About
A strategic and collaborative leader with 17 years of experience in clinical pharmacology…
Activity
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(An, 4/26/2024) Just received this thank you card from PharmD class 2027 minutes ago. My heart melted. I have never received a card with this many…
(An, 4/26/2024) Just received this thank you card from PharmD class 2027 minutes ago. My heart melted. I have never received a card with this many…
Liked by Li Yan
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(An, 5/7/2024) With immense joy, I would like to share that my single-author PK textbook (“Essentials in Clinical Pharmacokinetics - Concepts, Dose…
(An, 5/7/2024) With immense joy, I would like to share that my single-author PK textbook (“Essentials in Clinical Pharmacokinetics - Concepts, Dose…
Liked by Li Yan
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The new FDA CDER Quantitative Medicine Center of Excellence now has a website. Feel free to have a look. More to come 👇🏼 https://lnkd.in/eFDAEyYZ
The new FDA CDER Quantitative Medicine Center of Excellence now has a website. Feel free to have a look. More to come 👇🏼 https://lnkd.in/eFDAEyYZ
Liked by Li Yan
Experience
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Education
Publications
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Pharmacodynamic modeling and exposure-response assessment of inebilizumab in subjects with neuromyelitis optica spectrum disorders
British Journal of Clinical Pharmacology
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Benralizumab for PDGFRA-Negative Hypereosinophilic Syndrome
The New England Journal of Medicine
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Population Modeling of Prebronchodilator FEV1 Response to Benralizumab Treatment in Patients With Severe Asthma
ACoP2017
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Population pharmacokinetics and pharmacodynamics of benralizumab in healthy volunteers and patients with asthma
CPT Pharmacometrics Syst Pharmacol
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Population pharmacokinetics of piperaquine in young Ugandan children treated with dihydroartemisinin-piperaquine for uncomplicated malaria.
Clinical Pharmacology & Therapeutics
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Predictions of hepatic disposition properties using a mechanistically realistic, physiologically based model
Drug Metab Dispos. 36(4):759-68.
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The multiscale in silico liver
Journal of Critical Care. 22(4), 348-349
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Physiologically based synthetic models of hepatic disposition.
J Pharmacokinet Pharmacodyn. 33(6):737-72
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Role of Arg163 in the N-Glycosidase activity of neo-Trichosanthin.
Protein Eng. 12(11):999-1004
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Role of TYR70 in the N-glycosidase activity of neo-trichosanthin
Toxicon 37(7), 961-972
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Crystal structure of neo-Trichosanthin and its site-directed mutant Y70A neo-Trichosanthin.
Acta Biophysica Sinica. 15, 33-39.
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A Conformational Study on the Interaction of Saporin-S6 with Phospholipid Vesicles
Chemical Research in Chinese Universities 14(1), 42-45
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Fluorescence spectroscopic study of the interaction of Saporin with phospholipid vesicles
Mol Membr Biol. 14(1), 19-23
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Aggregation of phospholipid vesicles induced by the ribosome inactivating protein Saporin.
Biochem Mol Biol Int. 38(4), 701-709
More activity by Li
Today we announced that the first participant has been dosed in our Phase 1 clinical trial of A-005, a potential first-in-class, CNS penetrant TYK2…
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Today we announced that the first participant has been dosed in our Phase 1 clinical trial of A-005, a potential first-in-class, CNS penetrant TYK2…
Liked by Li Yan
Friday, April 26th, was my last day at Amgen, Inc. I will miss my Horizon colleagues that are still with Amgen and those that have moved on too! The…
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Friday, April 26th, was my last day at Amgen, Inc. I will miss my Horizon colleagues that are still with Amgen and those that have moved on too! The…
Liked by Li Yan
Is it just me or is R moving towards being more and more unreadable? The latest version of R (ver 4.4.0) has been released and in it they adapt a…
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Is it just me or is R moving towards being more and more unreadable? The latest version of R (ver 4.4.0) has been released and in it they adapt a…
Liked by Li Yan
I am pleased to co-chair with Dr. Nan Zheng from US FDA on Sept 10, 2024 in Symposium 15: Project Optimus: A Paradigm Shift in Quantitative Clinical…
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I am pleased to co-chair with Dr. Nan Zheng from US FDA on Sept 10, 2024 in Symposium 15: Project Optimus: A Paradigm Shift in Quantitative Clinical…
Liked by Li Yan
I frequently get asked about FDA’s views on AI. While we’ve discussed the use of #AI internally to #FDA operations in our FDA IT strategy and…
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I frequently get asked about FDA’s views on AI. While we’ve discussed the use of #AI internally to #FDA operations in our FDA IT strategy and…
Liked by Li Yan
Welcome to Spring to all my (Northern Hemisphere) LinkedIn network. Early in the year, I shared with you the url for my YouTube video “The…
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Welcome to Spring to all my (Northern Hemisphere) LinkedIn network. Early in the year, I shared with you the url for my YouTube video “The…
Liked by Li Yan
Beyond excited for the opportunity to interact, network and learn from the medical affairs community next few days! Looking forward to gaining…
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Beyond excited for the opportunity to interact, network and learn from the medical affairs community next few days! Looking forward to gaining…
Liked by Li Yan
This manuscript summarizes the first case where pediatric extrapolation approach was applied to support the FDA approval of an atypical antipsychotic…
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This manuscript summarizes the first case where pediatric extrapolation approach was applied to support the FDA approval of an atypical antipsychotic…
Liked by Li Yan
The AACR and the U.S. FDA Office of Clinical Pharmacology are hosting a workshop to discuss dosage optimization for oncology drug products, chaired…
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The AACR and the U.S. FDA Office of Clinical Pharmacology are hosting a workshop to discuss dosage optimization for oncology drug products, chaired…
Liked by Li Yan
Hello, UCSF Alumni! Great news, please spread the word. Thanks!
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Hello, UCSF Alumni! Great news, please spread the word. Thanks!
Liked by Li Yan
On February 15-16, the FDA Office of Clinical Pharmacology, in collaboration with American Association for Cancer Research, will hold a hybrid…
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On February 15-16, the FDA Office of Clinical Pharmacology, in collaboration with American Association for Cancer Research, will hold a hybrid…
Liked by Li Yan
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