US20040131499A1 - Automatic analytical instrument - Google Patents
Automatic analytical instrument Download PDFInfo
- Publication number
- US20040131499A1 US20040131499A1 US10/740,609 US74060903A US2004131499A1 US 20040131499 A1 US20040131499 A1 US 20040131499A1 US 74060903 A US74060903 A US 74060903A US 2004131499 A1 US2004131499 A1 US 2004131499A1
- Authority
- US
- United States
- Prior art keywords
- tubes
- turning table
- tube
- unit
- analytical instrument
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0439—Rotary sample carriers, i.e. carousels
- G01N2035/0453—Multiple carousels working in parallel
- G01N2035/0455—Coaxial carousels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0439—Rotary sample carriers, i.e. carousels
- G01N2035/0458—Multiple concentric rows of wells
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
- Y10T436/114165—Automated chemical analysis with conveyance of sample along a test line in a container or rack with step of insertion or removal from test line
Definitions
- an automatic analytical instrument P of the invention comprises a plurality of specimen tubes 2 , a plurality of storage tubes 4 , a first dispensing unit 6 , a first turning table 8 , a plurality of analytical tubes 10 , a second dispensing unit 12 , a second turning table 14 , an analytical unit 16 , a transferring unit 18 , an delivering unit 20 , a tube supply unit 22 and a control unit 24 .
- the cuvettes 4 , 10 used as the storage tube 4 and the analytical tube 10 can be set in the first turning table 8 and the second turning table 14 by a cuvette supply unit 22 that functions as the tube supply unit.
Abstract
An automatic analytical instrument comprising a plurality of specimen tubes to store specimens, a plurality of storage tubes to store a part of the specimens contained in the specimen tubes by dispensing, a first dispensing unit to dispense the specimens contained in the specimen tubes into the storage tubes, a first turning table to hold a plurality of the storage tubes and transfer them by revolution, a plurality of analytical tubes to store a part of the specimens contained in the storage tubes by dispensing, a second dispensing unit to dispense the specimens contained in the storage tubes into the analytical tubes, a second turning table to hold a plurality of the analytical tubes and transfer them by revolution, an analytical unit to analyze the specimens contained in the analytical tubes, a transfer unit to transfer the analytical tubes held in the second turning table to the analytical unit, an delivering unit to deliver the analytical tubes after analysis is completed, a tube supply unit to supply the storage tubes and the analytical tubes which fall naturally into the first turning table and the second turning table, and a control unit to control dispensing by the first dispensing unit and the second dispensing unit, revolution by the first turning table and the second turning table, analysis by the analytical unit, transfer by the transfer unit, delivery by the delivering unit and supply by the tube supply unit.
Description
- This application is a Divisional of co-pending application Ser. No. 09/568,804, filed on May 11, 2000, the entire contents of which are hereby incorporated by reference and for which priority is claimed under 35 U.S.C. § 120.
- This application is related to Japanese patent applications No. Hei 11(1999)-130666 filed on May 11, 1999 and No. Hei 2000-130369 filed on Apr. 28, 2000 whose priorities are claimed under 35 U.S.C. § 119, the disclosure of which is incorporated herein by reference in its entirety.
- 1. Field of the Invention
- This invention relates to an automatic analytical instrument and, more particularly, to an automatic analytical instrument that dispenses specimens such as blood and urine, and test reagents into storage tubes such as cuvettes and test tubes, allows to react in a reaction unit and optically measures various constituents contained in such specimens at a photometric unit.
- 2. Description of the Related Art
- In general a blood coagulation test or an immunoassay requires analysis of a plurality of items with respect to specimens. For instance, the blood coagulation test requires measurement of various items ranging from basic items including PT (prothrombin time), APTT (Activated Partial Thromboplastin Time), and Fibrinogen to complex factors including TTO (Thrombo Test), HPT (Hepaplastin test), chromogenic agents, FDP (Fibrinogen and fibrin degradation products) and Ddimer by the use of nephelometery.
- Some of the above items include those that have varying reaction conditions such as reaction time and reagent addition time and those that have to use separate photometric units. An analytical instrument that can analyze a number of the above items by the use of random access is desired, but to realize such an instrument, an advanced controlling system is required. Therefore, in recent years, more and more analytical instruments use disposable specimen tubes for reaction and measurement. The reason behind this is that using disposable tubes can dispose of a mechanism for washing the reaction unit and save washing time and that no controls for the above procedure is required.
- An advanced automatic analytical instrument using disposable tubes is disclosed in a Japanese Laid-Open Patents Publication No. Hei 8(1996)-9463. This automatic analytical instrument uses cuvettes (storage tubes) as disposable tubes, transfers these cuvettes one by one from a specimen supply unit, via a reagent supply unit, to a reaction measurement unit following a process flow and conducts each test in each cuvette. Since this analytical instrument can conduct individual tests for each specimen, it is perfect for the blood coagulation test that has items requiring various reaction conditions and varying reaction time.
- In addition, this analytical instrument can conduct reflect measurements, that is, measure specific items or other measured items again depending on the test results. Since at the time of measurement, first, specimens are distributed by being poured into cuvettes once and distributed by pouring into other cuvettes and then measured, the specimens can be stored in the cuvettes. Accordingly, this automatic analytical instrument enables reflect tests to be conducted without storing specimens of a blood collection tube in a sampler and the like until the test results are obtained and in this regard it is innovative.
- However, it is required that in this automatic analytical instrument cuvettes are supplied one by one. In other words, cuvettes are supplied to one by one by a cuvette supplying means (transferring means) disclosed in Japanese Laid-Open Utility Model Publication No. Hei 3(1991)-25157 so that a tube catcher (a turning member) may receive it. I,t is hard to make the supply speed faster than a certain speed owing to mechanical restrictions. Yet, it is undesirable to furnish this automatic analytical instrument with a plurality of cuvette supplying means from the viewpoint of costs and space.
- The objective of this invention is to provide an automatic analytical instrument that can supply simple tubes to fixed positions in a faster and easier way for the purpose of improving the performance of the automatic analytical instrument employing simple tubes such as cuvettes.
- This invention provides an automatic analytical instrument comprising a plurality of specimen tubes to store the specimens, a plurality of storage tubes to store a part of the specimens contained in the specimen tubes by dispensing, a first dispensing unit to dispense the specimens contained in the specimen tubes into the storage tubes, a first turning table to hold a plurality of the storage tubes and transfer them by revolution, a plurality of analytical tubes to store a part of the specimens contained in the storage tubes by dispensing, a second dispensing unit to dispense the specimens contained in the storage tubes into the analytical tubes, a second turning table to hold a plurality of the analytical tubes and transfer them by revolution, an analytical unit to analyze the specimens contained in the analytical tubes, a transferring unit to transfer the analytical tubes held in the second turning table to the analytical unit, an delivering unit to deliver the analytical tubes after analysis is completed, a tube supply unit to supply the storage tubes and the analytical tubes to the first turning table and the second turning table into which they fall naturally, and a control unit to control dispensing by the first dispensing unit and the second dispensing unit, revolution by the first turning table and the second turning table, analysis by the analytical unit, transfer by the transfer unit, delivery by the delivering unit and supply by the tube supply unit.
- Blood collection tubes, for instance, which can stand on racks, are desirable as specimen tubes. It is desired that the identical tubes be used for storage tubes and analytical tubes and so can be interchangeable, and cuvettes that can be held in a turning table are often used as such. Here, cuvettes mean small-sized tubes storing specimens and reagents for the purpose of observing reactions and conducting analysis and there are no restrictions in respect of shapes. A cylinder with a bottom, a rectangular tube with a bottom, a inverted circular cone, an inverted pyramid, and a combination of the above are desirable and are often used. There are no restrictions with respect to the materials of cuvettes, either, but transparent plastic materials are desirable. Cuvettes can be either washed and reused or thrown away after being used.
- The first turning table and the second turning table can respectively hold a plurality of storage tubes and a plurality of analytical tubes in a plurality of holding holes provided on the circumferences and can transfer them by their revolution. The first dispensing unit, the second dispensing unit, the analytical unit, the transferring unit and the delivering unit are provided at prescribed positions in this automatic analytical instrument and composed of known constitution and mechanism.
- The tube supply unit supplies storage tubes and analytical tubes to the first turning table and the second turning table, respectively, without using any of variety of means, such as grasping, moving and then letting them go, by making good use of the weight of tubes and dropping them naturally.
- The control unit controls at least, dispensing by the two dispensing units, revolution by the two turning tables, analysis by the analytical unit, transfer by the transferring unit, delivery by the delivering unit and supply by the tube supplying unit. This control unit consists of a CPU installed inside the main body of this instrument, various control circuits and various driving motors.
- It is desirable that the two turning tables be placed in concentric circles having different diameters. If they are provided as above, installation space and driving motors can be cut down on and miniaturization of the instrument and reduction of cost can be realized.
- FIG. 1 is a plan view of an automatic analytical instrument in accordance with one embodiment of the invention;
- FIG. 2 is a perspective view showing an internal constitution of the automatic analytical instrument shown in FIG. 1;
- FIG. 3 is a plan view showing an internal constitution of the automatic analytical instrument shown in FIG. 1;
- FIG. 4 is a perspective view of a first, a second and a third turning tables constituting the automatic analytical instrument shown in FIG. 1;
- FIG. 5 is a perspective view of a tube supply unit constituting the automatic analytical instrument shown in FIG. 1;
- FIG. 6 is a front view showing a part of the tube supply unit shown in FIG. 5;
- FIG. 7 is a front view showing another part of the tube supply unit shown in FIG. 5;
- FIG. 8 is a perspective view showing a part of the tube supply unit shown in FIG. 5;
- FIG. 9 is a plan view showing a state of a part of the tube supply unit shown in FIG. 5;
- FIG. 10 is a side view showing a state of a part of the tube supply unit shown in FIG. 5;
- FIG. 11 is a plan view showing another state of a part of the tube supply unit shown in FIG. 5; and
- FIG. 12 is a side view showing another state of a part of the tube supply unit shown in FIG. 5;
- The tube supply unit comprises a storage part, a chute and an allocation part. The storage part stores a plurality of storage tubes and/or analytical tubes. The chute is placed below the storage part, and aligns the tubes in the storage part, making them slide down. The allocation part is laid below the chute and holds the tubes that slid down the chute and then supplies them to the first turning table and the second turning table into which they fall naturally.
- If the tube supply unit is composed as above, it can supply the storage tubes and/or analytical tubes to the first turning table and/or the second turning table by making good use of the weight of the tubes and dropping them naturally without using any of a variety of means such as grasping them, transferring them and then letting them go.
- The following is a more specific constitution of the tube supply unit. It comprises the storage part that is composed of a hopper having a hole for passing tubes in the lower part, the chute that is composed of a guide rail running diagonally downwardly from the hole for passing tubes in the hopper and capable of swinging up and down and a shooter connected with the lower part of the guide rail and running diagonally downwardly from it, the allocation part that is composed of the first guide body provided diagonally below the chute, which is capable of swinging from side to side and having a hole for passing tubes in its center and the second guide body provided fixedly diagonally below the first guide body and having a portion for holding tubes in its center and one hole for passing tubes, respectively, at the sides.
- If the tube supply unit is composed as above, a number of aligned storage tubes and/or aligned analytical tubes put in the hopper then slide down the chute from the hole for passing tubes in the hopper by way of the guide rail. A front-running tube is held by the hand for holding tubes in the second guide body after it partially passes the hole for passing tubes in the first guide body. When the first guide body swings either to the left or to the right and its hole for passing tubes and one hole for dropping tubes in the second guide body overlap, this tube drops naturally through the hole for passing tubes and the hole for dropping tubes and lands in one of the holding holes in either the first turning table or the second turning table laid below.
- It is recommended that the two turning tables and the tube supply unit should be placed so that one of the holding holes in the first turning table and in the second turning table may be situated just below one of the holes for dropping tubes in the second guide body and that the other holding hole in the first turning table- and in the second turning table is situated just below the other hole for dropping tubes in the second guide body.
- It is desirable that the control unit can further control the swing of the guide rail and the swing of the first guide body. If it is constituted as above, it can freely control revolution of the first turning table and/or the second turning table and the free fall of the storage tubes and/or analytical tubes.
- It is desirable that in addition to the above the automatic analytical instrument of the invention should have a third turning table to hold a plurality of reagent storage tubes for the purpose of storing various reagents and to transfer them by revolution. It is more desirable that together with the first turning table and the second turning table the third turning table should be provided in concentric circles having different diameters.
- It is desirable that the automatic analytical instrument of the invention should have a heating/cooling unit that heats and/or cools at least one of the first turning table, the second turning table and the third turning table and that it be constituted so that the control unit may further control the heating/cooling unit. Here, an electrical heater is used as the heating unit and a water cooling mechanism is used as the cooling unit. If the automatic analytical instrument is constituted as above, by heating or cooling a desired turning table the tubes held by the turning table can be heated and/or cooled.
- Hereinafter, an explanation is made as to one embodiment of the invention with reference to the drawings. This does not impose any restrictions on the invention.
- Shown in FIG. 1 through FIG. 4, an automatic analytical instrument P of the invention comprises a plurality of
specimen tubes 2, a plurality ofstorage tubes 4, afirst dispensing unit 6, a first turning table 8, a plurality ofanalytical tubes 10, asecond dispensing unit 12, a second turning table 14, ananalytical unit 16, a transferringunit 18, an deliveringunit 20, atube supply unit 22 and acontrol unit 24. - The
specimen tubes 2 are blood collection tubes that contain plasma as specimens, and stand in asample rack 28 set in aright sampler tank 26 situated in the front of and to the right of this automatic analytical instrument P. Thestorage tubes 4 are supplied by thetube supply unit 22 and store a part of the specimen contained in thespecimen tubes 2 by distributing by pouring the specimen into them. Thefirst dispensing unit 6 is designed to dispense the specimen contained in thespecimen tubes 2 into thestorage tubes 4 on the first turning table 8 and comprises afirst pipette 30 and afirst arm 32 to move thefirst pipette 30 horizontally and vertically. The first turning table (primary taking-in loader) 8 is shaped like a ring and holds a plurality ofstorage tubes 4 in a plurality of holdingholes 9 provided on its circumference and transfers them by revolution. The first turning table 8 is designed to take the specimen contained in thespecimen tubes 2 into thestorage tubes 4. - The
analytical tubes 10 are designed to be supplied by thetube supply unit 22 and store a part of the specimens contained in thestorage tubes 4 by distributing by pouring the specimens into them. Thesecond dispensing unit 12 is a unit that dispenses the specimens contained in thestorage tubes 4 on the first turning table 8 into theanalytical tubes 10 on the second turning table 14 and comprises a second pipette 34 and asecond arm 36 to move the second pipette 34 horizontally and vertically. The second turning table (heating loader) 14 is shaped like a ring having a diameter larger than the first turning table 8 and holds a plurality of theanalytical tubes 10 in a plurality of holdingholes 15 on its circumference and transfers them by revolution. The second turning table 14 is heated to be 37±0.5° C. for the purpose of heating theanalytical tubes 10. - The
storage tubes 4 and theanalytical tubes 10 are identical and comprise a cylindrical main body having a bottom and an upper flange whose diameter is larger than that of the main body and made of a disposable, transparent plastic cuvette. - The
analytical unit 16 is a unit that analyzes the specimens contained in theanalytical tubes 10 and comprises acatcher 17 to hold theanalytical tubes 10, a heating table 38 to heat theanalytical tubes 10 and adetector 90. The transferringunit 18 is a unit that transfers theanalytical tubes 10 held in the second turning table 14 to theanalytical unit 16 and comprises acatcher 19 to hold theanalytical tubes 10. - The delivering
unit 20 is a unit that delivers theanalytical tubes 10 after analysis and comprises acatcher 21 to hold theanalytical tubes 10 and abelt 40 to convey theanalytical tubes 10 to thevent 42. Thetube supply unit 22 is a unit that supplies thestorage tubes 4 andanalytical tubes 10 to the first turning table 8 and the second turning table 14 into which they fall naturally. - The
control unit 24 controls dispensing by thefirst dispensing unit 6 and thesecond dispensing unit 12, revolution of the first turning table 8 and the second turning table 14, analysis of theanalytical unit 16, transfer of thetransfer unit 18, delivery of the deliveringunit 20 and supply by thetube supply unit 22. Thecontrol unit 24 contains a CPU, various driving motors and the like provided in the main body of the automatic analytical instrument P. - In addition to the above, this automatic analytical instrument P has a third turning table (holder of diluted solution and clearing fluid)46 to hold a plurality of
tubes storing reagents 44 for the purpose of storing various reagents, diluted solutions and clearing fluids and to transfer them by revolution. The third turning table 46 has a diameter smaller than that of the first turning table 8 and is provided in a concentric configuration together with the first turning table 8 and the second turning table 14. Each of the first turning table 8, the second turning table 14 and the third turning table 46 can independently be revolved by one driving motor. - Various reagents and the like stored in the
tubes storing reagents 44 in the third turning table 46 can be put into thestorage tubes 4 held by the first turning table 8 and/or theanalytical tubes 10 held by the second turning table 14 by the use of a third pipette 50 capable of moving back and forth from side to side horizontally, attached to athird arm 48. - A sampler left
tank 52 is provided to the left of thesampler right tank 26. Asample rack 28 set in thesample right tank 26 is sent into the automatic analytical instrument P automatically. And after the dispensing of the specimen,sample rack 28 is fed out in the sampler lefttank 52. In front of the first turning table 8, the second turning table 14 and the third turning table 46 asample holder 80 for an emergency is set. - A rack set
unit 54 is provided in the left part of the automatic analytical instrument P and a plurality of reagent racks can be set there. In each reagent rack, tubes containing reagents and calibrator controllers can be set appropriately. - Two arms for supplying
reagents reagents 60 are provided in the upper part of the rack setunit 54. - The
cuvettes storage tube 4 and theanalytical tube 10 can be set in the first turning table 8 and the second turning table 14 by acuvette supply unit 22 that functions as the tube supply unit. - As shown in FIG. 5, the
cuvette supply unit 22 comprises ahopper 62 that serves as a storage part, aguide rail 64 and ashooter 66 that serve as a chute and thefirst guide body 68 and thesecond guide body 69 that serve as an allocation part. - The
hopper 62 is a funnel having a hole for passingcuvette 63 in the lower part as a hole for passing tubes and stores a plurality ofcuvettes - The
guide rail 64 runs diagonally downwardly from the hole for passingcuvettes 63 in thehopper 62 and is capable of moving vertically. Explained in more detail, theguide rail 64 is supported by aswing member 72 so that it can move vertically. Theswing member 72 is attached to aswing rod 71 whose one end is supported by ahorizontal axis 65 and the other end is driven by a drivingmotor 70. The internal rail width of theguide rail 64 is larger than a external diameter of the main body of thecuvettes guide rail 64 appears and disappears from the hole for passingcuvettes 63 in thehopper 62 by the movements of theswing rod 71. Thecuvettes hopper 62 are guided downwardly by theguide rail 64 and sent to theshooter 66 with the upper flange facing upwardly and the main body facing downward. Theshooter 66 runs diagonally downwardly, connecting the lower end of theguide rail 64 and has thecuvettes guide rail 64 aligned and sliding down. The drive of theswing rod 71 is controlled by thecontrol unit 24. - The
first guide body 68 comprises aswing board 74 running upwardly along the lower part of theshooter 66 and is capable of moving from side to side, driven by a drivingmotor 73 and acurving guide board 75 attached to the lower end of theswing board 74. Shown in FIG. 6, a hole for passingcuvettes 76 is provided as a hole for passing tubes in the center of theguide board 75. This hole for passingcuvettes 76 is larger than the shape and the size of onecuvette second guide body 69 is provided fixedly diagonally below thefirst guide body 68 and has a portion for holdingcuvettes 77 in the center as a portion for holding tubes and a hole for droppingcuvettes swing board 74 is controlled by thecontrol unit 24. - Shown in FIG. 8, the holes for dropping
cuvettes second guide body 69 are set just above the holdinghole 9 in the first turning table 8 and the holdinghole 15 in the second turning table 14. - Shown in FIG. 9 and FIG. 10, the
first guide body 68 and thesecond guide body 69 hold a fore-running cuvette 4 (10) once, which has slid down theshooter 66 and partially passed the hole for passingcuvettes 76 in theguide board 75 with the portion for holdingcuvettes 77 in thesecond guide body 69. - Next, shown in FIG. 11 and FIG. 12, the
swing board 74 and theconnected guide board 75 vibrate to the right by the drivingmotor 73 and the hole for passingcuvettes 76 in theguide board 75 reaches the hole for droppingcuvettes 79 on thesecond guide body 69. The fore-running cuvette 4 (10) held falls on its own accord from the hole for passingcuvettes 76 in theguide board 75 through the hole for droppingcuvettes 79 in thesecond guide body 69 and is caught in the holdinghole 9 in the first turning table 8 situated below and whose revolution is controlled by thecontrol unit 24. On the other hand, when theswing board 74 and theconnected guide board 75 swing to the left and the hole for passingcuvettes 76 in theguide board 75 reaches the left hole for droppingcuvettes 78 in thesecond guide body 69, the cuvette 4 (10) held in the forefront falls of its own accord from the hole for passingcuvettes 76 in theguide board 75 through the hole for droppingcuvettes 78 in thesecond guide body 69 and is caught in the holdinghole 15 in the second turning table 14 situated below and whose revolution is controlled by thecontrol unit 24. - Next, with reference to FIG. 1 and FIG. 2, an analytical flow of this automatic analytical instrument P is explained. Specimen plasma, which is in a
specimen tube 2 that stands in thesample rack 28 placed in thesampler right tank 26, is sucked by thefirst pipette 30, and is distributed by pouring into the cuvette (the storage tube) 4 set in the first turning table 8. The specimen sucked into thecuvette 4 is distributed by pouring again according to desired analytic items. Namely, for the items requiring a heated specimen, the specimen is distributed by pouring into the cuvette (the analytical tube) 10 set in the heated second turning table 14. For the rest, the specimen is distributed by pouring into theother cuvette 4 set in the non-heated first turning table 8. At that time, a diluted solution is distributed by pouring into it, if necessary. In the second turning table 14, preincuvation of the specimen contained in thecuvette 10 is conducted for a prescribed time. Next, acatcher 19 takes out thecuvette 10 containing the specimen. At this time, if necessary, reagent is added to it byreagent pipette 60. Then, thecuvette 10 is transferred to the heating table 38 and there preincuvation is conducted for a prescribed time. After acatcher 17 takes out thecuvette 10 containing the specimen and the reagent is added to it, the vibrating portion furnished in thecatcher 17 vibrates thecuvette 10 and mixes the specimen. Next, thecuvette 10 is set in a prescribed hole in the photometry unit set at the back and to the left of the main body and analysis (measurement) is conducted. According to the order of analysis, when the analysis of thecuvette 10 is completed, thecuvettes 10 are conveyed onto thebelt 40 by thecatcher 21, and transported to thevent 42. - In this sequence, when the
cuvettes control unit 24 orders thecuvette supply unit 22 to set thecuvettes cuvettes cuvette supply unit 22 can supply thecuvettes pipettes arms cuvettes - When the analytical result is beside the setting valve, a reflect test is conducted to set a predetermined re-measuring item and other related analytical item automatically. The specimen is distributed by pouring again from the
cuvette 4 stored in the first turning table 8. Since the first turning table 8 is separate from the second turning table 14 that conducts preincuvation of the specimen, the specimen can be stored without being heated. If a reflect test is judged to be unnecessary, thecuvette 4 into which the specimen was distributed by pouring will be disposed of by thecatcher 19.
Claims (17)
1. An automatic analytical instrument, comprising:
a first turning table for holding a plurality of tubes;
a second turning table for holding a plurality tubes; and
a tube supply unit for supplying the tubes to the first turning table and the second turning table,
wherein the tube supply unit includes a tube supply part having a hole for supplying the tube to at least one of the first turning table and the second turning table by free fall of the tube, and a transporting part for transporting the tube to the tube supply part.
2. An automatic analytical instrument as set forth in claim 1 , wherein the first turning table and the second turning table are set in concentric circles having different diameters.
3. An automatic analytical instrument as set forth in claim 2 , wherein the first turning table and the second turning table have a plurality of holding holes on their circumference, respectively, to hold the tubes.
4. An automatic analytical instrument as set forth in claim 1 , wherein the transporting part has a storage part for storing the tubes and a chute for making the tubes align and slide down.
5. An automatic analytical instrument as set forth in claim 1 , wherein the tube supply part has a holding part for receiving the tube from the chute and holding the receiving tube.
6. An automatic analytical instrument as set forth in claim 5 , wherein the holding part has an allocation part having two holes for supplying the tube to at least one of the first turning table and the second turning table, the allocation part for allocating the tube to one of two holes.
7. An automatic analytical instrument, comprising:
a turning table for holding a plurality of tubes, and a tube supply unit for supplying the tubes to the turning table,
wherein the tube supply unit includes a tube supply part having a hole for supplying the tube to the turning table by free fall of the tube, and a transporting part for transporting the tube to the tube supply part.
8. An automatic analytical instrument as set forth in claim 1 , comprising:
a first dispensing unit for dispensing specimens from a specimen tube to the tubes in the first turning table;
a second dispensing unit for dispensing specimens from the tubes in the first turning table to the tubes in the second turning table; and
an analytical unit for analyzing specimens in the dispensed tubes.
9. An automatic analytical instrument as set forth in claim 8 , wherein the first and second turning table are set in concentric circles having different diameters. and second turning table have a plurality of holding holes on their circumference, respectively, to hold the tubes.
10. An automatic analytical instrument as set forth in claim 9 , wherein the first and second turning table have a plurality of holding holes on their circumference, respectively, to hold the tubes.
11. An automatic analytical instrument as set forth in claim 8 , wherein the transporting part has a storage part for storing the tubes and a chute for making the tubes align and slide down.
12. An automatic analytical instrument as set forth in claim 8 , wherein the tube supply part has a holding part for receiving the tube from the chute and holding the receiving tube.
13. An automatic analytical instrument as set forth in claim 12 , wherein the holding part has an allocation part which has two holes for supplying the tube to at least one of the first and second turning table, the allocation part for allocating the tube to one of two holes.
14. An automatic analytical instrument as set forth in claim 7 , comprising a dispensing unit for dispensing specimens from a specimen tube to the tubes in the turning table and an analytical unit for analyzing specimens in the dispensed tubes.
15. An automatic analytical instrument as set forth in claim 14 , wherein the turning table has a plurality of holding holes on their circumference to hold the tubes.
16. An automatic analytical instrument as set forth in claim 14 , wherein the transporting part has a storage part for storing the tubes and a chute for making the tubes align and slide down.
17. An automatic analytical instrument as set forth in claim 14 , wherein the tube supply part has a holding part for receiving the tube from the chute and holding the receiving tube.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/740,609 US20040131499A1 (en) | 1999-05-11 | 2003-12-22 | Automatic analytical instrument |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13066699 | 1999-05-11 | ||
JPHEI11-130666 | 1999-05-11 | ||
JP2000130369A JP4451539B2 (en) | 1999-05-11 | 2000-04-28 | Automatic analyzer and container supply device for automatic analyzer |
JP2000-130369 | 2000-04-28 | ||
US09/568,804 US6709634B1 (en) | 1999-05-11 | 2000-05-11 | Automatic analytical instrument |
US10/740,609 US20040131499A1 (en) | 1999-05-11 | 2003-12-22 | Automatic analytical instrument |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/568,804 Division US6709634B1 (en) | 1999-05-11 | 2000-05-11 | Automatic analytical instrument |
Publications (1)
Publication Number | Publication Date |
---|---|
US20040131499A1 true US20040131499A1 (en) | 2004-07-08 |
Family
ID=26465740
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/568,804 Expired - Fee Related US6709634B1 (en) | 1999-05-11 | 2000-05-11 | Automatic analytical instrument |
US10/740,609 Abandoned US20040131499A1 (en) | 1999-05-11 | 2003-12-22 | Automatic analytical instrument |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/568,804 Expired - Fee Related US6709634B1 (en) | 1999-05-11 | 2000-05-11 | Automatic analytical instrument |
Country Status (2)
Country | Link |
---|---|
US (2) | US6709634B1 (en) |
JP (1) | JP4451539B2 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060165560A1 (en) * | 2005-01-21 | 2006-07-27 | Tera Autotech Corporation | Fluid storage and injection mechanism for simultaneous analyzer |
US20060263248A1 (en) * | 2005-05-04 | 2006-11-23 | Gomm Cordell K | Reagent and sample handling device for automatic testing system |
EP2128627A1 (en) * | 2008-05-30 | 2009-12-02 | F.Hoffmann-La Roche Ag | Analyzer for performing medical diagnostic analysis |
US20140079591A1 (en) * | 2012-09-20 | 2014-03-20 | Sysmex Corporation | Specimen analyzer |
CN104076161A (en) * | 2013-03-28 | 2014-10-01 | 希森美康株式会社 | Analyzer and analyzing method |
US20140363259A1 (en) * | 2013-06-11 | 2014-12-11 | Roche Diagnostics Operations, Inc. | Apparatus and method for handling sample tubes and laboratory system |
CN109142772A (en) * | 2018-06-29 | 2019-01-04 | 迈克医疗电子有限公司 | Reaction cup motion path control method and device |
CN109142771A (en) * | 2018-06-29 | 2019-01-04 | 迈克医疗电子有限公司 | Reaction cup pushing block and reaction cup loading device |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4193566B2 (en) * | 2003-05-06 | 2008-12-10 | 東ソー株式会社 | Automatic analyzer |
DE602004004955T2 (en) * | 2003-08-20 | 2007-12-06 | Sysmex Corp. | Sample analyzer and a device for the detection of nucleic acids |
JP4505230B2 (en) * | 2004-01-20 | 2010-07-21 | シスメックス株式会社 | Analysis equipment |
WO2006104006A1 (en) | 2005-03-29 | 2006-10-05 | Sysmex Corporation | Specimen analyzing method and specimen analyzing device |
JP4528814B2 (en) * | 2007-09-10 | 2010-08-25 | 株式会社日立ハイテクノロジーズ | Automatic analyzer and method of operating automatic analyzer |
JP5097522B2 (en) * | 2007-12-07 | 2012-12-12 | 株式会社日立ハイテクノロジーズ | Automatic analyzer |
US8172072B2 (en) * | 2008-06-26 | 2012-05-08 | Horiba, Ltd. | Crucible feeder mechanism |
JP5086918B2 (en) * | 2008-06-26 | 2012-11-28 | 株式会社堀場製作所 | Crucible supply mechanism |
JP5155751B2 (en) * | 2008-06-26 | 2013-03-06 | 株式会社堀場製作所 | Elemental analyzer |
DE102008030330B4 (en) * | 2008-06-30 | 2011-12-08 | Andreas Hettich Gmbh & Co. Kg | Device for feeding sample containers with an analysis sample to be treated to a treatment device |
JP5378284B2 (en) * | 2010-03-29 | 2013-12-25 | シスメックス株式会社 | Container supply device and sample analyzer |
JP6148670B2 (en) * | 2012-06-25 | 2017-06-14 | 協和メデックス株式会社 | Container supply device |
EP3964839B1 (en) | 2013-03-15 | 2024-04-10 | Abbott Laboratories | Automated diagnostic analyzers having rear accessible track systems and related methods |
EP4109106A1 (en) | 2013-03-15 | 2022-12-28 | Abbott Laboratories | Automated diagnostic analyzers having vertically arranged carousels and related methods |
CN105164511B (en) | 2013-03-15 | 2019-03-22 | 雅培实验室 | The automated reagent manager of diagnostic analysis device system |
US9632103B2 (en) | 2013-03-15 | 2017-04-25 | Abbott Laboraties | Linear track diagnostic analyzer |
EP2972402B1 (en) | 2013-03-15 | 2023-12-20 | Abbott Laboratories | Diagnostic analyzers with pretreatment carousels and related methods |
WO2014144870A2 (en) | 2013-03-15 | 2014-09-18 | Abbott Laboratories | Light-blocking system for a diagnostic analyzer |
JP6152311B2 (en) | 2013-07-08 | 2017-06-21 | 日本電子株式会社 | Measuring container supply device |
CN105403719B (en) * | 2015-12-15 | 2018-04-20 | 苏州长光华医生物医学工程有限公司 | A kind of reaction cup auto feed mechanism |
JP6573541B2 (en) * | 2015-12-15 | 2019-09-11 | 日本電子株式会社 | Container supply unit and automatic analyzer |
CN106018784B (en) * | 2016-07-05 | 2019-02-22 | 深圳普门科技股份有限公司 | Small electrical chemical illumination immunity analysis instrument and its analysis method |
JP6684025B2 (en) * | 2016-07-14 | 2020-04-22 | 株式会社日立ハイテク | Automatic analyzer |
EP3755649B1 (en) * | 2018-02-23 | 2023-09-20 | Siemens Healthcare Diagnostics, Inc. | Clinical analyzers and methods for transporting cuvettes |
CN115541907B (en) * | 2022-10-09 | 2023-10-03 | 深圳市国赛生物技术有限公司 | Full-automatic chemiluminescence immunoassay instrument |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4781891A (en) * | 1979-04-14 | 1988-11-01 | Olympus Optical Co., Ltd. | Automatic analyzing apparatus |
US4808380A (en) * | 1986-02-21 | 1989-02-28 | Kabushiki Kaisha Toshiba | Automatic chemical analyzing apparatus |
US5051238A (en) * | 1987-11-20 | 1991-09-24 | Hitachi, Ltd. | Automatic analyzing system |
US5051838A (en) * | 1988-06-22 | 1991-09-24 | Fuji Photo Film Co., Ltd. | Portable electronic copying machine |
US5242659A (en) * | 1991-07-16 | 1993-09-07 | Eastman Kodak Company | Device for feeding objects into a waste bin of an analyzer |
US5482861A (en) * | 1992-03-27 | 1996-01-09 | Abbott Laboratories | Automated continuous and random access analytical system |
US5582796A (en) * | 1991-03-04 | 1996-12-10 | Ciba Corning Diagnostics Corp. | Feed and orientation mechanism in automated analyzer |
US5587129A (en) * | 1994-09-21 | 1996-12-24 | Toa Medical Electronics Co., Ltd. | Apparatus for automatically analyzing specimen |
US5795784A (en) * | 1996-09-19 | 1998-08-18 | Abbott Laboratories | Method of performing a process for determining an item of interest in a sample |
US5876668A (en) * | 1995-01-19 | 1999-03-02 | Joel Ltd. | Automatic biochemical analyzer |
US5882594A (en) * | 1996-06-14 | 1999-03-16 | Tosoh Corporation | Device and method for automatic sample pretreatment |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2745091B2 (en) | 1992-04-03 | 1998-04-28 | 東亞医用電子株式会社 | Immunoagglutination measuring device |
JP3404073B2 (en) | 1993-06-11 | 2003-05-06 | 株式会社ハッコー | Cleaning method for the inner surface of existing pipes |
-
2000
- 2000-04-28 JP JP2000130369A patent/JP4451539B2/en not_active Expired - Fee Related
- 2000-05-11 US US09/568,804 patent/US6709634B1/en not_active Expired - Fee Related
-
2003
- 2003-12-22 US US10/740,609 patent/US20040131499A1/en not_active Abandoned
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4781891A (en) * | 1979-04-14 | 1988-11-01 | Olympus Optical Co., Ltd. | Automatic analyzing apparatus |
US4808380A (en) * | 1986-02-21 | 1989-02-28 | Kabushiki Kaisha Toshiba | Automatic chemical analyzing apparatus |
US5051238A (en) * | 1987-11-20 | 1991-09-24 | Hitachi, Ltd. | Automatic analyzing system |
US5051838A (en) * | 1988-06-22 | 1991-09-24 | Fuji Photo Film Co., Ltd. | Portable electronic copying machine |
US5582796A (en) * | 1991-03-04 | 1996-12-10 | Ciba Corning Diagnostics Corp. | Feed and orientation mechanism in automated analyzer |
US6074615A (en) * | 1991-03-04 | 2000-06-13 | Bayer Corporation | Reagent container for an automated analyzer |
US5242659A (en) * | 1991-07-16 | 1993-09-07 | Eastman Kodak Company | Device for feeding objects into a waste bin of an analyzer |
US5482861A (en) * | 1992-03-27 | 1996-01-09 | Abbott Laboratories | Automated continuous and random access analytical system |
US5587129A (en) * | 1994-09-21 | 1996-12-24 | Toa Medical Electronics Co., Ltd. | Apparatus for automatically analyzing specimen |
US5876668A (en) * | 1995-01-19 | 1999-03-02 | Joel Ltd. | Automatic biochemical analyzer |
US5882594A (en) * | 1996-06-14 | 1999-03-16 | Tosoh Corporation | Device and method for automatic sample pretreatment |
US5795784A (en) * | 1996-09-19 | 1998-08-18 | Abbott Laboratories | Method of performing a process for determining an item of interest in a sample |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060165560A1 (en) * | 2005-01-21 | 2006-07-27 | Tera Autotech Corporation | Fluid storage and injection mechanism for simultaneous analyzer |
US20060263248A1 (en) * | 2005-05-04 | 2006-11-23 | Gomm Cordell K | Reagent and sample handling device for automatic testing system |
US7628954B2 (en) | 2005-05-04 | 2009-12-08 | Abbott Laboratories, Inc. | Reagent and sample handling device for automatic testing system |
US20100111765A1 (en) * | 2005-05-04 | 2010-05-06 | Abbott Laboratories | Reagent and sample handling device for automatic testing system |
US10191072B2 (en) | 2005-05-04 | 2019-01-29 | Abbott Laboratories | Reagent and sample handling device for automatic testing system |
US9057714B2 (en) | 2005-05-04 | 2015-06-16 | Abbott Laboratories | Reagent and sample handling device for automatic testing system |
EP2128627A1 (en) * | 2008-05-30 | 2009-12-02 | F.Hoffmann-La Roche Ag | Analyzer for performing medical diagnostic analysis |
WO2009144020A1 (en) * | 2008-05-30 | 2009-12-03 | Roche Diagnostics Gmbh | Analyzer for performing medical diagnostic analysis |
US8431079B2 (en) | 2008-05-30 | 2013-04-30 | Roche Diagnostics Operations, Inc. | Analyzer for performing medical diagnostic analysis |
US9285383B2 (en) * | 2012-09-20 | 2016-03-15 | Sysmex Corporation | Specimen analyzer |
US20140079591A1 (en) * | 2012-09-20 | 2014-03-20 | Sysmex Corporation | Specimen analyzer |
CN104076161A (en) * | 2013-03-28 | 2014-10-01 | 希森美康株式会社 | Analyzer and analyzing method |
US9671417B2 (en) | 2013-03-28 | 2017-06-06 | Sysmex Corporation | Analyzer and analyzing method |
US9562919B2 (en) * | 2013-06-11 | 2017-02-07 | Roche Diagnostics Operations, Inc. | Apparatus and method for handling sample tubes and laboratory system |
US20140363259A1 (en) * | 2013-06-11 | 2014-12-11 | Roche Diagnostics Operations, Inc. | Apparatus and method for handling sample tubes and laboratory system |
CN109142772A (en) * | 2018-06-29 | 2019-01-04 | 迈克医疗电子有限公司 | Reaction cup motion path control method and device |
CN109142771A (en) * | 2018-06-29 | 2019-01-04 | 迈克医疗电子有限公司 | Reaction cup pushing block and reaction cup loading device |
Also Published As
Publication number | Publication date |
---|---|
JP2001027643A (en) | 2001-01-30 |
US6709634B1 (en) | 2004-03-23 |
JP4451539B2 (en) | 2010-04-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6709634B1 (en) | Automatic analytical instrument | |
EP0703456B1 (en) | Apparatus and method for automatically analyzing specimen | |
US7842237B1 (en) | Automatic analyzer and rack transfer device | |
EP1381871B1 (en) | Method and system for automated immunochemistry analysis | |
US5434083A (en) | Method and apparatus for automatically analyzing a plurality of test items | |
JP4299403B2 (en) | Automatic analyzer | |
CN103674672B (en) | Analytical equipment and agitating device | |
JPH09503060A (en) | Automatic continuous random access analysis system and its components | |
EP1543334B1 (en) | Increasing throughput of an automatic clinical analyzer system by partitioning assays according to frequency of requested performance | |
EP0984284A3 (en) | Apparatus for use in automated analyzer | |
TR201806894T4 (en) | APPARATUS FOR AUTOMATIC CLINICAL ANALYSIS OF SAMPLES. | |
JP2007322287A (en) | Autoanalyer | |
JP2009008552A (en) | Automatic analysis apparatus and dispensing method for automatic analysis apparatus | |
JP6651380B2 (en) | Clinical test equipment | |
JP2004271265A (en) | Automatic analyzer | |
JP3990943B2 (en) | Automatic analysis system | |
JP2011522232A (en) | Unit for loading and identifying a biological sample and integrated device including the unit | |
JPH0266461A (en) | Automatic analyzer | |
JP3325338B2 (en) | Sample test equipment | |
JP2011013127A (en) | Automatic analyzer and control method of the same | |
JPH03279863A (en) | Automatic analysis apparatus | |
JPWO2020152991A1 (en) | Automatic analysis system and sample transport method | |
JPH06105259B2 (en) | Sample container transfer device | |
WO2021131296A1 (en) | Automatic analysis device and control program for automatic analysis device | |
JP4567776B2 (en) | Automatic analyzer |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: SYSMEX CORPORATION, JAPAN Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:RYUSYO INDUSTRIAL CO., LTD.;SYSMEX CORPORATION;REEL/FRAME:015739/0544 Effective date: 20040209 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |