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Page 15

Wisniewski et al., "Alzheimer's disease and soluble A beta,"
Neurobiol. Aging, 15(2):143-52 (1994).

Wisniewski et al., "Therapeutics in Alzheimer's and Prion Diseases,"
Biochemical Society Transactions, 30(4):574-587 (2002).
Whitcomb et al., "Characterization of saturable binding sites for
circulating pancreatic polypeptide in rat brain," Am J Pysiol
Gastrointest Liver Physiol, 259:G687-G691 (1990).
Wong et al., "Neuritic Plaques and Cerebrovascular Amyloid in
Alzheimer Disease are Antigenically Related,"PNAS, 82:8729-8732
(1985).

Wood et al., "Amyloid precursor protein processing and A|342 deposition in a transgenic mouse model of Alzheimer disease," PNAS, 94: 1550-1555 (1997).

Wood et al., "Prolines and amyloidogenicily in fragments of the
Alzheimer's peptide $iM" Biochemistry, 34:724-730 (1995).
Wu et al., "Expression of immunogenic epitopes of hepatitis B sur-
face antigen with hybrid fiagellin proteins by a vaccine strain of
Salmonella;'PNAS, 86:4726-4730 (1989).

Wu, et al., "Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor," J. Clin. Invest., 100:1804-1812(1997). Wyeth, Annual Review 2005: Creating Value . . . Advancing Health (Feb. 27, 2006).

Xiang et al., "Manipulation of the immune response to a plasmid

encoded viral antigen by coinoculation with plasmids expressing

cytokines," Immunity, 2(2): 129-135 Abstract (1995).

Xu et al., "Increased incidence of anti-|3-amyloid autoantibodies

secreted by Epstein-Barr virus transformed B cell lines from patients

with Alzheimer's disease," Mechanisms of Ageing and Development,

94:213-222(1997).

Yamaguchi et al., Diffuse plaques associated with astroglial amyloid |3 protein, possibly showing a disappearing stage of senile plaques, Acta Neuropathol, 95:217-222 (1998).

Yang et al., "Effects of Racemization on the Aggregational Properties of the Amyloid |3-Peptide in Alzheimer's Disease," abstract # 255 from American Chemical Society 214th National Meeting (1997). Yankner et al., "Neurotrophic and Neurotoxic effects of Amyloid |3 Protein: Reversal by Tachykinin Neuropeptides," Science, 250:279282 (1990).

Younkin, "Amyloid |3 vaccination: reduced plaques and improved cognition," Nature Medicine, 7:18-19 (2001). Zlokovic et al., "Clearance of amyloid |3-peptide from brain: transport or metabolism?," Nature Medicine, 6(7):718-719 (2000).

* cited by examiner

[merged small][merged small][merged small][merged small][merged small][merged small][table][merged small][merged small][merged small][merged small][merged small]

3d6vl.aa hum3d6VLvl.aa KABID 019230 A19.prot

[table]

65

—i—

75

—i—
85

[blocks in formation]

YYCWQGTHFPRT

Y Y CWQGTHFP R T

Y Y C

F G[_GJG T K|_LJE I K PGQGTKVEIK M|Q|A L Q TIP RTFGQGTKVEIK

Y Y CI M|_0J A L Q T IP.

106A 106A 106A 95

55 55 55 55

[table]

'Decoration #1': Box residues that match hum3D6VLvl.aa exactly. Residue numbering cf Kabat 3d6vl.aa - Donor murine sequence hum3d6VLvl.aa - humanized 3d6

KABID 019230 - human acceptor framework A19.prot - human germline VH

[blocks in formation]

-i 1 1 i r

10 20 30 ^ ► 40 *

■ ■ I i i

[table][merged small][merged small][merged small][merged small][merged small][table][merged small][merged small][merged small][merged small][merged small][merged small][merged small][merged small][merged small][merged small]

'Decoration #1': Box residues that match hum3d6VHvl.aa exactly. Residue Numbering cf Kabat

3d6vh.aa - Donor murine sequence hum3d6VHvl.aa - humanized 3d6 VH KABID 045919 - human acceptor framework VH3-23.prot - human germline VH

[graphic][merged small][merged small][graphic][merged small]
[merged small][graphic]
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