WO2016108332A1 - Active bio-implanted pulsatile high-frequency stimulator for catheter for stimulating transsacral epidural spinal nerve - Google Patents

Active bio-implanted pulsatile high-frequency stimulator for catheter for stimulating transsacral epidural spinal nerve Download PDF

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Publication number
WO2016108332A1
WO2016108332A1 PCT/KR2015/001113 KR2015001113W WO2016108332A1 WO 2016108332 A1 WO2016108332 A1 WO 2016108332A1 KR 2015001113 W KR2015001113 W KR 2015001113W WO 2016108332 A1 WO2016108332 A1 WO 2016108332A1
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Prior art keywords
high frequency
pulsatile
pulsatile high
frequency signal
information
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PCT/KR2015/001113
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French (fr)
Korean (ko)
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안상호
이상학
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영남대학교 산학협력단
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Publication of WO2016108332A1 publication Critical patent/WO2016108332A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/06—Electrodes for high-frequency therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36175—Pulse width or duty cycle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36189—Control systems using modulation techniques
    • A61N1/36196—Frequency modulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators
    • A61N1/37252—Details of algorithms or data aspects of communication system, e.g. handshaking, transmitting specific data or segmenting data

Definitions

  • the present invention relates to a pulsatile radiofrequency stimulator for catheter (hereinafter referred to as an in vitro pulsatile radiofrequency stimulator for active catheter) for active biograft cervical epidural spinal nerve stimulation, in particular pulsatile radiofrequency signal generation information and body determined according to the symptoms of the patient Generates the driving power for the operation of the implanted active catheter outside the body and provides it wirelessly, and receives the pulsatile high frequency signal generation information and the driving power through the antenna implanted in the spinal region of the human body, and the pulsatile high frequency in the implanted active catheter.
  • an extracorporeal pulsatile high frequency stimulator for an active catheter that generates a signal and causes electrical stimulation to the spinal nerve through the electrode.
  • Pulsatile radiofrequency has been used for the treatment of various chronic pain syndromes. Compared with persistent high frequency, there is almost no nerve damage, and it has recently emerged as a neuromodulator. It can also be seen as a tool to avoid steroid injections in elderly patients with chronic pain disorders, which can cause various complications due to repeated injections. Tricuspid neuralgia, failure syndrome after spinal surgery, complex site pain syndrome For the treatment of postherpetic neuralgia, peripheral nerve pulsatile radiofrequency therapy of spinal nerve, face and trunk and limbs is expanding. Recently, intraarticular pulsatile radiofrequency has been reported to reduce chronic joint pain. Intra-articular pulsatile radiofrequency is expected to act on intra-articular tissues rather than directly on nerve tissues to act as an anti-inflammatory and immune cell regulator.
  • Micropulmonary cells known to be important for the development of neuropathic pain in the dorsal horn, when pulsatile radiofrequency ablation is performed on the dorsal root ganglion of animals with neuropathic pain, It has been found that the activity of microglia), astrocytes, and substance P (substance P) are reduced. Peripheral nerves and joint pain, such as the central nervous system spinal cord and the pain perception of the brain becomes sensitive and central sensitization occurs, the central sensitization is involved in the activation of microglia. Central sensitization causes the pain in the local area to gradually expand, spreading the pain over a wide area, causing pain or spontaneous pain even with minor irritation and not responding well to any treatment.
  • pulsatile radiofrequency therapy that reduces the activity of microglia is required.
  • the pulsatile high frequency treatment of nerves over the entire length of the spine is required because it does not respond well to single-time pulsatile radiotherapy for local nerves.
  • the epidural spinal nerve pulsatile pulsatile high frequency treatment the effect of reducing pain or nerve abnormality does not last long, so the pulsation that can continuously control the pain or nerve abnormality of the patient by inserting a living implantable catheter A high frequency stimulation device is necessary.
  • the pulsatile stimulation of the high frequency of 500,000 Hz which is more effective than the low frequency stimulation, enables the implantation of a living implantable cervical dura that can be stimulated over the entire spinal field for the treatment of central sensitized chronic fullness pain or for the control of nerve abnormalities.
  • a pulsatile radiofrequency device for external spinal nerve stimulation There is a need for a pulsatile radiofrequency device for external spinal nerve stimulation.
  • the present invention generates and provides pulsatile high frequency signal information determined in accordance with a symptom of a patient and driving power for electric stimulation in vitro, and transmits pulsatile high frequency signal information through an antenna implanted into the sacral region of the human body. And it is an object to provide an extracorporeal pulsatile high frequency stimulation apparatus for an active catheter to receive the drive power to generate a pulsatile high frequency signal in the body to be electrical stimulation through the electrode.
  • the active extracorporeal pulsatile high frequency stimulation apparatus generates pulsatile high frequency signal information to generate and transmit pulsatile high frequency signal information and driving power, respectively, in response to a request for generating pulsatile high frequency signals according to a patient's condition, and transmits the generated pulsatile high frequency signal information.
  • Controller is implanted in the body of the patient, receives the driving power and uses the driving power for generating the pulsatile high frequency signal, receives the pulsatile high frequency signal generation information, and converts the pulsatile high frequency signal for spinal nerve stimulation into electrical stimulation at the corresponding site. It may include an active biograft catheter to be applied.
  • the apparatus for generating pulsatile high frequency signal information provides a pulsatile high frequency signal generating menu item so as to generate different pulsatile high frequency signals according to a patient's condition, and pulsatile high frequency generating menu item by the pulsatile high frequency signal generating menu item
  • the control unit for outputting the pulsatile high frequency generation control signal in response to the pulsatile high frequency signal generation information and outputting the power generation control signal to the power supply based on the pulsatile high frequency generation control signal in response to the input unit for outputting the signal generation information.
  • a pulsatile high frequency signal information generator for generating pulsatile high frequency signal information in response to the pulsatile high frequency generation control signal, and a data wireless transmitter for converting the pulsatile high frequency signal information into a radio type signal and transmitting the same through a antenna.
  • an active biotransplant catheter includes a voltage / current detector for detecting and feeding back a voltage and a current of an output terminal, and a voltage and current of the output terminal are fed back from the voltage / current detector, and a power generation control signal of the controller is provided. It may be composed of a power transmission control unit for outputting the driving power based on the feedback current and voltage, and the power generation control signal received from the input, and a wireless power transmitter for transmitting the driving power in a wireless manner.
  • two pulsatile high frequency signal information generators are placed in a synchronous mode for stimulating synchronization of two active biograft catheters to insert two active biograft catheters into the body to stimulate a desired spinal cord nerve segment. Can service.
  • the electrode in the implantable device is composed of a single electrode or a plurality of electrodes, so that the user can adjust the electrical stimulation point from the outside.
  • the input unit may serve to select a duration and treatment time of the frequency when selecting a frequency required for the treatment of pain or nerve abnormality.
  • a control unit provides a plurality of patient state information through an input unit and one of the patient state information is selected, the corresponding treatment frequency, duration, treatment time, synchronization mode, and internal electrode
  • An interface screen for providing a service for selecting a location may be provided.
  • the apparatus further includes a storage unit which stores the duration and treatment time information linked to the plurality of patient status information and the plurality of patient status information, and the controller inputs the information stored in the storage unit. Can be provided through wealth.
  • the input unit may be provided in the form of a touch screen.
  • the apparatus for generating pulsatile high frequency signal information may further include a wireless communication unit which receives a pulsatile high frequency generation request signal input according to a patient state transmitted from an external device and outputs it to a controller.
  • the wireless communication unit may be one of a Bluetooth communication module, a WIFI module, and a Zigbee communication module.
  • the present invention generates and provides a pulsatile high frequency signal information generation control signal and electric power for driving the stimulation determined in accordance with the symptoms of the patient in vitro, and through the antenna implanted in the lumbar region of the human body pulsatile high frequency signal generation information and driving power
  • a pulsatile high frequency signal information generation control signal and electric power for driving the stimulation determined in accordance with the symptoms of the patient in vitro, and through the antenna implanted in the lumbar region of the human body pulsatile high frequency signal generation information and driving power
  • the present invention by generating and transmitting the pulsatile radio frequency signal information required for treatment in vitro non-invasive, it is possible to eliminate unnecessary pain generated every time a high-frequency needle is inserted into the patient, according to the symptoms of the patient It is effective in controlling pain or nerve abnormalities.
  • FIG. 1 is a block diagram illustrating the configuration of an extracorporeal pulsatile high frequency stimulation apparatus for an active catheter according to the present invention.
  • 2 to 8 is a view for explaining the results of treatment through the extracorporeal pulsatile high frequency stimulation apparatus to which the present invention is applied.
  • 1 is a block diagram illustrating the configuration of an extracorporeal pulsatile high frequency stimulation apparatus for an active catheter according to the present invention.
  • 2 to 8 is a view for explaining the results of treatment through the extracorporeal pulsatile high frequency stimulation apparatus to which the present invention is applied.
  • the active extracorporeal pulsatile high frequency stimulation apparatus includes a pulsatile high frequency signal information generation control device 200 and an active biotransplantable catheter 300.
  • the pulsatile high frequency signal information generation and control apparatus 200 generates pulsatile high frequency signal information and driving power, respectively, in response to the pulsatile high frequency generation request signal input according to the patient state, and converts them into a wireless signal.
  • the pulsatile high frequency signal information generation control device 200 generates pulsatile high frequency signal information in response to a pulsatile high frequency signal generation request signal input according to a patient state, converts it into a wireless form, and transmits the pulsatile high frequency signal information generation unit 210; It is composed of a wireless power supply unit 220 for generating power based on the pulsatile high frequency signal information generated by the pulsatile high frequency signal information generating unit 210, and converts the generated power into a wireless form and transmits it.
  • the pulsatile high frequency signal information generating unit 210 provides the pulsatile high frequency signal generation menu item to generate different pulsatile high frequency signals according to the patient's condition, and the pulsatile high frequency signal generating information is generated by the pulsatile high frequency signal generating menu item, Outputs the pulsatile high frequency generation control signal in response to the input unit 211 and the pulsatile high frequency signal generation information of the input unit 211, and transmits the power generation control signal to the wireless power supply unit 220 based on the pulsatile high frequency generation control signal.
  • a control unit 212 for outputting, a pulsatile high frequency signal information generating unit 213 for generating pulsatile high frequency signal information in response to the pulsatile high frequency generation control signal, and converting a high frequency signal into a wireless signal and transmitting it through the antenna 214
  • the storage unit 216 stores time, synchronization mode, and internal electrode position information by linking, and receives a pulsatile high frequency generation request signal according to a patient state transmitted from an external device, and outputs it to the control unit 212. It consists of a communication unit 217.
  • the service may be configured to select a duration and treatment time of the frequency, an electrode position in the body, and whether to select a synchronization mode.
  • the input unit 211 is provided in the form of a touch screen. That is, when the input unit 211 forms the touch screen, the input unit 211 has the function of the output unit at the same time, and provides all menu items for generating a pulsatile high frequency signal for the treatment of pain or nerve abnormality control. Service to be able to select and input condition by selecting.
  • the output unit is provided separately, and based on the pulsatile high frequency signal selection and the selected pulsatile high frequency signal, the duration and treatment time can be selected by turning the knob switch.
  • the control unit 212 recognizes this and outputs the current value of the knob switch through the output unit, so that the doctor or therapist can check and select the values while viewing it.
  • the control unit 212 provides a plurality of patient state information through the input unit 211, and if one of the patient state information is selected, the service to select the corresponding treatment frequency, synchronization mode, duration, treatment time Interface screen to be provided.
  • the controller 212 reads the information stored in the storage 216 to be provided through the input unit 211.
  • the wireless communication unit 217 may employ any module having a communication function capable of receiving wireless data transmitted from an external device such as a Bluetooth communication module, a WIFI module, a Zigbee communication module, and the like.
  • the voltage / current detector 221 which the wireless power supply unit 220 detects and feeds back the voltage and current of the output terminal, receives the voltage and current of the output terminal from the voltage / current detector 221 and generates power of the controller 212.
  • the power transmission control unit 222 receives the control signal and outputs the driving power based on the fed back current and voltage and the power generation control signal, and the wireless power transmitter 223 transmitting the driving power in a wireless manner.
  • the active biograft catheter 300 is implanted in the patient's body and is provided as a driving power source for receiving pulsating high frequency signals and receiving data and converting the data radio signals into pulsating high frequency signals to generate electrical Allow the stimulus to be applied.
  • the active biograft type catheter 300 receives power of a wireless type and is supplied by a driving power supply for driving pulsatile high frequency signals and a driving power for driving pulsatile high frequency signals to generate pulsatile high frequency signal information. It consists of a pulsatile radio frequency signal generator 320 for receiving the therapeutic pulsatile radio frequency information transmitted from the control device 200 and converting it into a spinal nerve stimulus signal, and an electrode 330 for applying electrical stimulation to the corresponding site.
  • the pulsatile high frequency signal generator 320 receives the therapeutic pulsatile high frequency information transmitted from the pulsatile high frequency signal information generation control device 200 and outputs a pulsatile high frequency signal generating control unit 321 for outputting a control signal for generating a pulsatile high frequency signal. And a signal generator 322 for generating a pulsatile high frequency signal and outputting the pulsatile high frequency signal to the electrode 330 under the control of the pulsatile high frequency signal generation controller 321.
  • the doctor or therapist lays down the patient on the treatment bed, and then, through the input unit 211 of the pulsatile high frequency signal information generation unit 210 constituting the pulsatile high frequency signal information generation control device 200, to treat the pain of the patient.
  • the input unit 211 of the pulsatile high frequency signal information generation unit 210 constituting the pulsatile high frequency signal information generation control device 200 to treat the pain of the patient.
  • the active biograft catheter 300 is implanted in the sacral region between the spine and the lumbar spine through the procedure, and the signal generator 322 is connected to the electrode 330 and the signal generator 322. Pulsating high frequency signal generation control unit 321 is connected.
  • the input unit 211 is the pulsatile high frequency to the control unit 212.
  • the control unit 212 outputs the pulsatile high frequency generation control signal to the pulsatile high frequency information radio signal generator 213 based on the pulsatile high frequency signal generation information, the pulsatile high frequency information radio signal generator 213 Allow wirelessly generating pulsatile high frequency signal information.
  • the generated signal is input to the data wireless transmitter 215, converted into a wireless signal, and then transmitted to the active biograft catheter 300 implanted in the patient's body through the antenna 214.
  • the controller 212 generates a power generation control signal based on the pulsating high frequency generation control signal and outputs it to the power supply unit 220. Then, the power supply unit 220 generates driving power for generating a pulsatile high frequency signal in response to the power generation control signal, and transmits the generated power to the active biograft catheter 300 through the wireless power transmitter 223 and the antenna 224. .
  • the active biograft catheter 300 receives the driving power through the driving power receiving antenna 311 of the power supply unit 310 and stores the driving power in the power storage unit 312.
  • the driving power stored in the power storage unit 312 is supplied to the pulsatile high frequency signal generation controller 321 of the pulsatile high frequency signal generator 320 so that the pulsatile high frequency signal generation controller 321 receives the radio signal.
  • the signal generator 322 receives a radio signal through the 323, the signal generator 322 generates a pulsatile high frequency signal and supplies it to the electrode 330 of the internal electrode position specified by the medical staff, the electrode 330 is applied to the pulsatile high frequency signal patient Electrical stimulation is applied to the affected area in the body to relieve pain or to control nerve abnormalities.
  • the pulsatile high frequency signal information generation control device 200 of the present invention includes a wireless communication unit 217 made of a Bluetooth module, so that the doctor or therapist generates pulsatile high frequency signal information using a terminal in which the Bluetooth module is embedded. Remote control of the operating state of the control device 200, or to perform a plurality of setting actions for generating the patient state information and the pulsatile high frequency signal remotely.
  • Figure 2 implants the active catheter of the present invention for patients complaining urethral pain during urination, and initially "600sec 55V, 5Hz / 5ms, 300 ⁇ , 200mA done” conditions through the in vitro pulsatile high frequency stimulator (Fig. 2 (a Pulmonary radiofrequency signals were applied to the electrodes inserted into the sacral region between the spine and the vertebrae of the patient for 3 to 4 days. After one month of treatment, the pulsatile high frequency signal was passed through the in vitro pulsatile high frequency stimulator to have a "Pulsed RF 600sec 55V, 5Hz / 5ms, 300 ⁇ , 200mA done" condition (see FIG. 2 (b)). When applied to the electrical stimulation is made to the area to treat the pain, the pain was improved.
  • Figure 3 is a patient complaining of fever in the pain and back around the anus, MRI (see Fig. 3 (a)) and a picture of the present invention (see Fig. 3 (b)), the pain when sitting in a hard place
  • the patient is appealing.
  • the patient who was treated by breaking the tailbone after falling only 3m from the patient the patient was implanted with the active catheter of the present invention, and the pulsed RF 600sec 55V, 5Hz / 5ms, 360 ⁇ , 150mA
  • the heat sensitivity of the back is improved by 30% or more.
  • the pain in the tailbone was improved by 40-50% after 5 days more pain after treatment using pulsatile radiofrequency signals. After one month of treatment using these pulsatile radiofrequency signals, the pain in the tailbone was 70% better than in the first place.
  • Figure 4 shows that the whole arm is missing, we complain of pain at night, it is hard to fall asleep, pain in the left arm and left hand, lose weight, hard to stretch fingers, limp walking in limp because there is no strength in the left leg (Atrophic lateral sclerosis)
  • the patient is implanted with the active catheter of the present invention, and the pulsatile high frequency signal having the condition "Pulsed RF 600sec 55V, 5Hz / 5ms, 182ohm, 304mA done" through an in vitro pulsatile radiofrequency stimulator is applied to the site.
  • the electrical stimulation treatment the pain was eliminated and relaxed, the left arm pain improved from 70% to 85%, 0.5kg of dumbbell exercise was possible, Biceps increased, and no longer lost weight. It is possible to grab paper with the left hand, reduce the dim feeling when walking, and improve to walk 4 ⁇ 5km at a time.
  • 5 to 7 is a patient in a state of hospitalization for continuous rehabilitation treatment with neuropathic pain
  • the active catheter of the present invention to the patient complains of pain such as popping of the hands and feet and the pain of hot feeling such as the back lit
  • a pulsatile high frequency signal having a primary "Pulsed RF mode: 600sec, 55V, 5Hz / 20ms, 42 °C, 320 ⁇ " condition (see Fig. 5 (a)) through an in vitro pulsatile high frequency stimulator
  • the hand and foot and back pain after treatment fell the day after the procedure, after which there was a slight fluctuation, but appeared to be lower than before the procedure.
  • Fig. 5 (a) a pulsatile high frequency signal having a primary "Pulsed RF mode: 600sec, 55V, 5Hz / 20ms, 42 °C, 320 ⁇ " condition
  • Figure 8 implants the active catheter of the present invention to a patient who complains of sloppy and soles of stepping on gravel, and performs treatment to give electrical stimulation to the corresponding site by using an pulsatile radiofrequency signal through an in vitro pulsatile radiofrequency stimulator. After this treatment, it was possible to reduce the gritty pain of the patients' feet by 50%, and there was a feeling of stepping on the gravel of the two feet, but the pain was smaller than before.

Abstract

The present invention relates to an active in vitro pulsatile high-frequency stimulator enabling electric stimulation through an electrode by means of generating and providing, in vitro, a signal for controlling the generation of pulsatile high-frequency signal information determined according to the symptoms of a patient and a driving power for electric stimulation, receiving the pulsatile high-frequency signal information and the driving power through an antenna implanted on the coccygeal vertebral site of the human body, and generating a pulsatile high-frequency signal in vivo, the present invention comprising: a device for controlling the generation of pulsatile high-frequency signal information, the device responding to a pulsatile high-frequency generation request signal which is input according to the state of a patient, generating a pulsatile high-frequency signal and a driving power respectively, converting same into wireless signals, then transmitting same; and an active bio-implant-type catheter provided by being implanted inside the body of the patient, receiving the driving power and using same as a driving power source for generating a pulsatile high-frequency signal, receiving a high-frequency signal and converting same into a pulsatile high-frequency signal, and enabling an electric stimulus to be applied to a corresponding site. An electrode of the active bio-implant-type catheter is configured so as to be one or a plurality of electrodes; the location of a stimulating electrode may be selected on the basis of in vivo electrode location information set on an external device; and a synchronization mode may be serviced for stimulus-synchronizing two active bio-implant-type catheters for inserting the two active bio-implant-type catheters in vivo and stimulating a desired spinal nerve interval. As such, the present invention has the effect of not only enabling the alleviation of pain or a neurological abnormality of a patient, but also improving pain treatment or neuromodulation treatment for a neurological abnormality.

Description

능동형 생체이식 경천추 경막외 척수신경 자극을 위한 카테터용 박동성 고주파 자극장치Pulsatile high frequency stimulator for catheter for active biograft cervical spinal epidural nerve stimulation
본 발명은 능동형 생체이식 경천추 경막외 척수신경 자극을 위한 카테터용 박동성 고주파 자극장치(이하 능동형 카테타용 체외 박동성 고주파 자극장치)에 관한 것으로, 특히 환자의 증상에 따라 결정된 박동성 고주파 신호 발생 정보 및 체내 이식된 능동형 카테타의 동작을 위한 구동전력을 체외에서 생성시켜 무선으로 제공하고, 이를 인체의 척추 부위에 이식한 안테나 를 통해 박동성 고주파 신호 발생 정보 및 구동전력을 수신하여 체내 이식된 능동형 카테타에서 박동성고주파 신호를 발생시켜 전극을 통해 척수신경에 전기자극이 이루어지도록 하는 능동형 카테타용 체외 박동성 고주파 자극장치에 관늡 것이다.The present invention relates to a pulsatile radiofrequency stimulator for catheter (hereinafter referred to as an in vitro pulsatile radiofrequency stimulator for active catheter) for active biograft cervical epidural spinal nerve stimulation, in particular pulsatile radiofrequency signal generation information and body determined according to the symptoms of the patient Generates the driving power for the operation of the implanted active catheter outside the body and provides it wirelessly, and receives the pulsatile high frequency signal generation information and the driving power through the antenna implanted in the spinal region of the human body, and the pulsatile high frequency in the implanted active catheter. We will be concerned with an extracorporeal pulsatile high frequency stimulator for an active catheter that generates a signal and causes electrical stimulation to the spinal nerve through the electrode.
박동성 고주파는 다양한 만성통증 증후군의 치료를 위해 사용되어 왔다. 지속성 고주파에 비하여 신경손상이 거의 없는 장점이 있어, 최근 신경조절치료기로 부각되고 있다. 또한 만성 통증 질환을 가진 고령의 환자들에게 반복주사로 인해 다양한 합병증을 유발할 수 있는 스테로이드 주사를 피할 수 있는 도구로 볼 수 있다. 경추부와 요추부 후근신경절, 척추후지내측지 등에 박동성 고주파를 시행해 오던 것을 다양한 약물 치료에도 만족할만한 통증의 호전을 보이지 않는 만성 난치성 신경병증성 통증인 삼차신경통, 척추수술후 실패증후군, 복합부위 통증증후군, 대상포진 후 신경통증 등의 치료를 위해 척추신경, 얼굴 및 체간, 사지의 말초신경 박동성 고주파 치료가 확대되어 가고 있는 추세이다. 최근에는 관절강내 박동성 고주파를 시행하여 만성 관절통증을 감소시키는 효과가 있음이 보고되었다. 관절강내 박동성 고주파는 신경조직에 직접 작용하는 것이 아니라 관절강내 조직에 작용하여 항염증 작용, 면역세포 조절 작용을 하는 것을 추정된다.Pulsatile radiofrequency has been used for the treatment of various chronic pain syndromes. Compared with persistent high frequency, there is almost no nerve damage, and it has recently emerged as a neuromodulator. It can also be seen as a tool to avoid steroid injections in elderly patients with chronic pain disorders, which can cause various complications due to repeated injections. Tricuspid neuralgia, failure syndrome after spinal surgery, complex site pain syndrome For the treatment of postherpetic neuralgia, peripheral nerve pulsatile radiofrequency therapy of spinal nerve, face and trunk and limbs is expanding. Recently, intraarticular pulsatile radiofrequency has been reported to reduce chronic joint pain. Intra-articular pulsatile radiofrequency is expected to act on intra-articular tissues rather than directly on nerve tissues to act as an anti-inflammatory and immune cell regulator.
수핵탈출 동물모델을 이용하여 신경병증성 통증을 유발시킨 동물의 척추 후근신경절(dorsal root ganglion)에 박동성 고주파를 시행할 경우, 척추 후각(dorsal horn)에서 신경통증 발현에 중요하다고 알려져 있는 미세교세포(microglia), 성상신경세포(astrocyte), P 물질(substance P) 등의 활성이 감소되는 것이 밝혀져 있다. 말초신경이나 관절 등의 통증이 지속될 경우 중추신경인 척수와 뇌의 통증 지각 부위가 과민하게 되어 중심성 감작화(central sensitization)가 발생하게 되는데, 중심성 감작화는 미세교세포 등의 활성화가 관여하게 된다. 중심성 감작화가 생기면 국소 부위의 통증이 점차 확대되어 넓은 부위로 통증이 퍼지고, 사소한 자극에도 통증의 발생하거나 자발통이 심해지며 어떠한 치료에도 잘 반응하지 않게 된다.Micropulmonary cells, known to be important for the development of neuropathic pain in the dorsal horn, when pulsatile radiofrequency ablation is performed on the dorsal root ganglion of animals with neuropathic pain, It has been found that the activity of microglia), astrocytes, and substance P (substance P) are reduced. Peripheral nerves and joint pain, such as the central nervous system spinal cord and the pain perception of the brain becomes sensitive and central sensitization occurs, the central sensitization is involved in the activation of microglia. Central sensitization causes the pain in the local area to gradually expand, spreading the pain over a wide area, causing pain or spontaneous pain even with minor irritation and not responding well to any treatment.
이러한 난치성 통증을 근원적으로 줄이기 위해선 미세교세포의 활성을 감소시키는 박동성 고주파치료가 필요하다. 이미 확산된 중추신경의 감작화를 치료하기 위해선 국소 부위 신경에 대한 단회성 박동성 고주파 치료에는 잘 반응하지 않아 척추의 전장에 걸친 신경의 박동성 고주파 치료가 필요하다. 이를 위해선 활성전극을 경막외강에 두고 척수 신경의 전장에 걸쳐서 자극하는 것이 필요하다. 또한 이러한 경막외 척추신경 단회성 박동성 고주파 치료에 반응을 한다고 하더라도 통증이나 신경 이상 감소 효과가 효과가 오랫동안 지속되지는 않으므로 생체 이식형 카테타를 삽입하여 환자의 통증이나 신경 이상을 지속적으로 조절 수 있는 박동성 고주파 자극장치가 필요하다.To fundamentally reduce such intractable pain, pulsatile radiofrequency therapy that reduces the activity of microglia is required. In order to treat sensitization of the central nervous system that has already spread, the pulsatile high frequency treatment of nerves over the entire length of the spine is required because it does not respond well to single-time pulsatile radiotherapy for local nerves. To do this, it is necessary to place the active electrode in the epidural space and to stimulate the entire spinal cord nerve. In addition, even if the epidural spinal nerve pulsatile pulsatile high frequency treatment, the effect of reducing pain or nerve abnormality does not last long, so the pulsation that can continuously control the pain or nerve abnormality of the patient by inserting a living implantable catheter A high frequency stimulation device is necessary.
기존의 삽입형 척수신경자극술에서는 30~150Hz의 저주파 전기자극을 사용하나, 최근에는 10,000Hz 전기자극기가 개발되어 좀 더 나은 치료 결과를 보인다는 보고가 있다.Conventional spinal nerve stimulation uses low frequency electric stimulation of 30 ~ 150Hz, but recently it has been reported that 10,000Hz electric stimulator has been developed to show better treatment results.
그러나, 저주파 자극에 비해 치료효과가 좋은 500,000Hz의 고주파를 박동성으로 자극함으로써, 중심성 감작화가 된 만성 만치성 통증 치료나 신경 이상 조절을 위해 척추 전장에 걸쳐 자극을 할 수 있는 생체 이식형 경천추 경막외 척수신경자극을 위한 박동성 고주파 장치가 필요하게 되었다.However, the pulsatile stimulation of the high frequency of 500,000 Hz, which is more effective than the low frequency stimulation, enables the implantation of a living implantable cervical dura that can be stimulated over the entire spinal field for the treatment of central sensitized chronic fullness pain or for the control of nerve abnormalities. There is a need for a pulsatile radiofrequency device for external spinal nerve stimulation.
이와 같은 문제점을 해소시키기 위해 본 발명은 환자의 증상에 따라 결정된 박동성 고주파신호 정보 및 전기자극을 위한 구동전력을 체외에서 생성시켜 제공하고, 이를 인체의 천추 부위에 이식한 안테나를 통해 박동성 고주파신호 정보 및 구동전력을 수신받아 체내에서 박동성 고주파신호를 발생시켜 전극을 통해 전기자극이 이루어지도록 하는 능동형 카테타용 체외 박동성 고주파 자극장치 를 제공하는데 목적이 있다.In order to solve such a problem, the present invention generates and provides pulsatile high frequency signal information determined in accordance with a symptom of a patient and driving power for electric stimulation in vitro, and transmits pulsatile high frequency signal information through an antenna implanted into the sacral region of the human body. And it is an object to provide an extracorporeal pulsatile high frequency stimulation apparatus for an active catheter to receive the drive power to generate a pulsatile high frequency signal in the body to be electrical stimulation through the electrode.
본 발명의 실시 예에 따른 능동형 체외 박동성 고주파 자극장치는 환자 상태에 따라 입력되는 박동성 고주파 생성 요구에 응하여 박동성 고주파 신호 정보 및 구동전력을 각각 발생시켜 무선신호로 변환시킨 후 송출하는 박동성 고주파신호정보 발생제어장치; 및 환자의 몸속에 이식되어 구비되며, 구동전력을 수신받아 박동성 고주파 신호 발생용 구동전원으로 이용하고, 박동성 고주파 신호 생성 정보를 수신하여 척수신경 자극용 박동성 고주파 신호로 변환시켜 해당 부위에 전기적 자극이 인가되도록 하는 능동형 생체이식용 카테타를 포함할 수 있다.The active extracorporeal pulsatile high frequency stimulation apparatus according to an embodiment of the present invention generates pulsatile high frequency signal information to generate and transmit pulsatile high frequency signal information and driving power, respectively, in response to a request for generating pulsatile high frequency signals according to a patient's condition, and transmits the generated pulsatile high frequency signal information. Controller; And is implanted in the body of the patient, receives the driving power and uses the driving power for generating the pulsatile high frequency signal, receives the pulsatile high frequency signal generation information, and converts the pulsatile high frequency signal for spinal nerve stimulation into electrical stimulation at the corresponding site. It may include an active biograft catheter to be applied.
본 발명과 관련된 실시예로서, 박동성 고주파신호정보 발생제어장치가, 환자의 상태에 따라 서로 다른 박동성 고주파 신호를 발생시키도록 박동성 고주파 신호 발생 메뉴항목을 제공하고, 박동성 고주파 발생 메뉴항목에 의해 박동성 고주파 신호 발생정보가 결정되면, 이를 출력하는 입력부와, 입력부의 박동성 고주파 신호 발생정보에 응하여 박동성 고주파 생성 제어신호를 출력하고, 박동성 고주파 생성 제어신호에 기반하여 전력생성 제어신호를 전력공급부로 출력하는 제어부와, 박동성 고주파 생성 제어신호에 응하여 박동성 고주파 신호 정보를 발생시키는 박동성 고주파 신호 정보 발생부와, 박동성 고주파 신호 정보를 무선형태의 신호로 변환시켜 안테나를 통해 송출하는 데이터 무선 송신부로 이루어질 수 있다.In an embodiment related to the present invention, the apparatus for generating pulsatile high frequency signal information provides a pulsatile high frequency signal generating menu item so as to generate different pulsatile high frequency signals according to a patient's condition, and pulsatile high frequency generating menu item by the pulsatile high frequency signal generating menu item When the signal generation information is determined, the control unit for outputting the pulsatile high frequency generation control signal in response to the pulsatile high frequency signal generation information, and outputting the power generation control signal to the power supply based on the pulsatile high frequency generation control signal in response to the input unit for outputting the signal generation information. And a pulsatile high frequency signal information generator for generating pulsatile high frequency signal information in response to the pulsatile high frequency generation control signal, and a data wireless transmitter for converting the pulsatile high frequency signal information into a radio type signal and transmitting the same through a antenna.
본 발명과 관련된 실시예로서, 능동형 생체이식용 카테타가, 출력단의 전압 및 전류를 검출하여 피드백시키는 전압/전류 검출부와, 전압/전류 검출부로부터 출력단의 전압 및 전류를 피드백받고, 제어부의 전력생성 제어신호를 입력받아 피드백된 전류 및 전압, 그리고 전력생성 제어신호를 기반으로 구동전력을 출력하는 전력송신 제어부와, 구동전력을 무선방식으로 송출하는 무선 전력 송신부로 이루어질 수 있다.In an embodiment related to the present invention, an active biotransplant catheter includes a voltage / current detector for detecting and feeding back a voltage and a current of an output terminal, and a voltage and current of the output terminal are fed back from the voltage / current detector, and a power generation control signal of the controller is provided. It may be composed of a power transmission control unit for outputting the driving power based on the feedback current and voltage, and the power generation control signal received from the input, and a wireless power transmitter for transmitting the driving power in a wireless manner.
본 발명과 관련된 실시예로서, 2개의 능동형 생체이식용 카테타를 체내에 삽입하여 원하는 척수 신경구간을 자극하기 위해 2개의 능동형 생체이식용 카테타의 자극 동기화를 위하여 2개의 박동성 고주파 신호 정보 발생장치를 동기화 모드로 서비스 할 수 있다. In an embodiment related to the present invention, two pulsatile high frequency signal information generators are placed in a synchronous mode for stimulating synchronization of two active biograft catheters to insert two active biograft catheters into the body to stimulate a desired spinal cord nerve segment. Can service.
본 발명과 관련된 실시예로서 이식형 장치내의 전극은 단일 전극 혹은 복수 개의 전극으로 구성되어 있어 전기 자극 지점을 외부에서 사용자가 조정 할 수 있다.As an embodiment related to the present invention, the electrode in the implantable device is composed of a single electrode or a plurality of electrodes, so that the user can adjust the electrical stimulation point from the outside.
본 발명과 관련된 실시예로서, 입력부가, 통증이나 신경 이상의 조절 치료에 필요한 주파수를 선정 시, 주파수의 듀레이션(duration) 및 치료시간을 선정할 수 있도록 서비스할 수 있다.In an embodiment related to the present invention, the input unit may serve to select a duration and treatment time of the frequency when selecting a frequency required for the treatment of pain or nerve abnormality.
본 발명과 관련된 실시예로서, 제어부가, 입력부를 통해 복수의 환자상태정보를 제공하고, 환자상태정보 중 하나의 환자상태정보가 선택되면 해당 치료용 주파수, 듀레이션, 치료시간, 동기화 모드, 체내전극위치를 선정할 수 있도록 서비스하는 인터페이스 화면이 제공되도록 할 수 있다.In an embodiment related to the present invention, if a control unit provides a plurality of patient state information through an input unit and one of the patient state information is selected, the corresponding treatment frequency, duration, treatment time, synchronization mode, and internal electrode An interface screen for providing a service for selecting a location may be provided.
본 발명과 관련된 실시예로서, 복수의 환자상태정보 및 복수의 환자상태정보에 듀레이션 및 치료시간정보들을 링크시켜 저장하고 있는 저장부를 더 포함하고 있으며, 제어부가, 저장부에 저장된 정보들을 읽어들여 입력부를 통해 제공되도록 할 수 있다.In an embodiment related to the present invention, the apparatus further includes a storage unit which stores the duration and treatment time information linked to the plurality of patient status information and the plurality of patient status information, and the controller inputs the information stored in the storage unit. Can be provided through wealth.
본 발명과 관련된 실시예로서, 입력부가 터치스크린 형태로 제공될 수 있다.In an embodiment related to the present invention, the input unit may be provided in the form of a touch screen.
본 발명과 관련된 실시예로서, 박동성 고주파신호정보 발생제어장치가, 외부기기로부터 송출되는 환자 상태에 따라 입력되는 박동성 고주파 생성요청신호를 수신하여, 제어부로 출력하는 무선통신부를 더 포함할 수 있다.In an embodiment related to the present invention, the apparatus for generating pulsatile high frequency signal information may further include a wireless communication unit which receives a pulsatile high frequency generation request signal input according to a patient state transmitted from an external device and outputs it to a controller.
본 발명과 관련된 실시예로서, 무선통신부는 블루투스 통신모듈, WIFI 모듈 , 지그비 통신모듈 중 하나일 수 있다.In an embodiment related to the present invention, the wireless communication unit may be one of a Bluetooth communication module, a WIFI module, and a Zigbee communication module.
본 발명은 환자의 증상에 따라 결정된 박동성 고주파신호 정보 발생 제어신호 및 전기자극을 위한 구동전력을 체외에서 생성시켜 제공하고, 이를 인체의 미추 부위에 이식한 안테나를 통해 박동성 고주파 신호 발생 정보 및 구동전력을 수신받아 체내에서 박동성 고주파신호를 발생시켜 전극을 통해 전기자극이 이루어지도록 함으로써, 환자의 통증이나 신경 이상을 조절, 향상시킬 수 있도록 하는 효과가 있다.The present invention generates and provides a pulsatile high frequency signal information generation control signal and electric power for driving the stimulation determined in accordance with the symptoms of the patient in vitro, and through the antenna implanted in the lumbar region of the human body pulsatile high frequency signal generation information and driving power By receiving the pulsatile high frequency signal in the body to generate electrical stimulation through the electrode, there is an effect to control, improve the pain or nerve abnormalities of the patient.
또한, 본 발명은 체외에서 비 침습적으로 치료에 필요한 박동성 고주파 신호정보를 발생시켜 전달할 수 있도록 함으로써, 환자에게 고주파 바늘을 삽입할 때 마다 발생되는 불필요한 고통을 제거할 수 있으며, 환자의 증상에 따라 적절하게 통증이나 신경 이상을 제어하여 치료할 수 있도록 하는 효과가 있다.In addition, the present invention by generating and transmitting the pulsatile radio frequency signal information required for treatment in vitro non-invasive, it is possible to eliminate unnecessary pain generated every time a high-frequency needle is inserted into the patient, according to the symptoms of the patient It is effective in controlling pain or nerve abnormalities.
도 1은 본 발명에 따른 능동형 카테타용 체외 박동성 고주파 자극장치의 구성을 설명하기 위한 블록도이다.1 is a block diagram illustrating the configuration of an extracorporeal pulsatile high frequency stimulation apparatus for an active catheter according to the present invention.
도 2 내지 도 8은 본 발명이 적용된 체외 박동성 고주파 자극장치를 통해 치료한 결과를 설명하기 위한 도면이다.2 to 8 is a view for explaining the results of treatment through the extracorporeal pulsatile high frequency stimulation apparatus to which the present invention is applied.
본 발명에서 사용되는 기술적 용어는 단지 특정한 실시 예를 설명하기 위해 사용된 것으로, 본 발명을 한정하려는 의도가 아님을 유의해야 한다. 또한, 본 발명에서 사용되는 기술적 용어는 본 발명에서 특별히 다른 의미로 정의되지 않는 한, 본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자에 의해 일반적으로 이해되는 의미로 해석되어야 하며, 과도하게 포괄적인 의미로 해석되거나, 과도하게 축소된 의미로 해석되지 않아야 한다. 또한, 본 발명에서 사용되는 기술적인 용어가 본 발명의 사상을 정확하게 표현하지 못하는 잘못된 기술적 용어일 때에는, 당업자가 올바르게 이해할 수 있는 기술적 용어로 대체되어 이해되어야 할 것이다. 또한, 본 발명에서 사용되는 일반적인 용어는 사전에 정의되어 있는 바에 따라, 또는 전후 문맥상에 따라 해석되어야 하며, 과도하게 축소된 의미로 해석되지 않아야 한다.Technical terms used in the present invention are merely used to describe specific embodiments, it should be noted that it is not intended to limit the present invention. In addition, the technical terms used in the present invention should be interpreted as meanings generally understood by those skilled in the art unless the present invention has a special meaning defined in the present invention, and is excessively comprehensive. It should not be interpreted in the sense of or in the sense of being excessively reduced. In addition, when a technical term used in the present invention is an incorrect technical term that does not accurately express the spirit of the present invention, it should be replaced with a technical term that can be properly understood by those skilled in the art. In addition, the general terms used in the present invention should be interpreted as defined in the dictionary or according to the context before and after, and should not be interpreted in an excessively reduced sense.
또한, 본 발명에서 사용되는 단수의 표현은 문맥상 명백하게 다르게 뜻하지 않는 한 복수의 표현을 포함한다. 본 발명에서, "구성된다" 또는 "포함한다" 등의 용어는 발명에 기재된 여러 구성 요소들, 또는 여러 단계를 반드시 모두 포함하는 것으로 해석되지 않아야 하며, 그 중 일부 구성 요소들 또는 일부 단계들은 포함되지 않을 수도 있고, 또는 추가적인 구성 요소 또는 단계들을 더 포함할 수 있는 것으로 해석되어야 한다.Also, the singular forms used in the present invention include plural forms unless the context clearly indicates otherwise. In the present invention, terms such as “consisting of” or “comprising” should not be construed as necessarily including all of the various components or steps described in the invention, and some of the components or some of the steps are included. It should be construed that it may not be, or may further include additional components or steps.
이하, 첨부된 도면을 참조하여 본 발명에 따른 바람직한 실시 예를 상세히 설명하되, 도면 부호에 관계없이 동일하거나 유사한 구성 요소는 동일한 참조 번호를 부여하고 이에 대한 중복되는 설명은 생략하기로 한다.Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings, and the same or similar components will be given the same reference numerals regardless of the reference numerals, and redundant description thereof will be omitted.
또한, 본 발명을 설명함에 있어서 관련된 공지 기술에 대한 구체적인 설명이 본 발명의 요지를 흐릴 수 있다고 판단되는 경우 그 상세한 설명을 생략한다. In addition, in describing the present invention, when it is determined that the detailed description of the related known technology may obscure the gist of the present invention, the detailed description thereof will be omitted.
또한, 첨부된 도면은 본 발명의 사상을 쉽게 이해할 수 있도록 하기 위한 것일 뿐, 첨부된 도면에 의해 본 발명의 사상이 제한되는 것으로 해석되어서는 아니 됨을 유의해야 한다.In addition, it should be noted that the accompanying drawings are only for easily understanding the spirit of the present invention and should not be construed as limiting the spirit of the present invention by the accompanying drawings.
도 1은 본 발명에 따른 능동형 카테타용 체외 박동성 고주파 자극장치의 구성을 설명하기 위한 블록도이다. 도 2 내지 도 8은 본 발명이 적용된 체외 박동성 고주파 자극장치를 통해 치료한 결과를 설명하기 위한 도면이다.1 is a block diagram illustrating the configuration of an extracorporeal pulsatile high frequency stimulation apparatus for an active catheter according to the present invention. 2 to 8 is a view for explaining the results of treatment through the extracorporeal pulsatile high frequency stimulation apparatus to which the present invention is applied.
도 1에 도시된 바와 같이 능동형 체외 박동성 고주파 자극장치는 박동성 고주파신호정보 발생제어장치(200), 능동형 생체이식형 카테타(300)로 이루어진다.As shown in FIG. 1, the active extracorporeal pulsatile high frequency stimulation apparatus includes a pulsatile high frequency signal information generation control device 200 and an active biotransplantable catheter 300.
박동성 고주파신호정보 발생제어장치(200)는 환자 상태에 따라 입력되는 박동성고주파 생성요청신호에 응하여 박동성고주파 신호 정보 및 구동전력을 각각 발생시켜 무선신호로 변환시킨 후 송출한다.The pulsatile high frequency signal information generation and control apparatus 200 generates pulsatile high frequency signal information and driving power, respectively, in response to the pulsatile high frequency generation request signal input according to the patient state, and converts them into a wireless signal.
박동성 고주파신호정보 발생제어장치(200)는 환자 상태에 따라 입력되는 박동성고주파 생성요청신호에 응하여 박동성 고주파신호 정보를 발생시켜 무선형태로 변환시킨 후 송출하는 박동성 고주파신호 정보 발생부(210)와, 박동성 고주파신호 정보 발생부(210)에 의해 생성된 박동성 고주파신호 정보에 기반하여 전력을 생성시키고, 생성된 전력을 무선형태로 변환시켜 송출하는 무선 전력공급부(220)로 이루어진다.The pulsatile high frequency signal information generation control device 200 generates pulsatile high frequency signal information in response to a pulsatile high frequency signal generation request signal input according to a patient state, converts it into a wireless form, and transmits the pulsatile high frequency signal information generation unit 210; It is composed of a wireless power supply unit 220 for generating power based on the pulsatile high frequency signal information generated by the pulsatile high frequency signal information generating unit 210, and converts the generated power into a wireless form and transmits it.
박동성 고주파신호 정보 발생부(210)가 환자의 상태에 따라 서로 다른 박동성 고주파 신호를 발생시키도록 박동성 고주파 신호 발생 메뉴항목을 제공하고, 박동성 고주파 발생 메뉴항목에 의해 박동성 고주파 신호 발생정보가 생성되면, 이를 출력하는 입력부(211)와, 입력부(211)의 박동성 고주파 신호 발생정보에 응하여 박동성 고주파 생성 제어신호를 출력하고, 박동성 고주파 생성 제어신호에 기반하여 전력생성 제어신호를 무선전력공급부(220)로 출력하는 제어부(212)와, 박동성 고주파생성 제어신호에 응하여 박동성 고주파신호 정보를 발생시키는 박동성 고주파신호정보 발생부(213)와, 고주파 신호를 무선형태의 신호로 변환시켜 안테나(214)를 통해 송출하는 데이터 무선 송신부(215)와, 복수의 환자상태정보 및 복수의 환자상태정보에 듀레이션 및 치료시간, 동기화모드, 체내전극위치 정보들을 링크시켜 저장하고 있는 저장부(216)와, 외부기기로부터 송출되는 환자 상태에 따라 입력되는 박동성 고주파 생성요청신호를 수신하여, 제어부(212)로 출력하는 무선통신부(217)로 이루어진다.When the pulsatile high frequency signal information generating unit 210 provides the pulsatile high frequency signal generation menu item to generate different pulsatile high frequency signals according to the patient's condition, and the pulsatile high frequency signal generating information is generated by the pulsatile high frequency signal generating menu item, Outputs the pulsatile high frequency generation control signal in response to the input unit 211 and the pulsatile high frequency signal generation information of the input unit 211, and transmits the power generation control signal to the wireless power supply unit 220 based on the pulsatile high frequency generation control signal. A control unit 212 for outputting, a pulsatile high frequency signal information generating unit 213 for generating pulsatile high frequency signal information in response to the pulsatile high frequency generation control signal, and converting a high frequency signal into a wireless signal and transmitting it through the antenna 214 The data wireless transmitter 215 and the plurality of patient state information and the plurality of patient state information. The storage unit 216 stores time, synchronization mode, and internal electrode position information by linking, and receives a pulsatile high frequency generation request signal according to a patient state transmitted from an external device, and outputs it to the control unit 212. It consists of a communication unit 217.
입력부(211)가 통증이나 신경 이상의 조절 치료에 필요한 주파수를 선정 시, 주파수의 듀레이션(duration) 및 치료시간, 체내 전극 위치, 동기화 모드 선택 유,무를 선정할 수 있도록 서비스한다. 이때, 입력부(211)가 터치스크린 형태로 제공된다. 즉 입력부(211)가 터치스크린 형태를 이룰 경우 입력부(211)는 출력부의 기능을 동시에 가지게 되며, 통증이나 신경 이상의 조절 치료를 위한 박동성 고주파 신호를 발생시키기 위한 모든 메뉴항목을 제공하고, 메뉴항목을 선택하여 조건을 선택하여 입력할 수 있도록 서비스한다. 한편 입력부(211)가 복수의 노브 스위치들로 이루어지는 경우 출력부가 별도로 구비되어 있으며, 박동성 고주파 신호 선정 및 선정된 박동성 고주파 신호를 기반으로 하여 듀레이션 및 치료시간 등을 노브 스위치를 돌려서 선정할 수 있도록 하며, 노브 스위치를 회전시키면 제어부(212)가 이를 인식하여 출력부를 통해 노브 스위치의 현재 값을 출력시키고, 의사나 또는 치료자가 이를 보면서 확인하고 값들을 선정할 수 있도록 구현 가능하다.When the input unit 211 selects a frequency required for the treatment of pain or neurological abnormality, the service may be configured to select a duration and treatment time of the frequency, an electrode position in the body, and whether to select a synchronization mode. In this case, the input unit 211 is provided in the form of a touch screen. That is, when the input unit 211 forms the touch screen, the input unit 211 has the function of the output unit at the same time, and provides all menu items for generating a pulsatile high frequency signal for the treatment of pain or nerve abnormality control. Service to be able to select and input condition by selecting. On the other hand, when the input unit 211 is composed of a plurality of knob switches, the output unit is provided separately, and based on the pulsatile high frequency signal selection and the selected pulsatile high frequency signal, the duration and treatment time can be selected by turning the knob switch. When the knob switch is rotated, the control unit 212 recognizes this and outputs the current value of the knob switch through the output unit, so that the doctor or therapist can check and select the values while viewing it.
제어부(212)가 입력부(211)를 통해 복수의 환자상태정보를 제공하고, 환자상태정보 중 하나의 환자상태정보가 선택되면 해당 치료용 주파수, 동기화 모드, 듀레이션, 치료시간을 선정할 수 있도록 서비스하는 인터페이스 화면이 제공되도록 한다.The control unit 212 provides a plurality of patient state information through the input unit 211, and if one of the patient state information is selected, the service to select the corresponding treatment frequency, synchronization mode, duration, treatment time Interface screen to be provided.
제어부(212)가 저장부(216)에 저장된 정보들을 읽어들여 입력부(211)를 통해 제공되도록 한다.The controller 212 reads the information stored in the storage 216 to be provided through the input unit 211.
무선통신부(217)는 블루투스 통신모듈, WIFI 모듈, 지그비 통신모듈 등 외부기기에서 송출되는 무선데이터를 수신할 수 있는 통신기능이 구비된 모듈이면 모두 채용 가능하다.The wireless communication unit 217 may employ any module having a communication function capable of receiving wireless data transmitted from an external device such as a Bluetooth communication module, a WIFI module, a Zigbee communication module, and the like.
무선 전력공급부(220)가 출력단의 전압 및 전류를 검출하여 피드백시키는 전압/전류 검출부(221)와, 전압/전류 검출부(221)로부터 출력단의 전압 및 전류를 피드백받고, 제어부(212)의 전력생성 제어신호를 입력받아 피드백된 전류 및 전압, 그리고 전력생성 제어신호를 기반으로 구동전력을 출력하는 전력송신 제어부(222)와, 구동전력을 무선방식으로 송출하는 무선 전력 송신부(223)로 구성된다.The voltage / current detector 221 which the wireless power supply unit 220 detects and feeds back the voltage and current of the output terminal, receives the voltage and current of the output terminal from the voltage / current detector 221 and generates power of the controller 212. The power transmission control unit 222 receives the control signal and outputs the driving power based on the fed back current and voltage and the power generation control signal, and the wireless power transmitter 223 transmitting the driving power in a wireless manner.
능동형 생체이식형 카테타(300)는 환자의 몸속에 이식되어 구비되며, 구동전력을 수신받아 박동성 고주파 신호 발생용 구동전원으로 이용하고, 데이터무선신호를 수신하여 박동성 고주파 신호로 변환시켜 해당 부위에 전기적 자극이 인가되도록 한다.The active biograft catheter 300 is implanted in the patient's body and is provided as a driving power source for receiving pulsating high frequency signals and receiving data and converting the data radio signals into pulsating high frequency signals to generate electrical Allow the stimulus to be applied.
능동형 생체이식형 카테타(300)는 무선형태의 전력을 수신하여 박동성 고주파 신호 발생용 구동전원으로 공급하는 전력수급부(310)와, 박동성 고주파 신호 발생용 구동전원에 의해 구동되어 박동성 고주파신호 정보 발생제어장치(200)에서 송출되는 치료용 박동성 고주파 정보를 수신하여 척수신경자극신호로 변환시켜 출력하는 박동성 고주파신호 발생부(320)와, 해당 부위에 전기적 자극을 인가시키는 전극(330)으로 이루어진다.The active biograft type catheter 300 receives power of a wireless type and is supplied by a driving power supply for driving pulsatile high frequency signals and a driving power for driving pulsatile high frequency signals to generate pulsatile high frequency signal information. It consists of a pulsatile radio frequency signal generator 320 for receiving the therapeutic pulsatile radio frequency information transmitted from the control device 200 and converting it into a spinal nerve stimulus signal, and an electrode 330 for applying electrical stimulation to the corresponding site.
박동성 고주파신호 발생부(320)는 박동성 고주파신호정보 발생제어장치(200)에서 송출되는 치료용 박동성고주파 정보를 수신하여, 박동성 고주파신호를 발생시키기 위한 제어신호를 출력하는 박동성 고주파신호 발생 제어부(321)와, 박동성 고주파신호 발생 제어부(321)의 제어에 응하여 박동성 고주파신호를 발생시켜 전극(330)으로 출력하는 신호 발생부(322)로 이루어진다 .The pulsatile high frequency signal generator 320 receives the therapeutic pulsatile high frequency information transmitted from the pulsatile high frequency signal information generation control device 200 and outputs a pulsatile high frequency signal generating control unit 321 for outputting a control signal for generating a pulsatile high frequency signal. And a signal generator 322 for generating a pulsatile high frequency signal and outputting the pulsatile high frequency signal to the electrode 330 under the control of the pulsatile high frequency signal generation controller 321.
상기와 같이 구성된 능동형 카테타용 체외 박동성 고주파 자극장치의 작용에 대해서 설명하면 다음과 같다.Referring to the operation of the extracorporeal pulsatile high frequency stimulation device for an active catheter configured as described above are as follows.
먼저 의사 또는 치료자가 환자를 치료 침대에 엎드리는 자세로 눕힌 후 박동성 고주파신호정보 발생제어장치(200)를 구성하고 있는 박동성고주파 신호 정보발생부(210)의 입력부(211)를 통해 환자의 통증 치료에 적합한 박동성고주파 신호, 박동성고주파 신호의 듀레이션(duration), 치료시간(time), 체내 전극 위치, 동기화 모드 선택 유,무를을 설정한다.First, the doctor or therapist lays down the patient on the treatment bed, and then, through the input unit 211 of the pulsatile high frequency signal information generation unit 210 constituting the pulsatile high frequency signal information generation control device 200, to treat the pain of the patient. Set the appropriate pulsatile high frequency signal, duration of pulsatile high frequency signal, treatment time, internal electrode position, and synchronization mode selection.
이때 환자의 경우 능동형 생체이식형 카테타(300)는 시술을 통해 척추와 미추 사이인 천추 부위에 이식되어 있으며, 전극(330)에는 신호 발생부(322)가 연결되어 있으며,신호 발생부(322)에는 박동성 고주파신호 발생 제어부(321)가 연결되어 있다.In this case, the active biograft catheter 300 is implanted in the sacral region between the spine and the lumbar spine through the procedure, and the signal generator 322 is connected to the electrode 330 and the signal generator 322. Pulsating high frequency signal generation control unit 321 is connected.
위에서 기재한 바와 같이 입력부(211)릍 통해 박동성고주파 신호, 박동성고주파 신호의 듀레이션, 치료시간, 체내 전극 위치, 동기화 모드 선택 유,무 가 설정되면, 입력부(211)는 제어부(212)로 박동성고주파 신호 발생정보를 출력하고, 제어부(212)는 박동성고주파 신호 발생정보를 기반하여 박동성고주파 생성 제어신호를 박동성고주파 정보 무선신호 발생부(213)로 출력하여, 박동성고주파 정보 무선신호 발생부(213)로 하여금 박동성고주파 신호 정보를 무선으로 발생시키도록 한다. 이렇게 생성된 신호는 데이터 무선 송신부(215)로 입력되어 무선신호로 변환된 후 안테나(214)를 통해 환자 몸속에 이식되어 있는 능동형 생체이식형 카테타(300)로 송출된다.As described above, when the duration of the pulsating high frequency signal, the pulsating high frequency signal, the treatment time, the position of the electrode in the body, and whether the synchronization mode is selected or not are set through the input unit 211, the input unit 211 is the pulsatile high frequency to the control unit 212. Output the signal generation information, and the control unit 212 outputs the pulsatile high frequency generation control signal to the pulsatile high frequency information radio signal generator 213 based on the pulsatile high frequency signal generation information, the pulsatile high frequency information radio signal generator 213 Allow wirelessly generating pulsatile high frequency signal information. The generated signal is input to the data wireless transmitter 215, converted into a wireless signal, and then transmitted to the active biograft catheter 300 implanted in the patient's body through the antenna 214.
이때 제어부(212)는 박동성 고주파 생성 제어신호에 기반하여 전력생성 제어신호를 생성시켜 전력공급부(220)로 출력한다. 그러면 전력공급부(220)는 전력생성 제어신호에 응하여 박동성 고주파신호를 발생시키기 위한 구동전력을 생성시킨 후 무선전력 송신부(223) 및 안테나(224)를 통해 능동형 생체이식형 카테타(300)로 송출한다.At this time, the controller 212 generates a power generation control signal based on the pulsating high frequency generation control signal and outputs it to the power supply unit 220. Then, the power supply unit 220 generates driving power for generating a pulsatile high frequency signal in response to the power generation control signal, and transmits the generated power to the active biograft catheter 300 through the wireless power transmitter 223 and the antenna 224. .
그러면 능동형 생체이식형 카테타(300)는 전력수급부(310)의 구동전력 수신용 안테나(311)를 통해 구동전력을 수신받아 전원저장부(312)에 저장시킨다. 이렇게 전원저장부(312)에 저장된 구동전력은 박동성 고주파신호 발생부(320)의 박동성 고주파신호 발생제어부(321)로 공급되어, 박동성 고주파신호 발생제어부(321)로 하여금 무선신호를 수신하는 수신 안테나(323)를 통해 무선신호를 수신받아 신호 발생부(322)가 박동성 고주파 신호를 발생시켜 의료진이 지정한 체내전극 위치의 전극(330)으로 공급하고, 전극(330)이 박동성 고주파 신호를 인가받아 환자 몸속 해당 부위에 전기적 자극을 인가시켜 통증을 완화시키거나, 신경 이상을 조절하는 치료가 이루어지도록 한다.Then, the active biograft catheter 300 receives the driving power through the driving power receiving antenna 311 of the power supply unit 310 and stores the driving power in the power storage unit 312. The driving power stored in the power storage unit 312 is supplied to the pulsatile high frequency signal generation controller 321 of the pulsatile high frequency signal generator 320 so that the pulsatile high frequency signal generation controller 321 receives the radio signal. Receiving a radio signal through the 323, the signal generator 322 generates a pulsatile high frequency signal and supplies it to the electrode 330 of the internal electrode position specified by the medical staff, the electrode 330 is applied to the pulsatile high frequency signal patient Electrical stimulation is applied to the affected area in the body to relieve pain or to control nerve abnormalities.
한편, 본 발명의 박동성 고주파신호정보 발생제어장치(200)는 블루투스 모듈로 이루어진 무선통신부(217)를 구비하고 있으므로, 의사 또는 치료자가 블루투스 모듈이 내장되어 있는 단말기 등을 이용하여 박동성 고주파신호정보 발생제어장치(200)의 작동상태를 원격으로 제어하거나, 또는 환자상태 정보 및 박동성 고주파신호를 발생시키기 위한 복수의 설정행위를 원격으로 수행할 수 있도록 지원하고 있다.On the other hand, the pulsatile high frequency signal information generation control device 200 of the present invention includes a wireless communication unit 217 made of a Bluetooth module, so that the doctor or therapist generates pulsatile high frequency signal information using a terminal in which the Bluetooth module is embedded. Remote control of the operating state of the control device 200, or to perform a plurality of setting actions for generating the patient state information and the pulsatile high frequency signal remotely.
도 2는 배뇨시 요도 통증을 호소하는 환자에 대해서 본 발명인 능동형 카테타를 이식하고, 체외 박동성 고주파 자극장치를 통해 처음에는 "600sec 55V, 5Hz/5ms, 300Ω, 200mA done" 조건(도 2의 (a) 참조)을 가지도록 박동성 고주파 신호를 환자의 척추와 미추 사이인 천추부에 삽입된 전극으로 인가시키는 치료를 3~4일 지속적으로 한 경우로서 배뇨통증이 40% 호전되어, 비교적 편안하게 소변을 볼 수 있는 상태로 치료되었으며, 한달 후 체외 박동성 고주파 자극장치를 통해 "Pulsed RF 600sec 55V, 5Hz/5ms, 300Ω, 200mA done" 조건(도 2의 (b) 참조)을 가지도록 박동성 고주파 신호를 전극으로 인가시켜 해당 부위에 전기적 자극이 이루어지도록 하여 통증을 치료하여, 통증이 호전되었다.Figure 2 implants the active catheter of the present invention for patients complaining urethral pain during urination, and initially "600sec 55V, 5Hz / 5ms, 300Ω, 200mA done" conditions through the in vitro pulsatile high frequency stimulator (Fig. 2 (a Pulmonary radiofrequency signals were applied to the electrodes inserted into the sacral region between the spine and the vertebrae of the patient for 3 to 4 days. After one month of treatment, the pulsatile high frequency signal was passed through the in vitro pulsatile high frequency stimulator to have a "Pulsed RF 600sec 55V, 5Hz / 5ms, 300Ω, 200mA done" condition (see FIG. 2 (b)). When applied to the electrical stimulation is made to the area to treat the pain, the pain was improved.
도 3은 항문 주위 통증 및 등에서 열이 난다고 호소하는 환자로서, MRI 사진(도 3의 (a) 참조)과 본 발명을 시술한 사진(도 3의 (b) 참조)으로서, 딱딱한 곳에 앉으면 통증을 호소하는 환자이다. 이 환자의 겨우 3m 높이에서 떨어진 이후 꼬리뼈가 부러져 치료를 받았던 환자의 경우로서, 환자에게 본 발명인 능동형 카테타를 이식하고, 체외 박동성 고주파 자극장치를 통해 "Pulsed RF 600sec 55V, 5Hz/5ms, 360Ω, 150mA done"의 조건을 가지는 박동성 고주파 신호를 척추 및 미추 사이에 이식된 제 2 전극으로 송출시켜 박동성 고주파 신호를 이용하여 해당 부위에 전기적 자극을 30분동안 가해준 후 등의 열감이 30%이상 호전되고 그 이후 100%로 호전되었으며, 꼬리뼈쪽의 통증은 박동성 고주파 신호를 이용하여 치료한 후 5일 정도 더 아픈 후 40~50% 정도 호전되었다. 이러한 박동성 고주파 신호를 이용하여 한달 정도 치료한 후 꼬리뼈쪽 통증은 처음에 비해 70% 호전되었으며, 등에 열나는 느낌은 거의 없고, 좌측 팔쪽으로만 약간 남아 있는 것으로 확인되었다.Figure 3 is a patient complaining of fever in the pain and back around the anus, MRI (see Fig. 3 (a)) and a picture of the present invention (see Fig. 3 (b)), the pain when sitting in a hard place The patient is appealing. In the case of the patient who was treated by breaking the tailbone after falling only 3m from the patient, the patient was implanted with the active catheter of the present invention, and the pulsed RF 600sec 55V, 5Hz / 5ms, 360Ω, 150mA After transmitting the pulsatile radio frequency signal having the condition of “done” to the second electrode implanted between the spine and the vertebrae and applying electric stimulation to the corresponding area for 30 minutes using the pulsatile radio frequency signal, the heat sensitivity of the back is improved by 30% or more. After that, it improved to 100%, and the pain in the tailbone was improved by 40-50% after 5 days more pain after treatment using pulsatile radiofrequency signals. After one month of treatment using these pulsatile radiofrequency signals, the pain in the tailbone was 70% better than in the first place.
도 4는 양팔 전체가 빠질 듯 우리하고, 밤으로 쑤시는 통증을 호소하고, 통증으로 잠들기 힘들며, 왼팔 및 왼손에 힘이 떨어지고 살이 빠지고 손가락을 펴기 힘들며, 왼다리에 힘이 없어 절뚝거리며 걷는 루게릭병(근위축성 측색 경화증) 환자에게 본 발명인 능동형 카테타를 이식하고, 체외 박동성 고주파 자극장치를 통해 "Pulsed RF 600sec 55V, 5Hz/5ms, 182ohm, 304mA done" 조건을 가지는 박동성 고주파 신호를 이용하여 해당 부위에 전기적 자극을 주는 치료를 수행한 후 통증이 제거되어 편안한 상태로 되었고, 왼팔 통증의 경우 70%에서 85%로 호전되었으며, 0.5kg의 아령 운동이 가능하게 되었으며, Biceps 증가하고 더 이상 살 빠지지 않았으며, 왼쪽손으로 종이집기가 가능해졌으며, 걷는데도 어둔한 느낌 줄어들었으며, 한꺼번에 4~5km까지 걸을 수 있도록 호전되었다.Figure 4 shows that the whole arm is missing, we complain of pain at night, it is hard to fall asleep, pain in the left arm and left hand, lose weight, hard to stretch fingers, limp walking in limp because there is no strength in the left leg (Atrophic lateral sclerosis) The patient is implanted with the active catheter of the present invention, and the pulsatile high frequency signal having the condition "Pulsed RF 600sec 55V, 5Hz / 5ms, 182ohm, 304mA done" through an in vitro pulsatile radiofrequency stimulator is applied to the site. After the electrical stimulation treatment, the pain was eliminated and relaxed, the left arm pain improved from 70% to 85%, 0.5kg of dumbbell exercise was possible, Biceps increased, and no longer lost weight. It is possible to grab paper with the left hand, reduce the dim feeling when walking, and improve to walk 4 ~ 5km at a time.
도 5 내지 도 7은 신경병증성 통증으로 지속적인 재활 치료를 위해 입원한 상태의 환자로서, 손발이 터쳐나가는 듯한 통증 및 등에 불이 나고 있는 정도의 뜨거운 느낌의 통증을 호소하는 환자에게 본 발명인 능동형 카테타를 이식하고, 체외 박동성 고주파 자극장치를 통해 1차 "Pulsed RF mode : 600sec, 55V, 5Hz/20ms, 42℃, 320Ω" 조건(도 5의 (a) 참조)을 가지는 박동성 고주파 신호를 이용하여 해당 부위에 전기적 자극을 주는 치료를 수행한 후 도 6의 (a)에 도시된 바와 같이 치료 후 손발 및 등 통증의 경우 시술 다음날 떨어졌으며, 그 이후 약간의 등락은 있으나 시술전보다 떨어진 것으로 나타났으며 도 7에 도시된 바와 같이 침대의 기울기와 휠체어의 등받이 각도를 변경시켜도 될 정도로 통증이 완화되었으며, 또한 2차 "Pulsed RF mode : 600sec, 55V, 5Hz/5ms, 37℃, 445Ω, 130mA" 조건(도 5의 (b) 참조)을 가지는 박동성 고주파 신호를 이영하여 해당 부위에 전기적 자극을 주는 치료를 수행한 후 도 6의 (b)에 도시된 바와 같이 치료 후 손발 및 등 통증이 더 떨어진 것으로 나타났다.5 to 7 is a patient in a state of hospitalization for continuous rehabilitation treatment with neuropathic pain, the active catheter of the present invention to the patient complains of pain such as popping of the hands and feet and the pain of hot feeling such as the back lit Using a pulsatile high frequency signal having a primary "Pulsed RF mode: 600sec, 55V, 5Hz / 20ms, 42 ℃, 320Ω" condition (see Fig. 5 (a)) through an in vitro pulsatile high frequency stimulator After performing the treatment to give electrical stimulation to the site as shown in Fig. 6 (a), the hand and foot and back pain after treatment fell the day after the procedure, after which there was a slight fluctuation, but appeared to be lower than before the procedure. As shown in Fig. 7, the pain was relieved enough to change the inclination of the bed and the angle of the backrest of the wheelchair, and the second "Pulsed RF mode: 600sec, 55V, 5Hz / 5ms, 37 ℃, 445Ω, 1 After pulsating high frequency signal having a 30 mA "condition (see FIG. 5 (b)) to perform electrical stimulation treatment on the corresponding site, the limbs and back pain after treatment as shown in FIG. Appeared to fall further.
도 8은 지릿지릿하고 발바닥이 자갈을 밟는 듯한 통증을 호소하는 환자에게 본 발명인 능동형 카테타를 이식하고, 체외 박동성 고주파 자극장치를 통해 박동성 고주파 신호를 이용하여 해당 부위에 전기적 자극을 주는 치료를 수행하도록 하고, 이러한 치료 후 환자 양 발의 지릿지릿한 통증을 50% 감소시킬 수 있었으며, 두 발의 자갈 밟는 느낌은 있으나 이전보다 통증의 규모가 작아진 상태인 것으로 나타났다.Figure 8 implants the active catheter of the present invention to a patient who complains of sloppy and soles of stepping on gravel, and performs treatment to give electrical stimulation to the corresponding site by using an pulsatile radiofrequency signal through an in vitro pulsatile radiofrequency stimulator. After this treatment, it was possible to reduce the gritty pain of the patients' feet by 50%, and there was a feeling of stepping on the gravel of the two feet, but the pain was smaller than before.
전술한 내용은 본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자라면 본 발명의 본질적인 특성에서 벗어나지 않는 범위에서 수정 및 변형이 가능할 것이다. 따라서, 본 발명에 개시된 실시예들은 본 발명의 기술 사상을 한정하기 위한 것이 아니라 설명하기 위한 것이고, 이러한 실시예에 의하여 본 발명의 기술 사상의 범위가 한정되는 것은 아니다. 본 발명의 보호 범위는 아래의 청구범위에 의하여 해석되어야 하며, 그와 동등한 범위 내에 있는 모든 기술 사상은 본 발명의 권리범위에 포함되는 것으로 해석되어야 할 것이다.The foregoing description will be apparent to those skilled in the art that modifications and variations may be made without departing from the essential features of the present invention. Therefore, the embodiments disclosed in the present invention are not intended to limit the technical idea of the present invention but to describe the present invention, and the scope of the technical idea of the present invention is not limited by these embodiments. The protection scope of the present invention should be interpreted by the following claims, and all technical ideas within the equivalent scope should be interpreted as being included in the scope of the present invention.

Claims (12)

  1. 환자 상태에 따라 입력되는 박동성 고주파 생성요청신호에 응하여 박동성 고주파 신호 정보 및 구동전력을 각각 발생시켜 무선신호로 변환시킨 후 송출하는 박동성 고주파신호정보 발생제어장치; 및A pulsatile high frequency signal information generating and controlling device for generating pulsatile high frequency signal information and driving power, respectively, and transmitting the generated pulsatile high frequency signal information and driving power in response to a patient state input signal; And
    환자의 몸속에 이식되어 구비되며, 상기 구동전력을 수신받아 박동성 고주파 신호 발생용 구동전원으로 이용하고, 상기 고주파 신호를 수신하여 박동성 고주파 신호로 변환시켜 해당 부위에 전기적 자극이 인가되도록 하는 능동형 생체이식형 카테타;It is implanted in the patient's body, and receives the driving power, and uses it as a driving power source for generating a pulsating high frequency signal, and receives the high frequency signal and converts the pulsating high frequency signal into an active biological implant to apply an electrical stimulus to a corresponding site. Type catheters;
    를 포함하는 능동형 체외 박동성 고주파 자극장치.Active extracorporeal pulsatile high frequency stimulator comprising a.
  2. 제 1 항에 있어서,The method of claim 1,
    상기 박동성 고주파신호정보 발생제어장치가,The pulsatile high frequency signal information generation control device,
    환자 상태에 따라 입력되는 박동성 고주파 정보 생성요청신호에 응하여 무선데이터를 발생시켜 무선형태로 변환시킨 후 송출하는 박동성고주파 신호정보 발생부; 및 A pulsatile high frequency signal information generation unit for generating radio data in response to the pulsatile high frequency information generation request signal input according to a patient state and converting the radio data into a radio form and transmitting the radio data; And
    상기 박동성고주파 신호정보 발생부에 의해 생성된 박동성 고주파 정보에 기반하여 전력을 생성시키고, 생성된 전력을 무선형태로 변환시켜 송출하는 전력공급부로 이루어진 것을 특징으로 하는 능동형 카테타용 체외 박동성 고주파 자극장치.An extracorporeal pulsatile high frequency stimulation apparatus for an active catheter, comprising: a power supply unit generating power based on pulsatile high frequency information generated by the pulsatile high frequency signal information generating unit, and converting the generated power into a wireless form.
  3. 제 2 항에 있어서, The method of claim 2,
    상기 박동성 고주파신호정보 발생부가, The pulsatile high frequency signal information generation unit,
    환자의 상태에 따라 서로 다른 박동성 고주파 신호를 발생시키도록 박동성고주파 신호 발생 메뉴항목을 제공하고, 상기 박동성고주파 발생 메뉴항목에 의해 박동성고주파 신호 발생정보가 생성되면, 이를 출력하는 입력부와,An input unit for providing a pulsatile high frequency signal generation menu item to generate different pulsatile high frequency signals according to the state of the patient, and outputting pulsatile high frequency signal generation information by the pulsatile high frequency generation menu item;
    상기 입력부의 박동성고주파 신호 발생정보에 응하여 박동성고주파 생성 제어신호를 출력하고, 상기 박동성고주파 생성 제어신호에 기반하여 전력생성 제어신호를 상기 전력공급부로 출력하는 제어부와, A control unit which outputs a pulsating high frequency generation control signal in response to the pulsating high frequency signal generation information of the input unit, and outputs a power generation control signal to the power supply unit based on the pulsating high frequency generation control signal;
    상기 박동성고주파 생성 제어신호에 응하여 박동성고주파 신호 정보를 발생시키는 박동성 고주파 정보 무선신호 발생부와,A pulsatile high frequency information radio signal generator for generating pulsatile high frequency signal information in response to the pulsatile high frequency generation control signal;
    상기 박동성 고주파 정보 무선신호를 무선형태로 변환시켜 안테나를 통해 송출하는 데이터 무선 송신부로 이루어진 것을 특징으로 하는 능동형 카테타용 체외 박동성 고주파 자극장치.An extracorporeal pulsatile high frequency stimulation apparatus for an active catheter, characterized by comprising a data radio transmitter for converting the pulsatile high frequency information radio signal into a radio form and transmitting it through an antenna.
  4. 제 1 항에 있어서,The method of claim 1,
    상기 능동형 생체이식용 카테타가, The active biograft catheter,
    출력단의 전압 및 전류를 검출하여 피드백시키는 전압/전류 검출부와, A voltage / current detector for detecting and feeding back the voltage and current at the output stage;
    상기 전압/전류 검출부로부터 출력단의 전압 및 전류를 피드백받고, 제어부의 전력생성 제어신호를 입력받아 피드백된 전류 및 전압, 그리고 전력생성 제어신호를 기반으로 구동전력을 출력하는 전력송신 제어부와, A power transmission controller which receives the voltage and current of the output terminal from the voltage / current detector, receives the power generation control signal of the controller, and outputs driving power based on the fed back current and voltage and the power generation control signal;
    상기 구동전력을 무선방식으로 송출하는 무선 전력 송신부,A wireless power transmitter for transmitting the driving power in a wireless manner;
    로 이루어진 것을 특징으로 하는 능동형 카테타용 체외 박동성 고주파 자극장치.Extracorporeal pulsatile high frequency stimulator for active catheter, characterized in that consisting of.
  5. 제 1 항에 있어서,The method of claim 1,
    2개의 능동형 생체이식용 카테타를 체내에 삽입하여 원하는 척수 신경구간을 자극하기 위해 2개의 능동형 생체이식용 카테타의 자극 동기화를 위하여 2개의 박동성 고주파 신호 정보 발생장치를 동기화 모드로 서비스하는 것을 특징으로 하는 능동형 카테타용 체외 박동성 고주파 자극장치.An active catheter comprising two active biotransplant catheters in the body to service two pulsatile high frequency signal information generators in synchronization mode for stimulation synchronization of two active biotransplant catheters to stimulate desired spinal cord nerve segments. Extracorporeal pulsating high frequency stimulation device.
  6. 제 1 항에 있어서,The method of claim 1,
    이식형 장치내의 전극은 단일 전극 혹은 복수 개의 전극으로 구성되어 있어 전기 자극 지점을 외부에서 사용자가 조정하는 것을 특징으로 하는 능동형 카테타용 체외 박동성 고주파 자극장치.The electrode in the implantable device is composed of a single electrode or a plurality of electrodes, the external pulsatile high frequency stimulation device for an active catheter, characterized in that the user adjusts the electrical stimulation point from the outside.
  7. 제 3 항에 있어서,The method of claim 3, wherein
    상기 입력부가, 통증 치료나 신경 이상의 조절 치료에 필요한 주파수를 선정 시, 주파수의 듀레이션(duration) 및 치료시간을 선정할 수 있도록 서비스하는 것을 특징으로 하는 능동형 카테타용 체외 박동성 고주파 자극장치.Wherein the input unit, when selecting a frequency required for pain treatment or neurological control treatment, the frequency and duration (duration) of the active catheter for extracorporeal pulsatile high frequency stimulation apparatus, characterized in that the service.
  8. 제 3 항에 있어서, The method of claim 3, wherein
    상기 제어부가, 입력부를 통해 복수의 환자상태정보를 제공하고, 환자상태정보 중 하나의 환자상태정보가 선택되면 해당 치료용 주파수, 듀레이션, 치료시간, 동기화 모드, 체내전극위치를 선정할 수 있도록 서비스하는 인터페이스 화면이 제공되도록 하는 능동형 카테타용 체외 박동성 고주파 자극장치.The control unit provides a plurality of patient status information through an input unit, and if one of the patient status information is selected, the service frequency, duration, treatment time, synchronization mode, service to select the body electrode location Extracorporeal pulsatile high frequency stimulator for active catheter to provide an interface screen.
  9. 제 1 항에 있어서,The method of claim 1,
    상기 박동성 고주파신호정보 발생제어장치가,The pulsatile high frequency signal information generation control device,
    복수의 환자상태정보 및 복수의 환자상태정보에 듀레이션 및 치료시간정보들을 링크시켜 저장하고 있는 저장부를 더 포함하고 있으며, It further comprises a storage unit for storing the duration and treatment time information linked to the plurality of patient status information and a plurality of patient status information,
    상기 제어부가, 상기 저장부에 저장된 정보들을 읽어들여 상기 입력부를 통해 제공되도록 하는 것을 특징으로 하는 능동형 카테타용 체외 박동성 고주파 자극장치.And an external pulsatile high frequency stimulation apparatus for an active catheter, wherein the controller reads the information stored in the storage unit and provides the information through the input unit.
  10. 제 3 항에 있어서,The method of claim 3, wherein
    상기 입력부가 터치스크린 형태로 제공되는 것을 특징으로 하는 능동형 카테타용 체외 박동성 고주파 자극장치.In vitro pulsatile high frequency stimulation device for an active catheter, characterized in that the input unit is provided in the form of a touch screen.
  11. 제 1 항에 있어서,The method of claim 1,
    상기 박동성 고주파신호정보 발생제어장치가,The pulsatile high frequency signal information generation control device,
    외부기기로부터 송출되는 환자 상태에 따라 입력되는 박동성 고주파 생성요청신호를 수신하여, 상기 제어부로 출력하는 무선통신부를 더 포함하는 것을 특징으로 하는 능동형 카테타용 체외 박동성 고주파 자극장치. An extracorporeal pulsatile high frequency stimulation apparatus for an active catheter, further comprising a wireless communication unit for receiving the pulsatile high frequency generation request signal input according to a patient state transmitted from an external device and outputting the signal to the controller.
  12. 제 11 항에 있어서,The method of claim 11,
    상기 무선통신부는 블루투스 통신모듈, WIFI 모듈 , 지그비 통신모듈 중 하나인 것을 특징으로 하는 능동형 카테타용 체외 박동성 고주파 자극장치. The wireless communication unit in vitro pulsatile high frequency stimulation apparatus for an active catheter, characterized in that one of the Bluetooth communication module, WIFI module, Zigbee communication module.
PCT/KR2015/001113 2014-12-31 2015-02-03 Active bio-implanted pulsatile high-frequency stimulator for catheter for stimulating transsacral epidural spinal nerve WO2016108332A1 (en)

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