WO2016076742A1

WO2016076742A1 - Remote electrophysiological monitoring system for intensive care units

Info

Publication number: WO2016076742A1
Application number: PCT/RS2015/000024
Authority: WO
Inventors: Bogdan MIJOVIC; Ivan GLIGORIJEVIC; Dejan Popovic; Maarten DE VOS
Original assignee: MBRAINTRAIN LLC Belgrade
Priority date: 2014-11-14
Filing date: 2015-11-12
Publication date: 2016-05-19
Also published as: RS20140628A1

Abstract

The long-distance real-time electrophysiological monitoring system is proposed that comprises the mobile acquisition device that acquires electrophysiological signals and transmits them via digital communication network to the central server and central database, that further communicate to the displaying devices in distant centers, wherein the displays devices in distant centers have the functionalities of processing, displaying in real-time and storing the acquired electrophysiological data, and the central server, mobile acquisition device and distant displaying device are connected via digital wireless communication network.

Description

Remote electrophysiological monitoring system for intensive care units

Description of the Invention

FIELD OF THE INVENTION

This invention relates to the system for acquiring electrophysiological and, in particular, electroencephalographic (EEG) signals, with a mobile device that directly transmits acquired signals to the central server via Internet, or another network for digital long-distance transmission for further processing, storing, analysis and/or displaying.

According to the international patent classification system (IPC) this patent belongs to G06Q 50/00 and G06Q 90/00.

BRIEF SUMMARY OF THE INVENTION

The proposed invention allows measuring electrophysiological and, in particular, electroencephalographic (EEG) signals and an immediate transmission of the recorded data to the central server without the use of additional devices for acquisition and transmission. The signals can be stored in the central database, or forwarded to other devices for processing, storing, analysis or displaying. Signals can also be thereafter read from the central database and stored, processed, analyzed or displayed using other devices.

BACKGROUND OF THE INVENTION

Although electroencephalographic (EEG) devices are used since the first half of the 20^th century, a wider use of EEG recordings starts only around 1990. This is mostly thanks to the development of the digital recording devices that allowed the use of computer algorithms for storing, reading, analysis and processing of the recorded EEG signals.

Advances in electronics allowed EEG recording devices to become smaller, until they became so miniature to allow their use as fully mobile and wearable systems. Such devices are the Epoc system from Emotiv, USA, Smarting from mBrainTrain, Serbia, Nautilus and Sahara from G.Tec, Austria and others. These devices typically contain wireless transmitters that transmit recorded signals to other devices, such as personal computers and laptops, or mobile phones and smartphones that usually perform further processing.

Such systems allow that subjects whose EEG signals are being acquired (in case of scientific experiments) or patients (in case of clinical recordings) are provided with the freedom of movement. This, aside from enhanced comfort, also allowed significantly wider scope of possible applications of such EEG devices, mostly with introducing new paradigms of recording outside the laboratory or ambulatory environment.

Aside from the above use cases, the need arose for mobile (wearable) EEG devices that can directly communicate with central server systems. Existing patents assume the possibility to communicate to central server via a nerby computer or mobile phone. However, the advantage of direct connection with a central server via an integrated module for direct connection with central server, and central database are obvious. Several patents and scientific papers include recording EEG signals via mobile phone or computer.

US 20070255127 Al proposes a system for acquiring and storing of recorded electroencephalographic signals in the central database. However, the recorded signals are from the mobile acquisition device, first sent to a nearby device that can be a PC or a mobile phone, and thereafter, they are forwarded to a central server or a central database.

US 20130127708 Al proposes a system for acquiring electroencephalographic data with a feedback. The recording device, also wirelessly via Bluetooth connection, communicates with the nearby devices (PCs and mobile phones) and allows internal processing. However, this system does not foresee a communication with a distant central server.

US 6654633 B2 describes a system for transmitting recorded electrophysiological (neurophysiological) signal to a distance. However, this patent assumes that the analog signal is recorded without digitalization, which easily leads to a data quality loss of the recorded signal. Moreover, the robustness of the communication network is debatable.

US 6052619 A is one of the first descriptions of wireless EEG amplifiers that basically describes a device for acquiring, processing, and transmitting the recorded EEG signal to a distance, using an antenna, including numerous analysis modules. However, the use of a screen, keyboard and a printer on this device, as foreseen by the patent, would make the system large and therefore, it would not fall under wearable devices. The mentioned invention assumes that the recording device contains only an acquisition part, the analog-to-digital (A/D) conversion, program applications for signal processing and wireless transmission modules, so that the size of the system would remain small and wearable. Also, this patent assumes sending only digital information that are extracted from already processed signal, and do not support transmission of the raw data, as proposed by our solution. The benefit of sending raw signal comes from the fact that the controllers that control the device for storing, processing and displaying signals could independently choose signal processing and displaying techniques for such a signal. Moreover, this patent does not assume any central server or central database for storing the signal. Such an approach would allow additional processing using different signal processing algorithms in future when such new algorithms are proposed.

US 8111151 B2 describes a system for wireless transmission and early warning and communication with central server. As in the previous examples, the electrophysiological mobile acquisition device in this case also allows only the short-distance wireless transmission with mobile phone or other external devices, which then subsequently have an Internet access.

Each of the mentioned inventions either proposes the data transmission to a nearby device, or analog data transmission to a distance, that accordingly requires additional equipment. The invention proposed by this patent, assumes small, easy to use, system of great efficiency and allows the neurophysiological data transmission to a distance. The proposed transmission and data storing method allows the development of future data analysis systems, since the original physiological features of the signal do not change. DETAILED DESCRIPTION OF THE INVENTION

This invention proposes a remote electrophysiological monitoring system for intensive care units for signal acquisition, transmission and storing. The system in particular refers to electromyogram (EMG), electrocardiogram (ECG) and electroencephalogram (EEG).

Analog electrophysiological signals are acquired with a number of electrodes that adhere to a skin of a subject or a patient. The signals are led to a low-pass filter with conductive, electrically shielded wires. The amplifying and the multiplexing of the signals are subsequently done. Multiplexed signals are thereafter fed to analog-to-digital (A D) converter, and the digital signals are obtained. Using this high-precision A/D converters and making the electrode to mobile acquisition device distance smaller (the mobile acquisition device is very close to a head, or even in contact with the head) allows recording EEG signals, that are of very low amplitudes and until recently it was impossible to record those without the use of preamplifiers and amplifiers.

Such digital signal is further led to an integrated wireless digital signal transmission module (such as GPRS) and the signal is sent over an existing infrastructure (e.g. Internet network) to the central server, that is physically present within the central unit, or is distributed on an Internet network - so called "cloud" system.

Aside, the central system allows connection with the devices or computer programs for storing, processing or displaying the recorded systems that are placed in distant centers, and which can further access the signals stored in the central database and directly display those signals on the screens in the distant centers, or store them on local hard drive, or any other medium for digital data storing.

Therefore, in one aspect of the present invention, a mobile device for data acquisition, transmission, storing, processing and displaying electrophysiological signals is provided and their wireless transmission to a distance using the digital transmission methods through existing infrastructure, such as GPRS network, to the central server for further processing and storing in the central database.

In another aspect, a mobile device for acquiring electrophysiological signals and their short- distance wireless transmission is provided and, in particular, using Bluetooth and WiFi modules to the nearby device for further processing and displaying the signals.

In yet another aspect, a method for transmitting recorded electrophysiological signals to the central server from the device for acquisition and transmission of the digitalized electrophysiological signals is provided. The method further allows storing the said electrophysiological signals in the central database.

In the fourth aspect, a method is provided for displaying, processing and storing of the acquired electrophysiological signals from the central database to the distant centers. The signals are read from the central database by the central server, and transmitted to the devices for displaying, processing and storing the electrophysiological signals in the distant centers.

In the fifth aspect of the present invention, a method for displaying, processing and storing electrophysiological signals in the distant centers in real-time using devices for acquisition and processing of the electrophysiological signals and central server is provided. In the sixth aspect of the present invention, a method for displaying, processing and storing the electrophysiological signals by the devices that are found nearby the device for acquisition and transmission of the electrophysiological signals is provided.

The need for a system proposed by this invention arises mostly (although there may be other applications) in distant intensive care units, where the patients arrive after suffering serious injuries, which often include head injuries. These units often have no trained neurologist who could readily bring adequate conclusions, set a diagnosis and propose treatment of the said patient after doing a neurological examination. This examination often includes an EEG examination. However, an EEG mobile acquisition device that would be in direct connection with a central server, that would allow examination of the recorded signals to the trained neurology specialists in a central unit, or in other units that would have a remote access to the central server, would significantly enhance the quality of the examination, diagnosis and, in urgent cases, an adequate further steps within the medical treatment.

In another aspect, the proposed system is applied for continuous real-time home EEG signal monitoring with or without an automatic analysis system. In this case, the permanent residence of the monitored patient (his private house) represents the distant unit. If an automatic annotating system is implemented, e.g. for the purpose of automatic disorder diagnosis such as epileptic activity, this system would bring multiple benefits: longer monitoring without the increased expenses, since no additional medical personnel is to be engaged, better overview of the patient state, due to a natural environment (his home), on-demand medical personnel engagement (e.g. after an epileptic activity has started), and other.

Other and further features, advantages and benefits of the invention will become apparent in the following description taken in conjunction with the following drawings. It is to be understood that the foregoing general description and following detailed description are exemplary and explanatory but are not to be restrictive of the invention. The accompanying drawings are incorporated in and constitute a part of this application and, together with the description, serve to explain the principles of the invention in general terms. Like numerals refer to like parts throughout the disclosure.

BRIEF DESCRIPTION OF DRAWINGS

FIG 1. is a schematic representation showing the current state-of-the-art, which is a standard system that is nowadays used for electrophysiological signal acquisition.

FIG 2. is a schematic representation showing the system that comprises a mobile acquisition device and communicates with central server, central database and the devices for recording and displaying the signals (personal computers and mobile phones).

FIG 3. is a flowchart of the controlling method for controlling the mobile device for acquisition and transmission of electrophysiological signals by the controlling device.

FIG 4. is a flowchart of the transmitting method for transmitting electrophysiological signals to the central server by a mobile device for acquisition and transmission of digitalized electrophysiological signals and storing of the said signals in the central database by the central server. FIG 5. is a flowchart of the displaying, processing and storing method for displaying, processing and storing acquired digitalized electrophysiological signals in the distant centers, that are read from the central database, by the central server. The method includes central server, central database and the device for displaying, processing and storing of the acquired electrophysiological signals in distant centers.

FIG 6. is a flowchart of the displaying, processing and storing method for displaying, processing and storing electrophysiological signals in the distant centers in real-time. The method includes controlling device, a mobile device for acquisition and transmission of the electrophysiological signals and the central server.

FIG 7. is a flowchart of the displaying, processing and storing method for displaying, processing and storing electrophysiological signals nearby the mobile device for acquisition and transmission of the electrophysiological signals.

DESCRIPTION OF THE PREFERRED EMBODIMENT

FIG 2. shows a schematic representation of the remote electrophysiological monitoring system for intensive care units. The mobile system for acquisition, wireless transmission of the acquired digitalized data to a distance via the existing infrastructure (Internet), storing, processing and displaying the electrophysiological signals comprises electrodes that are in contact with the skin of the patients or a subject 21, the electrode cap that keeps the electrodes together 22 and comprises a connector for the acquisition and transmission device. The system further comprises the mobile acquisition device 23, central server 24 and central database 25, the local displaying devices 26 that are found nearby the mobile acquisition device, and distant displaying devices 27. The mobile acquisition device 23 is further controlled by the controlling device 28. The mobile acquisition device 23 comprises an electric circuit for signal acquisition 23 a, acting as an entry system for acquiring the signals from the electrodes, an electric circuit further comprising an amplification circuit, multiplexer and an analog-to-digital (AID) converter 23b, a circuit for basic signal processing 23 c, short-distance wireless communication module, such as WiFi or Bluetooth module 23d and a long-distance communication module, such as GPRS module 23e. The mobile acquisition device 23 can transmit digitalized acquired electrophysiological signals to the local displaying device 26, via the short-distance wireless communication module 23d. The mobile acquisition device 23 can further send the digitalized acquired electrophysiological signals together with the metadata to the central server 24 via Internet, using the long-distance wireless communication module 23e. The central server 24 can receive acquired data from the mobile acquisition device 23, and store them in the central database 25, or transmit them directly to the distant displaying devices 27. The central server 24 can read the data that is stored in the central database 25, and transmit them to the distant displaying devices 27. The local displaying devices 26, can receive the signals sent by the mobile acquisition device 23 using the short- distance communication module, such as Bluetooth or WiFi Direct 23d and can further store the acquired signals in the internal memory, or display them on the screen, after they first may have been processed using the signal processing applications. The local displaying devices 26 can further comprise a screen for displaying the signals, and memory for storing the signals, and the said devices can be controlled by a controller person. The local displaying devices 26 further comprise a short distance communication module and, in particular, a Bluetooth or WiFi Direct module. The distant displaying devices 27 can receive the data sent by the central server 24 using the long-distance communication module, and they store the signals in the internal memory, or display the on the display screen, after the signals have been previously processed by signal processing applications. The distant displaying devices 27 comprise a displaying screen, and storage memory and can be controlled by a controller person. The distant displaying devices 27 further comprise a long-distance communication ability (e.g. Internet connection). The controlling device 28 comprises a connection with the mobile acquisition device 23 and allows entering meta data into the mobile device for acquisition and transmission of the electrophysiological data 23, that are further sent to the central server 24. Meta data are entered into the controlling device using the program application.

FIG 3. is a complete operation diagram of the controlling method for controlling the mobile acquisition device 23 by the controlling device 28. The controlling device 28 is necessary to import commands to the mobile acquisition device 23, so that the acquired signals would correspondingly process on the central server 24, or store in the central database 25 or display, process or store on the distant displaying devices 27 or the local displaying devices 26. The controlling device 28 is controlled by a trained controller.

Step 311: The controlling device 28 connects to the mobile acquisition device 23 and via wired or wireless connection.

Step 312: The trained controller uses the program application on the controlling device to enter the identification of the patient or the subject. The identification can be an identification number, or an alphanumeric array or character array.

Step 313: The controller imports metadata that are important for the subject or the patient that is being recorded. The metadata can include, without limitation, name, surname, age, gender, recording time, location and other data that may be of interest for the recording.

Step 314: The controller selects if the acquired data will be transmitted to the central server 24, or to the local displaying devices 26, that can at the same time be the controlling device.

Further steps depend of the intended use of the system, and are described in the following figures.

FIG 4. is a complete operation diagram of the transmitting method for transmitting electrophysiological signals to the central server 24 by a mobile acquisition device 23 and storing of the said signals in the central database 25 by the central server 24. This diagram continues after the diagram from FIG 3, after the controller has made the choice to send the acquired data to the central server 24 on the step 314.

Step 411: The controlling device 28 sends the control to the mobile acquisition device 23 to turn on the long-distance communication module 23 d and to connect to the central server 24 via Internet.

Step 412: The controlling device 28 sends metadata via the mobile acquisition device 23 to the central server 24, thereby preparing the central server 24 to further receive the electrophysiological data sent by the mobile acquisition device 23.

Step 413: Central server 24 stores metadata in the central database 25 and prepares it for storing the expected electrophysiological signals that are to be received from the mobile acquisition device 23.

Step 414: Once the connection between the mobile acquisition device 23 and the central server 24 has been achieved, the controlling device 28 sends the command to the mobile acquisition device 23 to start acquiring electrophysiological signals and transmit them continuously to the central server 24.

Step 415: The central server 24 continuously stores the acquired signals in sent by the mobile acquisition device 23 in the Central database 25.

Step 416: when the trained controller of the controlling device 28 has entered the command for stopping the acquisition, the controlling device 28, sends the interrupt request to the mobile acquisition device 23 and the mobile acquisition device 23 interrupts the data acquisition. The mobile acquisition device23 also sends the interrupt message to the central server 24. The central server 24 stops writing the data in the central database 25.

FIG 5. is a complete operation diagram of the displaying, processing and storing method for displaying, processing and storing acquired digitalized electrophysiological signals in the distant centers, that are read from the central database 25, by the central server 24. The method includes central server 24, central database 25 and the distant displaying device27.

Step 511 : The trained controller of the distant displaying device 27 inputs the identification of the recorded patient or subject whose recorded data the controller wishes to access from the central database 25.

Step 512: The distant displaying device 27 sends the identifier to the central server 24 and the request to access the subject's or patient's data.

Step 513: The central server 24 reads the stored data from the central database 25 corresponding to the said identifier and sends the read data to the distant displaying device 27.

Step 514: The distant displaying device 27 stores the received data in the internal memory.

Step 515: The controller of the distant displaying device 27 can choose to display the said received signals.

Step 516: The distant displaying device 27 displays the received signals.

Step 517: the controller of the device for displaying, processing and storing of the acquired electrophysiological signals in distant centers 27 can choose to store the processed signals.

Steps 515 through 517 can repeat a number of times.

FIG 6. is a complete operation diagram of the displaying, processing and storing method for displaying, processing and storing electrophysiological signals in the distant centers in real-time. The method includes controlling device 28, a mobile acquisition device 23 and the central server 24. Step 611 continues after the trained controller has chosen to transmit the acquired electrophysiological signals to the central server 24 and then to the distant displaying devices 27 in step 314, FIG 3.

Step 611 : The controlling device 28 sends the request to the mobile acquisition device 23 to turn on the module for long-distance communication module (e.g. GPRS module) 23d.

Step 612: The mobile acquisition device 23 sends metadata to the central server 24 for the patient or subject that is being recorded.

Step 613: The central server 24 inputs the identifier of the mobile acquisition device 23 in the table of active devices.

Step 614: The distant displaying device 27 sends to the central server 24 the identifier of the mobile acquisition device 23 that it wants to access.

Step 615: The central server 24 checks if the identifier of the mobile acquisition device that is sent by the distant displaying device 27 is listed in the table of active devices. In case that the said identifier is not listed, the algorithm goes directly to step 620, skipping the steps 616- 619.

Step 616: The continuous acquisition of the electrophysiological signals starts, and their displaying on the distant displaying device 27.

Step 617: The said data is continuously stored, processed, and displayed a number of times on the distant displaying device 27.

Step 618: The mobile acquisition device 23 receives the stop recording signal that comes from the controlling device 28. Once the signal has arrived, the signal acquisition stops. Step 619: The central server 24 removes the identifier of the mobile acquisition device 23 from the table of active devices.

Step 620: The acquisition of the electrophysiological signals stops.

FIG 7. is a complete operation diagram of the displaying, processing and storing method for displaying, processing and storing electrophysiological signals nearby the mobile acquisition device 23. Step 711 continues after the trained controller has chosen to transmit the acquired electrophysiological signals to the local displaying devices 26 on step 314, FIG 3.

Step 711: After the controller has chosen to transmit the acquired electrophysiological signals to the local displaying device 26, the controlling device sends the command to the mobile acquisition device 23 to turn on the wireless short-distance communication module 23 e and to connect to the local displaying device 26.

Step 712: Once the said connection has been established, the controlling device 28 sends the command for starting the acquisition to the mobile acquisition device 23 and to transmit the acquired signals to the local displaying device 26 via wireless Bluetooth or WiFi network.

Step 713: The acquired data is continuously stored, processed and displayed on the local displaying device 26.

Step 714: The mobile acquisition device 23 receives the stop acquisition command.

Step 715: The acquisition is interrupted.

In the description of the present invention, the function of the controlling device 28 can be performed by the local displaying device 26.

Both the local displaying devices 26 and the distant displaying devices 27 can substantially be mobile devices, or personal computers,

While the preferred embodiment of the invention has been set forth for the purpose of disclosure, modifications of the disclosed embodiment of the invention, as well as other embodiments thereof, may occur to those skilled in the art. Accordingly, the appended claims are intended to cover all embodiments, which do not depart from the spirit and scope of the invention.

Claims

1. Long-distance electrophysiological monitoring system for intensive care units comprising: a electrodes that are in contact with the skin of the patient or subject (21), a cap that keeps the electrodes together (22), mobile acquisition device for acquiring and transmitting electrophysiological signals (23), a central server (24), a central database (25), controlling device for controlling the mobile acquisition device (28), local displaying devices for processing, storing and displaying acquired signals, that are placed nearby the mobile acquisition device (26) and distant displaying devices for processing, storing and displaying acquired signals, that are placed in distant centers (27).

2. Mobile system recited in claim 1, wherein the electrodes that are in contact with the skin of a patient or a subject (21) are connected with the cap (22), the cap (22) is further connected to the mobile acquisition device (23), the mobile acquisition device (23) is connected to the central server (24) via long-distance communication network, the central database (25) is connected to the central server (24), the distant displaying device (27) is connected to the central server (24), the mobile acquisition device (23) is connected to the controlling device (28) via digital wireless network .

3. Mobile system recited in claim 1, wherein the electrodes that are in contact with the skin of a patient or a subject (21) are connected with the cap (22), the cap (22) is further connected to the mobile acquisition device (23), the mobile acquisition device (23) is connected to the controlling device (28) via digital wireless network, the local displaying device (26) is connected to the mobile acquisition device (28) via digital wireless network.

4. Mobile system recited in claims 1 and 2, wherein the long-distance communication network is substantially the Internet.

5. Mobile system recited in claims 1-3, wherein digital wireless network is substantially a WiFi network.

6. Mobile system recited in claims 1-3, wherein digital wireless network is substantially a Bluetooth network.

7. Mobile system recited in claims 1-3, wherein the mobile acquisition device comprises a signal acquisition module (23a) that is substantially the entry circuit for acquired signals from the electrodes.

8. Mobile system recited in claims 1-3, wherein the mobile acquisition device (23) comprises an electrical circuit, or a chip, with an amplifier, multiplexer and an analog-to-digital converter (23b).

9. Mobile system recited in claims 1-3, wherein the mobile acquisition device (23) comprises a signal processing circuit (23c).

10. Mobile system recited in claims 1-3, wherein the mobile acquisition device (23) comprises a short-distance wireless communication module (23e).

11. Mobile system recited in claims 1, 2, 3 and 10, wherein the short-distance wireless communication module (23e) is substantially a Bluetooth module.

12. Mobile system recited in claims 1, 2, 3 and 10, wherein the short-distance wireless communication module (23e) is substantially a WiFi module.

13. Mobile system recited in claims 1-3, wherein the mobile acquisition device (23) comprises a long-distance communication module (23d).

14. Mobile system recited in claims 1, 2, 3 and 13, wherein the long-distance communication module (23d) is substantially a GPRS module.

15. Mobile system recited in claims 1, 2, 3 and 13, wherein the long-distance communication module (23d) is substantially a 3G module.

16. Mobile system recited in claims 1-3, wherein the mobile acquisition device (23) is substantially controlled by a controlling device (28).

17. Mobile system recited in claims 1-3, wherein the controlling device (28) comprises a recording metadata input module.

18. Mobile system recited in claims 1, 2, 3 and 17, wherein the recording metadata input module is substantially a touch screen.

19. Mobile system recited in claims 1, 2, 3 and 17, wherein the metadata is substantially name and surname of a patient, age, gender, recording time.

20. Mobile system recited in claims 1, 2, 3, 17 and 19 wherein the metadata is substantially the identifier of the patient.

21. Mobile system recited in claims 1, 2, 3, 17 and 19, wherein the controlling device (28) comprises the metadata display screen.

22. Mobile system recited in claims 1-3, wherein the controlling device (28) is substantially a programmable device.

23. Mobile system recited in claims 1, 2, 3, 5 and 6, wherein the controlling device (28) comprises a digital wireless communication module.

24. Mobile system recited in claims 1, 2, 3, 5, 6 and 23, wherein the digital wireless communication module is a WiFi module.

25. Mobile system recited in claims 1, 2, 3, 5, 6 and 23, wherein the digital wireless communication module is a Bluetooth module.

26. Mobile system recited in claims 1-3 and 17-25, wherein the controlling device (28) is substantially a personal computer.

27. Mobile system recited in claims 1-3 and 17-25, wherein the controlling device (28) is substantially a tablet device.

28. Mobile system recited in claims 1-3 and 17-25, wherein the controlling device (28) is substantially a smartphone.

29. Mobile system recited in claims 1-3 and 17-25, wherein the controlling device (28) is substantially a programmable computer device.

30. Mobile system recited in claims 1, 3, 5 and 6, wherein the local displaying device (26) connected to the mobile acquisition device (23) with a digital wireless network.

31. Mobile system recited in claims 1, 3 and 30, wherein the local displaying device (26) comprises a screen for displaying electrophysiological signals.

32. Mobile system recited in claims 1, 3 and 30, wherein the local displaying device (26) comprises memory for storing acquired electrophysiological signals.

33. Mobile system recited in claims 1, 3 and 30, wherein the local displaying device (26) comprises memory for storing acquired electrophysiological signals.

34. Mobile system recited in claims 1, 3, 30 and 33, wherein the local displaying device (26) comprises module for short-distance wireless communication.

35. Mobile system recited in claims 1, 3, 30 and 33, wherein the local displaying device (26) comprises module for short-distance wireless communication.

36. Mobile system recited in claims 1, 3, 30 and 35, wherein the short-distance communication module is substantially a Bluetooth module.

37. Mobile system recited in claims 1, 3, 30 and 35, wherein the short-distance communication module is substantially a WiFi module.

38. Mobile system recited in claims 1, 3 and 30-37, wherein the local displaying device (26) is substantially a personal computer.

39. Mobile system recited in claims 1, 3 and 30-37, wherein the local displaying device (26) is substantially a tablet device.

40. Mobile system recited in claims 1, 3 and 30-37, wherein the local displaying device (26) is substantially a smartphone.

41. Mobile system recited in claims 1, 3 and 30-37, wherein the local displaying device is substantially a programmable computer device comprising a screen, data input method and short-distance wireless communication module.

42. Mobile system recited in claims 1, 3 and 17-37, wherein the controlling device (28) and the local displaying device (26) are substantially integrated in the same device

43. Method for storing acquired electrophysiological data in the central database (24) comprises:

(a) Providing the mobile system recited in claims 1, 2, 4-12, 16-29.

(b) Providing at least one controller person that manages the controlling device (28). (c) Entering the patient or subject identifier by the controlling person into the controlling device (312).

(d) Entering the recording metadata, such as, but not limited to name, and surname of the patient, age, gender, time of the recording (313).

(e) Entering the controller person's choice into the controlling device that the data should be stored in the central database (314).

(f) Sending the metadata and the controller person's choice to store the data in the central database (25) to the mobile acquisition device (23) from the controlling device (28).

(g) Activating the long-distance communication module (411).

(h) Sending metadata (412) to the central server (24) by the mobile acquisition device

(23) .

(i) Storing the metadata (413) in the central database (25) by the central server (24).

(j) Sending the request for writing the electrophysiological signals according to the stored metadata in the central database (25) by the central server (24).

(k) Sending the confirmation about the prepared storage space for storing recorded electrophysiological signals to the central server (24) by the central database (25). (1) Sending the confirmation to the mobile acquisition device (23) by the central server

(24) that the central database (25) is ready to store electrophysiological signals that belong to the stored metadata.

(m) Starting the recording (414) by the mobile acquisition device (23).

(n) Continuous recording by the mobile acquisition device (23) and sending the acquired data to the central server (24).

(o) Continuous storing of the acquired signals (415) in the central database (25) by the central server (24) in the memory space that has been reserved to store the said electrophysiological signals according to the metadata,

(p) Entering the recording interrupt request (416) to the controlling device (28) by the controller person when the controller person has decided to stop the recording, (q) Sending the said interrupt request to the mobile acquisition device (23) by the controlling device (28).

(r) Sending the said interrupt request to the central server (24) by the mobile acquisition device (23).

(s) Sending the said interrupt request for storing in the central database (25) by the central server (24).

(t) Sending the confirmation that the storing in the central database (25) has been interrupted to the mobile acquisition device (23) by the central server (24).

(u) Stop recording electrophysiological signals (417) by the mobile acquisition device (23).

44. Mobile system recited in claims 1, 2, 4-12, 16-29, 43, wherein the metadata include the identifier of the recording patient or subject.

45. Method for displaying, processing and storing acquired electrophysiological signals in the distant centers that are already stored in the central database comprises:

(a) Providing the mobile system recited in claims 1, 2, 4-12, 16-29, 43 and 44.

(b) Providing at least one controller person of the distant displaying device (27).

(c) Entering identifier of the patient or subject (511) whose data are already stored in the central database (25) into the distant displaying device (27) by the said controller person. (d) Sending the identifier of the patient or subject (512) to the central server (24) by the distant displaying device (27) together with the request for receiving the data for the corresponding subject or patient.

(e) Reading the metadata and stored electrophysiological signals (513) from the central database (25) by the central server (24) according to the said identifier.

(f) Transmitting the read metadata and recorded electrophysiological signals from the central database (25) to the distant displaying device (27) by the central server (24).

(g) Storing the metadata and recorded electrophysiological signals (514) by in the memory of the distant displaying device (27) by the said controller person.

(h) Displaying electrophysiological signals (515) on the screen of the distant displaying device (27) by the said controller person.

(i) Using the signal processing program application (516) on the distant displaying device (27) by the said controller.

(j) Storing the metadata and processed electrophysiological signals (517) in the memory of the distant displaying device (27) by the said controller,

(k) Displaying processed electrophysiological signals (515) on the screen of the distant displaying device (27) by the said controller.

(1) Processing (516), displaying (515) and storing of the electrophysiological signals (517) in the distant displaying device (27) can cyclically repeat a number of times.

46. Mobile system recited in claims 1, 2, 4-12, 16-29, 43, 44 and 45, wherein the metadata include the identifier of the recorded patient or subject.

47. Mobile system recited in claims 1, 2, 4-12, 16-29 and 43-46, wherein the processing, displaying and storing the metadata and processed electrophysiological signals can repeat cyclically, an indefinite number of times, in an unspecified order.

48. Mobile system recited in claims 1, 2, 4 and 43-47, wherein the distant displaying device (27) comprises a screen.

49. Mobile system recited in claims 1, 2, 4 and 43-47, wherein the distant displaying device (27) comprises a data input module.

50. Mobile system recited in claims 1, 2, 4, 43-47 and 49, wherein the data input module is a touchscreen.

51. Mobile system recited in claims 1, 2, 4 and 43-47, wherein the distant displaying device (27) comprises memory for data storage.

52. Mobile system recited in claims 1, 2, 4 and 43-47, wherein the distant displaying device (27) comprises long-distance communication module.

53. Mobile system recited in claims 1, 2, 5, 6, 43-47 and 52, wherein the long-distance communication module is substantially a GPRS module.

54. Mobile system recited in claims 1, 2, 5, 6, 43-47 and 52, wherein the long-distance communication module is substantially a 3G module.

55. Mobile system recited in claims 1, 2, 4 and 43-47, wherein the distant displaying device (27) is substantially a personal computer.

56. Mobile system recited in claims 1, 2, 4 and 43-47, wherein the distant displaying device (27) is substantially a laptop.

57. Mobile system recited in claims 1, 2, 4 and 43-47, wherein the distant displaying device (27) is substantially a tablet device

58. Mobile system recited in claims 1, 2, 4-12, 16-29 and 43-47, wherein the distant displaying device (27) is substantially a smartphone.

59. Mobile system recited in claims 1, 2, 4-12, 16-29 and 43-58, wherein the distant displaying device (27) is substantially a programmable device.

60. Method for displaying, processing and storing acquired electrophysiological signals in the distant centers in real-time comprises:

(a) Providing the mobile system recited in claims 1, 2, 4-12, 16-29, 43-59.

(b) Providing at least one distant display device controller person.

(c) Providing at least one controller person of the controlling device (28).

(d) Entering identifier of the recording patient or subject (312) into the controlling device (28).

(e) Entering the recording metadata, such as, but not limited to the name and the surname of the patient, age, gender, time of the recording (313) into the controlling device (28).

(f) Entering the controller's choice (314) to send the acquired data to the central server (24) by the mobile acquisition device (23).

(g) Sending the metadata and the choice of the controller from the controlling device (28) to the mobile acquisition device (23) to transmit the acquired electrophysiological signals to the central server (24).

(h) Activating the long-distance communication module (611) on the mobile acquisition device (23) to transmit the data to the central server (24) via Internet.

(i) Sending the mobile acquisition device (23) identifier and metadata (612) to the central server (24) by the mobile acquisition device (23).

(j) Writing the said device identifier in the table of active mobile acquisition device (613). (k) Writing the said identifier in the distant displaying device (27) by the distant displaying device controller person.

(1) Sending the identifier of the mobile acquisition device (614) to the central server (24) by the distant displaying device (27).

(m) Checking if the said identifier exists in the table of active devices (615) by the central server (24).

(n) Sending the interrupt signal to the distant displaying device (27) in case the central server (24) cannot find the said identifier in the table of active devices (620). (o) Beginning of the continuous sending the acquired signals (616) to the distant displaying device (27) by the central server (24) in case the said identifier is found in the table of active devices,

(p) Storing the metadata and acquired electrophysiological signals (617) in the memory of the distant displaying device (27).

(q) Displaying the acquired electrophysiological signals (617) in the memory of the distant displaying device (27) when the distant displaying device controller person has chosen to display the signals on-the screen. (r) Using the signal processing program application to process the acquired electrophysiological data (617) on the distant displaying device (27) by the said controller.

(s) Storing the metadata and processed electrophysiological signals (617) in the memory of the distant displaying device (27) by the said controller,

(t) Displaying the processed electrophysiological signals (617) in the memory of the distant displaying device (27) when the distant displaying device controller person has chosen to display the signals on the screen,

(u) Displaying, processing and storing the electrophysiological signals (617) in the distant displaying device (27) can repeat continuously and cyclically an indefinite number of times.

(v) Entering the recording interrupt signal into the controlling device (28).

(w) Sending the said interrupt signal (618) to the mobile acquisition device (23) by the controlling device (28).

(x) Sending the said interrupt signal to the central server (24) by the mobile acquisition device (23).

(y) Erasing the identifier of the active mobile acquisition device (619) from the table of active devices by the central server (24).

(z) Sending the said interrupt signal to the distant displaying device (27) by the central server (24).

(aa) Interrupting the acquisition of the electrophysiological signals (620) by the mobile acquisition device (23).

61. Mobile system recited in claims 1, 2, 4-12 and 60, wherein the identifier of the mobile acquisition device (23) is unique and contained in each mobile acquisition device.

62. Mobile system recited in claims 1, 2, 4-12, 16-29, 43 and 60, wherein the metadata comprise the identifier of the recorded subject or patient.

63. Mobile system recited in claims 1, 2, 4-12, 16-29, 43 and 60, wherein the metadata comprise the list of the data that the controller person of the controlling device (28) chose to input as necessary for identification and further analysis of the recorded signals.

64. Mobile system recited in claims 1, 2, 4-12, 16-29 and 43-60, wherein the distant displaying device (27) comprises the signal processing program application for processing of the recorded electrophysiological signals.

65. Mobile system recited in claims 1, 2, 4-12, 16-29 and 43-60, wherein the method for storing acquired electrophysiological data in the central database and the method displaying, processing and storing acquired electrophysiological signals in the distant centers in real-time can proceed in parallel, independently and asynchronously using the same central server (24).

66. Method for diusplaying, processing and storing the acquired electrophysiological signals in the local displaying devices in realOtime comprises:

(a) Providing mobile system recited in claims 1, 3, 5-12 and 16-42.

(b) Providing at least one controller person of the local displaying device (26).

(c) Providing at least one controller person for the controlling device (28). (d) Entering metadata about the recording into the controlling device (28), such as, and not limited to the identifier of the recording patient or subject (312), name and surname of the patient, age, gender and time of the recording (313).

(e) Entering the controller person's choice (314) in the controlling device to send the acquired signals to the local displaying device (26).

(f) Sending the metadata, identifier of the mobile acquisition device and the choice of the said controller that the acquired signals are transmitted to the local displaying device (26) to the mobile acquisition device (23) by the controlling device (28).

(g) Activating the short-distance communication module (711) on the mobile acquisition device (23) and connecting the local displaying device (26) to the mobile acquisition device (23) over the wireless short-distance data-transmission network, such as and not limited to WiFi or Bluetooth.

(h) Begin continuous data transmission of the acquired electrophysiological signals (712) to the local displaying device (26) by the mobile acquisition device (23).

(i) Storing the metadata and the acquired electrophysiological signals (713) in the memory of the local displaying device (26).

(j) Displaying the acquired signals (713) on the screen of the local displaying device (26). (k) Using the electrophysiological signal processing program application (713) on the local displaying device (26) by the controller of the local displaying device.

(1) Storing the metadata and the processed electrophysiological signals (713) in the memory of the local displaying device (26).

(m) Displaying the processed electrophysiological signals (713) on the screen of the local displaying device (26).

(n) Entering the recording interrupt signal in the controlling device (28) by the controller, (o) Sending the said interruption signal to the mobile acquisition device (23) by the controlling device (28).

(p) Sending the said interruption signal to the local displaying device (26) by the mobile acquisition device (23).

(q) Recording interruption (714) by the mobile acquisition device (23).

67. Mobile system recited in claims 1, 2, 5, 6, 30-42 and 66, wherein the local displaying device (26) comprises the program application for electrophysiological signal processing.