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US006662032B1

(12) United States Patent ao) Patent No.: us 6,662,032 Bi

Gavish et al. (45) Date of Patent: Dec. 9,2003 Page 2

(54) INTERVENTIVE-DIAGNOSTIC DEVICE

(75) Inventors: Benjamin Gavish, Mevaseret Zion (IL); Tamir Massad, Moshav Ben-Shemen (IL); Naphtali Wagner, Jerusalem (IL)

(73) Assignee: Intercure Ltd., Neve-Iian (IL)

( * ) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 U.S.C. 154(b) by 229 days.

(21) Appl. No.: 09/611,304

(22) Filed: Jul. 6, 2000

(30) Foreign Application Priority Data

Jul. 6, 1999 (IL) 130818

(51) Int. C I. A61B 5/00

(52) U.S. CI 600/323; 600/529; 600/300;

600/483

(58) Field of Search 600/323, 324,

600/333, 529, 533, 534, 535, 536, 26-28, 300, 481, 483; 128/905

(56) References Cited

U.S. PATENT DOCUMENTS

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FOREIGN PATENT DOCUMENTS

WO WO 97/26822 7/1997

OTHER PUBLICATIONS

Abstract by B. Gavish, "Repeated Blood Pressure Measurements May Probe Directly an Arterial Property", American Journal of Hypertension, May-Jun. 2000, 13(4), part 2:190A.

D.R. Begault, "Challenges Facing 3-D Audio Display Design for Multimedia", Journal of the Acoustical Society of America, 1999, 105(2):1357.

(List continued on next page.)

Primary Examiner—Eric F. Winakur

(74) Attorney, Agent, or Firm—Ladas & Parry

(57) ABSTRACT

Apparatus for improving health of a user is provided, including a first sensor, adapted to measure a first physiological variable, which is indicative of a voluntary action of the user. A second sensor is adapted to measure a second physiological variable, which is substantially governed by an autonomic nervous system of the user. Circuitry is adapted to receive respective first and second sensor signals from the first and second sensors, and, responsive thereto, to generate an output signal which directs the user to modify a parameter of the voluntary action.

99 Claims, 16 Drawing Sheets

OTHER PUBLICATIONS

E.M. Wenzel et al., "Localization Using Nonindividualized
Head-Related Transfer Functions", Journal of the Acousti-
cal Society of America, Jul. 1993, 94(1), pp. 111-123.
W.H. Cooke et al., "Controlled Breathing Protocols Probe
Human Autonomic Cardiovascular Rhythms", American
Journal of Physiology, 1998, 274:H709-H718.
M.V. Pitzalis et al., "Effect of Respiratory Rate on the
Relationship Between RR Interval and Systolic Blood Pres-
sure Fluctuations: A Frequency-Dependent Phenomenon",
Cardiovascular Research, 1998, 38:332-339.
L. Benardi et al., "Effect of Breathing Rate on Oxygen
Saturation and Exercise Performance in Chronic Heart Fail-
ure", The Lancet, May 2, 1998, 351:1308-1311.
A. Mortara et al., "Abnormal Awake Respiratory Patterns
are Common in Chronic Heart Failure and May Prevent
Evaluation of Autonomic Tone by Measures of Heart Rate
Variability", Circulation, Jul. 1, 1997, 96:246-251.

M.T La Rovere et al., "Barorefiex Sensitivity and Heart-Rate Variability in Prediction of Total Cardiac Mortality after Myocardial Infarction", The Lancet, Feb. 14, 1998, 351:478-484.

P. Gimondo and P. Mirk, "A New Method for Evaluating Small Intestinal Motility Using Duplex Doppler Sonography", AJR American Journal of Roentgenology, Jan. 1997, 168(1): 187-192.

"Photoplefhysmography", 6 pages. (http://www.Iboro.ac.uk/ departments/el/research/optics/ppgraphy/ppgmain.htm.).

M. Busch, "Respiration: What Pilots Need to Know (But Aren't Taught)", AVweb, 1999, 7 pages, (http://www.avweb.com/articles/respirat.htm 1.).

* cited by examiner

[graphic]

Biorhythmic Activity Variables

Benefit Related Variables

LOCAL DEVICE 26

Health Status Variables

FIG. 2

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