Two proteins that are found in bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-.beta. assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. Each...http://www.google.de/patents/US4774322?utm_source=gb-gplus-sharePatent US4774322 - Polypeptide cartilage-inducing factors found in bone