Many stars have made appearances on Two and a Half Men

Guest star Morgan Fairchild (left) joins 'Men' star Charlie Sheen during a Season 4 episode.

Charlie (Charlie Sheen), left, tries to set up brother Alan (Jon Cryer) with beautiful neighbor Danielle (Brooke Shields) in a fourth-season episode.

Alan (Jon Cryer), left, hangs out with his mother's new boyfriend Teddy (guest star Robert Wagner) in the fourth-season finale.

Janeane Garofalo (left) guest stars as a new love interest for Alan (Jon Cryer) in a fifth-season episode.

'Men' mother Evelyn (Holland Taylor), left, talks with her 'almost' daughter-in-law (Jenny McCarthy) in a Season 5 episode. McCarthy guest-starred on numerous occasions.

Musical star Eddie Van Halen, left, and star Charlie Sheen talk during the Season 7 premiere episode.

Comedy legend Carl Reiner, right, joins series regular Holland Taylor during a scene in a Season 7 Christmas episode.

Alan (Jon Cryer), center, worries he is being stalked by Lyndsey's ex-husband (guest star and 'Breakfast Club'-ber Judd Nelson), left, in a Season 8 episode. Courtney Thorne-Smith, who plays Lyndsey, is at the right.

Guest star Georgia Engel, left joins 'Men' star Holland Taylor in a Season 9 episode where Lyndsey's and Alan's mothers meet.

Alan (Jon Cryer), left, recovering from a minor heart attack, sees Charlie's ghost (Oscar winner Kathy Bates) in a ninth-season episode. Bates won an Emmy for the role.

'Seinfeld's' Jason Alexander left, plays a cardiologist speaking to heart attack survivor Alan (Jon Cryer) in the series 200th episode in 2012.

Guest stars Ryan Stiles, Patton Oswalt and Willie Garson join star Ashton Kutcher during Season 10.

Ryan Stiles, standing, appears with star Ashton Kutcher in a Season 10 episode, one of 'The Drew Carey Show' alum's numerous guest appearances.

Musical star Miley Cyrus, seen on left with ÔMenÕ star Ashton Kutcher, appeared in two 10th-season episodes, playing the love interest of AlanÕs son, Jake.

Marilu Henner, left, and Hilary Duff play grandmother and granddaughter in a scene with star Ashton Kutcher in a 10th-season episode.

Alan (Jon Cryer), left, talks to Lyndsey's boyfriend (D.B. Sweeney) and Lyndsey (Courtney Thorne-Smith) in a Season 11 episode.

A behind-the-scenes shot captures guest star Jeff Probst in a somewhat compromising position during a Season 11 episode in which the 'Survivor' host played himself

Alan (Jon Cryer) left, dates a woman (guest star Paula Marshall) who tells him that she used to be a man in a Season 11 episode.

Guest star Odette Annable ('House, M.D.'), left, guest stars in a Season 11 episode with star Ashton Kutcher.

'Happy Days' Marion Ross, left, guest starred in a Season 11 episode, appearing here with star Jon Cryer.

Carl Reiner, with hand raised, returns as multi-millionaire Marty Pepper in a guest-star-studded 11th-season bachelor party scene that features Tim Conway, far left, Steve Lawrence, star Jon Cryer, Garry Marshall, second from right, and star Ashton Kutcher (far right).

Star Ashton Kutcher, left, and comedy legend Tim Conway chat behind the scenes during filming of a Season 11 episode.

Guest stars Kimberly Williams-Paisley, left, and Brad Paisley and recurring star Courtney Thorne-Smith, on the sofa, appear in the 11th-season finale with stars Jon Cryer, second from right, and Ashton Kutcher.