A single- or double-stranded deoxyribonucleic acid (DNA) is fragmented and labeled by chemically fragmenting the DNA by creating at least one abasic site on the DNA, and attaching a marker to at least one of the fragments by means of a labeling reagent, the reagent covalently and predominantly coupling...http://www.google.de/patents/US7060441?utm_source=gb-gplus-sharePatent US7060441 - Method for fragmenting and labeling DNA involving abasic sites and phosphate labeling
