The present invention retates to a substantially planar substrate for use in patch clamp analysis of the electrophysiological properties of a cell membrane comprising a glycocalyx, wherein the substrate comprises an aperture having a rim, the rim being adapted to form a gigaseal upon contact with the...http://www.google.de/patents/US20040005696?utm_source=gb-gplus-sharePatent US20040005696 - Substrate and method for measuring the electro-physiological properties of cell membranes