Maternal-fetal monitoring system

US007333850B2

(12) United States Patent

Marossero et al.

(io) Patent No.: (45) Date of Patent:

US 7,333,850 B2 Feb. 19, 2008

(54) MATERNAL-FETAL MONITORING SYSTEM

(75) Inventors: Dorothee Marossero, Gainesville, FL (US); Tammy Y. Euliano, Gainesville, FL (US); Neil Russell Euliano, II, Gainesville, FL (US); Jose C. Principe,

Gainesville, FL (US)

(73) Assignees: University of Florida Research

Foundation, Inc., Gainesville, FL (US);
Convergent Engineering, Inc.,

Gainesville, FL (US)

( * ) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 U.S.C. 154(b) by 305 days.

(21) Appl. No.: 10/857,107

(22) Filed: May 28, 2004

(65) Prior Publication Data

US 2005/0267376 Al Dec. 1, 2005

(51) Int. CI.

A61B 5/0444 (2006.01)

(52) U.S. CI 600/511

(58) Field of Classification Search 600/511,

600/376, 304 See application file for complete search history.

A maternal-fetal monitoring system for use during all stages of pregnancy, including antepartum and intrapartum stages. The maternal-fetal monitoring system of the subject invention comprises (1) a set of sensors; (2) an amplifying/ filtering means; (3) a computing means; and (4) a graphical user interface. Accurate clinical data, which can be extracted and provided to the user in real-time using the system of the invention, include without limitation, maternal electrocardiogram (ECG) signals, maternal uterine activity signals (EHG), maternal heart rate, fetal ECG signals, and fetal heart rate. In a preferred embodiment, the maternal-fetal monitoring system of the invention includes an intelligence means, such as a neural network system, to analyze and interpret clinical data for use in clinical diagnosis antepartum, intrapartum and postpartum, as well as delivery strategy

22 Claims, 23 Drawing Sheets

Marque, C. et al. "Uterine EHG Processing for Obstetrical Monitoring" IEEE Trans. Biomed. Eng., pp. 1182-1186, Dec. 1986, vol. BME-33, No. 12.

Callaerts D., Moor B., Vandewalle J., Sansen W., "Comparison of SVD Methods to Extract the Foetal Electrocardiogram From Cutanteous Electrode Signals," Med Biol Eng Comp, 1990, 28:217224.

Callaerts D., Sansen W., Vandewalle J., Vantrappen G., Janssens J., "Description of a Real-time System to Extract the Fetal Electrocardiogram," Clin Phys Physiol Meas., 1989, 10 Suppl B:7-10. (Abstract Only).

Ferrara E.R., Widrow B., "Fetal Electrocardiogram Enhancement by Time-Sequenced Adaptive Filtering," IEEE Trans Biomed Eng, 1982, 29:458-60.

"Home Uterine Activity Monitoring for Preterm Labor," JAMA, 1993, 270(3):369-376. CORRECTED.

Kanjilal P.P., Palit S., Saha G., "Fetal ECG Extraction From
Single-Channel Maternal ECG Using Singular Value Decomposi-
tion," IEEE Trans Biomed Eng, 1997, 44:51-59.
Leman H., Marque C, Gondry J., "Use of the Electrohysterogram
Signal for Characterization of Contractions During Pregnancy,"
IEEE Trans Biomed Eng, 1999, 46(10): 1222-9.
Marossero D., Erdogmus D., Euliano N., Principe J., Hild K.,
"Independent Components Analysis for Fetal Electrocardiogram
Extraction: A Case for the Data Efficient Mermaid Algorithm,"
Proceedings ofNNSP (Sep. 2003), pp. 399-408, Toulouse, France.
Never Published.

Van Alste J.A., Schilder T.S., "Removal of Base-Line Wander and
Power-Line Interference From the ECG by an Efficient FIR Filter
With a Reduced Number of Taps," IEEE Trans Biomed Eng, 1985,
32(12):1052-1060.

Verdenik I., Pajntar M., Leskosek B., "Uterine Electrical Activity as
Predictor of Preterm Birth in Women With Preterm Contractions,"
Eur J Obstet Gynecol Reprod Biol., 2001, 95:149-153.
Zarzoso V, Nandi A.K., "Noninvasive Fetal Electrocardiogram
Extraction: Blind Separation Versus Adaptive Noise Cancellation,"
IEEE Trans Biomed Eng, 2001, 48:12-18.