Different probes each having a specific base sequence are immobilized to each of independent areas formed on the surface of a substrate, complementary polynucleotides in a sample solution are hybridized to the probes, and each of the independent areas on the substrate is heated and then cooled in sequence,...http://www.google.de/patents/US6218126?utm_source=gb-gplus-sharePatent US6218126 - Polynucleotide separation method and apparatus therefor
