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Trichostatin A, Tocris Bioscience™

Catalog Number 14061
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Quantity:
1 mg
This item is not returnable. View return policy
58880-19-6
C17H22N2O3
302.37
MFCD03848392
RTKIYFITIVXBLE-WKWSCTOINA-N
trichostatin a, trichostatin a tsa, trichostatin, tsa, unii-3x2s926l3z, 2e,4e,6r-7-4-dimethylamino phenyl-n-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide, gnf-pf-1011, 2,4-heptadienamide, 7-4-dimethylamino phenyl-n-hydroxy-4,6-dimethyl-7-oxo, 7-4-dimethylamino phenyl-n-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide, r-e,e-7-4-dimethylamino phenyl-n-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
444732
CHEBI:46024
(2E,4E)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide
CC(\C=C(/C)\C=C\C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
This item is not returnable. View return policy
58880-19-6
C17H22N2O3
302.37
MFCD03848392
RTKIYFITIVXBLE-WKWSCTOINA-N
trichostatin a, trichostatin a tsa, trichostatin, tsa, unii-3x2s926l3z, 2e,4e,6r-7-4-dimethylamino phenyl-n-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide, gnf-pf-1011, 2,4-heptadienamide, 7-4-dimethylamino phenyl-n-hydroxy-4,6-dimethyl-7-oxo, 7-4-dimethylamino phenyl-n-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide, r-e,e-7-4-dimethylamino phenyl-n-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
444732
CHEBI:46024
(2E,4E)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide
CC(\C=C(/C)\C=C\C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C

Description

Potent histone deacetylase inhibitor

Trichostatin A is a selective and potent inhibitor of class I and II histone deacetylases (HDAC) (Ki = 3.4 nM, IC50 values are 4.99 nM, 5.21 nM, 16.4 nM, 24.3 nM, 27.6 nM for HDAC1, 3, 6, 10 and 4, respectively). Trichostatin A induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells. Trichostatin A potently inhibits a range of breast cancer and melanoma cell lines (IC50 = 29-400 nM) and induces apoptosis in prostate cancer cells. In an animal model of Huntington's disease, inhibition of HDAC by Trichostatin A rescues memory deficits and increases expression of CREB/CBP target genes in mutant mice. Activates autophagy, increases vesicular transport of BDNF (Cat. No. 2837) and is active in vivo.
Quantity 1 mg
Formula Weight 302.37
Percent Purity 97%
Chemical Name or Material Trichostatin A

Safety and Handling

Recommended Storage Desiccate at -20°C
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