Genotyping kit for diagnosis of human papilloma virus infection

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US007301015B2

(12) United States Patent

Yoon et al.

(io) Patent No.: (45) Date of Patent:

US 7,301,015 B2 Nov. 27, 2007

(54) GENOTYPING KIT FOR DIAGNOSIS OF HUMAN PAPILLOMA VIRUS INFECTION

(75) Inventors: Sung-Wook Yoon, Seoul (KR);

Tae-Shin Park, Seoul (KR); Jeong-Mi
Kim, Seoul (KR); Mi-Sun Park, Busan
(KR)

(73) Assignee: Biomedlab Corporation, Seoul (KR)

( * ) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 U.S.C. 154(b) by 160 days.

(21) Appl. No.: 10/489,550

PCT Filed: Sep. 18, 2001

PCT No.: PCT/KR01/01562

(22) (86)

(30)

§ 371 (c)(1), (2), (4) Date:

Aug. 9, 2004

(87) PCT Pub. No.: WO03/027323 PCT Pub. Date: Apr. 3, 2003

(65) Prior Publication Data

US 2004/0265794 Al Dec. 30, 2004

Foreign Application Priority Data

Sep. 14, 2001 (KR) 10-2001-0056827

(51) Int. CI.

C07H 21/04 (2006.01)
C07H 21/02 (2006.01)

(52) U.S. CI 536/23.1; 536/24.3; 435/287.2

Field of Classification Search None

See application file for complete search history.

(58) (56)

References Cited

U.S. PATENT DOCUMENTS 5,447,839 A * 9/1995 Manos et al 435/5

5,484,699 A * 1/1996 Bouma et al 435/5

5,861,242 A 1/1999 Chee et al 435/5

FOREIGN PATENT DOCUMENTS

WO WO

WO 95/22626 WO 99/14377

8/1995 3/1999

OTHER PUBLICATIONS

"The Use of the Polymerase Chain Reaction for the Detection of
Human Papillomavirus Type 13", Williamson et al., Journal of
Virological Methods, 31 1991, pp. 57-66.

"Human Papillomavirus Type 13 Coat Protein Gene (LI), Partial
cds", Database EMBL Online, Jan. 24, 1992, 2 pages.
"Human Papillomavirus Type 13 DNA", Database EMBL Online,
Oct. 23, 1992, 5 pages.

"Genotyping of 27 Human Papillomavirus Types by Using LI
Consensus PCR Products by a Single-Hybridization, Reverse Line
Blot Detection Method", Gravitt et al., Journal of Clinical
Microbiology, vol. 36, No. 10, Oct. 1998, pp. 3020-3027.
"Genotyping of the Human Papillomavirus in Condyloma
Acuminata", Jifeng Liu, et al, Chin J Derm Venereol, Jan. 2001.

* cited by examiner

Primary Examiner—Diana Johannsen
Assistant Examiner—Amanda Shaw

(74) Attorney, Agent, or Firm—Marshall, Gerstein & Borun LLP

The present invention relates to a genotyping kit for diagnosis of detecting the human papillomavirus (HPV) infection, probes for genotyping the HPV, and DNA chips including the probes. Also, the present invention relates to a method for diagnosis of HPV infection.

5 Claims, 33 Drawing Sheets