Methods of determining collagen degradation in vivo, by quantitating the concentration of a peptide in a body fluid, the peptide having the following structure: ##STR1## is hydroxylysyl pyridinoline or lysyl pyridinoline, and J is pyroglutamic acid or glutamine and (Leu) are optional leucines, are d...http://www.google.de/patents/US5320970?utm_source=gb-gplus-sharePatent US5320970 - Detection of collagen degradation in vivo