WO2011053790A3 - Assay of closely linked genetic targets in fetal diagnosis - Google Patents
Assay of closely linked genetic targets in fetal diagnosis Download PDFInfo
- Publication number
- WO2011053790A3 WO2011053790A3 PCT/US2010/054728 US2010054728W WO2011053790A3 WO 2011053790 A3 WO2011053790 A3 WO 2011053790A3 US 2010054728 W US2010054728 W US 2010054728W WO 2011053790 A3 WO2011053790 A3 WO 2011053790A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- assay
- closely linked
- genetic targets
- linked genetic
- fetal diagnosis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
Abstract
Methods for detecting chromosomal aneuploidy of a specified chromosome or chromosome region are provided. Also provided are methods for genetic analysis of heterogeneously sized chromosomal DNA fragments. The methods are useful for non-invasive prenatal diagnosis and other genetic analyses.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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US25652209P | 2009-10-30 | 2009-10-30 | |
US25651409P | 2009-10-30 | 2009-10-30 | |
US61/256,522 | 2009-10-30 | ||
US61/256,514 | 2009-10-30 |
Publications (2)
Publication Number | Publication Date |
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WO2011053790A2 WO2011053790A2 (en) | 2011-05-05 |
WO2011053790A3 true WO2011053790A3 (en) | 2011-07-07 |
Family
ID=43923002
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2010/054728 WO2011053790A2 (en) | 2009-10-30 | 2010-10-29 | Assay of closely linked targets in fetal diagnosis and coincidence detection assay for genetic analysis |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2011053790A2 (en) |
Families Citing this family (30)
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US6221654B1 (en) | 1996-09-25 | 2001-04-24 | California Institute Of Technology | Method and apparatus for analysis and sorting of polynucleotides based on size |
US7459022B2 (en) | 2001-04-06 | 2008-12-02 | California Institute Of Technology | Microfluidic protein crystallography |
US8709153B2 (en) | 1999-06-28 | 2014-04-29 | California Institute Of Technology | Microfludic protein crystallography techniques |
US7351376B1 (en) | 2000-06-05 | 2008-04-01 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
EP1343973B2 (en) | 2000-11-16 | 2020-09-16 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
US7407799B2 (en) | 2004-01-16 | 2008-08-05 | California Institute Of Technology | Microfluidic chemostat |
CN102680440A (en) | 2004-06-07 | 2012-09-19 | 先锋生物科技股份有限公司 | Optical lens system and method for microfluidic devices |
US20080264863A1 (en) | 2004-12-03 | 2008-10-30 | California Institute Of Technology | Microfluidic Sieve Valves |
US8055034B2 (en) | 2006-09-13 | 2011-11-08 | Fluidigm Corporation | Methods and systems for image processing of microfluidic devices |
WO2008067552A2 (en) | 2006-11-30 | 2008-06-05 | Fluidigm Corporation | Method and apparatus for biological sample analysis |
WO2008089493A2 (en) | 2007-01-19 | 2008-07-24 | Fluidigm Corporation | High precision microfluidic devices and methods |
CN104043490A (en) | 2008-07-25 | 2014-09-17 | 弗卢丁公司 | Method and system for manufacturing integrated fluidic chips |
US8551787B2 (en) | 2009-07-23 | 2013-10-08 | Fluidigm Corporation | Microfluidic devices and methods for binary mixing |
SG169918A1 (en) | 2009-10-02 | 2011-04-29 | Fluidigm Corp | Microfluidic devices with removable cover and methods of fabrication and application |
EP2496713B1 (en) | 2009-11-06 | 2018-07-18 | The Chinese University of Hong Kong | Size-based genomic analysis |
WO2012054933A2 (en) | 2010-10-22 | 2012-04-26 | Fluidigm Corporation | Universal probe assay methods |
US9168531B2 (en) | 2011-03-24 | 2015-10-27 | Fluidigm Corporation | Method for thermal cycling of microfluidic samples |
US9644231B2 (en) | 2011-05-09 | 2017-05-09 | Fluidigm Corporation | Nucleic acid detection using probes |
WO2012154876A1 (en) | 2011-05-09 | 2012-11-15 | Fluidigm Corporation | Probe based nucleic acid detection |
US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
US11261494B2 (en) | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
WO2016015058A2 (en) | 2014-07-25 | 2016-01-28 | University Of Washington | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same |
US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
PT3256605T (en) | 2015-02-10 | 2022-03-17 | Univ Hong Kong Chinese | Detecting mutations for cancer screening and fetal analysis |
CN105039571B (en) * | 2015-08-28 | 2018-12-07 | 博奥生物集团有限公司 | The quality-control product of chromosome aneuploid (T21, T18, T13) detection kit and its application |
CN110100013A (en) | 2016-10-24 | 2019-08-06 | 香港中文大学 | Method and system for lesion detection |
EP3574108A4 (en) | 2017-01-25 | 2020-12-23 | The Chinese University Of Hong Kong | Diagnostic applications using nucleic acid fragments |
CN106967796A (en) * | 2017-03-16 | 2017-07-21 | 中国科学院南海海洋研究所 | A kind of method that rapid batchization determines aquatic animal genome ploidy |
US20200263167A1 (en) * | 2017-09-26 | 2020-08-20 | Juno Diagnostics, Inc. | Devices, systems and methods for biomarker analysis |
US20200299677A1 (en) | 2017-10-27 | 2020-09-24 | Juno Diagnostics, Inc. | Devices, systems and methods for ultra-low volume liquid biopsy |
Citations (6)
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WO2007044091A2 (en) * | 2005-06-02 | 2007-04-19 | Fluidigm Corporation | Analysis using microfluidic partitioning devices |
US20070178478A1 (en) * | 2002-05-08 | 2007-08-02 | Dhallan Ravinder S | Methods for detection of genetic disorders |
US20090069194A1 (en) * | 2007-09-07 | 2009-03-12 | Fluidigm Corporation | Copy number variation determination, methods and systems |
US20090087847A1 (en) * | 2007-07-23 | 2009-04-02 | The Chinese University Of Hong Kong | Determining a nucleic acid sequence imbalance |
US20090170114A1 (en) * | 2006-02-02 | 2009-07-02 | The Board Of Trustees Of The Leland Stanford Junior University | Non-Invasive Fetal Genetic Screening by Digital Analysis |
US20100203538A1 (en) * | 2009-01-28 | 2010-08-12 | Fluidigm Corporation | Determination of copy number differences by amplification |
-
2010
- 2010-10-29 WO PCT/US2010/054728 patent/WO2011053790A2/en active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070178478A1 (en) * | 2002-05-08 | 2007-08-02 | Dhallan Ravinder S | Methods for detection of genetic disorders |
WO2007044091A2 (en) * | 2005-06-02 | 2007-04-19 | Fluidigm Corporation | Analysis using microfluidic partitioning devices |
US20090170114A1 (en) * | 2006-02-02 | 2009-07-02 | The Board Of Trustees Of The Leland Stanford Junior University | Non-Invasive Fetal Genetic Screening by Digital Analysis |
US20090087847A1 (en) * | 2007-07-23 | 2009-04-02 | The Chinese University Of Hong Kong | Determining a nucleic acid sequence imbalance |
US20090069194A1 (en) * | 2007-09-07 | 2009-03-12 | Fluidigm Corporation | Copy number variation determination, methods and systems |
US20100203538A1 (en) * | 2009-01-28 | 2010-08-12 | Fluidigm Corporation | Determination of copy number differences by amplification |
Non-Patent Citations (1)
Title |
---|
RAJAGOPALAN ET AL.: "Aneuploidy and cancer", NATURE, vol. 432, no. 7015, 18 November 2004 (2004-11-18), pages 338 - 341 * |
Also Published As
Publication number | Publication date |
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WO2011053790A2 (en) | 2011-05-05 |
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