Copolymers of tyrosine-based polycarbonate and poly(alkylene oxide)

[54] COPOLYMERS OF TYROSINE-BASED

POLYCARBONATE AND POLY(ALKYLENE
OXIDE)

[75] Inventors: Joachim B. Kohn, Highland Park;

Chun Yu, Piscataway, both of N.J.

[73] Assignee: Rutgers, The State University. New Brunswick. N.J.

[21] Appl. No.: 562,842

[22] Filed: Nov. 27,1995

[51] Int CI.6 C08L 69/00; C08L 77/00

[52] U.S. CI 525/432; 525/433; 525/434;

525/354; 525/467; 528/176; 528/196; 528/203;

528/204; 528/272; 528/332; 560/40

[58] Field of Search 528/176. 196.

528/332, 272, 203, 204; 560/40; 525/432, 433, 434. 454, 467

[56] References Cited

U.S. PATENT DOCUMENTS

4,069,151 1/1978 Higley et al 210/321

4,308,145 12/1981 Higley et al 210/646

4,436,839 3/1984 Behnke et al 521/64

4,686,044 8/1987 Behnke et al 210/500.22

5,084,173 1/1992 Nitadorietal 210/321.89

5,099,060 3/1992 Kohn et al 560/40

5,198,507 3/1993 Kohn et al 525/432

5^16,115 6/1993 Kohn et al 528/176

FOREIGN PATENT DOCUMENTS 0046817 3/1982 European Pat. Off. .

wherein R: is —CH=CH— or (—CH2—)j, in which j is zero or an integer from one to eight; R2 is selected from hydrogen, straight and branched alkyl and alkylaryl groups containing up to 18 carbon atoms and derivatives or biologically and pharmaceutically active compounds covalently bonded to said copolymer; each R3 is independently an alkylene group containing up to 4 carbon atoms; y is an integer between about 5 and about 3000; and f is the percent molar fraction of alkylene oxide in the copolymer and ranges between about 1 and about 99 mole percent. Implantable medical devices and drug delivery implants containing the random block copolymers are also disclosed, along with methods for drug delivery and for preventing the formation of adhesions between injured tissues employing the random block copolymers. Polyarylate random block copolymers are also described.

16 Claims, 3 Drawing Sheets