinergic anti-inflammatory pathway via a superior vena cava lead - Google Patents

Systems for stimulation of the cholinergic anti-inflammatory pathway via a superior vena cava lead Download PDF

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Publication number
WO2010027993A3
WO2010027993A3 PCT/US2009/055655 US2009055655W WO2010027993A3 WO 2010027993 A3 WO2010027993 A3 WO 2010027993A3 US 2009055655 W US2009055655 W US 2009055655W WO 2010027993 A3 WO2010027993 A3 WO 2010027993A3
Authority
WO
WIPO (PCT)
Prior art keywords
lead
systems
stimulation
vena cava
superior vena
Prior art date
Application number
PCT/US2009/055655
Other languages
French (fr)
Other versions
WO2010027993A2 (en
Inventor
James William Broderick
Michael Allen Faltys
Original Assignee
Setpoint Medical Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Setpoint Medical Corporation filed Critical Setpoint Medical Corporation
Publication of WO2010027993A2 publication Critical patent/WO2010027993A2/en
Publication of WO2010027993A3 publication Critical patent/WO2010027993A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36114—Cardiac control, e.g. by vagal stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A61N1/0558—Anchoring or fixation means therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/056—Transvascular endocardial electrode systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators
    • A61N1/37235—Aspects of the external programmer
    • A61N1/37241—Aspects of the external programmer providing test stimulations

Abstract

Described herein are devices, systems and methods for stimulation of the cholinergic anti-inflammatory pathway (CAP). In particular the devices and systems described herein are for intravascular stimulation of the CAP via the right vagus nerve by stimulating through the superior vena cava with minimal cardiac side effects. The systems described herein typically include one or more electrode leads configured to stimulate the cholinergic anti-inflammatory pathway (e.g., the vagus nerve) from a position within the patient's superior vena cava (SVC). The lead may include one or more electrodes and an anchor for securing the lead. The system may also include an implantable therapy administrator ("ITA") to which the lead may be connected. The ITA may be configured as a controller for controlling the stimulation applied. These devices and/or systems may also be referred to as "immune system pacemakers".
PCT/US2009/055655 2008-09-05 2009-09-02 Systems for stimulation of the cholinergic anti-inflammatory pathway via a superior vena cava lead WO2010027993A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19118808P 2008-09-05 2008-09-05
US61/191,188 2008-09-05
US10162508P 2008-09-30 2008-09-30
US61/101,625 2008-09-30

Publications (2)

Publication Number Publication Date
WO2010027993A2 WO2010027993A2 (en) 2010-03-11
WO2010027993A3 true WO2010027993A3 (en) 2010-06-10

Family

ID=41797815

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/055655 WO2010027993A2 (en) 2008-09-05 2009-09-02 Systems for stimulation of the cholinergic anti-inflammatory pathway via a superior vena cava lead

Country Status (1)

Country Link
WO (1) WO2010027993A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050075702A1 (en) * 2003-10-01 2005-04-07 Medtronic, Inc. Device and method for inhibiting release of pro-inflammatory mediator
US20060178703A1 (en) * 2004-12-27 2006-08-10 Huston Jared M Treating inflammatory disorders by electrical vagus nerve stimulation
US20080086182A1 (en) * 2005-02-22 2008-04-10 Biocontrol Medical Ltd. Treatment for disorders by parasympathetic stimulation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050075702A1 (en) * 2003-10-01 2005-04-07 Medtronic, Inc. Device and method for inhibiting release of pro-inflammatory mediator
US20060178703A1 (en) * 2004-12-27 2006-08-10 Huston Jared M Treating inflammatory disorders by electrical vagus nerve stimulation
US20080086182A1 (en) * 2005-02-22 2008-04-10 Biocontrol Medical Ltd. Treatment for disorders by parasympathetic stimulation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HATTON, KEVIN W. ET AL., VAGAL NERVE STIMULATION. OVERVIEW AND IMPLICATIONS FOR ANESTHESIOLOGISIS, vol. 103, no. 5, November 2006 (2006-11-01), pages 1241 - 1249 *

Also Published As

Publication number Publication date
WO2010027993A2 (en) 2010-03-11

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