WO2012166705A3 - Supramolecular nanofibers and hydrogels based on amino acid-nucleobase-glycoside conjugates - Google Patents

Supramolecular nanofibers and hydrogels based on amino acid-nucleobase-glycoside conjugates Download PDF

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Publication number
WO2012166705A3
WO2012166705A3 PCT/US2012/039821 US2012039821W WO2012166705A3 WO 2012166705 A3 WO2012166705 A3 WO 2012166705A3 US 2012039821 W US2012039821 W US 2012039821W WO 2012166705 A3 WO2012166705 A3 WO 2012166705A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleobase
amino acid
supramolecular
hydrogels based
glycoside conjugates
Prior art date
Application number
PCT/US2012/039821
Other languages
French (fr)
Other versions
WO2012166705A2 (en
Inventor
Bing Xu
Original Assignee
Brandeis University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brandeis University filed Critical Brandeis University
Publication of WO2012166705A2 publication Critical patent/WO2012166705A2/en
Publication of WO2012166705A3 publication Critical patent/WO2012166705A3/en
Priority to US14/093,974 priority Critical patent/US10093674B2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L31/129—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

Described herein are hydrogelators that include a nucleobase, an amino acid, and a glycoside. The hydrogelators have increased resistance to proteases and can self-assemble into supramolecular nanofibers or hydrogels. The supramolecular structures may be used to help grow cells or deliver a substance to a cell.
PCT/US2012/039821 2011-05-31 2012-05-29 Supramolecular nanofibers and hydrogels based on amino acid-nucleobase-glycoside conjugates WO2012166705A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US14/093,974 US10093674B2 (en) 2011-05-31 2013-12-02 Supramolecular nanofibers and hydrogels based on nucleic acids functionalized with nucleobases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161491544P 2011-05-31 2011-05-31
US61/491,544 2011-05-31

Related Child Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/039822 Continuation-In-Part WO2012166706A2 (en) 2011-05-31 2012-05-29 Supramolecular nanofibers and hydrogels based on oligopeptides functionalized with nucleobases

Publications (2)

Publication Number Publication Date
WO2012166705A2 WO2012166705A2 (en) 2012-12-06
WO2012166705A3 true WO2012166705A3 (en) 2013-02-28

Family

ID=47260243

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/039821 WO2012166705A2 (en) 2011-05-31 2012-05-29 Supramolecular nanofibers and hydrogels based on amino acid-nucleobase-glycoside conjugates

Country Status (1)

Country Link
WO (1) WO2012166705A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014138367A1 (en) * 2013-03-06 2014-09-12 Brandeis University Inhibition of tumor growth with aggregates of small molecules
US10232037B2 (en) 2014-02-03 2019-03-19 Brandeis University Supramolecular hydrogel of fMLF-based molecules and use thereof
WO2015157530A2 (en) 2014-04-09 2015-10-15 Brandeis University Enzymatically responsive magnetic particles and their use
US11160875B2 (en) 2015-06-16 2021-11-02 The Johns Hopkins University Therapeutic nanofiber hydrogels for local treatment of brain-related diseases
WO2019035928A1 (en) 2017-08-15 2019-02-21 Brandeis University Rapid formation of supramolecular hydrogels by short peptide and bioactive small molecules
US11191724B2 (en) 2017-09-18 2021-12-07 Brandeis University Branched peptides for enzymatic assembly and mitochondria drug delivery
US11834517B2 (en) 2017-09-18 2023-12-05 Brandeis University Branched peptides for enzymatic assembly and mitochondria drug delivery

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5278284A (en) * 1992-05-14 1994-01-11 Miller Brewing Company Protein purification method
US20020081726A1 (en) * 2000-09-25 2002-06-27 Brenda Russell Microfabrication of membranes for the growth of cells
US20080057005A1 (en) * 2005-03-24 2008-03-06 Jean-Marie Lehn Hydrogels for the controlled release of bioactive materials

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5278284A (en) * 1992-05-14 1994-01-11 Miller Brewing Company Protein purification method
US20020081726A1 (en) * 2000-09-25 2002-06-27 Brenda Russell Microfabrication of membranes for the growth of cells
US20080057005A1 (en) * 2005-03-24 2008-03-06 Jean-Marie Lehn Hydrogels for the controlled release of bioactive materials

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LI, X. ET AL.: "Multifunctional, Biocompatible Supramolecular Hydrogelators Consist Only for Nucleobase, Amino Acid, and Glycoside", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 133, 19 September 2011 (2011-09-19), pages 17513 - 17518 *
YANG, Z. ET AL.: "Supramolecular hydrogels based on biofunctional nanofibers of self-assembled small molecules", JOURNAL OF MATERIALS CHEMISTRY, vol. 17, 2007, pages 2385 - 2393 *

Also Published As

Publication number Publication date
WO2012166705A2 (en) 2012-12-06

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