[54] SYSTEM AND METHOD FOR MAPPING
THE DISTRIBUTION OF NORMAL AND
ABNORMAL CELLS IN SECTIONS OF
TISSUE
[75] Inventors: David S. Zakim, Armonk; Luis
Chiriboga, Carmel; Max Diem,
Croton-On-Hutson, all ol N.Y.; Ping
Xie, Morris Plains, N.J.
[73] Assignee: InPhoCyte, Inc.
[21] Appl. No.: 782,424
[22] Filed: Jan. 14, 1997
[51] Int. CI.6 G06K 9/00; G01N 33/48;
G01N 33/574
[52] U.S. CI 435/4; 436/63; 436/64;
435/7.23; 382/128; 382/133; 382/165; 382/170;
382/194
[58] Field of Search 435/1, 4, 7.23;
356/300; 436/63, 64; 382/128, 133, 165,
170, 194
[56] References Cited
U.S. PATENT DOCUMENTS
5,072,382 12/1991 Kamentsky 364/413.08
FOREIGN PATENT DOCUMENTS
A system and method is described for permitting the simultaneous automated collection ol data with regard to the presence ol diseased cells, in particular neo-plastic, dysplastic or cancerous cells, or normal cells at a given site in a section ol tissue. This is accomplished according to the following steps. First, IR spectral data are collected simultaneously for each cell or pixel ol the tissue. Next, these data are analyzed by identilying the cell types encountered in the sample by comparing them with relerence data sets for healthy and diseased cells. Finally, a lalse color mapping ol the distribution ol different types ol cells in the tissue section is presented that permits assessment ol the prevalence ol diseased cells.
