Our results provide new insights into the interplay between the NF-κB and p53 pathway and help to gain a more comprehensive understanding of the crosstalk.
Jun 26, 2020 · We developed a systematic approach to identify potential interactions between the pathways. We perturbed NF-κB signaling by inhibiting IKK2, a critical ...
Jun 26, 2020 · Here, we developed a systematic approach to identify potential interactions between the pathways. We perturbed NF-κB signaling by inhibiting ...
Single cell trajectories are clustered into subpopulations with similar dynamics (upper left panel). For each cluster, a peak-based mean is calculated.
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A systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics. Click here to expand; Fabian Konrath, Anna Mittermeier ...
In this review, we highlight examples of mathematical models of signalling pathways that regulate disease-relevant cell fate decisions.
A systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics. Article. Full-text available. Jun 2020; PLOS COMPUT BIOL.
The dynamics of p53 expression provide a mechanism to increase differentiation between cellular stresses and specificity in appropriate responses.
This study quantified the dynamics of p53 in individual cells in response to UV and observed a single pulse that increases in amplitude and duration in ...
In this review, we focused on how stresses are encoded into p53 dynamics and how the dynamics are decoded into cellular outcomes. Theoretical modeling may ...