A system and method may determine the orientation of an in-vivo imaging device relative to the earth's gravitation field. Some embodiments may enable indication of specific locations where other methods provide non-satisfactory imaging coverage. The system may include an in-vivo imaging system with a...http://www.google.de/patents/US7604589?utm_source=gb-gplus-sharePatent US7604589 - Device, system and method for determining orientation of in-vivo devices