WO2014160844A3 - Magnetic nanoparticles useful for magnetic sensor detection - Google Patents

Magnetic nanoparticles useful for magnetic sensor detection Download PDF

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Publication number
WO2014160844A3
WO2014160844A3 PCT/US2014/031985 US2014031985W WO2014160844A3 WO 2014160844 A3 WO2014160844 A3 WO 2014160844A3 US 2014031985 W US2014031985 W US 2014031985W WO 2014160844 A3 WO2014160844 A3 WO 2014160844A3
Authority
WO
WIPO (PCT)
Prior art keywords
mnps
magnetic
nanometers
variety
less
Prior art date
Application number
PCT/US2014/031985
Other languages
French (fr)
Other versions
WO2014160844A2 (en
Inventor
Makoto Murakami
Bing Liu
Original Assignee
Imra America, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imra America, Inc. filed Critical Imra America, Inc.
Priority to DE112014001699.3T priority Critical patent/DE112014001699T5/en
Priority to JP2016505563A priority patent/JP2016522983A/en
Publication of WO2014160844A2 publication Critical patent/WO2014160844A2/en
Publication of WO2014160844A3 publication Critical patent/WO2014160844A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1833—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule
    • A61K49/1839—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule the small organic molecule being a lipid, a fatty acid having 8 or more carbon atoms in the main chain, or a phospholipid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
    • B22F1/05—Metallic powder characterised by the size or surface area of the particles
    • B22F1/052—Metallic powder characterised by the size or surface area of the particles characterised by a mixture of particles of different sizes or by the particle size distribution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
    • B22F1/05—Metallic powder characterised by the size or surface area of the particles
    • B22F1/054—Nanosized particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/12—Measuring magnetic properties of articles or specimens of solids or fluids
    • G01R33/1269—Measuring magnetic properties of articles or specimens of solids or fluids of molecules labeled with magnetic beads
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/12—Measuring magnetic properties of articles or specimens of solids or fluids
    • G01R33/1276—Measuring magnetic properties of articles or specimens of solids or fluids of magnetic particles, e.g. imaging of magnetic nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F2304/00—Physical aspects of the powder
    • B22F2304/05—Submicron size particles
    • B22F2304/054—Particle size between 1 and 100 nm
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C2202/00—Physical properties
    • C22C2202/02—Magnetic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/932—Specified use of nanostructure for electronic or optoelectronic application

Abstract

Disclosed is process for preparing magnetic nanoparticles (MNPs) that results in very sensitive MNPs that can be used in a variety of diagnostic and analytical methods. The MNPs exhibit superparamagnetism and find special use in giant magnetoresistance sensors (GMRS). The MNPs are created by a process that permits one to tune the size of nanoparticles to a range of from 10 to 20 nanometers with a very small particle size distribution of +/- 2 nanometers or less. The MNPs can be tagged with a variety of markers and thus find use in many analytical assays, cell sorting techniques, imaging methods, drug delivery methods and cancer treatments. The inventive MNPs can be detected in magnetic file strengths of 2000 Oe or less.
PCT/US2014/031985 2013-03-27 2014-03-27 Magnetic nanoparticles useful for magnetic sensor detection especially in biosensor applications WO2014160844A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE112014001699.3T DE112014001699T5 (en) 2013-03-27 2014-03-27 Magnetic nanoparticles useful in magnetic sensor detection, especially in biosensor applications
JP2016505563A JP2016522983A (en) 2013-03-27 2014-03-27 Magnetic nanoparticles useful for magnetic sensor detection, especially in biosensor applications

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361805539P 2013-03-27 2013-03-27
US61/805,539 2013-03-27
US201461933989P 2014-01-31 2014-01-31
US61/933,989 2014-01-31

Publications (2)

Publication Number Publication Date
WO2014160844A2 WO2014160844A2 (en) 2014-10-02
WO2014160844A3 true WO2014160844A3 (en) 2014-12-04

Family

ID=51625674

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/031985 WO2014160844A2 (en) 2013-03-27 2014-03-27 Magnetic nanoparticles useful for magnetic sensor detection especially in biosensor applications

Country Status (4)

Country Link
US (1) US20160158155A1 (en)
JP (1) JP2016522983A (en)
DE (1) DE112014001699T5 (en)
WO (1) WO2014160844A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8593141B1 (en) 2009-11-24 2013-11-26 Hypres, Inc. Magnetic resonance system and method employing a digital squid
US8970217B1 (en) 2010-04-14 2015-03-03 Hypres, Inc. System and method for noise reduction in magnetic resonance imaging
CN115368916A (en) * 2016-04-05 2022-11-22 斯特拉斯堡大学 Droplet interior surface engineering for capture of molecular targets
TWI624661B (en) * 2016-09-05 2018-05-21 財團法人工業技術研究院 Biomolecule magnetic sensor
EP3290938A1 (en) 2016-09-05 2018-03-07 Industrial Technology Research Institute Biomolecule magnetic sensor
US11885800B2 (en) 2019-10-18 2024-01-30 Imra America, Inc. Method and system for detecting analyte of interest using magnetic field sensor and magnetic particles

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7560289B2 (en) * 2005-11-16 2009-07-14 Chin-Yih Rex Hong Methods of quantitatively measuring biomolecules
US7639359B2 (en) * 2006-10-23 2009-12-29 UChicagoArgonne, LLC Magneto-optic biosensor using bio-functionalized magnetized nanoparticles
US20110071335A1 (en) * 2009-09-22 2011-03-24 Empire Technology Development Llc Applications of alternating magnetic fields on magnetic nanoparticles
WO2011053435A1 (en) * 2009-10-05 2011-05-05 Scientific Nanomedicine, Inc. Cell detection using targeted nanoparticles and magnetic properties thereof
US20120027865A1 (en) * 2009-05-21 2012-02-02 Institute Of Life Sciences Water Dispersible Glyceryl Monooleate Magnetic Nanoparticle Formulation
US20120094852A1 (en) * 2010-10-15 2012-04-19 International Business Machines Corporation Magnetic nanoparticle detection across a membrane
WO2012054638A2 (en) * 2010-10-22 2012-04-26 T2 Biosystems, Inc. Nmr systems and methods for the detection of analytes
US20130040292A1 (en) * 2005-09-16 2013-02-14 Instituto Nacional De Tecnica Aeroespacial Nanoparticle biosensor, method of preparing same and uses thereof

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130040292A1 (en) * 2005-09-16 2013-02-14 Instituto Nacional De Tecnica Aeroespacial Nanoparticle biosensor, method of preparing same and uses thereof
US7560289B2 (en) * 2005-11-16 2009-07-14 Chin-Yih Rex Hong Methods of quantitatively measuring biomolecules
US7639359B2 (en) * 2006-10-23 2009-12-29 UChicagoArgonne, LLC Magneto-optic biosensor using bio-functionalized magnetized nanoparticles
US20120027865A1 (en) * 2009-05-21 2012-02-02 Institute Of Life Sciences Water Dispersible Glyceryl Monooleate Magnetic Nanoparticle Formulation
US20110071335A1 (en) * 2009-09-22 2011-03-24 Empire Technology Development Llc Applications of alternating magnetic fields on magnetic nanoparticles
WO2011053435A1 (en) * 2009-10-05 2011-05-05 Scientific Nanomedicine, Inc. Cell detection using targeted nanoparticles and magnetic properties thereof
US20120094852A1 (en) * 2010-10-15 2012-04-19 International Business Machines Corporation Magnetic nanoparticle detection across a membrane
WO2012054638A2 (en) * 2010-10-22 2012-04-26 T2 Biosystems, Inc. Nmr systems and methods for the detection of analytes

Also Published As

Publication number Publication date
WO2014160844A2 (en) 2014-10-02
DE112014001699T5 (en) 2015-12-10
US20160158155A1 (en) 2016-06-09
JP2016522983A (en) 2016-08-04

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